{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T22:11:26Z","timestamp":1755036686093},"reference-count":39,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian Scientific Research Fund","doi-asserted-by":"crossref","award":["OTKA K-73267"],"award-info":[{"award-number":["OTKA K-73267"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Norway Research Fund","award":["NNF77756"],"award-info":[{"award-number":["NNF77756"]}]},{"name":"National Development Agency","award":["T\u00c1MOP-4.2.2\/B-10\/"],"award-info":[{"award-number":["T\u00c1MOP-4.2.2\/B-10\/"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.steroids.2012.08.014","type":"journal-article","created":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T18:04:37Z","timestamp":1347645877000},"page":"1345-1351","source":"Crossref","is-referenced-by-count":20,"title":["The rs4844880 polymorphism in the promoter region of the HSD11B1 gene associates with bone mineral density in healthy and postmenopausal osteoporotic women"],"prefix":"10.1016","volume":"77","author":[{"given":"Karolina","family":"Feldman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gnes","family":"Szappanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriett","family":"Butz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vince","family":"Grolmusz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Majnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Istv\u00e1n","family":"Lik\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Kriszt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Lakatos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"T\u00f3th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1roly","family":"R\u00e1cz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Pat\u00f3cs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.steroids.2012.08.014_b0005","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1365-2265.2005.02281.x","article-title":"Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study","volume":"62","author":"Cooper","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.steroids.2012.08.014_b0010","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/187153007780832082","article-title":"Readjusting the glucocorticoid balance. an opportunity for modulators of 11beta-hydroxysteroid dehydrogenase type 1 activity?","volume":"7","author":"Atanasov","year":"2007","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"10.1016\/j.steroids.2012.08.014_b0015","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1210\/er.2003-0031","article-title":"11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response","volume":"25","author":"Tomlinson","year":"2004","journal-title":"Endocr Rev"},{"key":"10.1016\/j.steroids.2012.08.014_b0020","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1677\/joe.1.06019","article-title":"11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action","volume":"186","author":"Draper","year":"2005","journal-title":"J Endocrinol"},{"key":"10.1016\/j.steroids.2012.08.014_b0025","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S8756-3282(00)00344-6","article-title":"Expression and functional consequences of 11beta-hydroxysteroid dehydrogenase activity in human bone","volume":"27","author":"Cooper","year":"2000","journal-title":"Bone"},{"key":"10.1016\/j.steroids.2012.08.014_b0030","doi-asserted-by":"crossref","first-page":"16653","DOI":"10.1016\/S0021-9258(18)55351-5","article-title":"The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization","volume":"266","author":"Tannin","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.steroids.2012.08.014_b0035","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/01.HYP.0000144294.28985.d5","article-title":"Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians","volume":"44","author":"Franks","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.steroids.2012.08.014_b0040","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1210\/jc.2005-2222","article-title":"Genetic variation in 11beta-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome","volume":"91","author":"Gambineri","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.steroids.2012.08.014_b0045","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/sj.ijo.0802327","article-title":"Associations between a polymorphism in the 11 beta hydroxysteroid dehydrogenase type I gene and body composition","volume":"27","author":"Gelernter-Yaniv","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.steroids.2012.08.014_b0050","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/s00125-004-1407-6","article-title":"11beta-hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle","volume":"47","author":"Nair","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.steroids.2012.08.014_b0055","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/hmg\/ddg361","article-title":"Glucocorticoid-related genetic susceptibility for Alzheimer\u2019s disease","volume":"13","author":"de Quervain","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.steroids.2012.08.014_b0060","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/ng1214","article-title":"Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency","volume":"34","author":"Draper","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.steroids.2012.08.014_b0065","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.bone.2009.07.080","article-title":"HSD11B1 polymorphisms predicted bone mineral density and fracture risk in postmenopausal women without a clinically apparent hypercortisolemia","volume":"45","author":"Hwang","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.steroids.2012.08.014_b0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jsbmb.2010.11.009","article-title":"The 83,557insA variant of the gene coding 11beta-hydroxysteroid dehydrogenase type 1 enzyme associates with serum osteocalcin in patients with endogenous Cushing\u2019s syndrome","volume":"123","author":"Szappanos","year":"2011","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.steroids.2012.08.014_b0075","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.diabres.2009.05.017","article-title":"Association study of 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort","volume":"85","author":"Miyamoto","year":"2009","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.steroids.2012.08.014_b0200","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1210\/jc.2004-1523","article-title":"A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome","volume":"90","author":"San Millan","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.steroids.2012.08.014_b0085","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1210\/en.2009-0663","article-title":"Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels","volume":"151","author":"Malavasi","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2012.08.014_b0205","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1359\/jbmr.2001.16.1.97","article-title":"Comparison of trabecular bone microarchitecture and remodeling in glucocorticoid-induced and postmenopausal osteoporosis","volume":"16","author":"Dalle