{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T21:52:24Z","timestamp":1782165144233,"version":"3.54.5"},"reference-count":67,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001695","name":"Japan Science and Technology Corporation","doi-asserted-by":"publisher","award":["JPMJFR231Z"],"award-info":[{"award-number":["JPMJFR231Z"]}],"id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20gm1310008"],"award-info":[{"award-number":["JP20gm1310008"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23H00391"],"award-info":[{"award-number":["JP23H00391"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K18451"],"award-info":[{"award-number":["JP23K18451"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K14820"],"award-info":[{"award-number":["JP18K14820"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21H02808"],"award-info":[{"award-number":["JP21H02808"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003485","name":"Heiwa Nakajima Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003485","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015321","name":"Nara Institute of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.stemcr.2025.102789","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T15:33:40Z","timestamp":1769700820000},"page":"102789","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell identity during development"],"prefix":"10.1016","volume":"21","author":[{"given":"Haruka","family":"Sekiryu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakurako","family":"Shimokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanae","family":"Matsuda-Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanobu","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh-Hei","family":"Sonoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinichi","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9859-5967","authenticated-orcid":false,"given":"Taito","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2025.102789_bib1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.neuron.2017.04.022","article-title":"The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis","volume":"94","author":"Aldiri","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2025.102789_bib2","doi-asserted-by":"crossref","first-page":"W202","DOI":"10.1093\/nar\/gkp335","article-title":"MEME SUITE: tools for motif discovery and searching","volume":"37","author":"Bailey","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2025.102789_bib3","doi-asserted-by":"crossref","first-page":"5125","DOI":"10.1093\/nar\/gky325","article-title":"The fractured landscape of RNA-seq alignment: the default in our STARs","volume":"46","author":"Ballouz","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2025.102789_bib4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.tins.2012.05.004","article-title":"Cell fate determination in the vertebrate retina","volume":"35","author":"Bassett","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.stemcr.2025.102789_bib5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1101\/gad.177444.111","article-title":"PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription","volume":"26","author":"Beck","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2025.102789_bib6","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1523\/JNEUROSCI.2327-19.2020","article-title":"Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance","volume":"40","author":"Bosze","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102789_bib7","doi-asserted-by":"crossref","first-page":"21.29.1","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.stemcr.2025.102789_bib8","first-page":"715","article-title":"Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina","volume":"34","author":"Chan","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2025.102789_bib9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrn3767","article-title":"Intrinsically different retinal progenitor cells produce specific types of progeny","volume":"15","author":"Cepko","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102789_bib10","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stemcr.2025.102789_bib11","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.neuron.2019.04.010","article-title":"Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification","volume":"102","author":"Clark","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2025.102789_bib12","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature08677","article-title":"E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells","volume":"462","author":"Chong","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2025.102789_bib13","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31437","article-title":"The formation of the light-sensing compartment of cone photoreceptors coincides with a transcriptional switch","volume":"6","author":"Daum","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.stemcr.2025.102789_bib14","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1038\/s41467-024-47933-x","article-title":"Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina","volume":"15","author":"Dorgau","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2025.102789_bib15","first-page":"11300","article-title":"Lhx2 is an essential factor for retinal gliogenesis and Notch signaling","volume":"32","author":"de Melo","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102789_bib16","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.15252\/embr.201439434","article-title":"SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1","volume":"15","author":"Dulev","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.stemcr.2025.102789_bib17","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2013136118","article-title":"Meis homeobox genes control progenitor competence in the retina","volume":"118","author":"Dupacova","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2025.102789_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ydbio.2017.11.004","article-title":"Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation","volume":"433","author":"Fujimura","year":"2018","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stemcr.2025.102789_bib19","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1073\/pnas.94.7.3088","article-title":"rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina","volume":"94","author":"Furukawa","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2025.102789_bib20","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3389\/fncel.2018.00410","article-title":"Evidence