{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:46:01Z","timestamp":1792215961233,"version":"4.4.0"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"NICHD","doi-asserted-by":"publisher","award":["T32HD108079"],"award-info":[{"award-number":["T32HD108079"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01DK100917"],"award-info":[{"award-number":["R01DK100917"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["S10OD036313"],"award-info":[{"award-number":["S10OD036313"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["S10OD030423"],"award-info":[{"award-number":["S10OD030423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG062879"],"award-info":[{"award-number":["R01AG062879"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005188","name":"TRDRP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000936","name":"Gordon and Betty Moore Foundation","doi-asserted-by":"publisher","award":["GBMF13917"],"award-info":[{"award-number":["GBMF13917"]}],"id":[{"id":"10.13039\/100000936","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"CIRM","doi-asserted-by":"publisher","award":["EDUC4-12759"],"award-info":[{"award-number":["EDUC4-12759"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["R35GM137801"],"award-info":[{"award-number":["R35GM137801"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"NIGMS","doi-asserted-by":"publisher","award":["K12GM139185"],"award-info":[{"award-number":["K12GM139185"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Stem Cell Reports"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.stemcr.2026.103118","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:23:07Z","timestamp":1792077787000},"page":"103118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perinatal nicotine exposure disrupts hematopoietic stem cell development and elevates influenza severity in adulthood"],"prefix":"10.1016","author":[{"given":"M.G.E.","family":"Rommel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rodriguez y Baena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mattingly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bachinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chattopadhyaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.A.","family":"Manso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rajendiran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.","family":"Worthington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Poscablo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Deguzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3670-5212","authenticated-orcid":false,"given":"P.Q.","family":"Wimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.M.","family":"Voelker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Berger-Cahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Langroudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.F.","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Shariati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-5404","authenticated-orcid":false,"given":"S.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.F.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8740-4299","authenticated-orcid":false,"given":"E.C.","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.stemcr.2026.103118_bib1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fimmu.2020.00123","article-title":"Training the Fetal Immune System Through Maternal Inflammation\u2014A Layered Hygiene Hypothesis","volume":"11","author":"Apostol","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.stemcr.2026.103118_bib2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s12884-021-03729-1","article-title":"Health outcomes of smoking during pregnancy and the postpartum period: an umbrella review","volume":"21","author":"Av\u015far","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.stemcr.2026.103118_bib3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.exphem.2013.11.013","article-title":"Flk2\/Flt3 promotes both myeloid and lymphoid development by expanding non-self-renewing multipotent hematopoietic progenitor cells","volume":"42","author":"Beaudin","year":"2014","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.stemcr.2026.103118_bib4","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.stem.2016.08.013","article-title":"A transient developmental hematopoietic stem cell gives rise to innate-like B and T cells","volume":"19","author":"Beaudin","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2026.103118_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1465-9921-14-119","article-title":"Nicotine exposure during differentiation causes inhibition of N-myc expression","volume":"14","author":"Ben-Yehudah","year":"2013","journal-title":"Respir. Res."},{"key":"10.1016\/j.stemcr.2026.103118_bib6","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1182\/blood-2014-04-570762","article-title":"Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis","volume":"124","author":"Boettcher","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.stemcr.2026.103118_bib7","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nature08764","article-title":"In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium","volume":"464","author":"Boisset","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103118_bib8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2011.04.021","article-title":"All hematopoietic cells develop from hematopoietic stem cells through Flk2\/Flt3-positive progenitor cells","volume":"9","author":"Boyer","year":"2011","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2026.103118_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.cell.2013.06.013","article-title":"A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection","volume":"154","author":"Brandes","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2026.103118_bib10","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3389\/fimmu.2017.00550","article-title":"A Role for Neutrophils in Viral Respiratory Disease","volume":"8","author":"Camp","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.stemcr.2026.103118_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.aogh.2016.01.023","article-title":"Early-life Exposure to Widespread Environmental Toxicants and Health Risk: A Focus on the Immune and Respiratory Systems","volume":"82","author":"Cao","year":"2016","journal-title":"Ann. Glob. Health"},{"key":"10.1016\/j.stemcr.2026.103118_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.exphem.2024.104215","article-title":"Forged in the fire: Lasting impacts of inflammation on hematopoietic