{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:09:22Z","timestamp":1792789762465,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI137793"],"award-info":[{"award-number":["R21AI137793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N0175N92020C00005"],"award-info":[{"award-number":["N0175N92020C00005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI133486"],"award-info":[{"award-number":["R01AI133486"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI135912"],"award-info":[{"award-number":["R21AI135912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007035"],"award-info":[{"award-number":["T32HL007035"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TL1TR001410"],"award-info":[{"award-number":["TL1TR001410"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.stemcr.2022.08.003","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T10:26:25Z","timestamp":1662632785000},"page":"2286-2302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes"],"prefix":"10.1016","volume":"17","author":[{"given":"Whitney A.","family":"Scoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Mancio-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L.","family":"Suder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Villacorta-Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Lindstrom-Vautrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Bernbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Mazur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed F.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Olejnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Y.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Mithal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Hume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Kaserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"March-Riera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta N.","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"M\u00fchlberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Mostoslavsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2022.08.003_bib1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41586-018-0409-3","article-title":"Genetic and transcriptional evolution alters cancer cell line drug response","volume":"560","author":"Ben-David","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2022.08.003_bib2","doi-asserted-by":"crossref","first-page":"14481","DOI":"10.1073\/pnas.241349398","article-title":"A transcription factor regulatory circuit in differentiated pancreatic cells","volume":"98","author":"Boj","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2022.08.003_bib3","doi-asserted-by":"crossref","first-page":"e00297-20","DOI":"10.1128\/JVI.00297-20","article-title":"Interferon-induced protein 44 and interferon-induced protein 44-like restrict replication of respiratory syncytial virus","volume":"94","author":"Busse","year":"2020","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib4","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1186\/s12864-016-3060-0","article-title":"In\u00a0vivo Ebola virus infection leads to a strong innate response in circulating immune cells","volume":"17","author":"Caballero","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.stemcr.2022.08.003_bib5","doi-asserted-by":"crossref","first-page":"11548","DOI":"10.1128\/JVI.01773-12","article-title":"Viperin, MTAP44, and protein kinase R contribute to the interferon-induced inhibition of Bunyamwera Orthobunyavirus replication","volume":"86","author":"Carlton-Smith","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib6","doi-asserted-by":"crossref","first-page":"1910442","DOI":"10.1002\/adfm.201910442","article-title":"Controlled apoptosis of stromal cells to engineer human microlivers","volume":"30","author":"Chen","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.stemcr.2022.08.003_bib7","doi-asserted-by":"crossref","first-page":"S169","DOI":"10.1093\/infdis\/jiw216","article-title":"Ebola laboratory response at the eternal love winning africa campus, monrovia, Liberia, 2014-2015","volume":"214","author":"de Wit","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.stemcr.2022.08.003_bib8","doi-asserted-by":"crossref","first-page":"946","DOI":"10.2174\/1389200211314090002","article-title":"Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering","volume":"14","author":"Donato","year":"2013","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.stemcr.2022.08.003_bib9","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(10)60667-8","article-title":"Ebola haemorrhagic fever","volume":"377","author":"Feldmann","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.stemcr.2022.08.003_bib10","doi-asserted-by":"crossref","first-page":"E3831","DOI":"10.3390\/ijms21113831","article-title":"Human PSC-derived hepatocytes express low levels of viral pathogen recognition receptors, but are capable of mounting an effective innate immune response","volume":"21","author":"Fischer","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.stemcr.2022.08.003_bib11","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(03)15012-X","article-title":"Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa\/tissue factor: a study in rhesus monkeys","volume":"362","author":"Geisbert","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.stemcr.2022.08.003_bib12","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1016\/S0002-9440(10)63591-2","article-title":"Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection","volume":"163","author":"Geisbert","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib13","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1086\/379724","article-title":"Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes\/macrophages is a key event","volume":"188","author":"Geisbert","year":"2003","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.stemcr.2022.08.003_bib14","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1016\/S0002-9440(10)63592-4","article-title":"Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells","volume":"163","author":"Geisbert","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib15","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.ajpath.2020.03.003","article-title":"Quantification