{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:25:55Z","timestamp":1792009555089,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.steroids.2012.12.009","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T12:23:34Z","timestamp":1356956614000},"page":"379-385","source":"Crossref","is-referenced-by-count":54,"title":["Nandrolone decanoate determines cardiac remodelling and injury by an imbalance in cardiac inflammatory cytokines and ACE activity, blunting of the Bezold\u2013Jarisch reflex, resulting in the development of hypertension"],"prefix":"10.1016","volume":"78","author":[{"given":"Jo\u00e3o Vicente Maggioni","family":"Franquni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrews Marques","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eweliny Miranda","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girl\u00e2ndia Alexandre","family":"Brasil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ot\u00e1vio Arruda","family":"Heringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla Oliveira dos Santos","family":"Cassaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thony Vinicius Pita","family":"da Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Musso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmen L.F.","family":"Silva Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ieda Carneiro","family":"Kalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Coutinho","family":"Endringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Assis Pereirra","family":"Bo\u00ebchat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazar\u00e9 Souza","family":"Bissoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeu Uggere","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.steroids.2012.12.009_b0005","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2174\/138955711795445862","article-title":"Heart disease induced by AAS abuse, using experimental mice\/rats models and the role of exercise-induced cardiotoxicity","volume":"11","author":"Riezzo","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.steroids.2012.12.009_b0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/bjsm.31.1.54","article-title":"Gym & tonic: a profile of 100 male steroid users","volume":"31","author":"Evans","year":"1997","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.steroids.2012.12.009_b0015","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1249\/01.mss.0000210194.56834.5d","article-title":"Anabolic androgenic steroid: a survey of 500 users","volume":"38","author":"Parkinson","year":"2006","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.steroids.2012.12.009_b0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2165\/00007256-200232050-00001","article-title":"Anabolic steroids: a review for the clinician","volume":"32","author":"Kutscher","year":"2002","journal-title":"Sports Med"},{"key":"10.1016\/j.steroids.2012.12.009_b0025","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2165\/00007256-200232020-00001","article-title":"Steroid use and long termhealth risks informer athletes","volume":"32","author":"Parssinen","year":"2002","journal-title":"Sports Med"},{"key":"10.1016\/j.steroids.2012.12.009_b0030","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/00005344-200111000-00012","article-title":"Testosterone facilitates the baroreceptor control of reflex bradycardia: role of cardiac sympathetic and parasympathetic components","volume":"38","author":"El-Mas","year":"2001","journal-title":"J Card Pharmacol"},{"key":"10.1016\/j.steroids.2012.12.009_b0035","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1124\/jpet.301.1.346","article-title":"Cyclosporine adversely affects baroreflexes via inhibition of testosterone modulation of cardiac vagal control","volume":"301","author":"El-Mas","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.steroids.2012.12.009_b0040","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jsbmb.2004.11.003","article-title":"Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats","volume":"93","author":"Beutel","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"10.1016\/j.steroids.2012.12.009_b0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2210-5-9","article-title":"Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats","volume":"30","author":"Ward","year":"2005","journal-title":"BMC Pharmacol"},{"issue":"6","key":"10.1016\/j.steroids.2012.12.009_b0050","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2210-6-2","article-title":"Orchirctomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats","volume":"23","author":"Ward","year":"2006","journal-title":"BMC Pharmacol"},{"issue":"6","key":"10.1016\/j.steroids.2012.12.009_b0055","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.phrs.2009.03.001","article-title":"Long-term treatment with supraphysiological doses of nandrolone decanoate reduces the sensitivity of Bezold\u2013Jarisch reflex control of heart rate and blood pressure","volume":"59","author":"Bissoli","year":"2009","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.steroids.2012.12.009_b0285","article-title":"Role of the renin-angiotensin system in the nandrolone-decanoate-induced attenuation of the Bezold\u2013Jarisch reflex","volume":"89","author":"Andrade","year":"2011","journal-title":"Can J Physiol Pharmacol"},{"issue":"1","key":"10.1016\/j.steroids.2012.12.009_b0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.arcmed.2007.06.020","article-title":"Higher physiological doses of nandrolone decanoate do not influence the Bezold-Jarish reflex control of bradycardia","volume":"39","author":"Andrade","year":"2008","journal-title":"Arch