of Muller Glia Conversion Into Retina Ganglion Cells Using Neurogenin2","volume":"12","author":"Guimaraes","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102789_bib21","first-page":"1144","article-title":"Methylation of PCNA by Set8 mediates DNA damage response","volume":"16","author":"Guo","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.stemcr.2025.102789_bib22","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1126\/science.1069609","article-title":"Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity","volume":"295","author":"Hattar","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2025.102789_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb8598","article-title":"Gene regulatory networks controlling vertebrate retinal regeneration","volume":"370","author":"Hoang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2025.102789_bib24","first-page":"1","article-title":"The role of PCNA in the activation of Set8-mediated H4-K20 methylation","volume":"43","author":"Huen","year":"2011","journal-title":"Mol Cell"},{"key":"10.1016\/j.stemcr.2025.102789_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/srep43184","article-title":"Cell type-specific epigenomic analysis reveals a uniquely closed chromatin architecture in mouse rod photoreceptors","volume":"7","author":"Hughes","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2025.102789_bib26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/dneu.22261","article-title":"Roles of histone H3K27 trimethylase Ezh2 in retinal proliferation and differentiation","volume":"75","author":"Iida","year":"2015","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.stemcr.2025.102789_bib27","first-page":"233","article-title":"Temporal regulation of Cre recombinase activity in neural stem cells. Sp","volume":"44","author":"Imayoshi","year":"2006","journal-title":"Time"},{"key":"10.1016\/j.stemcr.2025.102789_bib28","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200436","article-title":"Ikaros family proteins redundantly regulate temporal patterning in the developing mouse retina","volume":"150","author":"Javed","year":"2023","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2025.102789_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature23283","article-title":"Stimulation of functional neuronal regeneration from Muller glia in adult mice","volume":"548","author":"Jorstad","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2025.102789_bib30","first-page":"11090","article-title":"Direct signaling by E2F transcription factors regulates neural progenitor cell proliferation","volume":"293","author":"Julian","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2025.102789_bib31","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.1523\/JNEUROSCI.0771-10.2010","article-title":"Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development","volume":"30","author":"Katoh","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102789_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108382","article-title":"Gbx2 Identifies Two Amacrine Cell Subtypes with Distinct Molecular, Morphological, and Physiological Properties","volume":"33","author":"Kerstein","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2025.102789_bib33","first-page":"1028","article-title":"Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina","volume":"27","author":"Koike","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102789_bib35","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(90)90662-X","article-title":"CNS stem cells express a new class of intermediate filament protein","volume":"60","author":"Lendahl","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2025.102789_bib36","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.stemcr.2025.102789_bib37","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1167\/iovs.19-27361","article-title":"Transcriptome and DNA Methylome Signatures Associated With Retinal Muller Glia Development, Injury Response, and Aging","volume":"60","author":"Lin","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.stemcr.2025.102789_bib38","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.stemcr.2025.102789_bib39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.devcel.2020.04.009","article-title":"Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development","volume":"53","author":"Lu","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stemcr.2025.102789_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109994","article-title":"Gene regulatory networks controlling temporal patterning, neurogenesis, and cell-fate specification in mammalian retina","volume":"37","author":"Lyu","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2025.102789_bib41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41586-020-2201-4","article-title":"Pharmacologic fibroblast reprogramming into photoreceptors restores vision","volume":"581","author":"Mahato","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2025.102789_bib42","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4103\/1673-5374.314305","article-title":"Current and future therapeutic strategies for the treatment of retinal neurodegenerative diseases","volume":"17","author":"Maneu","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.stemcr.2025.102789_bib43","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1038\/s44318-025-00455-8","article-title":"Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation","volume":"44","author":"Matsubara","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.stemcr.2025.102789_bib44","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neuron.2018.12.010","article-title":"Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion","volume":"101","author":"Matsuda","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.stemcr.2025.102789_bib45","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1091\/mbc.e07-11-1167","article-title":"Rad54B targeting to DNA double-strand break repair sites requires complex formation with