{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:42:47Z","timestamp":1790361767463,"version":"4.1.0"},"reference-count":225,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.steroids.2011.03.001","type":"journal-article","created":{"date-parts":[[2011,3,16]],"date-time":"2011-03-16T08:16:52Z","timestamp":1300263412000},"page":"636-652","source":"Crossref","is-referenced-by-count":202,"title":["Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception"],"prefix":"10.1016","volume":"76","author":[{"given":"Donita","family":"Africander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette","family":"Verhoog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet P.","family":"Hapgood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10\u201313","key":"10.1016\/j.steroids.2011.03.001_bib0005","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.steroids.2003.08.003","article-title":"All progestins are not created equal","volume":"68","author":"Stanczyk","year":"2003","journal-title":"Steroids"},{"issue":"10\u201313","key":"10.1016\/j.steroids.2011.03.001_bib0010","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.steroids.2003.07.001","article-title":"Antiprogestins as a model for progesterone withdrawal","volume":"68","author":"Critchley","year":"2003","journal-title":"Steroids"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0015","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/med.20083","article-title":"The evolution of progesterone receptor ligands","volume":"27","author":"Kevin","year":"2007","journal-title":"Med Res Rev"},{"key":"10.1016\/j.steroids.2011.03.001_bib1125","series-title":"A clinical guide for contraception","article-title":"Injectable contraception","author":"Speroff","year":"1996"},{"key":"10.1016\/j.steroids.2011.03.001_bib0025","doi-asserted-by":"crossref","first-page":"262","DOI":"10.7326\/0003-4819-130-4_Part_1-199902160-00003","article-title":"Effects of estrogen and estrogen-progestin on mammographic parenchymal density. Postmenopausal Estrogen\/Progestin Interventions (PEPI) Investigators","volume":"130","author":"Greendale","year":"1999","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0030","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1532-5415.1980.tb00530.x","article-title":"Estrogen therapy and breast cancer in postmenopausal women","volume":"28","author":"Gambrell","year":"1980","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0035","first-page":"207","article-title":"Norethindrone\u2014a review of therapeutic applications","volume":"40","author":"Taitel","year":"1995","journal-title":"Int J Fertil Menopausal Stud"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0040","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0378-5122(90)90003-O","article-title":"Pharmacokinetics of oestrogens and progestogens","volume":"12","author":"Kuhl","year":"1990","journal-title":"Maturitas"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib0045","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.contraception.2010.04.004","article-title":"The use of newer progestins for contraception","volume":"82","author":"Sitruk-Ware","year":"2010","journal-title":"Contraception"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1783\/147118902101195794","article-title":"Injectable contraceptives: a worldwide perspective","volume":"28","author":"Affandi","year":"2002","journal-title":"J Fam Plann Reprod Health Care"},{"issue":"Suppl. 1","key":"10.1016\/j.steroids.2011.03.001_bib0055","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.maturitas.2003.09.014","article-title":"Classification and pharmacology of progestins","volume":"46","author":"Schindler","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.steroids.2011.03.001_bib0060","first-page":"CD005214","article-title":"Depot medroxyprogesterone versus norethisterone oenanthate for long-acting progestogenic contraception","volume":"3","author":"Draper","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0065","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/GRF.0b013e318159c20a","article-title":"Injectable contraception","volume":"50","author":"Haider","year":"2007","journal-title":"Clin Obstet Gynecol"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0070","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"issue":"9382","key":"10.1016\/j.steroids.2011.03.001_bib0075","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0140-6736(03)14065-2","article-title":"Breast cancer and hormone-replacement therapy in the Million Women Study","volume":"362","author":"collaborators","year":"2003","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00002030-200401230-00009","article-title":"The effect of hormonal contraception on genital tract shedding of HIV-1","volume":"18","author":"Wang","year":"2004","journal-title":"AIDS"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0085","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1210\/jc.2002-020874","article-title":"A randomized controlled trial of estrogen replacement therapy in long-term users of depot medroxyprogesterone acetate","volume":"88","author":"Cundy","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0090","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jpag.2005.04.005","article-title":"In favor of continued use of depot medroxyprogesterone acetate (DMPA, Depo-Provera) in adolescents","volume":"18","author":"Cromer","year":"2005","journal-title":"J Pediatr Adolesc Gynecol"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0095","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/01.gme.0000196814.41871.ff","article-title":"Hormone therapy and breast cancer risk: trumping fear with facts","volume":"13","author":"Kaunitz","year":"2006","journal-title":"Menopause"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib0100","first-page":"248","article-title":"Comparative cardiovascular effects of different progestins in menopause","volume":"46","author":"Rosano","year":"2001","journal-title":"Int J Fertil Womens Med"},{"issue":"10","key":"10.1016\/j.steroids.2011.03.001_bib0105","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1001\/archneur.60.10.1379","article-title":"Increased risk of stroke in hypertensive women using hormone therapy: analyses based on the Danish Nurse Study","volume":"60","author":"Lokkegaard","year":"2003","journal-title":"Arch Neurol"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0110","first-page":"1285","article-title":"Immunocompetence of marginally nourished women on hormonal contraceptives","volume":"36","author":"Majumder","year":"1987","journal-title":"Nutr Rep Int"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0115","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000292057","article-title":"Hormone replacement therapy affects various immune cell subsets and natural cytotoxicity","volume":"41","author":"Brunelli","year":"1996","journal-title":"Gynecol Obstet Invest"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02778145","article-title":"Differential effects of estrogen and medroxyprogesterone on basal and stress-induced growth hormone release, IGF-1 levels, and cellular immunity in postmenopausal women","volume":"7","author":"Malarkey","year":"1997","journal-title":"Endocrine"},{"issue":"12","key":"10.1016\/j.steroids.2011.03.001_bib0125","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1161\/hc1202.105945","article-title":"Effect of medroxyprogesterone acetate on vascular inflammatory markers in postmenopausal women receiving estrogen","volume":"105","author":"Wakatsuki","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0130","first-page":"99","article-title":"Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer type: 7 case reports","volume":"6","author":"Ohkura","year":"1995","journal-title":"Dementia"},{"key":"10.1016\/j.steroids.2011.03.001_bib0135","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","article-title":"Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial","volume":"289","author":"Shumaker","year":"2003","journal-title":"JAMA"},{"issue":"9\u201310","key":"10.1016\/j.steroids.2011.03.001_bib0140","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.steroids.2007.12.004","article-title":"Honey, we need to talk about the membrane progestin receptors","volume":"73","author":"Fernandes","year":"2008","journal-title":"Steroids"},{"issue":"2 Pt 2","key":"10.1016\/j.steroids.2011.03.001_bib0145","doi-asserted-by":"crossref","first-page":"909s","DOI":"10.1158\/1078-0432.909s.11.2","article-title":"Estrogen, estrogen plus progestin therapy, and risk of breast