{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:13:04Z","timestamp":1790392384068,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["218461\/Z\/19\/Z"],"award-info":[{"award-number":["218461\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000380","name":"Guy's and Saint Thomas' Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T002735\/2"],"award-info":[{"award-number":["MR\/T002735\/2"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/V038559\/1"],"award-info":[{"award-number":["MR\/V038559\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J004553\/1"],"award-info":[{"award-number":["MR\/J004553\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.stemcr.2025.102470","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T12:20:14Z","timestamp":1743250814000},"page":"102470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human cone photoreceptor transplantation stimulates remodeling and restores function in AIPL1 model of end-stage Leber congenital amaurosis"],"prefix":"10.1016","volume":"20","author":[{"given":"Christopher A.","family":"Procyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Melati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Branch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie D.","family":"Delicata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menahil","family":"Tariq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini A.","family":"Kalarygrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid Moshtagh","family":"Khorsani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anai","family":"Gonzalez-Cordero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin R.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1107-1969","authenticated-orcid":false,"given":"Rachael A.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2025.102470_bib1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2413104121","article-title":"Cellular and circuit remodeling of the primate foveal midget pathway after acute photoreceptor loss","volume":"121","author":"Akiba","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2025.102470_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.65.12.8","article-title":"Host-Graft Synapses Form Functional Microstructures and Shape the Host Light Responses After Stem Cell-Derived Retinal Sheet Transplantation","volume":"65","author":"Akiba","year":"2024","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.stemcr.2025.102470_bib3","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1073\/pnas.1212677110","article-title":"Repair of the degenerate retina by photoreceptor transplantation","volume":"110","author":"Barber","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2025.102470_bib4","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1523\/JNEUROSCI.2570-16.2017","article-title":"Deafferented Adult Rod Bipolar Cells Create New Synapses with Photoreceptors to Restore Vision","volume":"37","author":"Beier","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.stemcr.2025.102470_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exer.2007.03.001","article-title":"Long-term visual prognoses in patients with retinitis pigmentosa: the Ludwig von Sallmann lecture","volume":"85","author":"Berson","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.stemcr.2025.102470_bib6","doi-asserted-by":"crossref","first-page":"13913","DOI":"10.1073\/pnas.250478897","article-title":"Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit","volume":"97","author":"Calvert","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2025.102470_bib7","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.tins.2014.07.009","article-title":"Neuronal remodeling in retinal circuit assembly, disassembly, and reassembly","volume":"37","author":"D'Orazi","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.stemcr.2025.102470_bib8","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1089\/hum.2018.027","article-title":"Assessment of AAV Vector Tropisms for Mouse and Human Pluripotent Stem Cell-Derived RPE and Photoreceptor Cells","volume":"29","author":"Gonzalez-Cordero","year":"2018","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.stemcr.2025.102470_bib9","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.stemcr.2017.07.022","article-title":"Recapitulation of Human Retinal\u00a0Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors","volume":"9","author":"Gonzalez-Cordero","year":"2017","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2025.102470_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120415","article-title":"Muller glia activation in response to inherited retinal degeneration is highly varied and disease-specific","volume":"10","author":"Hippert","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2025.102470_bib11","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1002\/glia.24034","article-title":"RNAi-mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Muller glial cell hypertrophy in progressive retinal degeneration","volume":"69","author":"Hippert","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.stemcr.2025.102470_bib12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/stcltm\/szae005","article-title":"Recent Progress in Photoreceptor Cell-Based Therapy for Degenerative Retinal Disease","volume":"13","author":"Klymenko","year":"2024","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.stemcr.2025.102470_bib13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1350-9462(03)00039-9","article-title":"Neural remodeling in retinal degeneration","volume":"22","author":"Marc","year":"2003","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.stemcr.2025.102470_bib14","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.1038\/s41598-022-11204-w","article-title":"A comprehensive atlas of Aggrecan, Versican, Neurocan and Phosphacan expression across time in wildtype retina and in retinal degeneration","volume":"12","author":"Matsuyama","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2025.102470_bib15","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.1038\/ncomms7006","article-title":"Gene therapy restores vision in rd1\u00a0mice after removal of a confounding mutation in Gpr179","volume":"6","author":"Nishiguchi","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2025.102470_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2023.1236826","article-title":"Current approaches to vision restoration using optogenetic therapy","volume":"17","author":"Parnami","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102470_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature10997","article-title":"Restoration of vision after transplantation of photoreceptors","volume":"485","author":"Pearson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2025.102470_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13029","article-title":"Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors","volume":"7","author":"Pearson","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2025.102470_bib19","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1152\/jn.00368.2015","article-title":"Spatial receptive fields in the retina and dorsal lateral geniculate nucleus of mice lacking rods and cones","volume":"114","author":"Procyk","year":"2015","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.stemcr.2025.102470_bib20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/cne.22234","article-title":"Localization of the calcium-binding protein secretagogin in cone bipolar cells of the mammalian retina","volume":"518","author":"Puthussery","year":"2010","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.stemcr.2025.102470_bib21","doi-asserted-by":"crossref","first-page":"13897","DOI":"10.1073\/pnas.0404197101","article-title":"Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesterase","volume":"101","author":"Ramamurthy","year":"2004","journal-title":"Proc. Natl. Acad. Sci.\u00a0USA"},{"key":"10.1016\/j.stemcr.2025.102470_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109022","article-title":"Restoration of visual function in advanced disease after transplantation of purified human pluripotent stem cell-derived cone photoreceptors","volume":"35","author":"Ribeiro","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2025.102470_bib23","first-page":"8256","article-title":"Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa","volume":"14","author":"Scalabrino","year":"2023","journal-title":"Nat.\u00a0Commun."},{"key":"10.1016\/j.stemcr.2025.102470_bib24","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1167\/iovs.13-13728","article-title":"Early alteration of retinal neurons in Aipl1-\/- animals","volume":"55","author":"Singh","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.stemcr.2025.102470_bib25","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0042-6989(02)00594-1","article-title":"Remodeling of second-order neurons in the retina of rd\/rd mutant mice","volume":"43","author":"Strettoi","year":"2003","journal-title":"Vis. Res."},{"key":"10.1016\/j.stemcr.2025.102470_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032330","article-title":"Leber congenital amaurosis associated with AIPL1:\u00a0challenges in ascribing disease causation, clinical findings, and implications for gene therapy","volume":"7","author":"Tan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2025.102470_bib27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1113\/jphysiol.2007.133751","article-title":"Synaptic influences on rat ganglion-cell photoreceptors","volume":"582","author":"Wong","year":"2007","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.stemcr.2025.102470_bib28","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1113\/jphysiol.2013.262782","article-title":"Photoresponse diversity among the five types of intrinsically photosensitive retinal ganglion cells","volume":"592","author":"Zhao","year":"2014","journal-title":"J.\u00a0Physiol."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671125000748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671125000748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:58:32Z","timestamp":1762610312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671125000748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S2213671125000748"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2025.102470","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human cone photoreceptor transplantation stimulates remodeling and restores function in AIPL1 model of end-stage Leber congenital amaurosis","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2025.102470","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"102470"}}