{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:34:13Z","timestamp":1783344853491,"version":"3.54.6"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:00:00Z","timestamp":1672963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016067","name":"Fondation Charles-Bruneau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016067","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019683","name":"Cole Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["HB2-164064"],"award-info":[{"award-number":["HB2-164064"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005241","name":"Institut de Recherche Clinique De Montr\u00e9al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.stemcr.2023.01.003","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T10:56:46Z","timestamp":1675335406000},"page":"597-612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Generation of functional human T\u00a0cell development in NOD\/SCID\/IL2r\u03b3null humanized mice without using fetal tissue: Application as a model of HIV infection and persistence"],"prefix":"10.1016","volume":"18","author":[{"given":"Chlo\u00e9","family":"Colas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Volodina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathie","family":"B\u00e9land","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tram N.Q.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Dallaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Soulard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Lemieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien B.L.","family":"Colamartino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Tremblay-Lagani\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e","family":"Dicaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Guimond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Vobecky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Poirier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Patey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric A.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2446-6879","authenticated-orcid":false,"given":"Elie","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2023.01.003_bib1","doi-asserted-by":"crossref","first-page":"7305","DOI":"10.1128\/JVI.02207-08","article-title":"Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice","volume":"83","author":"Brainard","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib2","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.stemcr.2018.02.011","article-title":"A humanized mouse model generated using surplus neonatal tissue","volume":"10","author":"Brown","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2023.01.003_bib3","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.3389\/fimmu.2019.02873","article-title":"Efficient and robust NK-cell transduction with baboon envelope pseudotyped lentivector","volume":"10","author":"Colamartino","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib4","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1038\/s41467-019-10366-y","article-title":"Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice","volume":"10","author":"Dash","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2023.01.003_bib5","first-page":"135","article-title":"Humanized mouse models of HIV infection","volume":"13","author":"Denton","year":"2011","journal-title":"AIDS Rev."},{"key":"10.1016\/j.stemcr.2023.01.003_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2012.03.009","article-title":"Humanized mice: current states and perspectives","volume":"146","author":"Garcia","year":"2012","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.stemcr.2023.01.003_bib7","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1182\/blood-2014-02-558163","article-title":"Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs","volume":"124","author":"Girard-Gagnepain","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2023.01.003_bib8","first-page":"3646","article-title":"Long-term immune reconstitution and outcome after HLA-nonidentical T-cell-depleted bone marrow transplantation for severe combined immunodeficiency: a European retrospective study of 116 patients","volume":"91","author":"Haddad","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2023.01.003_bib9","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.cell.2014.07.043","article-title":"Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice","volume":"158","author":"Halper-Stromberg","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2023.01.003_bib10","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nrmicro2911","article-title":"Animal models for HIV\/AIDS research","volume":"10","author":"Hatziioannou","year":"2012","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib11","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nbt.1663","article-title":"Human hematopoietic stem\/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in\u00a0vivo","volume":"28","author":"Holt","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib12","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1128\/JVI.02339-09","article-title":"Inhibition of in\u00a0vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody","volume":"84","author":"Joseph","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib13","doi-asserted-by":"crossref","first-page":"125ra130","DOI":"10.1126\/scitranslmed.3003481","article-title":"A model for personalized in\u00a0vivo analysis of human immune responsiveness","volume":"4","author":"Kalscheuer","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stemcr.2023.01.003_bib14","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.celrep.2017.09.080","article-title":"In\u00a0vivo suppression of HIV rebound by didehydro-cortistatin A, a \u201cBlock-and-Lock\u201d strategy for HIV-1 treatment","volume":"21","author":"Kessing","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2023.01.003_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1182\/blood-2005-11-4388","article-title":"Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus\/liver and CD34+ cell transplantation","volume":"108","author":"Lan","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2023.01.003_bib16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.12717\/DR.2019.23.2.079","article-title":"T lymphocyte development and activation in humanized mouse model","volume":"23","author":"Lee","year":"2019","journal-title":"Dev. Reprod."},{"key":"10.1016\/j.stemcr.2023.01.003_bib17","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1111\/j.1600-6143.2008.02301.x","article-title":"Factors affecting success of thymus transplantation for complete DiGeorge anomaly","volume":"8","author":"Markert","year":"2008","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.stemcr.2023.01.003_bib18","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.clim.2010.02.007","article-title":"Thymus transplantation","volume":"135","author":"Markert","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib19","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1182\/blood-2002-08-2545","article-title":"Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients","volume":"102","author":"Markert","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2023.01.003_bib20","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0301-472X(03)00193-0","article-title":"Functional CD5+ B cells develop predominantly in the spleen of NOD\/SCID\/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells","volume":"31","author":"Matsumura","year":"2003","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib21","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1099\/0022-1317-68-8-2253","article-title":"Small animals are not susceptible to human immunodeficiency virus infection","volume":"68","author":"Morrow","year":"1987","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41586-020-1951-3","article-title":"Systemic HIV and SIV latency reversal via non-canonical NF-kappaB signalling in\u00a0vivo","volume":"578","author":"Nixon","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2023.01.003_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/157016212799304689","article-title":"Mucosal transmission of human immunodeficiency virus","volume":"10","author":"Tebit","year":"2012","journal-title":"Curr. HIV Res."},{"key":"10.1016\/j.stemcr.2023.01.003_bib24","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12977-016-0268-7","article-title":"In\u00a0vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection","volume":"13","author":"Tsai","year":"2016","journal-title":"Retrovirology"},{"key":"10.1016\/j.stemcr.2023.01.003_bib25","doi-asserted-by":"crossref","first-page":"12385","DOI":"10.1128\/JVI.00609-14","article-title":"Cross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studies","volume":"88","author":"Vandergeeten","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coviro.2016.06.010","article-title":"Humanized mice for HIV and AIDS research","volume":"19","author":"Victor Garcia","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.stemcr.2023.01.003_bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1182\/blood-2006-04-017681","article-title":"Hematopoietic stem cell-engrafted NOD\/SCID\/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses","volume":"109","author":"Watanabe","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2023.01.003_bib28","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1172\/JCI89488","article-title":"Targeting type I interferon-mediated activation restores immune function in chronic HIV infection","volume":"127","author":"Zhen","year":"2017","journal-title":"J.\u00a0Clin. Invest."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671123000061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671123000061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:50:51Z","timestamp":1761990651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671123000061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2213671123000061"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2023.01.003","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.05.30.494009","asserted-by":"object"}]},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of functional human T\u00a0cell development in NOD\/SCID\/IL2r\u03b3null humanized mice without using fetal tissue: Application as a model of HIV infection and persistence","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2023.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}]}}