cancer","volume":"11","author":"Colditz","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jri.2005.07.006","article-title":"Effect of estrogen\/progesterone hormone replacement therapy on natural killer cell cytotoxicity and immunoregulatory cytokine release by peripheral blood mononuclear cells of postmenopausal women","volume":"69","author":"Stopinska-Gluszak","year":"2006","journal-title":"J Reprod Immunol"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0155","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jadohealth.2006.03.011","article-title":"Depot medroxyprogesterone acetate and bone mineral density in adolescents\u2014the Black Box Warning: a Position Paper of the Society for Adolescent Medicine","volume":"39","author":"Cromer","year":"2006","journal-title":"J Adolesc Health"},{"issue":"10\u201311","key":"10.1016\/j.steroids.2011.03.001_bib0160","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0039-128X(00)00174-4","article-title":"Progestins and cardiovascular risk markers","volume":"65","author":"Sitruk-Ware","year":"2000","journal-title":"Steroids"},{"issue":"5675","key":"10.1016\/j.steroids.2011.03.001_bib0165","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1126\/science.1096725","article-title":"Hormone therapy: physiological complexity belies therapeutic simplicity","volume":"304","author":"Turgeon","year":"2004","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0170","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.fertnstert.2003.07.041","article-title":"Effects of tibolone and continuous combined hormone therapy on mammographic breast density and breast histochemical markers in postmenopausal women","volume":"81","author":"Valdivia","year":"2004","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/09513590410001667265","article-title":"Long-term effects of two different continuous combined regimens of hormone replacement therapy on well-being","volume":"18","author":"Odmark","year":"2004","journal-title":"Gynecol Endocrinol"},{"issue":"1\u20132","key":"10.1016\/j.steroids.2011.03.001_bib0180","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.mce.2003.10.030","article-title":"Drospirenone, a progestogen with antimineralocorticoid properties: a short review","volume":"217","author":"Oelkers","year":"2004","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"10.1016\/j.steroids.2011.03.001_bib0185","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.tips.2004.09.005","article-title":"Not all progestins are the same: implications for usage","volume":"25","author":"Hapgood","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.steroids.2011.03.001_bib0190","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.maturitas.2004.01.001","article-title":"Pharmacological profile of progestins","volume":"47","author":"Sitruk-Ware","year":"2004","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0195","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.steroids.2007.10.003","article-title":"Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile","volume":"73","author":"Sasagawa","year":"2008","journal-title":"Steroids"},{"issue":"10\u201311","key":"10.1016\/j.steroids.2011.03.001_bib0200","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.mad.2004.04.007","article-title":"A contemporary understanding of progesterone receptor function","volume":"125","author":"Li","year":"2004","journal-title":"Mech Ageing Dev"},{"issue":"8","key":"10.1016\/j.steroids.2011.03.001_bib0205","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s001980200080","article-title":"Pharmacologic doses of medroxyprogesterone may cause bone loss through glucocorticoid activity: an hypothesis","volume":"13","author":"Ishida","year":"2002","journal-title":"Osteoporos Int"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0210","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2265.2007.03059.x","article-title":"Effect of progestins with different glucocorticoid activity on bone metabolism","volume":"68","author":"Ishida","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"10.1016\/j.steroids.2011.03.001_bib0215","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1210\/jc.84.11.4055","article-title":"Dissociative glucocorticoid activity of medroxyprogesterone acetate in normal human lymphocytes","volume":"84","author":"Bamberger","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0220","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1089\/105072503321582042","article-title":"Medroxyprogesterone acetate decreases secretion of interleukin-6 and parathyroid hormone-related protein in a new anaplastic thyroid cancer cell line, KTC-2","volume":"13","author":"Kurebayashi","year":"2003","journal-title":"Thyroid"},{"issue":"1\u20132","key":"10.1016\/j.steroids.2011.03.001_bib0225","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mce.2004.03.006","article-title":"Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells","volume":"221","author":"Koubovec","year":"2004","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib0230","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1161\/01.HYP.35.5.1099","article-title":"Role of 11beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries","volume":"35","author":"Alzamora","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.steroids.2011.03.001_bib0235","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/bse0400105","article-title":"Receptor mechanisms of rapid extranuclear signalling initiated by steroid hormones","volume":"40","author":"Boonyaratanakornkit","year":"2004","journal-title":"Essays Biochem"},{"issue":"11","key":"10.1016\/j.steroids.2011.03.001_bib0240","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1210\/me.2008-0160","article-title":"Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways","volume":"22","author":"Narayanan","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.steroids.2011.03.001_bib0245","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1749-6632.2009.04986.x","article-title":"Mechanisms generating diversity in glucocorticoid receptor signaling","volume":"1179","author":"Revollo","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"1A","key":"10.1016\/j.steroids.2011.03.001_bib0250","doi-asserted-by":"crossref","first-page":"104S","DOI":"10.1016\/S0002-9343(99)80067-9","article-title":"The androgenicity of progestins","volume":"98","author":"Darney","year":"1995","journal-title":"Am J Med"},{"issue":"10","key":"10.1016\/j.steroids.2011.03.001_bib0255","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1046\/j.1525-1497.1999.08108.x","article-title":"Benefits and risks of third-generation oral contraceptives","volume":"14","author":"LeBlanc","year":"1999","journal-title":"J Gen Intern Med"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0260","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2165\/00003495-199651020-00002","article-title":"Comparative pharmacology of newer progestogens","volume":"51","author":"Kuhl","year":"1996","journal-title":"Drugs"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0265","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1023\/A:1020072325818","article-title":"Pharmacokinetics and potency of progestins used for hormone replacement therapy and contraception","volume":"3","author":"Stanczyk","year":"2002","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.steroids.2011.03.001_bib0270","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1749-6632.1995.tb31386.x","article-title":"Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity","volume":"761","author":"Muhn","year":"1995","journal-title":"Ann N Y Acad Sci"},{"issue":"10\u201313","key":"10.1016\/j.steroids.2011.03.001_bib0275","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0039-128X(03)00142-9","article-title":"The preclinical biology of a new potent and selective progestin: trimegestone","volume":"68","author":"Winneker","year":"2003","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2011.03.001_bib1130","doi-asserted-by":"crossref","unstructured":"Mueck AO, Sitruk-Ware R. