{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:53:47Z","timestamp":1793199227468,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003107","name":"German Federal Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["PRAEDIKARD FKZ031L0236"],"award-info":[{"award-number":["PRAEDIKARD FKZ031L0236"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/16\/14\/32397"],"award-info":[{"award-number":["RG\/16\/14\/32397"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/16\/3\/3240 6"],"award-info":[{"award-number":["CH\/16\/3\/3240 6"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG Es 88\/12-1"],"award-info":[{"award-number":["DFG Es 88\/12-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG HA 3423\/5-1"],"award-info":[{"award-number":["DFG HA 3423\/5-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001838","name":"The Ministry of Economic Affairs and Employment","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001838","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.stemcr.2023.09.002","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:35:33Z","timestamp":1696502133000},"page":"2123-2137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism"],"prefix":"10.1016","volume":"18","author":[{"given":"Malte","family":"Loos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Klampe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Theofilatos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e4rbel Maria","family":"Ulmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotta S.","family":"Behrens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa Diana","family":"van Bergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Adami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Maatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Schweizer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Brodesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris V.","family":"Skryabin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timofey S.","family":"Rozhdestvensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Bodbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Stathopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Christ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Denning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"H\u00fcbner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Cuello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eschenhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2023.09.002_bib1","article-title":"Carnitine: Lessons from one hundred years of research","volume":"1033","author":"Alesci","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.stemcr.2023.09.002_bib2","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cardiores.2006.02.005","article-title":"Combined therapy with PPAR\u03b1 agonist and l-carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency","volume":"70","author":"Asai","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.stemcr.2023.09.002_bib3","first-page":"40","article-title":"CERT-Dependent Ceramide Transport, A Crucial Process in Cells","volume":"3","author":"Bandet","year":"2021","journal-title":"J Diabetes Clin Res"},{"key":"10.1016\/j.stemcr.2023.09.002_bib4","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/nprot.2017.033","article-title":"Differentiation of cardiomyocytes and generation of human engineered heart tissue","volume":"12","author":"Breckwoldt","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stemcr.2023.09.002_bib5","first-page":"815","article-title":"L-carnitine improvement of cardiac function is associated with a stimulation in glucose but not fatty acid metabolism in carnitine-deficient hearts","volume":"30","author":"Broderick","year":"1995","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.stemcr.2023.09.002_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41586-022-04817-8","article-title":"Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy","volume":"608","author":"Chaffin","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2023.09.002_bib7","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.stemcr.2023.09.002_bib8","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gky354","article-title":"CRISPOR: Intuitive guide selection for CRISPR\/Cas9 genome editing experiments and screens","volume":"46","author":"Concordet","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2023.09.002_bib9","doi-asserted-by":"crossref","first-page":"20023","DOI":"10.1074\/jbc.R115.663260","article-title":"Physiological consequences of compartmentalized acyl-CoA metabolism","volume":"290","author":"Cooper","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2023.09.002_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1023\/B:MCBI.0000012853.20116.06","article-title":"Fatty acid oxidation and related gene expression in heart depleted of carnitine by mildronate treatment in the rat","volume":"258","author":"Degrace","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.stemcr.2023.09.002_bib11","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2023.09.002_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.stemcr.2023.09.002_bib13","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2023.09.002_bib14","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Friedmann Angeli","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stemcr.2023.09.002_bib15","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1089\/dna.2018.4541","article-title":"Lipid Peroxidation and GPX4 Inhibition Are Common Causes for Myofibroblast Differentiation and Ferroptosis","volume":"38","author":"Gong","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.stemcr.2023.09.002_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.yjmcc.2014.05.009","article-title":"Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation","volume":"74","author":"Hirt","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.stemcr.2023.09.002_bib17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/biof.5520100232","article-title":"Pyruvate dehydrogenase kinase 4 mRNA is increased in the hypertrophied ventricles of carnitine-deficient juvenile visceral steatosis (JVS) mice","volume":"10","author":"Horiuchi","year":"1999","journal-title":"Biofactors"},{"key":"10.1016\/j.stemcr.2023.09.002_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0014-5793(93)81805-A","article-title":"Cardiac hypertrophy in juvenile visceral steatosis (jvs) mice with systemic carnitine deficiency","volume":"326","author":"Horiuchi","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.stemcr.2023.09.002_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.stemcr.2023.09.002_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1258\/002367788780746511","article-title":"Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2\u00b0 strain of mouse with similarities to Reye\u2019s syndrome","volume":"22","author":"Koizumi","year":"1988","journal-title":"Lab. Anim."