S100A11","volume":"19","author":"Murzik","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.stemcr.2025.102789_bib46","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/cne.22613","article-title":"Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina","volume":"519","author":"Nasonkin","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.stemcr.2025.102789_bib47","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/nn1155","article-title":"Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development","volume":"6","author":"Nishida","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.stemcr.2025.102789_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-21767-3","article-title":"Elk-1 regulates retinal ganglion cell axon regeneration after injury","volume":"12","author":"Noro","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2025.102789_bib49","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1128\/MCB.01768-08","article-title":"Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development","volume":"29","author":"Oda","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.stemcr.2025.102789_bib50","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1242\/dev.091355","article-title":"ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors","volume":"140","author":"Pollak","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2025.102789_bib51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13072-021-00384-w","article-title":"Epigenetic regulation of retinal development","volume":"14","author":"Raeisossadati","year":"2021","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.stemcr.2025.102789_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.165","article-title":"Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival","volume":"3","author":"Rhee","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.stemcr.2025.102789_bib53","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature10730","article-title":"Differential oestrogen receptor binding is associated with clinical outcome in breast cancer","volume":"481","author":"Ross-Innes","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2025.102789_bib54","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/dvg.20318","article-title":"Dkk3-Cre BAC transgenic mouse line: a tool for highly efficient gene deletion in retinal progenitor cells","volume":"45","author":"Sato","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.stemcr.2025.102789_bib55","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1242\/dev.040568","article-title":"COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis","volume":"137","author":"Tang","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2025.102789_bib56","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1101\/gad.1407906","article-title":"SOX2 is a dose-dependent regulator of retinal neural progenitor competence","volume":"20","author":"Taranova","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2025.102789_bib57","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.exer.2008.07.009","article-title":"Characterization of Muller glia and neuronal progenitors during adult zebrafish retinal regeneration","volume":"87","author":"Thummel","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.stemcr.2025.102789_bib58","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1365-2443.1996.tb00016.x","article-title":"Mash1 promotes neuronal differentiation in the retina","volume":"1","author":"Tomita","year":"1996","journal-title":"Genes Cells"},{"key":"10.1016\/j.stemcr.2025.102789_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/srep29264","article-title":"Transition of differential histone H3 methylation in photoreceptors and other retinal cells during retinal differentiation","volume":"6","author":"Ueno","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2025.102789_bib60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cell.2019.06.002","article-title":"Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer","volume":"178","author":"Wang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2025.102789_bib61","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1016\/j.celrep.2018.01.075","article-title":"Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures","volume":"22","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2025.102789_bib62","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1097\/00001756-200006260-00037","article-title":"Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice","volume":"11","author":"Yamaguchi","year":"2000","journal-title":"Neuroreport"},{"key":"10.1016\/j.stemcr.2025.102789_bib63","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/s41586-018-0425-3","article-title":"Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas","volume":"560","author":"Yao","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2025.102789_bib64","first-page":"6768","article-title":"E2F transcription factors regulate DNA replication and progression through S-phase by controlling expression of E2F target genes","volume":"283","author":"Zalmas","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2025.102789_bib65","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ydbio.2015.05.010","article-title":"Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation","volume":"403","author":"Zhang","year":"2015","journal-title":"Dev. Biol."},{"key":"10.1016\/j.stemcr.2025.102789_bib66","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1167\/iovs.64.15.32","article-title":"Retinal Ganglion Cell Fate Induction by Ngn-Family Transcription Factors","volume":"64","author":"Zhang","year":"2023","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.stemcr.2025.102789_bib67","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2020.03.024","article-title":"Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice","volume":"181","author":"Zhou","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2025.102789_bib68","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s42003-019-0375-9","article-title":"Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin","volume":"2","author":"Zibetti","year":"2019","journal-title":"Commun. Biol."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671125003935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671125003935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T21:18:01Z","timestamp":1782163081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671125003935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2213671125003935"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2025.102789","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell identity during development","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2025.102789","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"102789"}}