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids 2011; In Press, doi:10.1016\/j.steroids.2011.02.002.","DOI":"10.1016\/j.steroids.2011.02.002"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0285","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1046\/j.1523-1755.2000.00983.x","article-title":"Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology","volume":"57","author":"Delyani","year":"2000","journal-title":"Kidney Int"},{"issue":"10\u201313","key":"10.1016\/j.steroids.2011.03.001_bib0290","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.steroids.2003.08.008","article-title":"Conception and pharmacodynamic profile of drospirenone","volume":"68","author":"Elger","year":"2003","journal-title":"Steroids"},{"issue":"10\u201311","key":"10.1016\/j.steroids.2011.03.001_bib0295","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0039-128X(00)00120-3","article-title":"In vitro characterization of trimegestone: a new potent and selective progestin","volume":"65","author":"Zhang","year":"2000","journal-title":"Steroids"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib0300","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3109\/09513599909167574","article-title":"The pharmacological profile of a novel norpregnance progestin (trimegestone)","volume":"13","author":"Philibert","year":"1999","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.steroids.2011.03.001_bib0305","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev-physiol-021909-135917","article-title":"Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics","volume":"72","author":"Huang","year":"2010","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0310","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1210\/me.15.1.17","article-title":"Separable features of the ligand-binding domain determine the differential subcellular localization and ligand-binding specificity of glucocorticoid receptor and progesterone receptor","volume":"15","author":"Wan","year":"2001","journal-title":"Mol Endocrinol"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0315","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0092-8674(02)00817-6","article-title":"Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition","volume":"110","author":"Bledsoe","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.steroids.2011.03.001_bib0320","doi-asserted-by":"crossref","first-page":"e001","DOI":"10.1621\/nrs.05001","article-title":"Natural disordered sequences in the amino terminal domain of nuclear receptors: lessons from the androgen and glucocorticoid receptors","volume":"5","author":"McEwan","year":"2007","journal-title":"Nucl Recept Signal"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0325","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1042\/BJ20050872","article-title":"Structure and function of steroid receptor AF1 transactivation domains: induction of active conformations","volume":"391","author":"Lavery","year":"2005","journal-title":"Biochem J"},{"key":"10.1016\/j.steroids.2011.03.001_bib0330","doi-asserted-by":"crossref","first-page":"e003","DOI":"10.1621\/nrs.05003","article-title":"Visualizing the action of steroid hormone receptors in living cells","volume":"5","author":"Griekspoor","year":"2007","journal-title":"Nucl Recept Signal"},{"issue":"10","key":"10.1016\/j.steroids.2011.03.001_bib0335","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0165-6147(00)01548-0","article-title":"Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications","volume":"21","author":"Bourguet","year":"2000","journal-title":"Trends Pharmacol Sci"},{"issue":"9","key":"10.1016\/j.steroids.2011.03.001_bib0340","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1210\/me.12.9.1420","article-title":"The DNA-binding and {tau}2 transactivation domains of the rat glucocorticoid receptor constitute a nuclear matrix-targeting signal","volume":"12","author":"Tang","year":"1998","journal-title":"Mol Endocrinol"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0345","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/humupd\/6.3.225","article-title":"Steroid hormone receptors: an update","volume":"6","author":"Beato","year":"2000","journal-title":"Hum Reprod Update"},{"issue":"11","key":"10.1016\/j.steroids.2011.03.001_bib0350","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1073\/pnas.95.11.5998","article-title":"Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains","volume":"95","author":"Tanenbaum","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6683","key":"10.1016\/j.steroids.2011.03.001_bib0355","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/30775","article-title":"Atomic structure of progesterone complexed with its receptor","volume":"393","author":"Williams","year":"1998","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.steroids.2011.03.001_bib0360","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1096\/fasebj.5.15.1743440","article-title":"The steroid receptor superfamily: mechanisms of diversity","volume":"5","author":"Fuller","year":"1991","journal-title":"FASEB J"},{"issue":"4854","key":"10.1016\/j.steroids.2011.03.001_bib0365","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.3283939","article-title":"The steroid and thyroid hormone receptor superfamily","volume":"240","author":"Evans","year":"1988","journal-title":"Science"},{"issue":"23","key":"10.1016\/j.steroids.2011.03.001_bib0370","doi-asserted-by":"crossref","first-page":"9045","DOI":"10.1073\/pnas.83.23.9045","article-title":"Cloning and sequence analysis of rabbit progesterone-receptor complementary DNA","volume":"83","author":"Loosfelt","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0375","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1146\/annurev.biochem.68.1.559","article-title":"Nuclear-receptor ligands and ligand-binding domains","volume":"68","author":"Weatherman","year":"1999","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0380","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1210\/er.18.3.306","article-title":"Steroid receptor interactions with heat shock protein and immunophilin chaperones","volume":"18","author":"Pratt","year":"1997","journal-title":"Endocr Rev"},{"issue":"7","key":"10.1016\/j.steroids.2011.03.001_bib0385","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2007-0022","article-title":"Extranuclear steroid receptors: nature and actions","volume":"28","author":"Hammes","year":"2007","journal-title":"Endocr Rev"},{"issue":"5\u20137","key":"10.1016\/j.steroids.2011.03.001_bib0390","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.steroids.2005.02.006","article-title":"The human glucocorticoid receptor: one gene, multiple proteins and diverse responses","volume":"70","author":"Zhou","year":"2005","journal-title":"Steroids"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0395","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1124\/pr.58.4.9","article-title":"The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors","volume":"58","author":"Lu","year":"2006","journal-title":"Pharmacol Rev"},{"issue":"7","key":"10.1016\/j.steroids.2011.03.001_bib0400","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrm1680","article-title":"Controlling nuclear receptors: the circular logic of cofactor cycles","volume":"6","author":"Perissi","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0405","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0092-8674(89)90237-7","article-title":"Gene regulation by steroid hormones","volume":"56","author":"Beato","year":"1989","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0410","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1128\/MCB.23.6.1994-2008.2003","article-title":"Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src\/Erk pathway in mammalian cells","volume":"23","author":"Ballare","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"1\u20132","key":"10.1016\/j.steroids.2011.03.001_bib0415","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mce.2007.07.003","article-title":"Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects","volume":"275","author":"Kassel","year":"2007","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0420","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1210\/me.2008-0283","article-title":"Minireview: latest perspectives on antiinflammatory actions of glucocorticoids","volume":"23","author":"De Bosscher","year":"2009","journal-title":"Mol Endocrinol"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0425","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1152\/physrev.2001.81.4.1535","article-title":"Mechanisms of estrogen action","volume":"81","author":"Nilsson","year":"2001","journal-title":"Physiol Rev"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0430","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1210\/er.2002-0006","article-title":"The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression","volume":"24","author":"De Bosscher","year":"2003","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0435","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/bies.950190210","article-title":"Mechanism of gene expression by the glucocorticoid receptor: role of protein\u2013protein