{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:54:34Z","timestamp":1786467274323,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03680"],"award-info":[{"award-number":["20H03680"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K18273"],"award-info":[{"award-number":["21K18273"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H04291"],"award-info":[{"award-number":["17H04291"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22bm1123011"],"award-info":[{"award-number":["JP22bm1123011"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP22ama121016"],"award-info":[{"award-number":["JP22ama121016"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015311","name":"Novartis Institutes for BioMedical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022598","name":"Toray Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022598","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006264","name":"RIKEN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016923","name":"Hoansha Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.stemcr.2026.103019","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T14:47:45Z","timestamp":1784818065000},"page":"103019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["High and intermittent hydrostatic pressure promotes maturation of engineered cardiac tissues derived from human pluripotent stem cells"],"prefix":"10.1016","volume":"21","author":[{"given":"Wusiman","family":"Maihemuti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozue","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Jimba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Hakamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosha","family":"Abulaiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Yuriko","family":"Gonz\u00e1lez-Teshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Takatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kenmotsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Minatoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seitaro","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-2827","authenticated-orcid":false,"given":"Hidetoshi","family":"Masumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2026.103019_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76062-w","article-title":"Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function","volume":"10","author":"Abulaiti","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.103019_bib2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jcp.1041570321","article-title":"Morphological and proliferative responses of endothelial cells to hydrostatic pressure: role of fibroblast growth factor","volume":"157","author":"Acevedo","year":"1993","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.stemcr.2026.103019_bib3","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1016\/j.stemcr.2023.06.001","article-title":"Vascularized hiPSC-derived 3D cardiac microtissue on chip","volume":"18","author":"Arslan","year":"2023","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103019_bib4","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5082\/6\/2\/024109","article-title":"Controlling the structural and functional anisotropy of engineered cardiac tissues","volume":"6","author":"Bian","year":"2014","journal-title":"Biofabrication"},{"key":"10.1016\/j.stemcr.2026.103019_bib5","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1053\/joca.2001.0468","article-title":"Human chondrocyte apoptosis in response to mechanical injury","volume":"9","author":"D'Lima","year":"2001","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.stemcr.2026.103019_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejphar.2004.07.013","article-title":"Force-frequency relationship in intact mammalian ventricular myocardium: physiological and pathophysiological relevance","volume":"500","author":"Endoh","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.stemcr.2026.103019_bib7","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1089\/ars.2016.6904","article-title":"Modulation of Local and Systemic Heterocellular Communication by Mechanical Forces: A Role of Endothelial Nitric Oxide Synthase","volume":"26","author":"Erkens","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.stemcr.2026.103019_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac757","article-title":"GSEApy: a comprehensive package for performing gene set enrichment analysis in Python","volume":"39","author":"Fang","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stemcr.2026.103019_bib9","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1161\/CIRCULATIONAHA.117.030785","article-title":"Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine","volume":"137","author":"Gao","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.stemcr.2026.103019_bib10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.stem.2020.05.004","article-title":"Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease","volume":"26","author":"Giacomelli","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2026.103019_bib11","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.biomaterials.2015.03.055","article-title":"Physiologic force-frequency response in engineered heart muscle by electromechanical stimulation","volume":"60","author":"Godier-Furn\u00e9mont","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.stemcr.2026.103019_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chembiol.2021.02.016","article-title":"Human iPSC modeling of heart disease for drug development","volume":"28","author":"Hnatiuk","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.stemcr.2026.103019_bib13","doi-asserted-by":"crossref","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis","volume":"16","author":"Hwang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.stemcr.2026.103019_bib14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/01.RES.0000100389.57520.1A","article-title":"Developmental changes in ventricular diastolic function correlate with changes in ventricular myoarchitecture in normal mouse embryos","volume":"93","author":"Ishiwata","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2026.103019_bib15","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.biomaterials.2016.09.024","article-title":"Dynamic culture yields engineered myocardium with near-adult functional output","volume":"111","author":"Jackman","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.stemcr.2026.103019_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-024-08463-0","article-title":"Engineered heart muscle allografts for heart repair in primates and humans","volume":"639","author":"Jebran","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103019_bib17","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1161\/CIRCULATIONAHA.123.064876","article-title":"Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids","volume":"150","author":"Kobayashi","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.stemcr.2026.103019_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ceb.2016.04.011","article-title":"Forces and mechanotransduction in 3D vascular biology","volume":"42","author":"Kutys","year":"2016","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.stemcr.2026.103019_bib19","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1002\/art.21215","article-title":"Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression","volume":"52","author":"Lee","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.stemcr.2026.103019_bib20","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20188746","article-title":"Current best practices in single-cell RNA-seq analysis: a tutorial","volume":"15","author":"Luecken","year":"2019","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.stemcr.2026.103019_bib21","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1089\/scd.2012.0490","article-title":"Structural and functional maturation of cardiomyocytes derived from human pluripotent stem cells","volume":"22","author":"Lundy","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.stemcr.2026.103019_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150605","article-title":"Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells","volume":"733","author":"Maihemuti","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.stemcr.2026.103019_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/srep29933","article-title":"The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages","volume":"6","author":"Masumoto","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.103019_bib24","doi-asserted-by":"crossref","first-page":"E8372","DOI":"10.1073\/pnas.1707316114","article-title":"Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest","volume":"114","author":"Mills","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.103019_bib25","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.stem.2018.10.005","article-title":"Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy","volume":"23","author":"Minagawa","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2026.103019_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/srep41165","article-title":"Efficient