of viral and host biomarkers in the liver of rhesus macaques: a longitudinal study of Zaire ebolavirus strain kikwit (EBOV\/Kik)","volume":"190","author":"Greenberg","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.chom.2018.01.002","article-title":"In\u00a0vitro culture, drug sensitivity, and transcriptome of plasmodium vivax hypnozoites","volume":"23","author":"Gural","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.stemcr.2022.08.003_bib17","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.1128\/JVI.00215-08","article-title":"Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein","volume":"82","author":"Hartman","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib18","doi-asserted-by":"crossref","first-page":"34589","DOI":"10.1038\/srep34589","article-title":"Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells","volume":"6","author":"H\u00f6lzer","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2022.08.003_bib19","doi-asserted-by":"crossref","first-page":"e1010268","DOI":"10.1371\/journal.ppat.1010268","article-title":"Recombinant Lloviu virus as a tool to study viral replication and host responses","volume":"18","author":"Hume","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.stemcr.2022.08.003_bib20","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.pharmthera.2007.09.004","article-title":"Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects","volume":"116","author":"Ingelman-Sundberg","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.stemcr.2022.08.003_bib21","doi-asserted-by":"crossref","first-page":"e00250-20","DOI":"10.1128\/JVI.00250-20","article-title":"Early transcriptional changes within liver, adrenal gland, and lymphoid tissues significantly contribute to ebola virus pathogenesis in cynomolgus macaques","volume":"94","author":"Jankeel","year":"2020","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib22","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.isci.2019.07.003","article-title":"The FDA-approved oral drug nitazoxanide amplifies host antiviral responses and inhibits ebola virus","volume":"19","author":"Jasenosky","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.stemcr.2022.08.003_bib23","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1128\/JVI.80.6.3009-3020.2006","article-title":"Global suppression of the host antiviral response by Ebola- and Marburgviruses: increased antagonism of the type I interferon response is associated with enhanced virulence","volume":"80","author":"Kash","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nbt1361","article-title":"Microscale culture of human liver cells for drug development","volume":"26","author":"Khetani","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib25","first-page":"353","article-title":"Inside the cell: assembly of filoviruses","volume":"411","author":"Kolesnikova","year":"2017","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib26","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.cell.2020.10.002","article-title":"Single-cell profiling of ebola virus disease in\u00a0vivo reveals viral and host dynamics","volume":"183","author":"Kotliar","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2022.08.003_bib27","doi-asserted-by":"crossref","first-page":"e02471-16","DOI":"10.1128\/JVI.02471-16","article-title":"Innate immune responses of bat and human cells to filoviruses: commonalities and distinctions","volume":"91","author":"Kuzmin","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib28","doi-asserted-by":"crossref","first-page":"5L","DOI":"10.1016\/S0002-9149(00)01461-2","article-title":"The metabolic pathways of high-density lipoprotein, low-density lipoprotein, and triglycerides: a current review","volume":"86","author":"Kwiterovich","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.stemcr.2016.07.012","article-title":"Modeling dengue virus-hepatic cell interactions using human pluripotent stem cell-derived hepatocyte-like cells","volume":"7","author":"Lang","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2022.08.003_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/cid\/cix704","article-title":"Relationship between viremia and specific organ damage in ebola patients: a cohort study","volume":"66","author":"Lanini","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.stemcr.2022.08.003_bib31","doi-asserted-by":"crossref","first-page":"16739","DOI":"10.1074\/jbc.M414139200","article-title":"Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes","volume":"280","author":"Li","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2022.08.003_bib32","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2022.08.003_bib33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13059-016-1137-3","article-title":"Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus","volume":"18","author":"Liu","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib34","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1038\/nprot.2015.128","article-title":"Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens","volume":"10","author":"March","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stemcr.2022.08.003_bib35","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1038\/mt.2008.201","article-title":"Inhibition of the IFN-beta response in hepatocellular carcinoma by alternative spliced isoform of IFN regulatory factor-3","volume":"16","author":"Marozin","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.stemcr.2022.08.003_bib36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/path.4456","article-title":"Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses","volume":"235","author":"Martines","year":"2015","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib37","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/cid\/ciw334","article-title":"Kinetic