progenitors","volume":"134","author":"Cao","year":"2024","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.stemcr.2026.103118_bib13","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3389\/fimmu.2018.00781","article-title":"Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose","volume":"9","author":"Carlin","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.stemcr.2026.103118_bib14","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1542\/peds.2006-2837","article-title":"Maternal Asthma and Maternal Smoking Are Associated With Increased Risk of Bronchiolitis During Infancy","volume":"119","author":"Carroll","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.stemcr.2026.103118_bib15","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1038\/s41592-023-02014-7","article-title":"Extending support for mouse data in the Molecular Signatures Database (MSigDB)","volume":"20","author":"Castanza","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.stemcr.2026.103118_bib16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/1358863X10378377","article-title":"Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease?","volume":"15","author":"Chang","year":"2010","journal-title":"Vasc. Med."},{"key":"10.1016\/j.stemcr.2026.103118_bib17","doi-asserted-by":"crossref","first-page":"W305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene Suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"Chen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.stemcr.2026.103118_bib18","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.cell.2024.02.002","article-title":"Maternal inflammation regulates fetal emergency myelopoiesis","volume":"187","author":"Collins","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2026.103118_bib19","first-page":"004","article-title":"Oral Nicotine Self-Administration in Rodents","volume":"S2","author":"Collins","year":"2012","journal-title":"J. Addict. Res. Ther."},{"key":"10.1016\/j.stemcr.2026.103118_bib20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/thx.54.4.357","article-title":"Health effects of passive smoking 10: Summary of effects of parental smoking on the respiratory health of children and implications for research","volume":"54","author":"Cook","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.stemcr.2026.103118_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14010184","article-title":"Clearing the Haze: How Does Nicotine Affect Hematopoiesis before and after Birth?","volume":"14","author":"Cool","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.stemcr.2026.103118_bib22","first-page":"1","article-title":"Chasing Mavericks: The quest for defining developmental waves of hematopoiesis","volume":"132","author":"Cool","year":"2019","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.stemcr.2026.103118_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.exphem.2020.09.001","article-title":"Interleukin 7 receptor is required for myeloid cell homeostasis and reconstitution by hematopoietic stem cells","volume":"90","author":"Cool","year":"2020","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.stemcr.2026.103118_bib24","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.stem.2020.01.017","article-title":"C\/EBP\u03b2-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells","volume":"26","author":"de Laval","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2026.103118_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.amepre.2010.03.009","article-title":"Infant morbidity and mortality attributable to prenatal smoking in the U.S","volume":"39","author":"Dietz","year":"2010","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.stemcr.2026.103118_bib26","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1542\/peds.113.S3.1007","article-title":"Prenatal and postnatal environmental tobacco smoke exposure and children\u2019s health","volume":"113","author":"DiFranza","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.stemcr.2026.103118_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41590-020-00845-6","article-title":"Trained immunity, tolerance, priming and differentiation: distinct immunological processes","volume":"22","author":"Divangahi","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.stemcr.2026.103118_bib28","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac757","article-title":"GSEApy: a comprehensive package for performing gene set enrichment analysis in Python","volume":"39","author":"Fang","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stemcr.2026.103118_bib29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fcimb.2020.00425","article-title":"Dynamic Natural Killer Cell and T Cell Responses to Influenza Infection","volume":"10","author":"Frank","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.stemcr.2026.103118_bib30","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/s41586-024-07265-8","article-title":"Necroptosis blockade prevents lung injury in severe influenza","volume":"628","author":"Gautam","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103118_bib31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.mehy.2005.02.039","article-title":"Exposure to nicotine is probably a major cause of inflammatory diseases among non-smokers","volume":"65","author":"Gracia","year":"2005","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.stemcr.2026.103118_bib32","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1084\/jem.20131199","article-title":"Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF","volume":"210","author":"Guilliams","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.stemcr.2026.103118_bib33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.stem.2015.07.007","article-title":"Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors","volume":"17","author":"Haas","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.stemcr.2026.103118_bib34","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3390\/v11030272","article-title":"Tissue-Resident Innate and Innate-Like Lymphocyte Responses to Viral Infection","volume":"11","author":"Hildreth","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.stemcr.2026.103118_bib35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.95267","article-title":"Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP\/TAZ and Notch signal pathway","volume":"13","author":"Isotani","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.stemcr.2026.103118_bib36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1465-9921-7-48","article-title":"Prenatal and postnatal tobacco smoke exposure and respiratory health in Russian children","volume":"7","author":"Jaakkola","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.stemcr.2026.103118_bib37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.exphem.2023.02.001","article-title":"Trained immunity and epigenetic memory in long-term self-renewing hematopoietic cells","volume":"121","author":"Johansson","year":"2023","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.stemcr.2026.103118_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1465-9921-12-5","article-title":"Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis","volume":"12","author":"Jones","year":"2011","journal-title":"Respir. Res."