Adhesion Culture of Human Pluripotent Stem Cells Using Laminin Fragments in an Uncoated Manner","volume":"7","author":"Miyazaki","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.103019_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108641","article-title":"Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model","volume":"27","author":"Murata","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.stemcr.2026.103019_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/srep45641","article-title":"Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue","volume":"7","author":"Nakane","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.103019_bib29","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nmeth.2524","article-title":"Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes","volume":"10","author":"Nunes","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stemcr.2026.103019_bib30","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.xjon.2021.09.038","article-title":"Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues","volume":"8","author":"Osada","year":"2021","journal-title":"JTCVS Open"},{"key":"10.1016\/j.stemcr.2026.103019_bib31","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1161\/01.RES.0000020201.44772.67","article-title":"Cardiomyocyte cell cycle regulation","volume":"90","author":"Pasumarthi","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2026.103019_bib32","doi-asserted-by":"crossref","first-page":"R337","DOI":"10.1152\/ajpregu.00469.2004","article-title":"Mechanisms of disuse muscle atrophy: role of oxidative stress","volume":"288","author":"Powers","year":"2005","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.stemcr.2026.103019_bib33","series-title":"Units and Symbols in Physical Chemistry (IUPAC Chemical Data)","year":"1993"},{"key":"10.1016\/j.stemcr.2026.103019_bib34","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/stem.1331","article-title":"Concise review: maturation phases of human pluripotent stem cell-derived cardiomyocytes","volume":"31","author":"Robertson","year":"2013","journal-title":"Stem Cell."},{"key":"10.1016\/j.stemcr.2026.103019_bib35","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1021\/acsbiomaterials.8b01256","article-title":"Substrate Stiffness, Cell Anisotropy, and Cell-Cell Contact Contribute to Enhanced Structural and Calcium Handling Properties of Human Embryonic Stem Cell-Derived Cardiomyocytes","volume":"5","author":"Rodriguez","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.stemcr.2026.103019_bib36","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41586-018-0016-3","article-title":"Advanced maturation of human cardiac tissue grown from pluripotent stem cells","volume":"556","author":"Ronaldson-Bouchard","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103019_bib37","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/CIRCULATIONAHA.114.014998","article-title":"Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue","volume":"134","author":"Ruan","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.stemcr.2026.103019_bib38","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1161\/CIRCRESAHA.117.312067","article-title":"MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo","volume":"122","author":"Sala","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2026.103019_bib39","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stemcr.2026.103019_bib40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1161\/01.RES.84.3.315","article-title":"Exposure of human vascular endothelial cells to sustained hydrostatic pressure stimulates proliferation. Involvement of the alphaV integrins","volume":"84","author":"Schwartz","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2026.103019_bib41","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.jvs.2016.06.003","article-title":"Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model","volume":"65","author":"Setozaki","year":"2017","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.stemcr.2026.103019_bib42","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nature11317","article-title":"Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts","volume":"489","author":"Shiba","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103019_bib43","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1073\/pnas.1914433117","article-title":"Internal fluid pressure influences muscle contractile force","volume":"117","author":"Sleboda","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.103019_bib44","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.stemcr.2026.103019_bib45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jcp.1041580117","article-title":"Increased ambient pressure stimulates proliferation and morphologic changes in cultured endothelial cells","volume":"158","author":"Sumpio","year":"1994","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.stemcr.2026.103019_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm3471","article-title":"Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching","volume":"8","author":"Swiatlowska","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.stemcr.2026.103019_bib47","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2026.103019_bib48","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/s41569-023-00883-1","article-title":"Flow-induced reprogramming of endothelial cells in atherosclerosis","volume":"20","author":"Tamargo","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.stemcr.2026.103019_bib49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02631337","article-title":"Oscillatory shear stress and hydrostatic pressure modulate cell-matrix attachment proteins in cultured endothelial cells","volume":"31","author":"Thoumine","year":"1995","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"key":"10.1016\/j.stemcr.2026.103019_bib50","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/CIRCRESAHA.110.237206","article-title":"Growth of engineered human myocardium with mechanical loading and vascular coculture","volume":"109","author":"Tulloch","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.stemcr.2026.103019_bib51","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.yjmcc.2019.06.006","article-title":"Alteration in ventricular pressure stimulates cardiac repair and remodeling","volume":"133","author":"Unno","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.stemcr.2026.103019_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112322","article-title":"Vascular cells improve functionality of human cardiac organoids","volume":"42","author":"Voges","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103019_bib54","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.stemcr.2019.08.013","article-title":"Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells","volume":"13","author":"Yang","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103019_bib55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s42003-020-0881-9","article-title":"Hydrostatic pressure promotes endothelial tube formation through aquaporin 1 and Ras-ERK signaling","volume":"3","author":"Yoshino","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.stemcr.2026.103019_bib56","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/S0142-9612(03)00521-0","article-title":"Engineered heart tissue for regeneration of diseased hearts","volume":"25","author":"Zimmermann","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.stemcr.2026.103019_bib57","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/hh0202.103644","article-title":"Tissue engineering of a differentiated cardiac muscle construct","volume":"90","author":"Zimmermann","year":"2002","journal-title":"Circ. Res."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126002304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126002304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:14:23Z","timestamp":1786464863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671126002304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2213671126002304"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.103019","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High and intermittent hydrostatic pressure promotes maturation of engineered cardiac tissues derived from human pluripotent stem cells","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.103019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"103019"}}