analysis of biomarkers in a cohort of US patients with ebola virus disease","volume":"63","author":"McElroy","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.stemcr.2022.08.003_bib38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.coviro.2018.01.010","article-title":"Immune barriers of Ebola virus infection","volume":"28","author":"McElroy","year":"2018","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib39","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1073\/pnas.1919035117","article-title":"Expansion, in\u00a0vivo-ex\u00a0vivo cycling, and genetic manipulation of primary human hepatocytes","volume":"117","author":"Michailidis","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2022.08.003_bib40","doi-asserted-by":"crossref","first-page":"e00179-17","DOI":"10.1128\/JVI.00179-17","article-title":"Ebolaviruses associated with differential pathogenicity induce distinct host responses in human macrophages","volume":"91","author":"Olejnik","year":"2017","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib41","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.stemcr.2016.12.017","article-title":"A comprehensive, ethnically diverse library of sickle cell disease-specific induced pluripotent stem cells","volume":"8","author":"Park","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2022.08.003_bib42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.virol.2015.02.046","article-title":"IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency","volume":"481","author":"Power","year":"2015","journal-title":"Virology"},{"key":"10.1016\/j.stemcr.2022.08.003_bib43","doi-asserted-by":"crossref","first-page":"S364","DOI":"10.1086\/520613","article-title":"Blood chemistry measurements and D-Dimer levels associated with fatal and nonfatal outcomes in humans infected with Sudan Ebola virus","volume":"196","author":"Rollin","year":"2007","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.stemcr.2022.08.003_bib44","doi-asserted-by":"crossref","first-page":"45698","DOI":"10.1038\/srep45698","article-title":"Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in\u00a0vitro model of human hepatitis B virus infection","volume":"7","author":"Sakurai","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2022.08.003_bib45","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1073\/pnas.1121400109","article-title":"Modeling hepatitis C virus infection using human induced pluripotent stem cells","volume":"109","author":"Schwartz","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2022.08.003_bib46","doi-asserted-by":"crossref","first-page":"12193","DOI":"10.1073\/pnas.1412631111","article-title":"Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems","volume":"111","author":"Shlomai","year":"2014","journal-title":"Proc. Natl. Acad. Sci.\u00a0USA"},{"key":"10.1016\/j.stemcr.2022.08.003_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/v11070647","article-title":"Haemostatic changes in five patients infected with ebola virus","volume":"11","author":"Smither","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.stemcr.2022.08.003_bib48","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/stem.495","article-title":"Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette","volume":"28","author":"Somers","year":"2010","journal-title":"Stem Cell."},{"key":"10.1016\/j.stemcr.2022.08.003_bib49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.virol.2004.10.048","article-title":"Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening","volume":"332","author":"Towner","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.stemcr.2022.08.003_bib50","doi-asserted-by":"crossref","first-page":"e0209097","DOI":"10.1371\/journal.pone.0209097","article-title":"Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals","volume":"13","author":"Tricot","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2022.08.003_bib51","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1056\/NEJMoa1504874","article-title":"Clinical management of ebola virus disease in the United States and europe","volume":"374","author":"Uyeki","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.stemcr.2022.08.003_bib52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12014-019-9227-3","article-title":"Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison","volume":"16","author":"Ward","year":"2019","journal-title":"Clin. Proteomics"},{"key":"10.1016\/j.stemcr.2022.08.003_bib53","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.stemcr.2015.02.021","article-title":"Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells","volume":"4","author":"Wilson","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2022.08.003_bib54","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1126\/science.aau7307","article-title":"Long-term functional maintenance of primary human hepatocytes in\u00a0vitro","volume":"364","author":"Xiang","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2022.08.003_bib55","first-page":"97","article-title":"Pathologic features of filovirus infections in humans","volume":"235","author":"Zaki","year":"1999","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.stemcr.2022.08.003_bib56","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.stemcr.2014.04.018","article-title":"Modulating innate immunity improves hepatitis C virus infection and replication in stem cell-derived hepatocytes","volume":"3","author":"Zhou","year":"2014","journal-title":"Stem Cell Rep."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221367112200412X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221367112200412X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:48:25Z","timestamp":1761990505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221367112200412X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S221367112200412X"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2022.08.003","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2022.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}]}}