Carbonare","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.steroids.2012.08.014_b0095","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1210\/endo.140.10.7034","article-title":"Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis","volume":"140","author":"Hofbauer","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2012.08.014_b0100","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1172\/JCI108762","article-title":"Intestinal calcium absorption in exogenous hypercortisonism. Role of 25-hydroxyvitamin D and corticosteroid dose","volume":"60","author":"Klein","year":"1977","journal-title":"J Clin Invest"},{"key":"10.1016\/j.steroids.2012.08.014_b0210","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1210\/en.2009-0663","article-title":"Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels","volume":"151","author":"Malavasi","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2012.08.014_b0110","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neulet.2005.09.047","article-title":"Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change","volume":"393","author":"Deary","year":"2006","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.steroids.2012.08.014_b0115","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1210\/jc.2005-0942","article-title":"Genotypes at 11beta-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample","volume":"90","author":"White","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.steroids.2012.08.014_b0120","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1677\/JME-08-0003","article-title":"Tumour necrosis factor superfamily member 11 gene promoter polymorphisms modulate promoter activity and influence bone mineral density in postmenopausal women with osteoporosis","volume":"40","author":"Mencej","year":"2008","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.steroids.2012.08.014_b0125","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1530\/JME-11-0067","article-title":"Functional polymorphisms within the TNFRSF11B (osteoprotegerin) gene increase the risk for low bone mineral density","volume":"47","author":"Vidal","year":"2011","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.steroids.2012.08.014_b0130","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1359\/jbmr.2001.16.6.1037","article-title":"Modulation of 11beta-hydroxysteroid dehydrogenase isozymes by proinflammatory cytokines in osteoblasts: an autocrine switch from glucocorticoid inactivation to activation","volume":"16","author":"Cooper","year":"2001","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.steroids.2012.08.014_b0135","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/me.2004-0212","article-title":"11beta-hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation","volume":"19","author":"Eijken","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.steroids.2012.08.014_b0140","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1677\/joe.0.1610455","article-title":"Characterization of 11beta-hydroxysteroid dehydrogenase activity and corticosteroid receptor expression in human osteosarcoma cell lines","volume":"161","author":"Bland","year":"1999","journal-title":"J Endocrinol"},{"key":"10.1016\/j.steroids.2012.08.014_b0145","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1677\/joe.0.1630159","article-title":"Glucocorticoid activity, inactivity and the osteoblast","volume":"163","author":"Cooper","year":"1999","journal-title":"J Endocrinol"},{"key":"10.1016\/j.steroids.2012.08.014_b0150","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1210\/en.2005-1621","article-title":"A novel promoter for the 11beta-hydroxysteroid dehydrogenase type 1 gene is active in lung and is C\/EBPalpha independent","volume":"147","author":"Bruley","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2012.08.014_b0155","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1210\/me.2007-0489","article-title":"Glucocorticoid regulation of the promoter of 11beta-hydroxysteroid dehydrogenase type 1 is indirect and requires CCAAT\/enhancer-binding protein-beta","volume":"22","author":"Sai","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.steroids.2012.08.014_b0160","doi-asserted-by":"crossref","first-page":"30232","DOI":"10.1074\/jbc.M001286200","article-title":"C\/EBP regulates hepatic transcription of 11beta-hydroxysteroid dehydrogenase type 1. A novel mechanism for cross-talk between the C\/EBP and glucocorticoid signaling pathways","volume":"275","author":"Williams","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.steroids.2012.08.014_b0165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1677\/JOE-07-0303","article-title":"Role of glucocorticoid receptor and CCAAT\/enhancer-binding protein alpha in the feed-forward induction of 11beta-hydroxysteroid dehydrogenase type 1 expression by cortisol in human amnion fibroblasts","volume":"195","author":"Yang","year":"2007","journal-title":"J Endocrinol"},{"key":"10.1016\/j.steroids.2012.08.014_b0170","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.biochi.2006.05.020","article-title":"CCAAT\/enhancer-binding proteins (C\/EBPs) regulate the basal and cAMP-induced transcription of the human 11beta-hydroxysteroid dehydrogenase encoding gene in adipose cells","volume":"88","author":"Gout","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.steroids.2012.08.014_b0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cbi.2010.12.027","article-title":"Analysis of alternative promoter usage in expression of HSD11B1 including the development of a transcript-specific quantitative real-time PCR method","volume":"191","author":"Staab","year":"2011","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.steroids.2012.08.014_b0180","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1042\/CS20040070","article-title":"Sensitivity of bone to glucocorticoids","volume":"107","author":"Cooper","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.steroids.2012.08.014_b0185","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.bone.2006.04.029","article-title":"T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures","volume":"39","author":"Kung","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.steroids.2012.08.014_b0190","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.bone.2010.05.009","article-title":"Polymorphisms in the macrophage migration inhibitory factor gene and bone loss in postmenopausal women","volume":"47","author":"Swanberg","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.steroids.2012.08.014_b0195","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1093\/hmg\/ddp205","article-title":"Promoter and intron 1 polymorphisms of COL1A1 interact to regulate transcription and susceptibility to osteoporosis","volume":"18","author":"Jin","year":"2009","journal-title":"Hum Mol Genet"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X12002425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X12002425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:12:33Z","timestamp":1643415153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X12002425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":39,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0039128X12002425"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2012.08.014","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}