{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:58:52Z","timestamp":1792799932172,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000402","name":"The Kay Kendall Leukaemia Fund","doi-asserted-by":"publisher","award":["KKL1051 \/ KKL1446"],"award-info":[{"award-number":["KKL1051 \/ KKL1446"]}],"id":[{"id":"10.13039\/501100000402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011692","name":"The Children&apos;s Cancer and Leukaemia Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032388","name":"Sussex Cancer Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/V001701\/1"],"award-info":[{"award-number":["BB\/V001701\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000376","name":"British Society for Haematology","doi-asserted-by":"publisher","award":["44299"],"award-info":[{"award-number":["44299"]}],"id":[{"id":"10.13039\/501100000376","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.stemcr.2026.102894","type":"journal-article","created":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T14:42:24Z","timestamp":1776955344000},"page":"102894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["TOE1 is a \u03b2-catenin interacting protein regulating the proliferation of hematopoietic cells through PAK2 modulation"],"prefix":"10.1016","volume":"21","author":[{"given":"Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Sevim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Wagstaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Goff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Heesom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah F.","family":"Newbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan L.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin P.","family":"Towler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Chevassut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-6294","authenticated-orcid":false,"given":"Rhys G.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2026.102894_bib1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41598-025-29408-1","article-title":"Transcriptomic analysis reveals the potential role of TOE1 in hepatocellular carcinoma","volume":"16","author":"Ao","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.102894_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12964-025-02107-0","article-title":"Phosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells","volume":"23","author":"Casado","year":"2025","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.stemcr.2026.102894_bib3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.stemcr.2026.102894_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189246","article-title":"PAK2 as a therapeutic target in cancer: Mechanisms, challenges, and future perspectives","volume":"1880","author":"Chen","year":"2025","journal-title":"Biochim. Biophys. Acta. Rev. Cancer"},{"key":"10.1016\/j.stemcr.2026.102894_bib5","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1158\/1078-0432.CCR-18-3033","article-title":"PAK Kinase Inhibition Has Therapeutic Activity in Novel Preclinical Models of Adult T-Cell Leukemia\/Lymphoma","volume":"25","author":"Chung","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.stemcr.2026.102894_bib6","doi-asserted-by":"crossref","first-page":"14306","DOI":"10.1074\/jbc.M210502200","article-title":"In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1","volume":"278","author":"De Belle","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2026.102894_bib7","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1158\/0008-5472.CAN-23-0816","article-title":"Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma Collaborative in cBioPortal","volume":"83","author":"de Bruijn","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.stemcr.2026.102894_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/nar\/gky1019","article-title":"TOE1 acts as a 3' exonuclease for telomerase RNA and regulates telomere maintenance","volume":"47","author":"Deng","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2026.102894_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e39535","article-title":"Toe1 promotes proliferation and differentiation of neural progenitor cells","volume":"10","author":"Deng","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.stemcr.2026.102894_bib10","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1182\/blood-2013-10-532523","article-title":"GPR84 sustains aberrant beta-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis","volume":"124","author":"Dietrich","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2026.102894_bib11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41571-021-00509-w","article-title":"Towards precision medicine for AML","volume":"18","author":"D\u00f6hner","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.stemcr.2026.102894_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/bjh.14833","article-title":"Expansion of BCR\/ABL1(+) cells requires PAK2 but not PAK1","volume":"179","author":"Edlinger","year":"2017","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.stemcr.2026.102894_bib13","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature14888","article-title":"BET inhibitor resistance emerges from leukaemia stem cells","volume":"525","author":"Fong","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102894_bib14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1083\/jcb.201303145","article-title":"Whole-genome screening identifies proteins localized to distinct nuclear bodies","volume":"203","author":"Fong","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.stemcr.2026.102894_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.stemcr.2026.102894_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14071689","article-title":"Refining AML Treatment: The Role of Genetics in Response and Resistance Evaluation to New Agents","volume":"14","author":"Halik","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.stemcr.2026.102894_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105139","article-title":"The PARN, TOE1, and USB1 RNA deadenylases and their roles in non-coding RNA regulation","volume":"299","author":"Huynh","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2026.102894_bib18","doi-asserted-by":"crossref","first-page":"38675","DOI":"10.1074\/jbc.M306494200","article-title":"Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation","volume":"278","author":"Jakobi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2026.102894_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/10799893.2024.2411690","article-title":"Allosteric