{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:48:08Z","timestamp":1791607688108,"version":"4.3.4"},"reference-count":61,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1102704"],"award-info":[{"award-number":["APP1102704"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2026395"],"award-info":[{"award-number":["GNT2026395"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.stemcr.2025.102480","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:42:18Z","timestamp":1745494938000},"page":"102480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exercise promotes the functional integration of human stem cell-derived neural grafts in a rodent model of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"20","author":[{"given":"Niamh","family":"Moriarty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyra D.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron P.J.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Eleftheriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Kauhausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan H.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare L.","family":"Parish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2025.102480_bib1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1212\/WNL.0b013e318225ab66","article-title":"Does vigorous exercise have a neuroprotective effect in Parkinson disease?","volume":"77","author":"Ahlskog","year":"2011","journal-title":"Neurology"},{"key":"10.1016\/j.stemcr.2025.102480_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tins.2010.11.001","article-title":"Repairing the parkinsonian brain with neurotrophic factors","volume":"34","author":"Aron","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib3","article-title":"G-Force PD: a global initiative in coordinating stem cell-based dopamine treatments for Parkinson\u2019s disease","volume":"1","author":"Barker","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2025.102480_bib4","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1474-4422(12)70295-8","article-title":"Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease","volume":"12","author":"Barker","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.stemcr.2025.102480_bib5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.stem.2017.09.014","article-title":"Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era","volume":"21","author":"Barker","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2025.102480_bib6","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1523\/JNEUROSCI.2273-21.2022","article-title":"Voluntary Exercise Boosts Striatal Dopamine Release: Evidence for the Necessary and Sufficient Role of BDNF","volume":"42","author":"Bastioli","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib7","doi-asserted-by":"crossref","first-page":"10524","DOI":"10.1073\/pnas.96.18.10524","article-title":"Associative plasticity in striatal transplants","volume":"96","author":"Brasted","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2025.102480_bib8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s002210050877","article-title":"Behavioural recovery following striatal transplantation: effects of postoperative training and P-zone volume","volume":"128","author":"Brasted","year":"1999","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.stemcr.2025.102480_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1037\/0735-7044.114.2.431","article-title":"Behavioral recovery after transplantation into a rat model of Huntington's disease: dependence on anatomical connectivity and extensive postoperative training","volume":"114","author":"Brasted","year":"2000","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0079-6123(02)37020-1","article-title":"Transplants and neurotrophic factors increase regeneration and recovery of function after spinal cord injury","volume":"137","author":"Bregman","year":"2002","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.stemcr.2025.102480_bib11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/0306-4522(92)90196-9","article-title":"Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum","volume":"46","author":"Cenci","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.stemcr.2025.102480_bib12","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0306-4522(98)00217-6","article-title":"Biochemical and anatomical characterization of forepaw adjusting steps in rat models of Parkinson's disease: studies on medial forebrain bundle and striatal lesions","volume":"88","author":"Chang","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.stemcr.2025.102480_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jns.2016.02.017","article-title":"Neurotrophic factors in Parkinson's disease are regulated by exercise: Evidence-based practice","volume":"363","author":"da Silva","year":"2016","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.stemcr.2025.102480_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41531-024-00641-1","article-title":"Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson's disease","volume":"10","author":"de Laat","year":"2024","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.stemcr.2025.102480_bib15","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1038\/s41467-021-23125-9","article-title":"Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats","volume":"12","author":"de Luzy","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2025.102480_bib16","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/exnr.2000.7462","article-title":"Influence of environment on the efficacy of intrastriatal dopaminergic grafts","volume":"165","author":"Dobrossy","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.stemcr.2025.102480_bib17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1136\/bjsm.2008.052498","article-title":"Aerobic exercise effects on cognitive and neural plasticity in older adults","volume":"43","author":"Erickson","year":"2009","journal-title":"Br. J. Sports Med."