{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:56:33Z","timestamp":1793332593775,"version":"4.5.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN204319"],"award-info":[{"award-number":["IN204319"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.steroids.2019.108509","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T19:13:54Z","timestamp":1570130034000},"page":"108509","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Androgens are effective bronchodilators with anti-inflammatory properties: A potential alternative for asthma therapy"],"prefix":"10.1016","volume":"153","author":[{"given":"Luis M.","family":"Monta\u00f1o","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Flores-Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Sommer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0692-6931","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Sol\u00eds-Chagoy\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Perusqu\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.steroids.2019.108509_b0005","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1210\/en.2016-1395","article-title":"Minireview: Lymphangioleiomyomatosis (LAM): The \u201cOther\u201d Steroid-Sensitive Cancer","volume":"157","author":"Prizant","year":"2016","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0010","doi-asserted-by":"crossref","first-page":"294","DOI":"10.4103\/2045-8932.114756","article-title":"Gender, sex hormones and pulmonary hypertension","volume":"3","author":"Austin","year":"2013","journal-title":"Pulm. Circ."},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0015","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00983-2017","article-title":"Inhibiting oestrogen signalling in pulmonary arterial hypertension: sex, drugs and research","volume":"50","author":"Lahm","year":"2017","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/cvr\/cvv106","article-title":"Oestrogen receptor alpha in pulmonary hypertension","volume":"106","author":"Wright","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2010-0031","article-title":"Sex differences and sex steroids in lung health and disease","volume":"33","author":"Townsend","year":"2012","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.steroids.2019.108509_b0030","unstructured":"L.J. Akinbami, X. Liu, Chronic obstructive pulmonary disease among adults aged 18 and over in the United States, 1998-2009, NCHS Data Brief (63) (2011) 1-8."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1472-6874-14-31","article-title":"Clinical characteristics and quality of life in women with COPD: an observational study","volume":"14","author":"Raherison","year":"2014","journal-title":"BMC Womens Health"},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.lungcan.2006.09.008","article-title":"Women and lung cancer: epidemiology, tumor biology, and emerging trends in clinical research","volume":"55","author":"Belani","year":"2007","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11033-016-4086-8","article-title":"Exploring estrogenic activity in lung cancer","volume":"44","author":"Slowikowski","year":"2017","journal-title":"Mol. Biol. Rep."},{"issue":"13","key":"10.1016\/j.steroids.2019.108509_b0050","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1042\/CS20170090","article-title":"Genomic and non-genomic effects of androgens in the cardiovascular system: clinical implications","volume":"131","author":"Lucas-Herald","year":"2017","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.steroids.2019.108509_b0055","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0079-6123(08)81010-2","article-title":"The intracrine sex steroid biosynthesis pathways","volume":"181","author":"Luu-The","year":"2010","journal-title":"Prog. Brain Res."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0060","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/er.2010-0013","article-title":"The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders","volume":"32","author":"Miller","year":"2011","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.steroids.2019.108509_b0065","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.bi.63.070194.000325","article-title":"Steroid 5\u03b1-reductase: two genes\/two enzymes","volume":"63","author":"Russell","year":"1994","journal-title":"Annu. Rev. Biochem."},{"issue":"1\u20132","key":"10.1016\/j.steroids.2019.108509_b0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.mce.2008.09.013","article-title":"Structure and catalytic mechanism of human steroid 5\u03b2-reductase (AKR1D1)","volume":"301","author":"Di Costanzo","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nri3786","article-title":"Type 2 inflammation in asthma\u2013present in most, absent in many","volume":"15","author":"Fahy","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0080","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ni.3049","article-title":"The immunology of asthma","volume":"16","author":"Lambrecht","year":"2015","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0085","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.anai.2018.01.016","article-title":"Hormones, sex, and asthma","volume":"120","author":"Yung","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0090","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1164\/ajrccm.162.1.9907008","article-title":"Differences in incidence of reported asthma related to age in men and women. A retrospective analysis of the data of the European Respiratory Health Survey","volume":"162","author":"de Marco","year":"2000","journal-title":"Am. J. Respir. Crit. Care. Med"},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0095","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0272-5231(21)00281-1","article-title":"The epidemiology and natural history of asthma","volume":"5","author":"Bonner","year":"1984","journal-title":"Clin. Chest Med."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0100","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1053\/rmed.1999.0764","article-title":"Asthma from childhood to adulthood: asthma severity, allergies, sensitization, living conditions, gender influence and social consequences","volume":"94","author":"Kjellman","year":"2000","journal-title":"Respir. Med."