Med Res"},{"issue":"11","key":"10.1016\/j.steroids.2012.12.009_b0070","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0192-0561(95)00078-X","article-title":"Modulation of immune responses by anabolic androgenic steroids","volume":"17","author":"Hughes","year":"1995","journal-title":"Int J Immunopharmacol"},{"issue":"4","key":"10.1016\/j.steroids.2012.12.009_b0075","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.bbrc.2006.07.002","article-title":"Matrix metalloproteinase-2 contributes to tumor necrosis factor alpha induced apoptosis in cultured rat cardiac myocytes","volume":"347","author":"Shen","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.steroids.2012.12.009_b0080","first-page":"691","article-title":"The utility of troponin measurement to detect myocardial infarction: Review of the current findings","volume":"6","author":"Daubert","year":"2010","journal-title":"Vasc Health Risk Manag"},{"key":"10.1016\/j.steroids.2012.12.009_b0085","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2011.13202","article-title":"High-sensitive cardiac troponin: Friend or foe?","author":"Twerenbold","year":"2011","journal-title":"Swiss Med Wkly"},{"issue":"4","key":"10.1016\/j.steroids.2012.12.009_b0090","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01002772","article-title":"Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections","volume":"11","author":"Junqueira","year":"1979","journal-title":"Histochem J"},{"issue":"1","key":"10.1016\/j.steroids.2012.12.009_b0095","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1006\/cbir.1996.0004","article-title":"Structural biology of the fibres of the collagenous and elastic systems","volume":"20","author":"Montes","year":"1996","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.steroids.2012.12.009_b0100","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.RES.0000144125.61927.1c","article-title":"Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy","volume":"95","author":"Akar","year":"2004","journal-title":"Circ Res"},{"issue":"4","key":"10.1016\/j.steroids.2012.12.009_b0105","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1507\/endocrj.51.425","article-title":"Endocrinological and pathological effects of anabolic-androgenic steroid in male rats","volume":"51","author":"Takahashi","year":"2004","journal-title":"Endocr J"},{"issue":"17\u201318","key":"10.1016\/j.steroids.2012.12.009_b0245","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.lfs.2011.08.004","article-title":"Nandrolone and resistance training induce heart remodeling: Role of fetal genes and implications for cardiac pathophysiology","volume":"89","author":"Tanno","year":"2011","journal-title":"Life Sci"},{"issue":"4","key":"10.1016\/j.steroids.2012.12.009_b0115","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1152\/japplphysiol.01079.2007","article-title":"Effects of IL-10 and age on IL-6, IL-1beta, and TNF-alpha responses in mouse skeletal and cardiac muscle to an acute inflammatory insult","volume":"104","author":"Meador","year":"2008","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.steroids.2012.12.009_b0120","doi-asserted-by":"crossref","first-page":"H977","DOI":"10.1152\/ajpheart.2001.280.3.H977","article-title":"Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart","volume":"280","author":"Boehm","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.steroids.2012.12.009_b0125","first-page":"36","article-title":"Image processing with ImageJ","volume":"11","author":"Abramoff","year":"2004","journal-title":"Biophotonics Int"},{"key":"10.1016\/j.steroids.2012.12.009_b0250","article-title":"ImageJ","author":"Rasband","year":"1997","journal-title":"US National Institutes of Health"},{"issue":"6\u20137","key":"10.1016\/j.steroids.2012.12.009_b0135","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.phymed.2004.07.002","article-title":"Validation of a colorimetric assay for the in vitro screening of inhibitors of agiotensin-converting enzyme (ACE) from plant extracts","volume":"12","author":"Serra","year":"2005","journal-title":"Phytomedicine"},{"key":"10.1016\/j.steroids.2012.12.009_b0140","first-page":"13","article-title":"Mechanical ventilation with high tidal volumes attenuates myocardial dysfunction by decreasing cardiac edema in a rat model of LPS-induced peritonitis","volume":"20","author":"Smeding","year":"2012","journal-title":"Respir Res"},{"key":"10.1016\/j.steroids.2012.12.009_b0255","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1113\/jphysiol.1965.sp007572","article-title":"The effect of sympathetic nerve stimulation on vasoconstrictor response in perfused mesenteric blood vessels of the rat","volume":"177","author":"Mc Gregor","year":"1965","journal-title":"J Physiol"},{"issue":"2","key":"10.1016\/j.steroids.2012.12.009_b0150","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/00365510151097700","article-title":"Cytokine responses and myocardial injury in coronary artery bypass grafting","volume":"61","author":"Wei","year":"2001","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"10.1016\/j.steroids.2012.12.009_b0155","first-page":"21","article-title":"Proposed mechanisms for the anabolic steroid-induced increase in myocardial susceptibility to ischaemia\/reperfusion injury","volume":"16","author":"Du Toit","year":"2005","journal-title":"Cardiovasc J S Afr"},{"issue":"10","key":"10.1016\/j.steroids.2012.12.009_b0260","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1249\/MSS.0b013e318217e8b6","article-title":"Anabolic steroid associated to physical training induces deleterious cardiac effects","volume":"43","author":"Do