interactions","volume":"19","author":"McEwan","year":"1997","journal-title":"Bioessays"},{"issue":"10","key":"10.1016\/j.steroids.2011.03.001_bib0440","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1043-2760(99)00186-1","article-title":"Mechanisms of glucocorticoid-receptor-mediated repression of gene expression","volume":"10","author":"Webster","year":"1999","journal-title":"Trends Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.steroids.2011.03.001_bib0445","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1136\/thorax.55.7.603","article-title":"Molecular mechanisms of glucocorticoid action: what is important?","volume":"55","author":"Newton","year":"2000","journal-title":"Thorax"},{"issue":"11","key":"10.1016\/j.steroids.2011.03.001_bib0450","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.1074\/jbc.271.11.6217","article-title":"Negative interaction between the RelA(p65) subunit of NF-kappaB and the progesterone receptor","volume":"271","author":"Kalkhoven","year":"1996","journal-title":"J Biol Chem"},{"issue":"39","key":"10.1016\/j.steroids.2011.03.001_bib0455","doi-asserted-by":"crossref","first-page":"24151","DOI":"10.1074\/jbc.271.39.24151","article-title":"Mutual transcriptional interference between RelA and androgen receptor","volume":"271","author":"Palvimo","year":"1996","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0460","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1172\/JCI117995","article-title":"Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor","volume":"95","author":"Bellido","year":"1995","journal-title":"J Clin Invest"},{"issue":"34","key":"10.1016\/j.steroids.2011.03.001_bib0465","doi-asserted-by":"crossref","first-page":"21467","DOI":"10.1074\/jbc.272.34.21467","article-title":"A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation","volume":"272","author":"Liden","year":"1997","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0470","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1210\/er.20.4.435","article-title":"Molecular control of immune\/inflammatory responses: interactions between nuclear factor-{kappa}B and steroid receptor-signaling pathways","volume":"20","author":"McKay","year":"1999","journal-title":"Endocr Rev"},{"key":"10.1016\/j.steroids.2011.03.001_bib0475","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.physiol.66.032802.154710","article-title":"Ligand control of coregulator recruitment to nuclear receptors","volume":"67","author":"Nettles","year":"2005","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0480","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1210\/er.20.3.321","article-title":"Nuclear receptor coregulators: cellular and molecular biology","volume":"20","author":"McKenna","year":"1999","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0485","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1210\/er.23.2.175","article-title":"Androgen receptor (AR) coregulators: an overview","volume":"23","author":"Heinlein","year":"2002","journal-title":"Endocr Rev"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0490","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1513\/pats.200402-015MS","article-title":"Post-transcriptional and nongenomic effects of glucocorticoids","volume":"1","author":"Stellato","year":"2004","journal-title":"Proc Am Thorac Soc"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0495","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1152\/advan.00086.2006","article-title":"Sex steroid effects at target tissues: mechanisms of action","volume":"31","author":"Wierman","year":"2007","journal-title":"Adv Physiol Educ"},{"issue":"1\u20132","key":"10.1016\/j.steroids.2011.03.001_bib0500","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mce.2009.02.005","article-title":"New aspects of rapid aldosterone signaling","volume":"308","author":"Grossmann","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0505","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cbpc.2008.05.019","article-title":"Candidates for membrane progestin receptors\u2014past approaches and future challenges","volume":"148","author":"Zhu","year":"2008","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"issue":"11","key":"10.1016\/j.steroids.2011.03.001_bib0510","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1172\/JCI0215481","article-title":"Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids","volume":"110","author":"Limbourg","year":"2002","journal-title":"J Clin Invest"},{"issue":"2\u20133","key":"10.1016\/j.steroids.2011.03.001_bib0515","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000111559","article-title":"Rapid estrogen signaling in the brain","volume":"16","author":"Raz","year":"2008","journal-title":"Neurosignals"},{"key":"10.1016\/j.steroids.2011.03.001_bib0520","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0070-2153(03)01006-8","article-title":"Nongenomic actions of androgen in Sertoli cells","volume":"56","author":"Walker","year":"2003","journal-title":"Curr Top Dev Biol"},{"key":"10.1016\/j.steroids.2011.03.001_bib0525","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1073\/pnas.1334098100","article-title":"Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling","volume":"100","author":"Nilsen","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0530","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1055\/s-2007-973427","article-title":"Receptor mechanisms mediating non-genomic actions of sex steroids","volume":"25","author":"Boonyaratanakornkit","year":"2007","journal-title":"Semin Reprod Med"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0535","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.yfrne.2008.01.001","article-title":"Characteristics of membrane progestin receptor alpha (mPR[alpha]) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions","volume":"29","author":"Thomas","year":"2008","journal-title":"Front Neuroendocrinol"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0540","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1210\/en.2006-0974","article-title":"Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor {alpha} subtypes and their evolutionary origins","volume":"148","author":"Thomas","year":"2007","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0545","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1677\/JOE-07-0317","article-title":"Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone","volume":"196","author":"Dosiou","year":"2008","journal-title":"J Endocrinol"},{"issue":"39","key":"10.1016\/j.steroids.2011.03.001_bib0550","doi-asserted-by":"crossref","first-page":"30106","DOI":"10.1074\/jbc.M005418200","article-title":"Evidence for a common step in three different processes for modulating the kinetic properties of glucocorticoid receptor-induced gene transcription","volume":"275","author":"Chen","year":"2000","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0555","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.mce.2008.10.008","article-title":"Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction","volume":"299","author":"Ronacher","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.steroids.2011.03.001_bib0560","series-title":"Textbook of receptor pharmacology","author":"Foreman","year":"2010"},{"key":"10.1016\/j.steroids.2011.03.001_bib0565","unstructured":"Inc GS. GraphPad Prism Manual Version 5.00; 1992\u20132007."},{"issue":"8","key":"10.1016\/j.steroids.2011.03.001_bib0570","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/bies.20792","article-title":"What goes on behind closed doors: physiological versus pharmacological steroid hormone actions","volume":"30","author":"Simons","year":"2008","journal-title":"Bioessays"},{"issue":"13\u201314","key":"10.1016\/j.steroids.2011.03.001_bib0575","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.intimp.2003.08.005","article-title":"Receptor density dictates the behavior of a subset of steroid ligands in glucocorticoid receptor-mediated transrepression","volume":"3","author":"Zhao","year":"2003","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0580","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0889-8545(02)00008-6","article-title":"Access of reproductive steroids to target tissues","volume":"29","author":"Hammond","year":"2002","journal-title":"Obstet Gynecol Clin North Am"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0585","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0010-7824(74)90130-9","article-title":"Return of ovulatory cyclicity following an intramuscular injection of medroxyprogesterone acetate (Provera)","volume":"10","author":"Kirton","year":"1974","journal-title":"Contraception"},{"issue":"1C","key":"10.1016\/j.steroids.2011.03.001_bib0590","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0022-4731(83)90017-1","article-title":"Variability