{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:59:20Z","timestamp":1790830760192,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010785","name":"Canada First Research Excellence Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010785","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.stemcr.2026.102975","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:25:50Z","timestamp":1782401150000},"page":"102975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["aPKC-\u03b6 III promotes trophoblast fusion by altering Par-3 interactions with Hippo signaling kinase LATS1"],"prefix":"10.1016","volume":"21","author":[{"given":"Sumaiyah Z.","family":"Shaha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K.","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Garcia","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan K.","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3203-2897","authenticated-orcid":false,"given":"Meghan","family":"Riddell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2026.102975_bib1","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1091\/mbc.E15-05-0265","article-title":"Atypical protein kinase C induces cell transformation by disrupting Hippo\/Yap signaling","volume":"26","author":"Archibald","year":"2015","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.stemcr.2026.102975_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-023-05869-0","article-title":"Spatial multiomics map of trophoblast development in early pregnancy","volume":"616","author":"Arutyunyan","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102975_bib3","doi-asserted-by":"crossref","first-page":"14280","DOI":"10.1073\/pnas.1920201117","article-title":"Atypical protein kinase C iota (PKC\u03bb\/\u03b9) ensures mammalian development by establishing the maternal\u2013fetal exchange interface","volume":"117","author":"Bhattacharya","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102975_bib4","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1007\/s00018-006-6201-9","article-title":"Syncytin is involved in breast cancer-endothelial cell fusions","volume":"63","author":"Bjerregaard","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.stemcr.2026.102975_bib5","doi-asserted-by":"crossref","first-page":"13013","DOI":"10.1073\/pnas.2132646100","article-title":"Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution","volume":"100","author":"Blaise","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102975_bib6","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1038\/s41598-019-40823-z","article-title":"Histone acetylation determines transcription of atypical protein kinases in rat neurons","volume":"9","author":"Borodinova","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.102975_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072061","article-title":"Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism","volume":"8","author":"Butler","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.stemcr.2026.102975_bib8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102975_bib9","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/sj.onc.1208445","article-title":"The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1","volume":"24","author":"Chan","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.stemcr.2026.102975_bib10","doi-asserted-by":"crossref","first-page":"8401","DOI":"10.1128\/MCB.25.19.8401-8414.2005","article-title":"Stimulation of GCMa Transcriptional Activity by Cyclic AMP\/Protein Kinase A Signaling Is Attributed to CBP-Mediated Acetylation of GCMa","volume":"25","author":"Chang","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.stemcr.2026.102975_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1471-0528.2005.00843.x","article-title":"Altered placental syncytin and its receptor ASCT2 expression in placental development and pre-eclampsia","volume":"113","author":"Chen","year":"2006","journal-title":"BJOG"},{"key":"10.1016\/j.stemcr.2026.102975_bib12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41573-020-0070-z","article-title":"Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine","volume":"19","author":"Dey","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.stemcr.2026.102975_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stemcr.2026.102975_bib14","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201903031","article-title":"A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity","volume":"219","author":"Dong","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.stemcr.2026.102975_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/dev.204619","article-title":"Placental cytotrophoblast microvillar stabilization is required for cell-cell fusion","volume":"152","author":"Duan","year":"2025","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2026.102975_bib16","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1128\/MCB.23.10.3566-3574.2003","article-title":"Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation","volume":"23","author":"Frendo","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.stemcr.2026.102975_bib17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","article-title":"The Hippo signalling pathway and its implications in human health and diseases","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.stemcr.2026.102975_bib18","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.placenta.2014.12.015","article-title":"Review: An overview of molecular events occurring in human trophoblast fusion","volume":"36","author":"Gerbaud","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.stemcr.2026.102975_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41586-020-2759-x","article-title":"Initiation of a conserved trophectoderm program in human, cow and mouse embryos","volume":"587","author":"Gerri","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102975_bib20","doi-asserted-by":"crossref","first-page":"21003","DOI":"10.1074\/jbc.M112.360495","article-title":"Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement","volume":"287","author":"Graybill","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2026.102975_bib21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/plac.2001.0756","article-title":"Preparation and Functional Characterization of Villous Cytotrophoblasts Free of Syncytial Fragments","volume":"23","author":"Guilbert","year":"2002","journal-title":"Placenta"},{"key":"10.1016\/j.stemcr.2026.102975_bib22","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.stemcr.2018.07.004","article-title":"Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta","volume":"11","author":"Haider","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.102975_bib23","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12967-019-1869-4","article-title":"Analysis