},{"key":"10.1016\/j.stemcr.2025.102480_bib18","article-title":"Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis","volume":"1","author":"Ernst","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.stemcr.2025.102480_bib19","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3233\/JPD-225116","article-title":"Physical Exercise as a Potential Treatment for Fatigue in Parkinson's Disease? A Systematic Review and Meta-Analysis of Pharmacological and Non-Pharmacological Interventions","volume":"13","author":"Folkerts","year":"2023","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.stemcr.2025.102480_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100065","article-title":"An Optimized Protocol for the Generation of Midbrain Dopamine Neurons under Defined Conditions","volume":"1","author":"Gantner","year":"2020","journal-title":"STAR Protoc."},{"key":"10.1016\/j.stemcr.2025.102480_bib21","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.stem.2020.01.010","article-title":"Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease","volume":"26","author":"Gantner","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2025.102480_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.stem.2020.01.010","article-title":"Viral delivery of GDNF promotes functional integration of human stem cell grafts in Parkinson\u2019s disase","volume":"26","author":"Gantner","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2025.102480_bib23","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.stem.2014.09.017","article-title":"Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease","volume":"15","author":"Grealish","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2025.102480_bib24","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/brain\/awp328","article-title":"The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease","volume":"133","author":"Grealish","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.stemcr.2025.102480_bib25","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/j.neubiorev.2013.04.005","article-title":"Beneficial effects of physical exercise on neuroplasticity and cognition","volume":"37","author":"Hotting","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.stemcr.2025.102480_bib26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbr.2005.06.044","article-title":"Stress reduces the neuroprotective effect of exercise in a rat model for Parkinson's disease","volume":"165","author":"Howells","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.stemcr.2025.102480_bib27","doi-asserted-by":"crossref","first-page":"12788","DOI":"10.1523\/JNEUROSCI.5359-13.2014","article-title":"Survival of neural stem cell grafts in the lesioned spinal cord is enhanced by a combination of treadmill locomotor training via insulin-like growth factor-1 signaling","volume":"34","author":"Hwang","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/ana.26291","article-title":"Aerobic Exercise Alters Brain Function and Structure in Parkinson's Disease: A Randomized Controlled Trial","volume":"91","author":"Johansson","year":"2022","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.stemcr.2025.102480_bib29","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1113\/jphysiol.2012.243063","article-title":"Cell intrinsic and extrinsic factors contribute to enhance neural circuit reconstruction following transplantation in Parkinsonian mice","volume":"591","author":"Kauhausen","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.stemcr.2025.102480_bib30","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1016\/j.febslet.2015.11.006","article-title":"GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease","volume":"589","author":"Kramer","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.stemcr.2025.102480_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202305771","article-title":"A Selective, Hydrogel-Based Prodrug Delivery System Efficiently Activates a Suicide Gene to Remove Undifferentiated Human Stem Cells Within Neural Grafts","volume":"33","author":"Law","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.stemcr.2025.102480_bib32","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/0959-4388(94)90019-1","article-title":"Clinical application of cell transplantation and neurotrophic factors in CNS disorders","volume":"4","author":"Lindvall","year":"1994","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.stemcr.2025.102480_bib33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrneurol.2017.128","article-title":"Long-term effects of exercise and physical therapy in people with Parkinson disease","volume":"13","author":"Mak","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.stemcr.2025.102480_bib34","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1007\/s40520-022-02153-5","article-title":"High-intensity interval training modulates inflammatory response in Parkinson's disease","volume":"34","author":"Malczynska-Sims","year":"2022","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.stemcr.2025.102480_bib35","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1111\/j.1460-9568.1990.tb00400.x","article-title":"The Importance of Graft Placement and Task Complexity for Transplant-Induced Recovery of Simple and Complex Sensorimotor Deficits in Dopamine Denervated Rats","volume":"2","author":"Mandel","year":"1990","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh1403","article-title":"Intensive exercise ameliorates motor and cognitive symptoms in experimental Parkinson's disease restoring striatal synaptic plasticity","volume":"9","author":"Marino","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.stemcr.2025.102480_bib37","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1460-9568.1992.tb00858.x","article-title":"Striatal graft-associated recovery of a lesion-induced performance deficit in the rat requires learning to use the transplant","volume":"4","author":"Mayer","year":"1992","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib38","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuron.2013.06.028","article-title":"The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course","volume":"79","author":"McEwen","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2025.102480_bib39","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.1007\/s12035-023-03869-9","article-title":"A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise","volume":"61","author":"Methi","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.stemcr.2025.102480_bib40","doi-asserted-by":"crossref","first-page":"R1321","DOI":"10.1152\/ajpregu.2000.279.4.R1321","article-title":"Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats","volume":"279","author":"Moraska","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.stemcr.2025.102480_bib41","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.stem.2022.01.013","article-title":"A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cells","volume":"29","author":"Moriarty","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2025.102480_bib42","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1523\/JNEUROSCI.2431-21.2022","article-title":"Understanding