{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T01:48:05Z","timestamp":1785721685513,"version":"3.56.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"11-12","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.steroids.2004.07.005","type":"journal-article","created":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T15:17:41Z","timestamp":1096557461000},"page":"727-734","source":"Crossref","is-referenced-by-count":18,"title":["Plant 2-arylobenzofurans demonstrate a selective estrogen receptor modulator profile"],"prefix":"10.1016","volume":"69","author":[{"given":"Zoi","family":"Papoutsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Papaevangeliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harris","family":"Pratsinis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Zoumpourlis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Halabalaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Mitakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Kalofoutis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Moutsatsou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.steroids.2004.07.005_bib1","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1210\/jc.83.7.2223","article-title":"Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological and mechanistic evidence","volume":"83","author":"Tham","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.steroids.2004.07.005_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0301-2115(98)00281-4","article-title":"Phytoestrogens: the \u201cnatural\u201d selective estrogen receptor modulators?","volume":"85","author":"Brzezinski","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.steroids.2004.07.005_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1053\/beog.2002.0290","article-title":"Use of alternative therapies in menopause","volume":"16","author":"Warren","year":"2002","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.steroids.2004.07.005_bib4","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/np000071b","article-title":"Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor","volume":"63","author":"Halabalaki","year":"2000","journal-title":"J Nat Prod"},{"key":"10.1016\/j.steroids.2004.07.005_bib5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1124\/jpet.300.3.802","article-title":"Effects of 3-phenyl-4-[4-[2(1-piperidinyl)ethoxy]phenyl]methyl-2H-1-benzopyran-7-ol (CHF 4056), a novel nonsteroid estrogen agonist\/antagonist, on reproductive and nonreproductive tissue","volume":"300","author":"Galbiati","year":"2002","journal-title":"J Pharmacol Exp Ther."},{"key":"10.1016\/j.steroids.2004.07.005_bib6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1749-6632.1995.tb31378.x","article-title":"Studies on heterocycle-based pure estrogen antagonists","volume":"761","author":"Von Angerer","year":"1995","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.steroids.2004.07.005_bib7","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1074\/jbc.271.2.1016","article-title":"Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells","volume":"271","author":"Huynh","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.steroids.2004.07.005_bib8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1359\/jbmr.2002.17.3.394","article-title":"Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis","volume":"17","author":"Dang","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.steroids.2004.07.005_bib9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1749-6632.1997.tb52134.x","article-title":"Estrogen and progesterone receptors in the endometrium","volume":"816","author":"Moutsatsou","year":"1997","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.steroids.2004.07.005_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00001813-199302000-00010","article-title":"Differential interaction of cisplatin with the HIV-1 long terminal repeat in a resistant ovarian carcinoma cell line","volume":"4","author":"Zoumpourlis","year":"1993","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.steroids.2004.07.005_bib11","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1006\/bbrc.2000.4232","article-title":"Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells","volume":"280","author":"Maeda","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.steroids.2004.07.005_bib12","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1128\/MCB.7.8.2745","article-title":"High-efficiency transformation of mammalian cells by plasmid DNA","volume":"7","author":"Chen","year":"1987","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.steroids.2004.07.005_bib13","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/MCB.12.10.4531","article-title":"Examination of the DNA-binding ability of estrogen receptor in whole cells: implications for hormone-independent transactivation and the actions of antiestrogens","volume":"12","author":"Reese","year":"1992","journal-title":"Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.steroids.2004.07.005_bib14","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/1097-0142(20000815)89:4<817::AID-CNCR14>3.0.CO;2-6","article-title":"ICI 182780 (Faslodex): development of a novel,\u201cpure\u201d antiestrogen","volume":"89","author":"Howell","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.steroids.2004.07.005_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-1999-13980","article-title":"In vitro test systems for the evaluation of the estrogenic activity of natural products","volume":"65","author":"Diel","year":"1999","journal-title":"Planta Med"},{"key":"10.1016\/j.steroids.2004.07.005_bib16","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1210\/en.136.3.1219","article-title":"Insulin-like growth factor-binding protein-3 produciton by MCF-7 breast cancer cells: Stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol","volume":"136","author":"Martin","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2004.07.005_bib17","first-page":"5193","article-title":"Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media","volume":"53","author":"Pratt","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.steroids.2004.07.005_bib18","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1172\/JCI112742","article-title":"Radioimmunoassay of growth hormone-dependent insulinlike growth factor binding protein in human plasma","volume":"78","author":"Baxter","year":"1986","journal-title":"J Clin Invest"},{"key":"10.1016\/j.steroids.2004.07.005_bib19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S1470-2045(02)00731-3","article-title":"Insulin-like growth factors and cancer","volume":"3","author":"F\u00fcrstenberger","year":"2002","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.steroids.2004.07.005_bib20","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1210\/jc.85.9.3043","article-title":"Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women","volume":"85","author":"Wangen","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.steroids.2004.07.005_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s002230050012","article-title":"The synthetic phytoestrogen, ipriflavone, and estrogen prevent bone loss by different mechanisms","volume":"66","author":"Arjmandi","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.steroids.2004.07.005_bib22","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1006\/bbrc.1998.9870","article-title":"Resveratrol stimulates the proliferation and differentiation of osteoblastic MC3T3-E1 cells","volume":"253","author":"Mizutani","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.steroids.2004.07.005_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","article-title":"Rapid colorimetric assay for cell growth and survival: modifications to the tetrozolium dye procedure giving improved sensitivity and reliability","volume":"89","author":"Denizof","year":"1986","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.steroids.2004.07.005_bib24","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0039-128X(01)00099-X","article-title":"Purification and characterization of nuclear type II [3H] estradiol binding sites from the rat uterus: covalent labeling with [3H] luteolin","volume":"66","author":"Markaverich","year":"2001","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2004.07.005_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1165\/ajrcmb.17.1.2728","article-title":"Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancer","volume":"17","author":"Caltagirone","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.steroids.2004.07.005_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1046\/j.1525-1438.1993.03020080.x","article-title":"Type I and type II estrogen and progesterone binding sites in endometrial carcinomas: their value in predicting survival","volume":"3","author":"Sivridis","year":"1993","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.steroids.2004.07.005_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1089\/109793301316882531","article-title":"Bisphenol a binds to the low-affinity estrogen binding site","volume":"14","author":"Washington","year":"2001","journal-title":"In Vitro Mol Toxicol"},{"key":"10.1016\/j.steroids.2004.07.005_bib28","first-page":"3902","article-title":"Tamoxifen-induced antitumorigenic\/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator","volume":"61","author":"McDougal","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.steroids.2004.07.005_bib29","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1021\/jm00128a006","article-title":"Structure-activity relationship of antiestrogens: a study using triarylbutenone, benzofuran, and triarylfuran analogues as models for triarylethylenes and triarylpropenones","volume":"32","author":"Durani","year":"1989","journal-title":"J Med Chem"},{"key":"10.1016\/j.steroids.2004.07.005_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/jm9606352","article-title":"Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene","volume":"40","author":"Grese","year":"1997","journal-title":"J Med Chem"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X04001539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X04001539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T10:50:08Z","timestamp":1549191008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X04001539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":30,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0039128X04001539"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2004.07.005","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}