of the role of the Hippo pathway in cancer","volume":"17","author":"Han","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.stemcr.2026.102975_bib24","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1074\/jbc.M709037200","article-title":"Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP","volume":"283","author":"Hao","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2026.102975_bib25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2026.102975_bib26","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201745253","article-title":"PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow","volume":"19","author":"Hikita","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.stemcr.2026.102975_bib27","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/dgd.12235","article-title":"Par-aPKC-dependent and -independent mechanisms cooperatively control cell polarity, Hippo signaling, and cell positioning in 16-cell stage mouse embryos","volume":"57","author":"Hirate","year":"2015","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.stemcr.2026.102975_bib28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.cub.2019.12.055","article-title":"A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity","volume":"30","author":"Holly","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.stemcr.2026.102975_bib29","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1073\/pnas.1201595109","article-title":"Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment","volume":"109","author":"Home","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102975_bib30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.placenta.2023.12.022","article-title":"Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction","volume":"146","author":"Hua","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.stemcr.2026.102975_bib31","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.107.107607","article-title":"Placental Origins of Preeclampsia","volume":"51","author":"Huppertz","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.stemcr.2026.102975_bib32","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbamcr.2018.02.002","article-title":"Protein Kinase C-\u03b6 stimulates colorectal cancer cell carcinogenesis via PKC-\u03b6\/Rac1\/Pak1\/\u03b2-Catenin signaling cascade","volume":"1865","author":"Islam","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.stemcr.2026.102975_bib33","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ajpath.2023.03.006","article-title":"Genome-Wide Analysis of Hypoxia-Inducible Factor Binding Reveals Targets Implicated in Impaired Human Placental Syncytiotrophoblast Formation under Low Oxygen","volume":"193","author":"Jaremek","year":"2023","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.stemcr.2026.102975_bib34","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203071119","article-title":"The multifaceted role of GCM1 during trophoblast differentiation in the human placenta","volume":"119","author":"Jeyarajah","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102975_bib35","article-title":"Cooperative regulation of C1-domain membrane recruitment polarizes atypical protein kinase C","volume":"222","author":"Jones","year":"2023","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.stemcr.2026.102975_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2206113119","article-title":"Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs","volume":"119","author":"Kastan","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102975_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.101170.3","article-title":"Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing","volume":"13","author":"Keenen","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.stemcr.2026.102975_bib38","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1242\/jcs.111.7.995","article-title":"Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro","volume":"111","author":"Keryer","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.stemcr.2026.102975_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/mrd.20729","article-title":"Impaired cytotrophoblast cell\u2013cell fusion is associated with reduced Syncytin and increased apoptosis in patients with placental dysfunction","volume":"75","author":"Langbein","year":"2008","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.stemcr.2026.102975_bib40","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S1097-2765(01)00361-6","article-title":"Targeted Disruption of the \u03b6PKC Gene Results in the Impairment of the NF-\u03baB Pathway","volume":"8","author":"Leitges","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stemcr.2026.102975_bib41","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkz114","article-title":"The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2026.102975_bib42","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.tibs.2017.09.003","article-title":"Regulation of the Hippo Pathway Transcription Factor TEAD","volume":"42","author":"Lin","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.stemcr.2026.102975_bib43","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s12964-023-01371-2","article-title":"YAP-mediated trophoblast dysfunction: the common pathway underlying pregnancy complications","volume":"21","author":"Lin","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.stemcr.2026.102975_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preghy.2019.11.002","article-title":"Hippo-YAP1 signaling pathway and severe preeclampsia (sPE) in the Chinese population","volume":"19","author":"Liu","year":"2020","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.stemcr.2026.102975_bib45","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41422-018-0066-y","article-title":"Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.stemcr.2026.102975_bib46","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.stemcr.2026.102975_bib47","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.stemcr.2026.102975_bib48","doi-asserted-by":"crossref","first-page":"975","DOI":"10.15252\/embr.201439951","article-title":"PARD3 induces TAZ activation and cell growth by promoting LATS1 and PP1 interaction","volume":"16","author":"Lv","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.stemcr.2026.102975_bib49","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.stemcr.2015.09.021","article-title":"Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway","volume":"5","author":"Mah","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.102975_bib50","doi-asserted-by":"crossref","first-page":"13562","DOI":"10.1073\/pnas.2002630117","article-title":"Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta","volume":"117","author":"Meinhardt","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102975_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.274027.115","article-title":"Mechanisms