of pharmacokinetic parameters for contraceptive steroids","volume":"19","author":"Fotherby","year":"1983","journal-title":"J Steroid Biochem"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0595","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0022-4731(78)90631-3","article-title":"A radioimmunoassay for serum medroxyprogesterone acetate","volume":"9","author":"Shrimanker","year":"1978","journal-title":"J Steroid Biochem"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0600","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0039-128X(75)90082-3","article-title":"Radioimmunoassay of serum medroxyprogesterone acetate (Provera) in women following oral and intravaginal administration","volume":"26","author":"Hiroi","year":"1975","journal-title":"Steroids"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0605","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0010-7824(79)80032-3","article-title":"Plasma levels of norethindrone and effect upon ovarian function during treatment with silastic implants containing norethindrone","volume":"19","author":"Odlind","year":"1979","journal-title":"Contraception"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0610","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0010-7824(77)90004-X","article-title":"Injectable depot contraceptives on d-norgestrel basis. II. Clinical pharmacokinetic studies with d-norgestrel undecylate in women","volume":"15","author":"Spona","year":"1977","journal-title":"Contraception"},{"issue":"7","key":"10.1016\/j.steroids.2011.03.001_bib0615","first-page":"541","article-title":"The endocrinologic profile of metabolites of the progestin dienogest","volume":"48","author":"Oettel","year":"1993","journal-title":"Pharmazie"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0620","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1080\/13625180008500407","article-title":"A 1-year pharmacokinetic investigation of a novel oral contraceptive containing drospirenone in healthy female volunteers","volume":"5","author":"Blode","year":"2000","journal-title":"Eur J Contracept Reprod Health Care"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0625","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.maturitas.2007.02.015","article-title":"Routes of delivery for progesterone and progestins","volume":"57","author":"Sitruk-Ware","year":"2007","journal-title":"Maturitas"},{"issue":"Suppl. 3","key":"10.1016\/j.steroids.2011.03.001_bib0630","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1080\/13697130500330382","article-title":"Pharmacology of different progestogens: the special case of drospirenone","volume":"8","author":"Sitruk-Ware","year":"2005","journal-title":"Climacteric"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0635","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.contraception.2005.08.019","article-title":"Contraception: an international perspective","volume":"73","author":"Sitruk-Ware","year":"2006","journal-title":"Contraception"},{"issue":"Suppl. 1","key":"10.1016\/j.steroids.2011.03.001_bib0640","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13697130500148875","article-title":"Pharmacology of estrogens and progestogens: influence of different routes of administration","volume":"8","author":"Kuhl","year":"2005","journal-title":"Climacteric"},{"issue":"10\u201311","key":"10.1016\/j.steroids.2011.03.001_bib0645","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0039-128X(00)00119-7","article-title":"Nestorone: a progestin with a unique pharmacological profile","volume":"65","author":"Kumar","year":"2000","journal-title":"Steroids"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0650","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1046\/j.1468-2982.2000.00042.x","article-title":"Pharmacodynamics of oestrogens and progestogens","volume":"20","author":"de Lignieres","year":"2000","journal-title":"Cephalalgia"},{"issue":"4\u20136","key":"10.1016\/j.steroids.2011.03.001_bib0655","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0960-0760(97)00119-2","article-title":"Differential expression of uterine progesterone receptor forms A and B during the menstrual cycle","volume":"63","author":"Mangal","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0660","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/gene.20098","article-title":"Cre-mediated recombination in cell lineages that express the progesterone receptor","volume":"41","author":"Soyal","year":"2005","journal-title":"Genesis"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0665","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1210\/rp.57.1.339","article-title":"Reproductive Functions of Progesterone Receptors","volume":"57","author":"Conneely","year":"2002","journal-title":"Recent Prog Horm Res"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0670","doi-asserted-by":"crossref","first-page":"C29","DOI":"10.1016\/0303-7207(90)90210-Y","article-title":"Cell-specific regulation of progesterone receptor in the female reproductive system","volume":"70","author":"Clarke","year":"1990","journal-title":"Mol Cell Endocrinol"},{"issue":"7","key":"10.1016\/j.steroids.2011.03.001_bib0675","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1074\/jbc.M110090200","article-title":"Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells","volume":"277","author":"Richer","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0680","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1210\/jcem-53-1-58","article-title":"Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma","volume":"53","author":"Dunn","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0685","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0960-0760(97)00036-8","article-title":"A sequence in the 5\u2032 flanking region confers progestin responsiveness on the human c-myc gene","volume":"62","author":"Moore","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.steroids.2011.03.001_bib1135","doi-asserted-by":"crossref","first-page":"10696","DOI":"10.1074\/jbc.273.17.10696","article-title":"Progesterone regulates transcription of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP\/p300","volume":"273","author":"Owen","year":"1998","journal-title":"J Biol Chem"},{"issue":"47","key":"10.1016\/j.steroids.2011.03.001_bib0695","doi-asserted-by":"crossref","first-page":"31308","DOI":"10.1074\/jbc.273.47.31308","article-title":"Convergence of progesterone and epidermal growth factor signaling in breast cancer. Potentiation of mitogen-activated protein kinase pathways","volume":"273","author":"Lange","year":"1998","journal-title":"J Biol Chem"},{"issue":"21","key":"10.1016\/j.steroids.2011.03.001_bib0700","doi-asserted-by":"crossref","first-page":"12163","DOI":"10.1016\/S0021-9258(19)38326-7","article-title":"Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms","volume":"265","author":"Kastner","year":"1990","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.steroids.2011.03.001_bib0705","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1210\/me.8.10.1347","article-title":"A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform","volume":"8","author":"Sartorius","year":"1994","journal-title":"Mol Endocrinol"},{"issue":"12","key":"10.1016\/j.steroids.2011.03.001_bib0710","doi-asserted-by":"crossref","first-page":"8356","DOI":"10.1128\/MCB.14.12.8356","article-title":"The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells","volume":"14","author":"Wen","year":"1994","journal-title":"Mol Cell Biol"},{"issue":"9","key":"10.1016\/j.steroids.2011.03.001_bib0715","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1128\/MCB.20.9.3102-3115.2000","article-title":"The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding","volume":"20","author":"Giangrande","year":"2000","journal-title":"Mol Cell Biol"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0720","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1210\/endo-126-6-2882","article-title":"Developmental regulation of murine mammary progesterone receptor gene expression","volume":"126","author":"Shyamala","year":"1990","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0725","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/rep.1.00189","article-title":"Reproductive tissue selective actions of progesterone receptors","volume":"128","author":"Mulac-Jericevic","year":"2004","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib0730","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/0022-4731(83)90371-0","article-title":"Binding of progestagens to receptor proteins in MCF-7 