{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:29:29Z","timestamp":1774366169075,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"State Key Program of Basic Research of China","award":["2010CB912501"],"award-info":[{"award-number":["2010CB912501"]}]},{"name":"State Key Program of Basic Research of China","award":["2012ZX09301001-004"],"award-info":[{"award-number":["2012ZX09301001-004"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81173105"],"award-info":[{"award-number":["81173105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81220108025"],"award-info":[{"award-number":["81220108025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["91213306"],"award-info":[{"award-number":["91213306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Foundation of Chinese Academy of Sciences","award":["KSCX2-EW-Q-3"],"award-info":[{"award-number":["KSCX2-EW-Q-3"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.steroids.2013.06.005","type":"journal-article","created":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T05:47:33Z","timestamp":1372657653000},"page":"987-995","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Blockage of progesterone receptor effectively protects pancreatic islet beta cell viability"],"prefix":"10.1016","volume":"78","author":[{"given":"Rong","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.steroids.2013.06.005_b0005","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S1043-2760(03)00003-1","article-title":"Progesterone in gestational diabetes mellitus: guilty or not guilty?","volume":"14","author":"Branisteanu","year":"2003","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.steroids.2013.06.005_b0010","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2337\/diacare.29.03.06.dc05-1118","article-title":"Gestational diabetes identifies women at risk for permanent type 1 and type 2 diabetes in fertile age: predictive role of autoantibodies","volume":"29","author":"Jarvela","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.steroids.2013.06.005_b0015","first-page":"568","article-title":"Insulin secretion during and after pregnancy in patients with gestational diabetes mellitus","volume":"86","author":"Homko","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.steroids.2013.06.005_b0020","doi-asserted-by":"crossref","first-page":"15644","DOI":"10.1073\/pnas.202612199","article-title":"Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation","volume":"99","author":"Picard","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.steroids.2013.06.005_b0025","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00109-003-0450-y","article-title":"Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes","volume":"81","author":"Donath","year":"2003","journal-title":"J Mol Med"},{"key":"10.1016\/j.steroids.2013.06.005_b0030","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1152\/physiol.00032.2009","article-title":"Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes","volume":"24","author":"Donath","year":"2009","journal-title":"Physiology"},{"key":"10.1016\/j.steroids.2013.06.005_b0035","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1007\/s001250100021","article-title":"A choice of death \u2013 the signal-transduction of immune-mediated beta-cell apoptosis","volume":"44","author":"Eizirik","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.steroids.2013.06.005_b0040","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2337\/diabetes.52.1.102","article-title":"Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes","volume":"52","author":"Butler","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.steroids.2013.06.005_b0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.it.2003.10.013","article-title":"Inflammation: the link between insulin resistance, obesity and diabetes","volume":"25","author":"Dandona","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.steroids.2013.06.005_b0050","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.1074\/jbc.M110090200","article-title":"Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells","volume":"277","author":"Richer","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.steroids.2013.06.005_b0055","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1128\/MCB.20.9.3102-3115.2000","article-title":"The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding","volume":"20","author":"Giangrande","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.steroids.2013.06.005_b0060","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1097-2765(01)00304-5","article-title":"Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases","volume":"8","author":"Boonyaratanakornkit","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.steroids.2013.06.005_b0065","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/me.2010-0424","article-title":"Progesterone receptor activation of extranuclear signaling pathways in regulating p53 expression in vascular endothelial cells","volume":"25","author":"Hsu","year":"2011","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.steroids.2013.06.005_b0070","first-page":"267","article-title":"Activation of extracellular signal-regulated kinase (ERK)1\/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells","volume":"11","author":"Pavlovic","year":"2000","journal-title":"Eur Cytokine Netw"},{"key":"10.1016\/j.steroids.2013.06.005_b0075","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/emboj\/16.5.1080","article-title":"Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2","volume":"16","author":"Reinhard","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.steroids.2013.06.005_b0080","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1021\/jm00074a010","article-title":"N-substituted dibenzoxazepines as analgesic PGE2 antagonists","volume":"36","author":"Hallinan","year":"1993","journal-title":"J Med Chem"},{"key":"10.1016\/j.steroids.2013.06.005_b0085","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/jm950454k","article-title":"Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs","volume":"39","author":"Hallinan","year":"1996","journal-title":"J Med Chem"},{"key":"10.1016\/j.steroids.2013.06.005_b0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0306-4522(94)90369-7","article-title":"Comparison of prostaglandin E1- and prostaglandin E2-induced hyperalgesia in the rat","volume":"62","author":"Khasar","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.steroids.2013.06.005_b0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0304-3940(94)90181-3","article-title":"Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat","volume":"173","author":"Malmberg","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.steroids.2013.06.005_b0100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/jcbfm.2008.88","article-title":"The neuroprotective effect of prostaglandin E2 EP1 receptor inhibition has a wide therapeutic window, is sustained in time and is not sexually dimorphic","volume":"29","author":"Abe","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.steroids.2013.06.005_b0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/B:NEON.0000014537.15902.73","article-title":"Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089","volume":"66","author":"Matsuo","year":"2004","journal-title":"Journal of neuro-oncology."},{"key":"10.1016\/j.steroids.2013.06.005_b0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0090-6980(02)00014-X","article-title":"Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway","volume":"70","author":"Wolkowicz","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.steroids.2013.06.005_b0115","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.bcp.2008.08.016","article-title":"Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism","volume":"76","author":"Lin","year":"2008","journal-title":"Biochemical Pharmacol"},{"key":"10.1016\/j.steroids.2013.06.005_b0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsbmb.2010.03.090","article-title":"Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways","volume":"120","author":"Liu","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.steroids.2013.06.005_b0125","first-page":"5771","article-title":"Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth","volume":"61","author":"Oesterreich","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.steroids.2013.06.005_b0130","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/dmrr.2310","article-title":"Effects of glucocorticoids and exercise on pancreatic beta-cell function and diabetes development","volume":"28","author":"Beaudry","year":"2012","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.steroids.2013.06.005_b0135","doi-asserted-by":"crossref","first-page":"5031","DOI":"10.1113\/jphysiol.2009.177188","article-title":"The role of oestrogens in the adaptation of islets to insulin resistance","volume":"587","author":"Nadal","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.steroids.2013.06.005_b0140","doi-asserted-by":"crossref","first-page":"645","DOI":"10.2337\/diacare.27.3.645","article-title":"Transdermal 17-beta-estradiol and risk of developing type 2 diabetes in a population of healthy, nonobese postmenopausal women","volume":"27","author":"Rossi","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.steroids.2013.06.005_b0145","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0039-128X(03)00129-6","article-title":"Progesterone receptor transcription and non-transcription signaling mechanisms","volume":"68","author":"Leonhardt","year":"2003","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2013.06.005_b0150","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0960-0760(94)90190-2","article-title":"The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity","volume":"48","author":"McDonnell","year":"1994","journal-title":"J Steroid Biochem Mol Biol"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X13001463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X13001463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T22:30:24Z","timestamp":1539556224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X13001463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0039128X13001463"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2013.06.005","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blockage of progesterone receptor effectively protects pancreatic islet beta cell viability","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2013.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}