Carmo","year":"2011","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"10.1016\/j.steroids.2012.12.009_b0265","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2613.2008.00601.x","article-title":"Adverse effect of the anabolic-androgenic steroid mesterolone on cardiac remodeling and lipoprotein profile is attenuated by aerobicz exercise training","volume":"89","author":"Fontana","year":"2008","journal-title":"Int J Exp Pathol"},{"issue":"6","key":"10.1016\/j.steroids.2012.12.009_b0170","doi-asserted-by":"crossref","first-page":"H3575","DOI":"10.1152\/ajpheart.01251.2006","article-title":"Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats","volume":"293","author":"Rocha","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.steroids.2012.12.009_b0175","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1161\/01.RES.85.3.272","article-title":"Tumor necrosis factor-alpha upregulates angiotensin II type 1 receptors on cardiac fibroblasts","volume":"85","author":"Gurantz","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.steroids.2012.12.009_b0270","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1161\/01.HYP.12.3.227","article-title":"Cardiopulmonary reflex before and after regression of left ventricular hypertrophy in essential hypertension","volume":"12","author":"Grassi","year":"1988","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.steroids.2012.12.009_b0275","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1161\/01.CIR.82.4.1222","article-title":"Cardiovascular receptor reflexes in normotensive athletes with cardiac hypertrophy","volume":"82","author":"Giannattasio","year":"1990","journal-title":"Circulation"},{"key":"10.1016\/j.steroids.2012.12.009_b0190","first-page":"544","article-title":"Cardiopulmonary and baroreceptor reflexes in rats with chronic myocardial infarction","volume":"21","author":"Vasquez","year":"1993","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.steroids.2012.12.009_b0195","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/01.HYP.24.5.564","article-title":"Impaired cardiovascular reflexes precede deoxycorticosterone acetate-salt hypertension","volume":"24","author":"Veelken","year":"1994","journal-title":"Hypertension"},{"issue":"2\u20133","key":"10.1016\/j.steroids.2012.12.009_b0200","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0165-1838(98)00129-5","article-title":"Effects of myocardial hypertrophy on neural reflexes controlling cardiovascular function","volume":"73","author":"Meyrelles","year":"1998","journal-title":"J Auton N Syst"},{"issue":"3","key":"10.1016\/j.steroids.2012.12.009_b0205","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1161\/01.HYP.32.3.548","article-title":"ANP and bradycardic reflexes in hypertensive rats: influence of cardiac hypertrophy","volume":"32","author":"Thomas","year":"1998","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.steroids.2012.12.009_b0210","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1006\/phrs.1999.0608","article-title":"The diuretic chlortalidone normalizes baroreceptor and Bezold\u2013Jarisch reflexes in DOCA-salt hypertensive rats","volume":"41","author":"Bissoli","year":"2000","journal-title":"Pharmacol Res"},{"issue":"5","key":"10.1016\/j.steroids.2012.12.009_b0215","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1590\/S0100-879X2000000500014","article-title":"The cardiopulmonary reflexes of spontaneously hypertensive rats are normalized after regression of left ventricular hypertrophy and hypertension","volume":"33","author":"Uggere","year":"2000","journal-title":"Bras J Med Biol Res"},{"issue":"7","key":"10.1016\/j.steroids.2012.12.009_b0220","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1440-1681.2007.04613.x","article-title":"Effect of enalapril treatment on the sensitivity of cardiopulmonary reflexes in rats with myocardial infarction","volume":"34","author":"Andrade","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"9","key":"10.1016\/j.steroids.2012.12.009_b0225","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/j.1440-1681.2007.04750.x","article-title":"Role of cardiac hypertrophy in reducing the sensitivity of cardiopulmonary reflex control of renal sympathetic nerve activity in spontaneously hypertensive rats","volume":"35","author":"de Andrade","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"Suppl. III","key":"10.1016\/j.steroids.2012.12.009_b0280","article-title":"Cardiovascular reflexes and hypertension","volume":"18","author":"Zanchetti","year":"1991","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.steroids.2012.12.009_b0235","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1365-2362.2006.01667.x","article-title":"Impaired vasoreactivity in bodybuilders using androgenic anabolic steroids","volume":"36","author":"Lane","year":"2006","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"10.1016\/j.steroids.2012.12.009_b0240","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1161\/01.HYP.0000174600.51515.e7","article-title":"Vascular sensitivity to phenylephrine in rats submitted to anaerobic training and nandrolone treatment","volume":"46","author":"Cunha","year":"2005","journal-title":"Hypertension"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X12003406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X12003406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,7]],"date-time":"2019-07-07T14:58:46Z","timestamp":1562511526000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X12003406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0039128X12003406"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2012.12.009","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}