of Hippo pathway regulation","volume":"30","author":"Meng","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2026.102975_bib52","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/35001608","article-title":"Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis","volume":"403","author":"Mi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102975_bib53","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1038\/onc.2012.5","article-title":"YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes","volume":"31","author":"Mizuno","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.stemcr.2026.102975_bib54","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaac032","article-title":"Inhibition of YAP\/TAZ-TEAD activity induces cytotrophoblast differentiation into syncytiotrophoblast in human trophoblast","volume":"28","author":"Mizutani","year":"2022","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.stemcr.2026.102975_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2013.00285","article-title":"Placental pseudo-malignancy from a DNA methylation perspective: unanswered questions and future directions","volume":"4","author":"Novakovic","year":"2013","journal-title":"Front. Genet."},{"key":"10.1016\/j.stemcr.2026.102975_bib56","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2017.11.004","article-title":"Derivation of Human Trophoblast Stem Cells","volume":"22","author":"Okae","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2026.102975_bib57","doi-asserted-by":"crossref","first-page":"14450","DOI":"10.1073\/pnas.1301588110","article-title":"Competing molecular interactions of aPKC isoforms regulate neuronal polarity","volume":"110","author":"Parker","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102975_bib58","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202301946","article-title":"Loss of polarity regulators initiates gasdermin-E-mediated pyroptosis in syncytiotrophoblasts","volume":"6","author":"Patel","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.stemcr.2026.102975_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/srep12520","article-title":"PKC\u03b6 Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NF\u03baB-p65","volume":"5","author":"Paul","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.102975_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagrm.2023.194909","article-title":"DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKM\u03b6","volume":"1866","author":"Pramio","year":"2023","journal-title":"Biochim. Biophys. Acta, Gene Regul. Mech."},{"key":"10.1016\/j.stemcr.2026.102975_bib61","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ccell.2019.07.010","article-title":"The Dual Roles of the Atypical Protein Kinase Cs in Cancer","volume":"36","author":"Reina-Campos","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.stemcr.2026.102975_bib62","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1038\/s41467-018-07739-0","article-title":"aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability","volume":"9","author":"Riddell","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2026.102975_bib63","doi-asserted-by":"crossref","first-page":"186ra66","DOI":"10.1126\/scitranslmed.3005723","article-title":"Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers","volume":"5","author":"Rousseaux","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.stemcr.2026.102975_bib64","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00109-010-0656-8","article-title":"Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes","volume":"88","author":"Ruebner","year":"2010","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.stemcr.2026.102975_bib65","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/jcb.24110","article-title":"Regulation of the human endogenous retroviral Syncytin-1 and cell\u2013cell fusion by the nuclear hormone receptors PPAR\u03b3\/RXR\u03b1 in placentogenesis","volume":"113","author":"Ruebner","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.stemcr.2026.102975_bib66","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1093\/nar\/gkn306","article-title":"bZIP-Type transcription factors CREB and OASIS bind and stimulate the promoter of the mammalian transcription factor GCMa\/Gcm1 in trophoblast cells","volume":"36","author":"Schubert","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2026.102975_bib67","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1242\/bio.2012505","article-title":"Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling","volume":"1","author":"Seidl","year":"2012","journal-title":"Biol. Open"},{"key":"10.1016\/j.stemcr.2026.102975_bib68","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.placenta.2022.01.015","article-title":"Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c","volume":"119","author":"Shaha","year":"2022","journal-title":"Placenta"},{"key":"10.1016\/j.stemcr.2026.102975_bib69","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.placenta.2022.11.007","article-title":"Cell polarity signaling in the regulation of syncytiotrophoblast homeostasis and inflammatory response","volume":"141","author":"Shaha","year":"2023","journal-title":"Placenta"},{"key":"10.1016\/j.stemcr.2026.102975_bib70","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.devcel.2024.01.023","article-title":"Single-cell assessment of primary and stem cell-derived human trophoblast organoids as placenta-modeling platforms","volume":"59","author":"Shannon","year":"2024","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stemcr.2026.102975_bib71","doi-asserted-by":"crossref","DOI":"10.1242\/dev.199749","article-title":"Characterization of primary models of human trophoblast","volume":"148","author":"Sheridan","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2026.102975_bib72","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00441-022-03653-6","article-title":"Downregulation of CDC42 inhibits the proliferation and stemness of human trophoblast stem cell via EZRIN\/YAP inactivation","volume":"389","author":"Shilei","year":"2022","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.stemcr.2026.102975_bib73","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1210\/en.2012-1823","article-title":"Where Polarity Meets Fusion: Role of Par6 in Trophoblast Differentiation during Placental Development and