},{"key":"10.1016\/j.stemcr.2023.09.002_bib21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s41392-020-00216-5","article-title":"The interaction between ferroptosis and lipid metabolism in cancer","volume":"5","author":"Li","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.stemcr.2023.09.002_bib22","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.lfs.2008.08.008","article-title":"Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart","volume":"83","author":"Liepinsh","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.stemcr.2023.09.002_bib23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ajmg.c.30087","article-title":"Disorders of carnitine transport and the carnitine cycle","volume":"142C C","author":"Longo","year":"2006","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.stemcr.2023.09.002_bib24","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.bbamcr.2016.01.023","article-title":"Carnitine transport and fatty acid oxidation","volume":"1863","author":"Longo","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.stemcr.2023.09.002_bib25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"MacEyka","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2023.09.002_bib26","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1750-1172-7-68","article-title":"Systemic primary carnitine deficiency: An overview of clinical manifestations, diagnosis, and management","volume":"7","author":"Magoulas","year":"2012","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.stemcr.2023.09.002_bib27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.stemcr.2016.04.011","article-title":"Human Engineered Heart Tissue: Analysis of Contractile Force","volume":"7","author":"Mannhardt","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2023.09.002_bib28","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.stemcr.2020.09.002","article-title":"Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format","volume":"15","author":"Mannhardt","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2023.09.002_bib29","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1161\/CIRCULATIONAHA.120.051391","article-title":"Single Nuclei Sequencing Reveals Novel Insights into the Regulation of Cellular Signatures in Children with Dilated Cardiomyopathy","volume":"143","author":"Nicin","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.stemcr.2023.09.002_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jimd.12158","article-title":"Increased risk of sudden death in untreated primary carnitine deficiency","volume":"43","author":"Rasmussen","year":"2020","journal-title":"J.\u00a0Inherit. Metab. Dis."},{"key":"10.1016\/j.stemcr.2023.09.002_bib31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s10545-013-9606-2","article-title":"Carnitine levels in 26,462 individuals from the nationwide screening program for primary carnitine deficiency in the Faroe Islands","volume":"37","author":"Rasmussen","year":"2014","journal-title":"J.\u00a0Inherit. Metab. Dis."},{"key":"10.1016\/j.stemcr.2023.09.002_bib32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1196\/annals.1320.003","article-title":"Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism","volume":"1033","author":"Rebouche","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.stemcr.2023.09.002_bib33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.hrthm.2015.07.027","article-title":"Carnitine deficiency induces a short QT syndrome","volume":"13","author":"Roussel","year":"2016","journal-title":"Hear Rhythm"},{"key":"10.1016\/j.stemcr.2023.09.002_bib34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0008-6363(02)00608-9","article-title":"Changes in distinct species of 1,2-diacylglycerol in cardiac hypertrophy due to energy metabolic disorder","volume":"57","author":"Saburi","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.stemcr.2023.09.002_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cpsc.127","article-title":"Cell Banking of hiPSCs: A Practical Guide to Cryopreservation and Quality Control in Basic Research","volume":"55","author":"Shibamiya","year":"2020","journal-title":"Curr Protoc Stem Cell Biol"},{"key":"10.1016\/j.stemcr.2023.09.002_bib36","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1046\/j.1432-1327.2001.02065.x","article-title":"Development and characterization of an animal model of carnitine deficiency","volume":"268","author":"Spaniol","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.stemcr.2023.09.002_bib37","doi-asserted-by":"crossref","first-page":"20378","DOI":"10.1074\/jbc.273.32.20378","article-title":"Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2","volume":"273","author":"Tamai","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.stemcr.2023.09.002_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102730","article-title":"Lifetime risk of autosomal recessive mitochondrial disorders calculated from genetic databases","volume":"54","author":"Tan","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.stemcr.2023.09.002_bib39","first-page":"232105","article-title":"Primary Carnitine Deficiency: A Rare, Reversible Metabolic Cardiomyopathy","volume":"2018","author":"Tomlinson","year":"2018","journal-title":"Case Reports Cardiol"},{"key":"10.1016\/j.stemcr.2023.09.002_bib40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0925-4439(92)90058-U","article-title":"Abnormal expression of urea cycle enzyme genes in juvenile visceral steatosis (jvs) mice","volume":"1138","author":"Tomomura","year":"1992","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.stemcr.2023.09.002_bib41","doi-asserted-by":"crossref","first-page":"F584","DOI":"10.1152\/ajprenal.2000.279.3.F584","article-title":"Functional and pharmacological characterization of human Na+-carnitine cotransporter hOCTN2","volume":"279","author":"Wagner","year":"2000","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.stemcr.2023.09.002_bib42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijcard.2014.03.190","article-title":"Primary carnitine deficiency cardiomyopathy","volume":"174","author":"Wang","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.stemcr.2023.09.002_bib43","first-page":"1034","article-title":"Palmitoyl transient carnitine modifies sodium currents and induces inward current in ventricular myocytes","volume":"266","author":"Wu","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.stemcr.2023.09.002_bib44","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nature05859","article-title":"RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2023.09.002_bib45","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2023.09.002_bib46","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/s41419-021-04137-1","article-title":"Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671123003612?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671123003612?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:21:54Z","timestamp":1778858514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671123003612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S2213671123003612"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2023.09.002","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human model of primary carnitine deficiency cardiomyopathy reveals ferroptosis as a novel mechanism","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2023.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}]}}