},{"key":"10.1016\/j.stemcr.2026.103118_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107596","article-title":"Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models","volume":"26","author":"Kain","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.stemcr.2026.103118_bib40","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41370-024-00680-z","article-title":"Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases","volume":"34","author":"Karthikeyan","year":"2024","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.stemcr.2026.103118_bib41","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/j.1745-7270.2006.00240.x","article-title":"Nicotine Treatment Induces Expression of Matrix Metalloproteinases in Human Osteoblastic Saos-2 Cells","volume":"38","author":"Katono","year":"2006","journal-title":"ABBS"},{"key":"10.1016\/j.stemcr.2026.103118_bib42","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","article-title":"BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis","volume":"172","author":"Kaufmann","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2026.103118_bib43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/15569543.2020.1790604","article-title":"Nicotine lowers TNF-\u03b1, IL-1b secretion and leukocyte accumulation via nAChR in rat stomach","volume":"40","author":"Kizildag","year":"2021","journal-title":"Toxin Rev."},{"key":"10.1016\/j.stemcr.2026.103118_bib44","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.bbrc.2020.04.045","article-title":"Paracrine CCL17 and CCL22 signaling regulates hematopoietic stem\/progenitor cell migration and retention in mouse fetal liver","volume":"527","author":"Konno","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.stemcr.2026.103118_bib45","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41586-023-06002-x","article-title":"Physiology and diseases of tissue-resident macrophages","volume":"618","author":"Lazarov","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.stemcr.2026.103118_bib46","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s13287-021-02189-w","article-title":"Fetal liver hematopoiesis: from development to delivery","volume":"12","author":"Lewis","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.stemcr.2026.103118_bib47","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1159\/000329982","article-title":"Nicotine reduces TNF-\u03b1 expression through a \u03b17 nAChR\/MyD88\/NF-\u0138B pathway in HBE16 airway epithelial cells","volume":"27","author":"Li","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.stemcr.2026.103118_bib48","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0301-472X(00)00157-0","article-title":"Origins and functions of phagocytes in the embryo","volume":"28","author":"Lichanska","year":"2000","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.stemcr.2026.103118_bib49","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112693","article-title":"Both maternal IFN\u03b3 exposure and acute prenatal infection with Toxoplasma gondii activate fetal hematopoietic stem cells","volume":"42","author":"L\u00f3pez","year":"2023","journal-title":"EMBO J."},{"key":"10.1016\/j.stemcr.2026.103118_bib50","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1158\/1940-6207.CAPR-11-0365","article-title":"Nicotine Does Not Enhance Tumorigenesis in Mutant K - Ras \u2013Driven Mouse Models of Lung Cancer","volume":"4","author":"Maier","year":"2011","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.stemcr.2026.103118_bib51","doi-asserted-by":"crossref","unstructured":"Manso, B.A., Medina, P., Smith-Berdan, S., Rodriguez Y Baena, A., Bachinsky, E., Mok, L., Deguzman, A., Avila, S.B., Van Voorhis, C., Chattopadhyaya, S., et al., 2025. A Rare Hematopoietic Stem Cell-Derived Megakaryocyte Progenitor Accumulates via Enhanced Survival and Contributes to Exacerbated Thrombopoiesis Upon Aging. Aging Cell. 24: e70221. https:\/\/doi.org\/10.1111\/acel.70221.","DOI":"10.1111\/acel.70221"},{"key":"10.1016\/j.stemcr.2026.103118_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.stemcr.2026.102965","article-title":"Aging of hematopoietic stem cells is inconsequential to progenitor cell function","volume":"21","author":"Myers","year":"2026","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103118_bib53","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nri3660","article-title":"Emergency granulopoiesis","volume":"14","author":"Manz","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.stemcr.2026.103118_bib54","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1113\/jphysiol.1952.sp004789","article-title":"Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of guinea-pigs","volume":"118","author":"Miles","year":"1952","journal-title":"J. Physiol."},{"key":"10.1016\/j.stemcr.2026.103118_bib55","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/274048","article-title":"Prenatal exposure to nicotine in pregnant rat increased inflammatory marker in Newborn Rat","volume":"2014","author":"Mohsenzadeh","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.stemcr.2026.103118_bib56","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btad547","article-title":"PyDESeq2: a python package for bulk RNA-seq differential expression analysis","volume":"39","author":"Muzellec","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.stemcr.2026.103118_bib57","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.stemcr.2026.103118_bib58","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/aps.2009.67","article-title":"Nicotine and inflammatory neurological disorders","volume":"30","author":"Piao","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.stemcr.2026.103118_bib59","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1084\/jem.20131043","article-title":"Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons","volume":"211","author":"Pietras","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.stemcr.2026.103118_bib60","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.stemcr.2021.04.016","article-title":"Megakaryocyte progenitor cell function is enhanced upon aging despite the functional decline of aged hematopoietic stem