the Influence of Target Acquisition on Survival, Integration, and Phenotypic Maturation of Dopamine Neurons within Stem Cell-Derived Neural Grafts in a Parkinson's Disease Model","volume":"42","author":"Moriarty","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib43","doi-asserted-by":"crossref","first-page":"937","DOI":"10.5966\/sctm.2016-0073","article-title":"Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents","volume":"6","author":"Niclis","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.stemcr.2025.102480_bib44","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","volume":"7","author":"Nithianantharajah","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib45","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/1545968308326427","article-title":"Cortical plasticity following motor skill learning during mental practice in stroke","volume":"23","author":"Page","year":"2009","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.stemcr.2025.102480_bib46","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3988\/jcn.2015.11.3.212","article-title":"Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review","volume":"11","author":"Paillard","year":"2015","journal-title":"J. Clin. Neurol."},{"key":"10.1016\/j.stemcr.2025.102480_bib47","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1093\/brain\/awh649","article-title":"Factors affecting the clinical outcome after neural transplantation in Parkinson's disease","volume":"128","author":"Piccini","year":"2005","journal-title":"Brain"},{"key":"10.1016\/j.stemcr.2025.102480_bib48","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.omtm.2023.04.008","article-title":"Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo","volume":"29","author":"Rajova","year":"2023","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.stemcr.2025.102480_bib49","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1097\/00001756-199611040-00029","article-title":"GDNF enhances dopaminergic cell survival and fibre outgrowth in embryonic nigral grafts","volume":"7","author":"Sinclair","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.stemcr.2025.102480_bib50","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.celrep.2017.07.069","article-title":"Peptide-Based Scaffolds Support Human Cortical Progenitor Graft Integration to Reduce Atrophy and Promote Functional Repair in a Model of Stroke","volume":"20","author":"Somaa","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2025.102480_bib51","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/78829","article-title":"Competitive Hebbian learning through spike-timing-dependent synaptic plasticity","volume":"3","author":"Song","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/srep30898","article-title":"Functional Recovery from Neural Stem\/Progenitor Cell Transplantation Combined with Treadmill Training in Mice with Chronic Spinal Cord Injury","volume":"6","author":"Tashiro","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2025.102480_bib53","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1038\/s41467-020-16225-5","article-title":"Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease","volume":"11","author":"Tiklova","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2025.102480_bib54","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3233\/JPD-191755","article-title":"Exercise Promotes Neurite Extensions from Grafted Dopaminergic Neurons in the Direction of the Dorsolateral Striatum in Parkinson's Disease Model Rats","volume":"10","author":"Torikoshi","year":"2020","journal-title":"J. Parkinsons Dis."},{"key":"10.1016\/j.stemcr.2025.102480_bib55","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.nbd.2013.11.017","article-title":"Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease","volume":"63","author":"Toy","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.stemcr.2025.102480_bib56","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nrn1327","article-title":"Homeostatic plasticity in the developing nervous system","volume":"5","author":"Turrigiano","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib57","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102480_bib58","doi-asserted-by":"crossref","first-page":"15044","DOI":"10.1074\/jbc.M113.537381","article-title":"Characterization of the stability and bio-functionality of tethered proteins on bioengineered scaffolds: implications for stem cell biology and tissue repair","volume":"289","author":"Wang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2025.102480_bib59","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.stemcr.2021.12.006","article-title":"Physical exercise promotes integration of grafted cells and functional recovery in an acute stroke rat model","volume":"17","author":"Wu","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2025.102480_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190160","article-title":"Running wheel exercise reduces alpha-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease","volume":"12","author":"Zhou","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2025.102480_bib61","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1016\/S1353-8020(11)70046-3","article-title":"Neurorestoration by physical exercise: moving forward","volume":"18","author":"Zigmond","year":"2012","journal-title":"Parkinsonism Relat. Disord."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671125000840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671125000840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T23:55:48Z","timestamp":1761436548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671125000840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2213671125000840"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2025.102480","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise promotes the functional integration of human stem cell-derived neural grafts in a rodent model of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2025.102480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"102480"}}