{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:01:00Z","timestamp":1790830860663,"version":"4.1.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/W018381\/1"],"award-info":[{"award-number":["BB\/W018381\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003990","name":"Conseil R\u00e9gional, \u00cele-de-France","doi-asserted-by":"publisher","award":["ED 569"],"award-info":[{"award-number":["ED 569"]}],"id":[{"id":"10.13039\/501100003990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/Z504488\/1"],"award-info":[{"award-number":["MR\/Z504488\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000735","name":"University of Cambridge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012357","name":"LifeArc","doi-asserted-by":"publisher","award":["P2019-0004"],"award-info":[{"award-number":["P2019-0004"]}],"id":[{"id":"10.13039\/100012357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000317","name":"Action Medical Research","doi-asserted-by":"publisher","award":["GN3049"],"award-info":[{"award-number":["GN3049"]}],"id":[{"id":"10.13039\/501100000317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007241","name":"Universit\u00e9 Paris-Saclay","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.stemcr.2026.102976","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:25:27Z","timestamp":1782401127000},"page":"102976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rewiring ALS by modulating the autophagy receptor SQSTM1"],"prefix":"10.1016","volume":"21","author":[{"given":"Laetitia","family":"Aubry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor I.","family":"Korolchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9456-4362","authenticated-orcid":false,"given":"Sovan","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2026.102976_bib1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/17460441.2025.2474661","article-title":"Drug repurposing in amyotrophic lateral sclerosis (ALS)","volume":"20","author":"Carroll","year":"2025","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.stemcr.2026.102976_bib2","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/15548627.2019.1644076","article-title":"ALS-FTLD-linked mutations of SQSTM1\/p62 disrupt selective autophagy and NFE2L2\/NRF2 anti-oxidative stress pathway","volume":"16","author":"Deng","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.stemcr.2026.102976_bib3","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/archneurol.2011.250","article-title":"SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"68","author":"Fecto","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.stemcr.2026.102976_bib4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/jb\/mvad089","article-title":"p62 bodies: cytosolic zoning by phase separation","volume":"175","author":"Kurusu","year":"2024","journal-title":"J. Biochem."},{"key":"10.1016\/j.stemcr.2026.102976_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24044188","article-title":"alpha(1)-Adrenergic Receptors: Insights into Potential Therapeutic Opportunities for COVID-19, Heart Failure, and Alzheimer's Disease","volume":"24","author":"Perez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.stemcr.2026.102976_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.molcel.2013.12.014","article-title":"Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy","volume":"53","author":"Rogov","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.stemcr.2026.102976_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.stemcr.2026.102977","article-title":"Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics","volume":"21","author":"Roussange","year":"2026","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.102976_bib8","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1016\/j.jmb.2020.01.024","article-title":"Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy","volume":"432","author":"Seranova","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.stemcr.2026.102976_bib9","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","article-title":"A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles","volume":"171","author":"Subramanian","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2026.102976_bib10","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s41573-022-00472-w","article-title":"Phenotypic drug discovery: recent successes, lessons learned and new directions","volume":"21","author":"Vincent","year":"2022","journal-title":"Nat. Rev. Drug Discov."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126001876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126001876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:39:42Z","timestamp":1790829582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671126001876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2213671126001876"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.102976","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rewiring ALS by modulating the autophagy receptor SQSTM1","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.102976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.102977","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"102976"}}