cells","volume":"16","author":"Poscablo","year":"2021","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103118_bib61","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1186\/s12889-018-6137-7","article-title":"The association between active tobacco use during pregnancy and growth outcomes of children under five years of age: a systematic review and meta-analysis","volume":"18","author":"Quelhas","year":"2018","journal-title":"BMC Public Health"},{"key":"10.1016\/j.stemcr.2026.103118_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2020.102145","article-title":"A quantitative hematopoietic stem cell reconstitution protocol: Accounting for recipient variability, tissue distribution and cell half-lives","volume":"50","author":"Rajendiran","year":"2021","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.stemcr.2026.103118_bib63","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1038\/s41598-022-07041-6","article-title":"New transgenic mouse models enabling pan-hematopoietic or selective hematopoietic stem cell depletion in vivo","volume":"12","author":"Rodriguez y Baena","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.stemcr.2026.103118_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111447","article-title":"Influenza A virus infection instructs hematopoiesis to megakaryocyte-lineage output","volume":"41","author":"Rommel","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103118_bib65","doi-asserted-by":"crossref","first-page":"L481","DOI":"10.1152\/ajplung.00343.2012","article-title":"Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels","volume":"304","author":"Sanders","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.stemcr.2026.103118_bib66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1158\/1541-7786.MCR-13-0541","article-title":"Nicotine-Mediated Cell Proliferation and Tumor Progression in Smoking-Related Cancers","volume":"12","author":"Schaal","year":"2014","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.stemcr.2026.103118_bib67","doi-asserted-by":"crossref","first-page":"102547","DOI":"10.1016\/j.stemcr.2025.102547","article-title":"Vascular endothelial growth factor-induced vascular permeability results in drastic and reversible hematopoietic stem cell mobilization","volume":"20","author":"Smith-Berdan","year":"2025","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103118_bib68","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.stemcr.2014.12.013","article-title":"ROBO4-mediated vascular integrity regulates the directionality of hematopoietic stem cell trafficking","volume":"4","author":"Smith-Berdan","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.stemcr.2026.103118_bib69","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/ar.1092320410","article-title":"Macrophage development: II. Early ontogeny of macrophage populations in brain, liver, and lungs of rat embryos as revealed by a lectin marker","volume":"232","author":"Sorokin","year":"1992","journal-title":"Anat. Rec."},{"key":"10.1016\/j.stemcr.2026.103118_bib70","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1136\/adc.62.8.786","article-title":"Maternal smoking during pregnancy and lower respiratory tract illness in early life","volume":"62","author":"Taylor","year":"1987","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.stemcr.2026.103118_bib71","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.106610","article-title":"Hematopoietic stem and progenitor cells as a reservoir for trained immunity","volume":"14","author":"Tran","year":"2025","journal-title":"eLife"},{"key":"10.1016\/j.stemcr.2026.103118_bib72","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/cei.13388","article-title":"Nicotine modulates molecules of the innate immune response in epithelial cells and macrophages during infection with M. tuberculosis","volume":"199","author":"Valdez-Miramontes","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.stemcr.2026.103118_bib73","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate Lymphoid Cells: 10 Years On","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.stemcr.2026.103118_bib74","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.3390\/molecules27123715","article-title":"Effects of Smoking on Inflammatory-Related Cytokine Levels in Human Serum","volume":"27","author":"Wang","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.stemcr.2026.103118_bib75","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2310\/JIM.0b013e3181db874e","article-title":"Cigarette smoke alters tissue inhibitor of metalloproteinase 1 and matrix metalloproteinase 9 levels in the basolateral secretions of human asthmatic bronchial epithelium in vitro","volume":"58","author":"Watson","year":"2010","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.stemcr.2026.103118_bib76","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.stemcr.2026.103118_bib77","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200139","article-title":"IL7R\u03b1, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells","volume":"149","author":"Worthington","year":"2022","journal-title":"Development"},{"key":"10.1016\/j.stemcr.2026.103118_bib78","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1056\/NEJM198102193040806","article-title":"Leukocyte Count, Smoking, and Myocardial Infarction","volume":"304","author":"Zalokar","year":"1981","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.stemcr.2026.103118_bib79","doi-asserted-by":"crossref","first-page":"eaea1260","DOI":"10.1126\/science.aea1260","article-title":"Mucosal vaccination in mice provides protection from diverse respiratory threats","volume":"392","author":"Zhang","year":"2026","journal-title":"Science"}],"container-title":["Stem Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126003292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213671126003292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:33:38Z","timestamp":1792215218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213671126003292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":79,"alternative-id":["S2213671126003292"],"URL":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.103118","relation":{},"ISSN":["2213-6711"],"issn-type":[{"value":"2213-6711","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Perinatal nicotine exposure disrupts hematopoietic stem cell development and elevates influenza severity in adulthood","name":"articletitle","label":"Article Title"},{"value":"Stem Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.stemcr.2026.103118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of International Society for Stem Cell Research.","name":"copyright","label":"Copyright"}],"article-number":"103118"}}