{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:49:00Z","timestamp":1791906540083,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000999"],"award-info":[{"award-number":["82000999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xzy012020048"],"award-info":[{"award-number":["xzy012020048"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Shaanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2025SF-YBXM-229"],"award-info":[{"award-number":["2025SF-YBXM-229"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.stemcr.2026.103088","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:17:48Z","timestamp":1790263068000},"page":"103088","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diminished RELB impairs osteogenesis in mature periodontal ligament stem cells"],"prefix":"10.1016","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6146-8405","authenticated-orcid":false,"given":"Xin","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2026.103088_bib1","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.stemcr.2024.06.011","article-title":"An in vitro model of acute horizontal basal cell activation reveals gene regulatory networks underlying the nascent activation phase","volume":"19","author":"Barrios-Camacho","year":"2024","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103088_bib2","article-title":"Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.stemcr.2026.103088_bib3","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.7150\/thno.65694","article-title":"Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.stemcr.2026.103088_bib4","article-title":"DPP promotes odontogenic differentiation of DPSCs through NF-\u03baB signaling","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.103088_bib5","doi-asserted-by":"crossref","DOI":"10.1093\/ejo\/cjad067","article-title":"Prognostic factors, outcomes, and complications for dental autotransplantation: an umbrella review","volume":"46","author":"Cremona","year":"2024","journal-title":"Eur. J. Orthod."},{"key":"10.1016\/j.stemcr.2026.103088_bib6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/00220345231220915","article-title":"Gli1+ Periodontal Mesenchymal Stem Cells in Periodontitis","volume":"103","author":"Deng","year":"2024","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.stemcr.2026.103088_bib7","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.3390\/ijms23052503","article-title":"Effect of Cold Atmospheric Plasma (CAP) on Osteogenic Differentiation Potential of Human Osteoblasts","volume":"23","author":"Eggers","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.stemcr.2026.103088_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82537","article-title":"Creating an atlas of the bone microenvironment during oral inflammatory-related bone disease using single-cell profiling","volume":"12","author":"Fan","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.stemcr.2026.103088_bib9","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41419-024-06868-3","article-title":"A mitochondrial checkpoint to NF-\u03baB signaling","volume":"15","author":"Guilbaud","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.stemcr.2026.103088_bib10","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/jcpe.13798","article-title":"Human gingival mesenchymal stem cell-derived exosomes cross-regulate the Wnt\/\u03b2-catenin and NF-\u03baB signalling pathways in the periodontal inflammation microenvironment","volume":"50","author":"Hu","year":"2023","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.stemcr.2026.103088_bib11","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.stemcr.2022.06.006","article-title":"Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3","volume":"17","author":"Huang","year":"2022","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103088_bib12","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.1093\/eurheartj\/ehae407","article-title":"Lumican promotes calcific aortic valve disease through H3 histone lactylation","volume":"45","author":"Huang","year":"2024","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.stemcr.2026.103088_bib13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1186\/s13287-021-02618-w","article-title":"SUMO1 modification of IGF-1R combining with SNAI2 inhibited osteogenic differentiation of PDLSCs stimulated by high glucose","volume":"12","author":"Jiang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.stemcr.2026.103088_bib14","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.3390\/ma15093379","article-title":"Does Root Development Status Affect the Outcome of Tooth Autotransplantation? A Systematic Review and Meta-Analysis","volume":"15","author":"Lucas-Taul\u00e9","year":"2022","journal-title":"Materials"},{"key":"10.1016\/j.stemcr.2026.103088_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jebdp.2024.101984","article-title":"AUTOTRANSPLANTATION OF TEETH WITH OPEN APICES MAY RESULT IN HIGH SURVIVAL RATES BUT EVIDENCE IS LIMITED","volume":"24","author":"Lazic","year":"2024","journal-title":"J. Evid. Based. Dent. Pract."},{"key":"10.1016\/j.stemcr.2026.103088_bib16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41413-021-00141-5","article-title":"Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution","volume":"9","author":"Lin","year":"2021","journal-title":"Bone Res."},{"key":"10.1016\/j.stemcr.2026.103088_bib17","article-title":"An Osteoimmunomodulatory Biopatch Potentiates Stem Cell Therapies for Bone Regeneration by Simultaneously Regulating IL-17\/Ferroptosis Signaling Pathways","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.stemcr.2026.103088_bib18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12964-024-01533-w","article-title":"Role of the NF-kB signalling pathway in heterotopic ossification: biological and therapeutic significance","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.stemcr.2026.103088_bib19","first-page":"100101","article-title":"Tissue Engineering for Maxillofacial Defect Reconstruction: Strategies, Applications, and Future Directions","author":"Liu","year":"2026","journal-title":"Transl. Dental Res."