{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:24:38Z","timestamp":1793467478824,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.steroids.2013.11.006","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T12:53:35Z","timestamp":1385038415000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Rapid actions of xenoestrogens disrupt normal estrogenic signaling"],"prefix":"10.1016","volume":"81","author":[{"given":"Cheryl S.","family":"Watson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangzhen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana A.","family":"Paulucci-Holthauzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 7","key":"10.1016\/j.steroids.2013.11.006_b0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1289\/ehp.95103s783","article-title":"Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens","volume":"103","author":"Newbold","year":"1995","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.steroids.2013.11.006_b0010","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1098\/rstb.2009.0053","article-title":"Plastics, the environment and human health: current consensus and future trends","volume":"364","author":"Thompson","year":"2009","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.steroids.2013.11.006_b0015","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1289\/ehp.1205826","article-title":"Bisphenol s disrupts estradiol-induced nongenomic signaling in a rat pituitary cell line: effects on cell functions","volume":"121","author":"Vinas","year":"2013","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.steroids.2013.11.006_b0020","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1289\/ehp.0901253","article-title":"Polyethylene terephthalate may yield endocrine disruptors","volume":"118","author":"Sax","year":"2010","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.steroids.2013.11.006_b0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2605.2007.00862.x","article-title":"Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology","volume":"31","author":"Kortenkamp","year":"2008","journal-title":"Int J Androl"},{"key":"10.1016\/j.steroids.2013.11.006_b0030","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1191\/0960327105ht551oa","article-title":"Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response","volume":"24","author":"Weltje","year":"2005","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.steroids.2013.11.006_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kfp288","article-title":"Nongenomic signaling pathways of estrogen toxicity","volume":"115","author":"Watson","year":"2010","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.steroids.2013.11.006_b0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.molcel.2012.11.002","article-title":"Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals","volume":"49","author":"Albeck","year":"2013","journal-title":"Mol Cell"},{"key":"10.1016\/j.steroids.2013.11.006_b0045","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/1471-2407-9-334","article-title":"Proliferative and anti-proliferative effects of dietary levels of phytoestrogens in rat pituitary GH3\/B6\/F10 cells \u2013 the involvement of rapidly activated kinases and caspases","volume":"9","author":"Jeng","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.steroids.2013.11.006_b0050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.steroids.2003.12.003","article-title":"Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathways","volume":"69","author":"Bulayeva","year":"2004","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2013.11.006_b0055","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1289\/ehp.1002512","article-title":"Combinations of physiologic estrogens with xenoestrogens alter ERK phosphorylation profiles in rat pituitary cells","volume":"119","author":"Jeng","year":"2011","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.steroids.2013.11.006_b0060","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1111\/j.1471-4159.2008.05491.x","article-title":"The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC-12 cells","volume":"106","author":"Alyea","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.steroids.2013.11.006_b0065","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1038\/sj.onc.1211040","article-title":"Post-translational regulation of the ERK phosphatase DUSP6\/MKP3 by the mTOR pathway","volume":"27","author":"Bermudez","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.steroids.2013.11.006_b0070","doi-asserted-by":"crossref","first-page":"41377","DOI":"10.1074\/jbc.M400017200","article-title":"Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)\/pp32 in response to the antiproliferative lectin, jacalin","volume":"279","author":"Yu","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.steroids.2013.11.006_b0075","doi-asserted-by":"crossref","first-page":"R130","DOI":"10.1186\/bcr959","article-title":"Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1\/2 activation in MCF-7 cells","volume":"7","author":"Zivadinovic","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.steroids.2013.11.006_b0080","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/jcp.20297","article-title":"Cdc25A and ERK interaction: EGFR-independent ERK activation by a protein phosphatase Cdc25A inhibitor, compound 5","volume":"204","author":"Wang","year":"2005","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.steroids.2013.11.006_b0085","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.1210\/en.2005-0564","article-title":"Rapid estrogenic regulation of extracellular signal-regulated kinase 1\/2 signaling in cerebellar granule cells involves a G protein- and protein kinase A-dependent mechanism and intracellular activation of protein phosphatase 2A","volume":"146","author":"Belcher","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2013.11.006_b0090","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0003-2697(86)90314-3","article-title":"Determination of cell number in monolayer cultures","volume":"159","author":"Gillies","year":"1986","journal-title":"Anal Biochem"},{"key":"10.1016\/j.steroids.2013.11.006_b0095","first-page":"12","article-title":"Mixtures of xenoestrogens disrupt estradiol-induced non-genomic signaling and downstream functions in pituitary cells","author":"Vinas","year":"2013","journal-title":"Environ Health"},{"key":"10.1016\/j.steroids.2013.11.006_b0100","first-page":"1","article-title":"Rapid estrogenic signaling activities of modified (chlorinated, sulfonated, and glucuronidated) endocrine disruptor bisphenol A","author":"Vinas","year":"2013","journal-title":"Endocr Disruptors"},{"key":"10.1016\/j.steroids.2013.11.006_b0105","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1096\/fasebj.9.5.7896011","article-title":"Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding","volume":"9","author":"Pappas","year":"1995","journal-title":"FASEB J"},{"key":"10.1016\/j.steroids.2013.11.006_b0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1096\/fasebj.14.1.157","article-title":"Antibodies to the estrogen receptor-alpha modulate rapid prolactin release from rat pituitary tumor cells through plasma membrane estrogen receptors","volume":"14","author":"Norfleet","year":"2000","journal-title":"FASEB J"},{"key":"10.1016\/j.steroids.2013.11.006_b0115","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0039-128X(01)00106-4","article-title":"A comparison of membrane vs. intracellular estrogen receptor-alpha in GH(3)\/B6 pituitary tumor cells using a quantitative plate