covalent inhibition of TOE1 as potential unexplored anti-cancer target: structure-based virtual screening and covalent molecular dynamics analysis","volume":"44","author":"Kehinde","year":"2024","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.stemcr.2026.102894_bib20","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1093\/nar\/gks331","article-title":"beta-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells","volume":"40","author":"Kim","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2026.102894_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrc1892","article-title":"p21-activated kinases in cancer","volume":"6","author":"Kumar","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.stemcr.2026.102894_bib22","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1101\/gad.336891.120","article-title":"Competition between maturation and degradation drives human snRNA 3' end quality control","volume":"34","author":"Lardelli","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2026.102894_bib23","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng.3762","article-title":"Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing","volume":"49","author":"Lardelli","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stemcr.2026.102894_bib24","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.1093\/nar\/gkl698","article-title":"Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR","volume":"34","author":"Lee","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2026.102894_bib25","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1038\/s41589-023-01428-w","article-title":"Assigning functionality to cysteines by base editing of cancer dependency genes","volume":"19","author":"Li","year":"2023","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.stemcr.2026.102894_bib26","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/leu.2011.387","article-title":"Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development","volume":"26","author":"Luis","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.stemcr.2026.102894_bib27","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/leu.2011.260","article-title":"Signal transduction pathways regulating hematopoietic stem cell biology: Introduction to a series of Spotlight Reviews","volume":"26","author":"Luis","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.stemcr.2026.102894_bib28","article-title":"Sm complex assembly and 5' cap trimethylation promote selective processing of snRNAs by the 3' exonuclease TOE1","volume":"121","author":"Ma","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102894_bib29","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nmeth.2557","article-title":"The CRAPome: a contaminant repository for affinity purification-mass spectrometry data","volume":"10","author":"Mellacheruvu","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stemcr.2026.102894_bib30","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/leu.2012.221","article-title":"\u03b3-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of \u03b2-catenin","volume":"27","author":"Morgan","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.stemcr.2026.102894_bib31","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3324\/haematol.2018.202846","article-title":"LEF-1 drives aberrant beta-catenin nuclear localization in myeloid leukemia cells","volume":"104","author":"Morgan","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.stemcr.2026.102894_bib32","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1038\/s41467-020-15814-8","article-title":"HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells","volume":"11","author":"Nguyen","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2026.102894_bib33","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2026.102894_bib34","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41556-020-0507-y","article-title":"Overcoming Wnt-beta-catenin dependent anticancer therapy resistance in leukaemia stem cells","volume":"22","author":"Perry","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.stemcr.2026.102894_bib35","doi-asserted-by":"crossref","DOI":"10.4161\/sgtp.28003","article-title":"P21 activated kinases: structure, regulation, and functions","volume":"5","author":"Rane","year":"2014","journal-title":"Small GTPases"},{"key":"10.1016\/j.stemcr.2026.102894_bib36","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1182\/blood-2016-01-693572","article-title":"p21-activated kinase 2 regulates HSPC cytoskeleton, migration, and homing via CDC42 activation and interaction with beta-Pix","volume":"127","author":"Reddy","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2026.102894_bib37","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature01593","article-title":"A role for Wnt signalling in self-renewal of haematopoietic stem cells","volume":"423","author":"Reya","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102894_bib38","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1126\/science.276.5318.1571","article-title":"Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2","volume":"276","author":"Rudel","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2026.102894_bib39","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1038\/s41388-025-03470-5","article-title":"Post-transcriptional control of gene expression by beta-catenin: expanding the non-canonical ARMoury","volume":"44","author":"Sevim","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.stemcr.2026.102894_bib40","article-title":"Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG","volume":"8","author":"Shao","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.stemcr.2026.102894_bib41","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41467-019-09273-z","article-title":"Gfi1b regulates the level of Wnt\/beta-catenin signaling in hematopoietic stem cells and megakaryocytes","volume":"10","author":"Shooshtarizadeh","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2026.102894_bib42","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1182\/bloodadvances.2018020693","article-title":"Combined inhibition of receptor tyrosine and p21-activated kinases as a therapeutic strategy in childhood ALL","volume":"2","author":"Siekmann","year":"2018","journal-title":"Blood Adv."