{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:33:49Z","timestamp":1787906029805,"version":"build-2784847793"},"reference-count":25,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UKRI Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T04604X\/1"],"award-info":[{"award-number":["MR\/T04604X\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UKRI Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M024962\/1"],"award-info":[{"award-number":["MR\/M024962\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UKRI Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L010305\/1"],"award-info":[{"award-number":["MR\/L010305\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UK DRI-3201"],"award-info":[{"award-number":["UK DRI-3201"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UKDRI-3003"],"award-info":[{"award-number":["UKDRI-3003"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000320","name":"Alzheimer's Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022942","name":"Moondance Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022942","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015846","name":"Llywodraeth Cymru","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015846","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.stemcr.2025.102570","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:01:50Z","timestamp":1751544110000},"page":"102570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Modeling common Alzheimer\u2019s disease with high and low polygenic risk in human iPSC: A large-scale research resource"],"prefix":"10.1016","volume":"20","author":[{"given":"Emily","family":"Maguire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincy","family":"Winston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Ellwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"O\u2019Donoghue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atahualpa Castillo","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Keat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Luckcuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Salis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganna","family":"Leonenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Denning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Escott-Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Sims","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Cowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Carpanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0330-9604","authenticated-orcid":false,"given":"Hazel","family":"Hall-Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2025.102570_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/biores.2019.0046","article-title":"Induced Pluripotent Stem Cells: Reprogramming Platforms and Applications in Cell Replacement Therapy","volume":"9","author":"Al Abbar","year":"2020","journal-title":"Biores. Open Access"},{"key":"10.1016\/j.stemcr.2025.102570_bib2","series-title":"Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision (DSM-IV-TR)","author":"Association","year":"2000"},{"key":"10.1016\/j.stemcr.2025.102570_bib3","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stemcr.2025.102570_bib4","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1001\/jamaneurol.2023.3599","article-title":"APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry","volume":"80","author":"Belloy","year":"2023","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.stemcr.2025.102570_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/genes12030443","article-title":"The Impact of Complement Genes on the Risk of Late-Onset Alzheimer\u2019s Disease","volume":"12","author":"Carpanini","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.stemcr.2025.102570_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00401-016-1662-x","article-title":"Alzheimer\u2019s Disease: Experimental Models and Reality","volume":"133","author":"Drummond","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.stemcr.2025.102570_bib7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/ana.24999","article-title":"Polygenic Risk Score Analysis of Pathologically Confirmed Alzheimer\u2019s Disease","volume":"82","author":"Escott-Price","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.stemcr.2025.102570_bib8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s00702-017-1729-4","article-title":"Innate immunity in Alzheimer\u2019s disease: the relevance of animal models?","volume":"125","author":"Franco Bocanegra","year":"2018","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.stemcr.2025.102570_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1357405","article-title":"Modeling sporadic Alzheimer\u2019s disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors","volume":"16","author":"Ganesan","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.stemcr.2025.102570_bib10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s43587-021-00158-9","article-title":"Dissection of the polygenic architecture of neuronal A\u03b2 production using a large sample of individual iPSC lines derived from Alzheimer\u2019s disease patients","volume":"2","author":"Kondo","year":"2022","journal-title":"Nat. Aging"},{"key":"10.1016\/j.stemcr.2025.102570_bib11","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/0895-4356(96)00195-3","article-title":"Apolipoprotein E in Alzheimer\u2019s disease risk and case detection: A case-control study","volume":"49","author":"Kukull","year":"1996","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.stemcr.2025.102570_bib12","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1016\/j.neuron.2021.08.003","article-title":"Stem cell derived neurons reflect features of protein networks, neuropathology and cognitive outcome of their aged human donors","volume":"109","author":"Lagomarsino","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2025.102570_bib13","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1038\/s41593-019-0525-x","article-title":"Stem-cell-derived human microglia transplanted in mouse brain to study human disease","volume":"22","author":"Mancuso","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102570_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222313168","article-title":"A Review of the Current Mammalian Models of Alzheimer\u2019s Disease and Challenges That Need to Be Overcome","volume":"22","author":"McKean","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.stemcr.2025.102570_bib15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.stemcr.2025.102570_bib16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41380-019-0468-3","article-title":"Modeling Alzheimer\u2019s disease with iPSC-derived brain cells","volume":"25","author":"Penney","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.stemcr.2025.102570_bib17","article-title":"Generation of six human iPSC lines from patients with a familial Alzheimer\u2019s disease (n = 3) and sex- and age-matched healthy controls (n = 3)","volume":"53","author":"Raska","year":"2021","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.stemcr.2025.102570_bib18","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000512","article-title":"Late-onset vs nonmendelian early-onset Alzheimer disease: A distinction without a difference?","volume":"6","author":"Reitz","year":"2020","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.stemcr.2025.102570_bib19","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/jnen\/nlv028","article-title":"Neuropathology of autosomal dominant Alzheimer disease in the National Alzheimer Coordinating Center database","volume":"75","author":"Ringman","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.stemcr.2025.102570_bib20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/WAD.0b013e3181b76415","article-title":"The CERAD Neuropsychological Battery Total Score and the Progression of Alzheimer\u2019s Disease","volume":"24","author":"Rossetti","year":"2010","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.stemcr.2025.102570_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003289","article-title":"Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker\u2013based case\u2013control study","volume":"17","author":"Saddiki","year":"2020","journal-title":"PLoS Med."},{"key":"10.1016\/j.stemcr.2025.102570_bib22","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006189","article-title":"Neuropathological Alterations in Alzheimer Disease","volume":"1","author":"Serrano-Pozo","year":"2011","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.stemcr.2025.102570_bib23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41593-020-0599-5","article-title":"The multiplex model of the genetics of Alzheimer\u2019s disease","volume":"23","author":"Sims","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102570_bib24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13024-023-00598-4","article-title":"A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques","volume":"18","author":"Tran","year":"2023","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.stemcr.2025.102570_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/archneurol.2011.221","article-title":"Autosomal Recessive Causes Likely in Early-Onset Alzheimer Disease","volume":"69","author":"Wingo","year":"2012","journal-title":"Arch. Neurol."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671125001742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671125001742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:57:39Z","timestamp":1762610259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671125001742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2213671125001742"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2025.102570","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modeling common Alzheimer\u2019s disease with high and low polygenic risk in human iPSC: A large-scale research resource","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2025.102570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"102570"}}