Preeclampsia","volume":"154","author":"Sivasubramaniyam","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.stemcr.2026.102975_bib74","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.4049\/jimmunol.173.5.3250","article-title":"Targeted Deletion of Protein Kinase C \u03bb Reveals a Distribution of Functions between the Two Atypical Protein Kinase C Isoforms","volume":"173","author":"Soloff","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.stemcr.2026.102975_bib75","doi-asserted-by":"crossref","first-page":"20354","DOI":"10.1073\/pnas.2013559117","article-title":"Role of Hippo signaling pathway in early placental development","volume":"117","author":"Soncin","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.102975_bib76","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.devcel.2016.07.018","article-title":"aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization","volume":"38","author":"Soriano","year":"2016","journal-title":"Dev. Cell"},{"key":"10.1016\/j.stemcr.2026.102975_bib77","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/febs.15754","article-title":"Par-3 family proteins in cell polarity & adhesion","volume":"289","author":"Thompson","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.stemcr.2026.102975_bib78","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.stemcr.2026.102975_bib79","doi-asserted-by":"crossref","first-page":"21845","DOI":"10.1074\/jbc.M115.676221","article-title":"Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62","volume":"290","author":"Tsai","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.stemcr.2026.102975_bib80","doi-asserted-by":"crossref","DOI":"10.1242\/dev.163428","article-title":"Development of the human placenta","volume":"146","author":"Turco","year":"2019","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2026.102975_bib81","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41586-018-0753-3","article-title":"Trophoblast organoids as a model for maternal\u2013fetal interactions during human placentation","volume":"564","author":"Turco","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102975_bib82","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jmb.2009.07.025","article-title":"Syncytin-2 plays an important role in the fusion of human trophoblast cells","volume":"392","author":"Vargas","year":"2009","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.stemcr.2026.102975_bib83","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1101\/gad.888601","article-title":"TEAD\/TEF transcription factors utilize the activation domain of YAP65, a Src\/Yes-associated protein localized in the cytoplasm","volume":"15","author":"Vassilev","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2026.102975_bib84","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal\u2013fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.102975_bib85","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41588-023-01647-w","article-title":"Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy","volume":"56","author":"Wang","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.stemcr.2026.102975_bib86","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1016\/j.jmb.2017.09.013","article-title":"Protein Complex Assemblies in Epithelial Cell Polarity and Asymmetric Cell Division","volume":"430","author":"Wen","year":"2018","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.stemcr.2026.102975_bib87","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0014-4827(90)90310-7","article-title":"Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro","volume":"186","author":"Wice","year":"1990","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.stemcr.2026.102975_bib88","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1093\/biolre\/ioae097","article-title":"Human trophoblast invasion and migration are mediated by the YAP1-CCN1 pathway: defective signaling in trophoblasts during early-onset severe preeclampsia","volume":"111","author":"Wu","year":"2024","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.stemcr.2026.102975_bib89","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.stemcr.2026.102975_bib90","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1038\/s41596-024-01020-z","article-title":"Using clusterProfiler to characterize multiomics data","volume":"19","author":"Xu","year":"2024","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.stemcr.2026.102975_bib91","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/bjc.2012.162","article-title":"Splice variant PRKC-\u03b6-PrC is a novel biomarker of human prostate cancer","volume":"107","author":"Yao","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.stemcr.2026.102975_bib92","article-title":"Thirteen years of clusterProfiler","volume":"5","author":"Yu","year":"2024","journal-title":"Innovation"},{"key":"10.1016\/j.stemcr.2026.102975_bib93","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2015.10.044","article-title":"Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer","volume":"163","author":"Yu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2026.102975_bib94","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.stemcr.2026.102975_bib95","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2016.21","article-title":"Dual function of partitioning-defective 3 in the regulation of YAP phosphorylation and activation","volume":"2","author":"Zhang","year":"2016","journal-title":"Cell Discov."},{"key":"10.1016\/j.stemcr.2026.102975_bib96","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.stemcr.2026.102975_bib97","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.stemcr.2026.102975_bib98","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1186\/s12864-023-09690-x","article-title":"Single-cell characterization of self-renewing primary trophoblast organoids as modeling of EVT differentiation and interactions with decidual natural killer cells","volume":"24","author":"Zhuang","year":"2023","journal-title":"BMC Genom."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126001864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126001864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:40:46Z","timestamp":1790829646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671126001864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":98,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2213671126001864"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.102975","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"aPKC-\u03b6 III promotes trophoblast fusion by altering Par-3 interactions with Hippo signaling kinase LATS1","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.102975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"102975"}}