cells","volume":"19","author":"Bergink","year":"1983","journal-title":"J Steroid Biochem"},{"key":"10.1016\/j.steroids.2011.03.001_bib0735","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-1-4757-6589-2_12","article-title":"The use of medroxyprogesterone acetate to study progestin receptors in immature, pregnant, and adult rabbit uterus","volume":"117","author":"Feil","year":"1979","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0740","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0039-128X(95)00216-D","article-title":"Binding specificity of medroxyprogesterone acetate and proligestone for the progesterone and glucocorticoid receptor in the dog","volume":"61","author":"Selman","year":"1996","journal-title":"Steroids"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0745","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0960-0760(00)00093-5","article-title":"Influence of the substitution of 11-methylene, delta(15), and\/or 18-methyl groups in norethisterone on receptor binding, transactivation assays and biological activities in animals","volume":"74","author":"Deckers","year":"2000","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0750","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0022-4731(85)90151-7","article-title":"Stereospecificity of the intracellular binding of norethisterone and its A-ring reduced metabolites","volume":"22","author":"Chavez","year":"1985","journal-title":"J Steroid Biochem"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0755","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1530\/acta.0.0780574","article-title":"Progesterone-binding proteins: In vitro binding and biological activity of different steroidal ligands","volume":"78","author":"Kontula","year":"1975","journal-title":"Acta Endocrinol"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0760","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0010-7824(96)00195-3","article-title":"The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential","volume":"54","author":"Fuhrmann","year":"1996","journal-title":"Contraception"},{"key":"10.1016\/j.steroids.2011.03.001_bib0765","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0010-7824(00)00133-5","article-title":"Drospirenone: pharmacology and pharmacokinetics of a unique progestogen","volume":"62","author":"Krattenmacher","year":"2000","journal-title":"Contraception"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0770","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0010-7824(88)90104-7","article-title":"Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives","volume":"38","author":"Kloosterboer","year":"1988","journal-title":"Contraception"},{"issue":"3\u20134","key":"10.1016\/j.steroids.2011.03.001_bib0775","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0960-0760(97)00161-1","article-title":"Human progesterone receptor A and B isoforms in CHO cells. II. Comparison of binding, transactivation and ed50 values of several synthetic (anti)progestagens in vitro in CHO and MCF-7 cells and in vivo in rabbits and rats","volume":"64","author":"Schoonen","year":"1998","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0780","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1210\/en.142.6.2194","article-title":"Perspective: female steroid hormone action","volume":"142","author":"Conneely","year":"2001","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0785","doi-asserted-by":"crossref","first-page":"R1036","DOI":"10.1186\/bcr1340","article-title":"The progestational and androgenic properties of medroxyprogesterone acetate: gene regulatory overlap with dihydrotestosterone in breast cancer cells","volume":"7","author":"Ghatge","year":"2005","journal-title":"Breast Cancer Res"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0790","first-page":"392","article-title":"Progestin regulation of vascular endothelial growth factor in human breast cancer cells","volume":"58","author":"Hyder","year":"1998","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0795","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jsbmb.2005.06.032","article-title":"Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells","volume":"97","author":"Bray","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"11","key":"10.1016\/j.steroids.2011.03.001_bib0800","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1210\/en.2004-1535","article-title":"Medroxyprogesterone acetate induces cell proliferation through up-regulation of cyclin D1 expression via phosphatidylinositol 3-kinase\/Akt\/nuclear factor-kappaB cascade in human breast cancer cells","volume":"146","author":"Saitoh","year":"2005","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib0805","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1210\/jc.87.6.2514","article-title":"Long-term progestin treatment inhibits RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) gene expression in human endometrial stromal cells","volume":"87","author":"Zhao","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"5\u20136","key":"10.1016\/j.steroids.2011.03.001_bib0810","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1600-0897.2006.00430.x","article-title":"Induction of maternal tolerance to fetal alloantigens by RANTES production","volume":"56","author":"Ramhorst","year":"2006","journal-title":"Am J Reprod Immunol"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0815","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0378-5122(02)00157-3","article-title":"Lack of stimulatory effect of dienogest on the expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 by endothelial cell as compared with other synthetic progestins","volume":"42","author":"Tatsumi","year":"2002","journal-title":"Maturitas"},{"issue":"12","key":"10.1016\/j.steroids.2011.03.001_bib0820","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.1210\/en.2004-0510","article-title":"Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells","volume":"145","author":"Simoncini","year":"2004","journal-title":"Endocrinology"},{"issue":"Suppl. 1","key":"10.1016\/j.steroids.2011.03.001_bib0825","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/09513590701585094","article-title":"Comparative effects of dydrogesterone and medroxyprogesterone acetate in critical areas: the brain and the vessels","volume":"23","author":"Simoncini","year":"2007","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0830","first-page":"41","article-title":"Vasoprotective effects of nitric oxide in atherosclerosis","volume":"30","author":"Yasa","year":"2005","journal-title":"FABAD J Pharm Sci"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0835","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0015-0282(02)04577-6","article-title":"Progestins activate vascular endothelial growth factor gene transcription in endometrial adenocarcinoma cells","volume":"79","author":"Mueller","year":"2003","journal-title":"Fertil Steril"},{"issue":"9\u201310","key":"10.1016\/j.steroids.2011.03.001_bib0840","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.steroids.2008.01.010","article-title":"The role and mechanism of progesterone receptor activation of extra-nuclear signaling pathways in regulating gene transcription and cell cycle progression","volume":"73","author":"Boonyaratanakornk","year":"2008","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2011.03.001_bib0845","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1471-2407-8-166","article-title":"Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion","volume":"8","author":"Fu","year":"2008","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib0850","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1074\/jbc.R110.179325","article-title":"Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids","volume":"286","author":"Oakley","year":"2011","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"10.1016\/j.steroids.2011.03.001_bib0855","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2005.07.001","article-title":"Synthetic progestins used in HRT have different glucocorticoid agonist properties","volume":"242","author":"Koubovec","year":"2005","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.steroids.2011.03.001_bib0860","first-page":"2557","article-title":"Estrogen, androgen, glucocorticoid, and progesterone receptors in progestin-induced regression of human breast cancer","volume":"40","author":"Teulings","year":"1980","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.steroids.2011.03.001_bib0865","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/0006-2952(83)90474-4","article-title":"Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes","volume":"32","author":"Kontula","year":"1983","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0870","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0010-7824(94)00003-F","article-title":"Characterization