},{"key":"10.1016\/j.stemcr.2026.102894_bib43","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.celrep.2018.03.089","article-title":"PARN and TOE1 Constitute a 3' End Maturation Module for Nuclear Non-coding RNAs","volume":"23","author":"Son","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2026.102894_bib44","doi-asserted-by":"crossref","first-page":"E3392","DOI":"10.1073\/pnas.1500857112","article-title":"TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability","volume":"112","author":"Sperandio","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102894_bib45","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/j.febslet.2009.06.004","article-title":"TOE1 interacts with p53 to modulate its transactivation potential","volume":"583","author":"Sperandio","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.stemcr.2026.102894_bib46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/BS9.0000000000000169","article-title":"Targeting P21-activated kinase suppresses proliferation and enhances chemosensitivity in T-cell lymphoblastic lymphoma","volume":"5","author":"Su","year":"2023","journal-title":"Blood Sci."},{"key":"10.1016\/j.stemcr.2026.102894_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2024.130736","article-title":"TOE1 deadenylase inhibits gastric cancer cell proliferation by regulating cell cycle progression","volume":"1869","author":"Sun","year":"2025","journal-title":"Biochim. Biophys. Acta. Gen. Subj."},{"key":"10.1016\/j.stemcr.2026.102894_bib48","doi-asserted-by":"crossref","first-page":"6542","DOI":"10.1073\/pnas.0600824103","article-title":"Posttranslational myristoylation of caspase-activated p21-activated protein kinase 2 (PAK2) potentiates late apoptotic events","volume":"103","author":"Vilas","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102894_bib49","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1128\/MCB.01483-06","article-title":"An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies","volume":"27","author":"Wagner","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.stemcr.2026.102894_bib50","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20211841","article-title":"Targeting beta-catenin in acute myeloid leukaemia: past, present, and future perspectives","volume":"42","author":"Wagstaff","year":"2022","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.stemcr.2026.102894_bib52","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1038\/s41388-025-03415-y","article-title":"\u03b2-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells","volume":"44","author":"Wagstaff","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.stemcr.2026.102894_bib53","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3324\/haematol.2021.280294","article-title":"Crosstalk between beta-catenin and WT1 signaling activity in acute myeloid leukemia","volume":"108","author":"Wagstaff","year":"2023","journal-title":"Haematologica"},{"key":"10.1016\/j.stemcr.2026.102894_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147250","article-title":"Novel compound heterozygous missense variants in TOE1 gene associated with pontocerebellar hypoplasia type 7","volume":"862","author":"Wang","year":"2023","journal-title":"Gene"},{"key":"10.1016\/j.stemcr.2026.102894_bib55","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1186624","article-title":"The Wnt\/beta-catenin pathway is required for the development of leukemia stem cells in AML","volume":"327","author":"Wang","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.stemcr.2026.102894_bib56","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.beha.2018.09.010","article-title":"Patterns of mutations in TP53 mutated AML","volume":"31","author":"Welch","year":"2018","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.stemcr.2026.102894_bib57","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature01611","article-title":"Wnt proteins are lipid-modified and can act as stem cell growth factors","volume":"423","author":"Willert","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102894_bib58","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41375-021-01451-7","article-title":"p21-Activated kinases as promising therapeutic targets in hematological malignancies","volume":"36","author":"Wu","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.stemcr.2026.102894_bib59","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ccr.2010.10.032","article-title":"beta-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells","volume":"18","author":"Yeung","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stemcr.2026.102894_bib60","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/stem.1951","article-title":"Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation","volume":"33","author":"Zeng","year":"2015","journal-title":"Stem Cell."},{"key":"10.1016\/j.stemcr.2026.102894_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114812","article-title":"A MYC-STAMBPL1-TOE1 positive feedback loop mediates EGFR stability in hepatocellular carcinoma","volume":"43","author":"Zhang","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2026.102894_bib62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4161\/cl.21912","article-title":"PAK family kinases: Physiological roles and regulation","volume":"2","author":"Zhao","year":"2012","journal-title":"Cell. Logist."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126001050?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126001050?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:33:45Z","timestamp":1783128825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671126001050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":61,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2213671126001050"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.102894","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TOE1 is a \u03b2-catenin interacting protein regulating the proliferation of hematopoietic cells through PAK2 modulation","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.102894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Society for Stem Cell Research. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102894"}}