{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:36:29Z","timestamp":1783038989789,"version":"3.54.6"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Lucile-Packard Children\u2019s hospital at Stanford","award":["1094204-100-GHANE"],"award-info":[{"award-number":["1094204-100-GHANE"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.steroids.2017.11.014","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T09:54:31Z","timestamp":1512208471000},"page":"35-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Clinical utility of an ultrasensitive late night salivary cortisol assay by tandem mass spectrometry"],"prefix":"10.1016","volume":"129","author":[{"given":"Lillian R.","family":"Sturmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina S.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run-Zhang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.steroids.2017.11.014_b0005","series-title":"Williams Textbook of Endocrinology","first-page":"489","article-title":"The adrenal cortex","author":"Stewart","year":"2016"},{"key":"10.1016\/j.steroids.2017.11.014_b0010","series-title":"Contemporary Endocrinology: Cushing\u2019s Syndrome: Pathophysiology, Diagnosis and Treatment","author":"Bronstein","year":"2011"},{"key":"10.1016\/j.steroids.2017.11.014_b0015","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/jclinpath-2016-203933","article-title":"Cushing\u2019s syndrome: a practical approach to diagnosis and differential diagnosis","volume":"70","author":"Pappachan","year":"2017","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.steroids.2017.11.014_b0020","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing\u2019s syndrome: an endocrine society clinical practice guideline","volume":"93","author":"Nieman","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cca.2007.04.011","article-title":"Saliva specimen: a new laboratory tool for diagnostic and basic investigation","volume":"383","author":"Chiappin","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.steroids.2017.11.014_b0030","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s12020-012-9855-0","article-title":"Concordance of the late night salivary cortisol in patients with Cushing's syndrome and elevated urine-free cortisol","volume":"43","author":"Doi","year":"2013","journal-title":"Endocrine"},{"key":"10.1016\/j.steroids.2017.11.014_b0035","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1210\/jc.2013-4262","article-title":"Late-night salivary cortisol has a better performance than urinary free cortisol in the diagnosis of Cushing's syndrome","volume":"99","author":"Elias","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0040","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1373\/clinchem.2008.108910","article-title":"Current status of salivary hormone analysis","volume":"54","author":"Groschl","year":"2008","journal-title":"Clin. Chem."},{"key":"10.1016\/j.steroids.2017.11.014_b0045","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1093\/clinchem\/29.10.1752","article-title":"Hormones in saliva: mode of entry and consequent implications for clinical interpretation","volume":"29","author":"Vining","year":"1983","journal-title":"Clin. Chem."},{"key":"10.1016\/j.steroids.2017.11.014_b0050","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0022-4731(87)90297-4","article-title":"The measurement of hormones in saliva: possibilities and pitfalls","volume":"27","author":"Vining","year":"1987","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.steroids.2017.11.014_b0055","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cca.2007.03.009","article-title":"Saliva collection method affects predictability of serum cortisol","volume":"382","author":"Poll","year":"2007","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.steroids.2017.11.014_b0060","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1210\/jc.2002-020534","article-title":"Nighttime salivary cortisol: a useful test for the diagnosis of Cushing\u2019s syndrome","volume":"87","author":"Papanicolaou","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0065","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1210\/jc.2003-031790","article-title":"Midnight salivary cortisol for the initial diagnosis of Cushing\u2019s syndrome of various causes","volume":"89","author":"Yaneva","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0070","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1210\/jc.2003-030312","article-title":"Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening tests for Cushing\u2019s syndrome","volume":"88","author":"Putignano","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0075","doi-asserted-by":"crossref","first-page":"5730","DOI":"10.1210\/jc.2004-2264","article-title":"Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test","volume":"90","author":"Viardot","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0080","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1210\/jc.2008-1542","article-title":"Late-night salivary cortisol for diagnosis of overt and subclinical Cushing's syndrome in hospitalized and ambulatory patients","volume":"94","author":"Nunes","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0085","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cca.2009.11.033","article-title":"Cutoff values of midnight salivary cortisol for the diagnosis of overt hypercortisolism are highly influenced by methods","volume":"411","author":"Beko","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.steroids.2017.11.014_b0090","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1530\/EJE-13-0159","article-title":"Performance of salivary cortisol in the diagnosis of Cushing\u2019s syndrome, adrenal incidentaloma, and adrenal insufficiency","volume":"169","author":"Ceccato","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.steroids.2017.11.014_b0095","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1210\/jc.2009-2458","article-title":"Diagnostic characteristics of late-night salivary cortisol using liquid chromatography-tandem mass spectrometry","volume":"95","author":"Zerikly","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0100","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1210\/jc.2006-2861","article-title":"Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism","volume":"92","author":"Baid","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2017.11.014_b0105","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2265.2011.04239.x","article-title":"Late-night salivary cortisol for diagnosis of Cushing\u2019s syndrome by liquid chromatography\/tandem mass spectrometry assay","volume":"76","author":"Erickson","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.steroids.2017.11.014_b0110","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2265.2012.04508.x","article-title":"Measurement of salivary cortisol in 2012 - laboratory techniques and clinical indications","volume":"77","author":"Inder","year":"2012","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.steroids.2017.11.014_b0115","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/clinchem\/48.9.1511","article-title":"Validation of a high-throughput liquid chromatography \u2013 tandem mass spectrometry method for urinary cortisol and cortisone","volume":"48","author":"Taylor","year":"2002","journal-title":"Clin. Chem."},{"key":"10.1016\/j.steroids.2017.11.014_b0120","first-page":"5","article-title":"LC-MS\/MS in the clinical laboratory-Where to from here?","volume":"32","author":"Grebe","year":"2011","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.steroids.2017.11.014_b0125","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1210\/jc.2015-3694","article-title":"Salivary cortisone reflects cortisol exposure under physiological conditions and after hydrocortisone","volume":"101","author":"Debono","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X17302258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X17302258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T16:01:28Z","timestamp":1603468888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X17302258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":25,"alternative-id":["S0039128X17302258"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2017.11.014","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical utility of an ultrasensitive late night salivary cortisol assay by tandem mass spectrometry","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2017.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}