of the novel progestin gestodene by receptor binding studies and transactivation assays","volume":"51","author":"Fuhrmann","year":"1995","journal-title":"Contraception"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib0875","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0960-0760(00)00125-4","article-title":"Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives","volume":"74","author":"Schoonen","year":"2000","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"10","key":"10.1016\/j.steroids.2011.03.001_bib0880","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1210\/jc.86.10.4679","article-title":"Serum cortisol and 17-hydroxyprogesterone interrelation in classic 21-hydroxylase deficiency: is current replacement therapy satisfactory?","volume":"86","author":"Charmandari","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.steroids.2011.03.001_bib0885","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1016\/S0021-9258(18)53327-5","article-title":"Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids","volume":"268","author":"Imai","year":"1993","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0890","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1161\/01.HYP.27.3.465","article-title":"Mechanisms for inducible control of angiotensinogen gene transcription","volume":"27","author":"Brasier","year":"1996","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0895","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/frne.1995.1001","article-title":"Role of the cytokines in the neuroendocrine-immune system axis","volume":"16","author":"Spangelo","year":"1995","journal-title":"Front Neuroendocrinol"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0900","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1096\/fj.01-0245com","article-title":"Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells","volume":"16","author":"Galon","year":"2002","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib0905","doi-asserted-by":"crossref","first-page":"F306","DOI":"10.1152\/ajprenal.00062.2005","article-title":"Medroxyprogesterone acetate binds the glucocorticoid receptor to stimulate alpha-ENaC and sgk1 expression in renal collecting duct epithelia","volume":"290","author":"Thomas","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"issue":"23","key":"10.1016\/j.steroids.2011.03.001_bib0910","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1161\/hc4801.099737","article-title":"Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin receptor (PAR-1) expression: role of the glucocorticoid receptor","volume":"104","author":"Herkert","year":"2001","journal-title":"Circulation"},{"issue":"10 Pt 1","key":"10.1016\/j.steroids.2011.03.001_bib0915","first-page":"3763","article-title":"Dexamethasone and medroxyprogesterone acetate elevate Nm23-H1 metastasis suppressor gene expression in metastatic human breast carcinoma cells: new uses for old compounds","volume":"9","author":"Ouatas","year":"2003","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0920","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1096\/fj.06-6840com","article-title":"Progestins overcome inhibition of platelet aggregation by endothelial cells by down-regulating endothelial NO synthase via glucocorticoid receptors","volume":"21","author":"Zerr-Fouineau","year":"2007","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib0925","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0960-0760(97)00012-5","article-title":"The antiovulatory effect of the antiprogestin onapristone could be related to down-regulation of intraovarian progesterone (receptors)","volume":"62","author":"Donath","year":"1997","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"10","key":"10.1016\/j.steroids.2011.03.001_bib0930","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/carcin\/23.10.1701","article-title":"Interrelationships among angiogenesis, proliferation, and apoptosis in the tumor microenvironment during N-methyl-N-nitrosourea androgen-induced prostate carcinogenesis in rats","volume":"23","author":"Liao","year":"2002","journal-title":"Carcinogenesis"},{"issue":"7","key":"10.1016\/j.steroids.2011.03.001_bib0935","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1210\/en.2008-1750","article-title":"Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function","volume":"150","author":"Walters","year":"2009","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.steroids.2011.03.001_bib0940","first-page":"705","article-title":"Managing acne vulgaris effectively","volume":"35","author":"Goodman","year":"2006","journal-title":"Aust Fam Phys"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0945","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1210\/me.13.3.440","article-title":"Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone","volume":"13","author":"Kemppainen","year":"1999","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.steroids.2011.03.001_bib0950","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-4731(81)90266-1","article-title":"Mechanism of action of contraceptive synthetic progestins","volume":"15","author":"Perez-Palacios","year":"1981","journal-title":"J Steroid Biochem"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib0955","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00689836","article-title":"Medroxyprogesterone acetate inhibits the proliferation of estrogen- and progesterone-receptor negative MFM-223 human mammary cancer cells via the androgen receptor","volume":"25","author":"Hackenberg","year":"1993","journal-title":"Breast Cancer Res Treat"},{"issue":"1\u20132","key":"10.1016\/j.steroids.2011.03.001_bib0960","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0303-7207(99)00109-4","article-title":"Androgen receptor agonist activity of the synthetic progestin, medroxyprogesterone acetate, in human breast cancer cells","volume":"154","author":"Bentel","year":"1999","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib0965","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2165\/11532130-000000000-00000","article-title":"Nomegestrol acetate: pharmacology, safety profile and therapeutic efficacy","volume":"70","author":"Lello","year":"2010","journal-title":"Drugs"},{"key":"10.1016\/j.steroids.2011.03.001_bib1140","doi-asserted-by":"crossref","unstructured":"van Diepen HA, Lam TW, Kuil CW. Nomegestrol acetate: steroid receptor transactivation profile in Chinese hamster ovary cells and ovulation inhibition in rat and monkey. Contraception 2011; In Press, doi:10.1016\/j.contraception.2010.11.017.","DOI":"10.1016\/j.contraception.2010.11.017"},{"issue":"6 Pt 2","key":"10.1016\/j.steroids.2011.03.001_bib0975","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/0002-9378(90)90556-M","article-title":"Interactions with oral contraceptives","volume":"163","author":"Fotherby","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.steroids.2011.03.001_bib0980","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1196\/annals.1290.033","article-title":"Androgens and antiandrogens","volume":"997","author":"Schneider","year":"2003","journal-title":"Ann N Y Acad Sci"},{"issue":"1\u20132","key":"10.1016\/j.steroids.2011.03.001_bib0985","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jsbmb.2004.02.003","article-title":"Comparative evaluation of androgen and progesterone receptor transcription selectivity indices of 19-nortestosterone-derived progestins","volume":"91","author":"Garcia-Becerra","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"10","key":"10.1016\/j.steroids.2011.03.001_bib0990","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1096\/fj.06-7518com","article-title":"Disruption of androgen receptor signaling by synthetic progestins may increase risk of developing breast cancer","volume":"21","author":"Birrell","year":"2007","journal-title":"FASEB J"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib0995","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jsbmb.2004.10.011","article-title":"Major impact of hormonal therapy in localized prostate cancer\u2014death can already be an exception","volume":"92","author":"Labrie","year":"2004","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"19","key":"10.1016\/j.steroids.2011.03.001_bib1000","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1073\/pnas.80.19.6056","article-title":"Renal mineralocorticoid receptors and hippocampal corticosterone-binding species have identical intrinsic steroid