immunoassay","volume":"66","author":"Campbell","year":"2001","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2013.11.006_b0120","doi-asserted-by":"crossref","first-page":"E388","DOI":"10.1152\/ajpendo.00349.2004","article-title":"Mechanisms of membrane estrogen receptor-{alpha}-mediated rapid stimulation of Ca2+ levels and prolactin release in a pituitary cell line","volume":"288","author":"Bulayeva","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.steroids.2013.11.006_b0125","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/j.molimm.2006.09.030","article-title":"Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx PMCID:17084457","volume":"44","author":"Zaitsu","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1016\/j.steroids.2013.11.006_b0130","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-2187-4-2","article-title":"Membrane estrogen receptor-alpha-mediated nongenomic actions of phytoestrogens in GH3\/B6\/F10 pituitary tumor cells","volume":"4","author":"Jeng","year":"2009","journal-title":"J Mol Signal"},{"key":"10.1016\/j.steroids.2013.11.006_b0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ymeth.2008.06.014","article-title":"Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay","volume":"45","author":"Soderberg","year":"2008","journal-title":"Methods"},{"key":"10.1016\/j.steroids.2013.11.006_b0140","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1128\/MCB.23.5.1633-1646.2003","article-title":"Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane","volume":"23","author":"Razandi","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.steroids.2013.11.006_b0145","doi-asserted-by":"crossref","first-page":"33551","DOI":"10.1074\/jbc.274.47.33551","article-title":"Caveolin-1 potentiates estrogen receptor alpha (ER alpha) signaling \u2013 caveolin-1 drives ligand-independent nuclear translocation and activation of ER alpha","volume":"274","author":"Schlegel","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.steroids.2013.11.006_b0150","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1289\/ehp.0800182","article-title":"Alkylphenol xenoestrogens with varying carbon chain lengths differentially and potently activate signaling and functional responses in GH3\/B6\/F10 somatomammotropes","volume":"117","author":"Kochukov","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.steroids.2013.11.006_b0155","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1096\/fj.08-107672","article-title":"Nongenomic actions of estradiol compared with estrone and estriol in pituitary tumor cell signaling and proliferation","volume":"22","author":"Watson","year":"2008","journal-title":"FASEB J"},{"key":"10.1016\/j.steroids.2013.11.006_b0160","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1289\/ehp.7175","article-title":"Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways","volume":"112","author":"Bulayeva","year":"2004","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.steroids.2013.11.006_b0165","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4067\/S0716-97602006000300004","article-title":"Pituitary cell type-specific electrical activity, calcium signaling and secretion","volume":"39","author":"Stojilkovic","year":"2006","journal-title":"Biol Res"},{"key":"10.1016\/j.steroids.2013.11.006_b0170","article-title":"Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-alpha interactions with G protein-alphai and caveolin I","author":"Watson","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2013.11.006_b0175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1006\/taap.2000.9051","article-title":"Metabolism and disposition of bisphenol A in female rats","volume":"168","author":"Snyder","year":"2000","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.steroids.2013.11.006_b0180","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0887-2333(02)00055-3","article-title":"Sulfation of bisphenol A abolished its estrogenicity based on proliferation and gene expression in human breast cancer MCF-7 cells","volume":"16","author":"Shimizu","year":"2002","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.steroids.2013.11.006_b0185","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.etap.2004.05.009","article-title":"Estrogenic activity of alkylphenols, bisphenol S, and their chlorinated derivatives using a GFP expression system","volume":"19","author":"Kuruto-Niwa","year":"2005","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.steroids.2013.11.006_b0190","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jsbmb.2006.06.028","article-title":"The mammary gland response to estradiol: monotonic at the cellular level, non-monotonic at the tissue-level of organization?","volume":"101","author":"Vandenberg","year":"2006","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.steroids.2013.11.006_b0195","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1289\/ehp.0800026","article-title":"Differential regulation of dopamine transporter function and location by low concentrations of environmental estrogens and 17beta-estradiol","volume":"117","author":"Alyea","year":"2009","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.steroids.2013.11.006_b0200","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/13547500902893744","article-title":"Assessment of the total effective xenoestrogen burden in extracts of human placentas","volume":"14","author":"Lopez-Espinosa","year":"2009","journal-title":"Biomarkers"},{"key":"10.1016\/j.steroids.2013.11.006_b0205","doi-asserted-by":"crossref","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","author":"Vandenberg","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1016\/j.steroids.2013.11.006_b0210","series-title":"Basic and clinical endocrinology","first-page":"925","article-title":"Appendix: normal hormone reference ranges","author":"Greenspan","year":"2004"},{"key":"10.1016\/j.steroids.2013.11.006_b0215","article-title":"Designing endocrine disruption out of the next generation of chemicals","author":"Schug","year":"2012","journal-title":"R Soc Chem \u2013 Green Chem"},{"key":"10.1016\/j.steroids.2013.11.006_b9000","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1083\/jcb.201003081","article-title":"Syndecan-3 and Notch cooperate in regulating adult myogenesis","volume":"190","author":"Pisconti","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.steroids.2013.11.006_b9005","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nmeth.f.306","article-title":"Visualization and quantification of protein-protein interactions in cells and tissues","volume":"7","author":"Gullberg","year":"2010","journal-title":"Nature Methods"},{"key":"10.1016\/j.steroids.2013.11.006_b9010","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1096\/fasebj.9.5.7896011","article-title":"Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding","volume":"9","author":"Pappas","year":"1995","journal-title":"FASEB J."}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X13002596?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X13002596?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,3]],"date-time":"2019-08-03T18:53:30Z","timestamp":1564858410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X13002596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":46,"alternative-id":["S0039128X13002596"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2013.11.006","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapid actions of xenoestrogens disrupt normal estrogenic signaling","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2013.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}