},{"key":"10.1016\/j.stemcr.2026.103088_bib20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/stmcls\/sxac037","article-title":"PD-1 Suppresses the Osteogenic and Odontogenic Differentiation of Stem Cells from Dental Apical Papilla via Targeting SHP2\/NF-\u03baB Axis","volume":"40","author":"Li","year":"2022","journal-title":"Stem Cell."},{"key":"10.1016\/j.stemcr.2026.103088_bib21","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3389\/fphys.2017.00936","article-title":"Early Determination of the Periodontal Domain by the Wnt-Antagonist Frzb\/Sfrp3","volume":"8","author":"Mitsiadis","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.stemcr.2026.103088_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102405","article-title":"A single-cell atlas of human teeth","volume":"24","author":"Pagella","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.stemcr.2026.103088_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ajodo.2013.03.019","article-title":"Survival and success rates of autotransplanted premolars: a prospective study of the protocol for developing teeth","volume":"144","author":"Plakwicz","year":"2013","journal-title":"Am. J. Orthod. Dentofacial Orthop."},{"key":"10.1016\/j.stemcr.2026.103088_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/JPER.23-0469","article-title":"Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats","volume":"95","author":"Qiu","year":"2024","journal-title":"J. Periodontol."},{"key":"10.1016\/j.stemcr.2026.103088_bib25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13578-021-00691-5","article-title":"A single-cell interactome of human tooth germ from growing third molar elucidates signaling networks regulating dental development","volume":"11","author":"Shi","year":"2021","journal-title":"Cell Biosci."},{"key":"10.1016\/j.stemcr.2026.103088_bib26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1089\/scd.2024.0087","article-title":"The Effects of Different Developmental Stages on Bone Regeneration of Periodontal Ligament Stem Cells and Periodontal Ligament Cell Sheets In Vitro and Vivo","volume":"33","author":"Shao","year":"2024","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.stemcr.2026.103088_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/edt.12836","article-title":"Tooth autotransplantation: An umbrella review","volume":"39","author":"Tan","year":"2023","journal-title":"Dent. Traumatol."},{"key":"10.1016\/j.stemcr.2026.103088_bib28","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1089\/scd.2019.0025","article-title":"Periodontal Ligament Stem Cells: Current Knowledge and Future Perspectives","volume":"28","author":"Trubiani","year":"2019","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.stemcr.2026.103088_bib29","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jcyt.2019.08.002","article-title":"Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT\u00ae) Mesenchymal Stromal Cell committee position statement on nomenclature","volume":"21","author":"Viswanathan","year":"2019","journal-title":"Cytotherapy"},{"key":"10.1016\/j.stemcr.2026.103088_bib30","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1002\/JPER.20-0354","article-title":"Proteinase bone morphogenetic protein 1, but not tolloid-like 1, plays a dominant role in maintaining periodontal homeostasis","volume":"92","author":"Wang","year":"2021","journal-title":"J. Periodontol."},{"key":"10.1016\/j.stemcr.2026.103088_bib31","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.7150\/thno.35914","article-title":"COL4A2 in the tissue-specific extracellular matrix plays important role on osteogenic differentiation of periodontal ligament stem cells","volume":"9","author":"Wen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.stemcr.2026.103088_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/00220345231205283","article-title":"Single-Cell Transcriptomic Analysis of Dental Pulp and Periodontal Ligament Stem Cells","volume":"103","author":"Yang","year":"2024","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.stemcr.2026.103088_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1071472","article-title":"Periodontal ligament stem cell-based bioactive constructs for bone tissue engineering","volume":"10","author":"Zhao","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.stemcr.2026.103088_bib34","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/jcpe.70031","article-title":"Parkin Acetylation-Mediated Mitophagy Orchestrates Periodontal Ligament Stem Cell Osteogenesis and Bone Regeneration During Ageing","volume":"53","author":"Zhang","year":"2026","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.stemcr.2026.103088_bib35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13046-018-0849-5","article-title":"HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells","volume":"37","author":"Zhang","year":"2018","journal-title":"J. Exp. Clin. Cancer Res."}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126002997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126002997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:20:20Z","timestamp":1791904820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671126002997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S2213671126002997"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.103088","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diminished RELB impairs osteogenesis in mature periodontal ligament stem cells","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.103088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"103088"}}