specificity","volume":"80","author":"Krozowski","year":"1983","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib1005","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1046\/j.1523-1755.2000.00971.x","article-title":"Brain mineralocorticoid receptors and centrally regulated functions","volume":"57","author":"de Kloet","year":"2000","journal-title":"Kidney Int"},{"issue":"1\u20132","key":"10.1016\/j.steroids.2011.03.001_bib1010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.mce.2003.10.054","article-title":"Aldosterone, mineralocorticoid receptors and vascular inflammation","volume":"217","author":"Funder","year":"2004","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib1015","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1530\/acta.0.0920560","article-title":"Interaction of synthetic progestagens with renal mineralocorticoid receptors","volume":"92","author":"Wambach","year":"1979","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"3\u20138","key":"10.1016\/j.steroids.2011.03.001_bib1020","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0960-0760(92)90430-Q","article-title":"Differences between aldosterone and its antagonists in binding kinetics and ligand-induced hsp90 release from mineralocorticosteroid receptor","volume":"41","author":"Rafestin-Oblin","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib1025","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1081\/ERC-120016824","article-title":"Difference of in vivo and in vitro antimineralocorticoid potency of progesterone","volume":"28","author":"Quinkler","year":"2002","journal-title":"Endocr Res"},{"issue":"6","key":"10.1016\/j.steroids.2011.03.001_bib1030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1530\/eje.0.1460789","article-title":"Agonistic and antagonistic properties of progesterone metabolites at the human mineralocorticoid receptor","volume":"146","author":"Quinkler","year":"2002","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib1035","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0039-128X(96)00007-4","article-title":"Effects of estrogens and progestogens on the renin\u2013aldosterone system and blood pressure","volume":"61","author":"Oelkers","year":"1996","journal-title":"Steroids"},{"issue":"6461","key":"10.1016\/j.steroids.2011.03.001_bib1040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/bmj.290.6461.13","article-title":"Natural progesterone and antihypertensive action","volume":"290","author":"Rylance","year":"1985","journal-title":"Br Med J (Clin Res Ed)"},{"issue":"8","key":"10.1016\/j.steroids.2011.03.001_bib1045","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/09513590701577869","article-title":"Italian position statement on hormone replacement therapy following the National Conference on Menopause and Hormone Replacement Therapy, Villa Tuscolana, Frascati (Rome), May 8\u20139, 2007","volume":"23","author":"Genazzani","year":"2007","journal-title":"Gynecol Endocrinol"},{"issue":"4","key":"10.1016\/j.steroids.2011.03.001_bib1050","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.maturitas.2006.07.009","article-title":"Advances in hormone replacement therapy with drospirenone, a unique progestogen with aldosterone receptor antagonism","volume":"55","author":"Palacios","year":"2006","journal-title":"Maturitas"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib1055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/13697130802403994","article-title":"Effects of drospirenone on cardiovascular markers in human aortic endothelial cells","volume":"12","author":"Seeger","year":"2009","journal-title":"Climacteric"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib1060","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1210\/jcem-50-1-158","article-title":"Characteristics of aldosterone binding in human plasma","volume":"50","author":"Zipser","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl. 6","key":"10.1016\/j.steroids.2011.03.001_bib1065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/gye.15.s6.9.17","article-title":"How progestins influence the cardiovascular effect of hormone replacement therapy","volume":"15","author":"Rosano","year":"2001","journal-title":"Gynecol Endocrinol"},{"issue":"7","key":"10.1016\/j.steroids.2011.03.001_bib1070","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1177\/0192623309350475","article-title":"Differential effects of 17beta-estradiol and of synthetic progestins on aldosterone-salt-induced kidney disease","volume":"37","author":"Arias-Loza","year":"2009","journal-title":"Toxicol Pathol"},{"issue":"Suppl. 3","key":"10.1016\/j.steroids.2011.03.001_bib1075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/13697130500330341","article-title":"Drospirenone in combination with estrogens: for contraception and hormone replacement therapy","volume":"8","author":"Oelkers","year":"2005","journal-title":"Climacteric"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib1080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/138161280401221007111005","article-title":"Selective estrogen receptor modulators (SERMs)","volume":"4","author":"Grese","year":"1998","journal-title":"Curr Pharm Des"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib1085","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1677\/joe.0.0980385","article-title":"Changes in the binding of oestradiol to uterine oestrogen receptors induced by some progesterone and 19-nor-testosterone derivatives","volume":"98","author":"Di Carlo","year":"1983","journal-title":"J Endocrinol"},{"issue":"1","key":"10.1016\/j.steroids.2011.03.001_bib1090","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0960-0760(94)90254-2","article-title":"Estrogenic and progestagenic activities coexisting in steroidal drugs: quantitative evaluation by in vitro bioassays with human cells","volume":"48","author":"Markiewicz","year":"1994","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"10.1016\/j.steroids.2011.03.001_bib1095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0010-7824(99)00039-6","article-title":"Variations of progesterone receptor and c-fos gene expression in the rat uterus after treatment with norethisterone and its A-ring reduced metabolites","volume":"59","author":"Mendoza-Rodriguez","year":"1999","journal-title":"Contraception"},{"issue":"9","key":"10.1016\/j.steroids.2011.03.001_bib1100","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1210\/en.142.9.3791","article-title":"A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alpha","volume":"142","author":"Larrea","year":"2001","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib1145","doi-asserted-by":"crossref","first-page":"e9814","DOI":"10.1371\/journal.pone.0009814","article-title":"Depo-provera treatment does not abrogate protection from intravenous SIV challenge in female macaques immunized with an attenuated AIDS virus","volume":"5","author":"Genesca","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.steroids.2011.03.001_bib1110","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0010-7824(03)00136-7","article-title":"Depot-medroxyprogesterone acetate injection (Depo-Provera\u00ae): a highly effective contraceptive option with proven long-term safety","volume":"68","author":"Westhoff","year":"2003","journal-title":"Contraception"},{"issue":"3","key":"10.1016\/j.steroids.2011.03.001_bib1115","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ajog.2003.10.693","article-title":"Medroxyprogesterone acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise","volume":"190","author":"Elovitz","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.steroids.2011.03.001_bib1120","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1097\/QAD.0b013e32833a2537","article-title":"Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling","volume":"24","author":"Morrison","year":"2010","journal-title":"AIDS"},{"issue":"9","key":"10.1016\/j.steroids.2011.03.001_bib1150","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tem.2008.07.009","article-title":"Tissue-specific glucocorticoid action: a family affair","volume":"19","author":"Gross","year":"2008","journal-title":"Trends Endocrinol Metab"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X11000997?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X11000997?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T19:30:18Z","timestamp":1685993418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X11000997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":225,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0039128X11000997"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2011.03.001","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}