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0306-9877(97)90020-7","article-title":"Does puberty interfere with asthma?","volume":"48","author":"Zannolli","year":"1997","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.steroids.2019.108509_b0110","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.mce.2016.10.004","article-title":"Sex steroids effects on guinea pig airway smooth muscle tone and intracellular Ca2+ basal levels","volume":"439","author":"Flores-Soto","year":"2017","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.steroids.2019.108509_b0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mce.2017.12.010","article-title":"Testosterone induces hyporesponsiveness by interfering with IP3 receptors in guinea pig airway smooth muscle","volume":"473","author":"Monta\u00f1o","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0120","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00424-014-1534-y","article-title":"Testosterone-induced relaxation involves L-type and store-operated Ca2+ channels blockade, and PGE2 in guinea pig airway smooth muscle","volume":"467","author":"Perusqu\u00eda","year":"2015","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.steroids.2019.108509_b0125","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jsbmb.2013.05.009","article-title":"Nongenomic bronchodilating action elicited by dehydroepiandrosterone (DHEA) in a guinea pig asthma model","volume":"138","author":"Espinoza","year":"2013","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0130","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1084\/jem.20161807","article-title":"Androgen signaling negatively controls group 2 innate lymphoid cells","volume":"214","author":"Laffont","year":"2017","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.steroids.2019.108509_b0135","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1016\/j.celrep.2017.10.110","article-title":"Testosterone attenuates group 2 innate lymphoid cell-mediated airway inflammation","volume":"21","author":"Cephus","year":"2017","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0140","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11882-017-0686-1","article-title":"Mechanisms driving gender differences in asthma","volume":"17","author":"Fuseini","year":"2017","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"7","key":"10.1016\/j.steroids.2019.108509_b0145","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.4049\/jimmunol.1800293","article-title":"Testosterone decreases house dust mite-induced type 2 and IL-17A-mediated airway inflammation","volume":"201","author":"Fuseini","year":"2018","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0150","doi-asserted-by":"crossref","first-page":"215","DOI":"10.33594\/000000131","article-title":"Androgen receptor-mediated regulation of intracellular calcium in human airway smooth muscle cells","volume":"53","author":"Kalidhindi","year":"2019","journal-title":"Cell. Physiol. Biochem."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0155","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1210\/en.2007-1288","article-title":"Relaxation of androgens on rat thoracic aorta: testosterone concentration dependent agonist\/antagonist L-type Ca2+ channel activity, and 5\u03b2-dihydrotestosterone restricted to L-type Ca2+ channel blockade","volume":"149","author":"Monta\u00f1o","year":"2008","journal-title":"Endocrinology"},{"issue":"3\u20134","key":"10.1016\/j.steroids.2019.108509_b0160","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.vph.2012.01.008","article-title":"Regional differences in the vasorelaxing effects of testosterone and its 5-reduced metabolites in the canine vasculature","volume":"56","author":"Perusqu\u00eda","year":"2012","journal-title":"Vasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0165","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1095\/biolreprod.104.036954","article-title":"Androgens induce relaxation of contractile activity in pregnant human myometrium at term: a nongenomic action on L-type calcium channels","volume":"73","author":"Perusqu\u00eda","year":"2005","journal-title":"Biol. Reprod."},{"issue":"11","key":"10.1016\/j.steroids.2019.108509_b0170","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/en.2014-1198","article-title":"Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: I. Discovery in female atlantic croaker and evidence ZIP9 mediates testosterone-induced apoptosis of ovarian follicle cells","volume":"155","author":"Berg","year":"2014","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.steroids.2019.108509_b0175","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1210\/me.2015-1161","article-title":"Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues","volume":"29","author":"Pi","year":"2015","journal-title":"Mol. Endocrinol."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0180","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/bph.12365","article-title":"The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function","volume":"171","author":"Clemmensen","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.steroids.2019.108509_b0185","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ygcen.2017.04.016","article-title":"ZIP9, a novel membrane androgen receptor and zinc transporter protein","volume":"257","author":"Thomas","year":"2018","journal-title":"Gen. Comp. Endocrinol."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0190","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0022-3565(25)12828-0","article-title":"Testosterone causes direct relaxation of rat thoracic aorta","volume":"277","author":"Costarella","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0195","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20050354","article-title":"Effect of testosterone on ex vivo vascular reactivity in man","volume":"111","author":"Malkin","year":"2006","journal-title":"Clin. Sci. (Lond)"},{"issue":"15\u201316","key":"10.1016\/j.steroids.2019.108509_b0200","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.lfs.2008.08.009","article-title":"Mechanisms involved in testosterone-induced vasodilatation in pig prostatic small arteries","volume":"83","author":"Navarro-Dorado","year":"2008","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-2003-39229","article-title":"Androgen-induced vasorelaxation: a potential vascular protective effect","volume":"111","author":"Perusqu\u00eda","year":"2003","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0210","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0306-3623(95)00091-7","article-title":"Role of endothelium in the vasodilating effect of progestins and androgens on the rat thoracic aorta","volume":"27","author":"Perusqu\u00eda","year":"1996","journal-title":"Gen. Pharmacol."},{"issue":"12","key":"10.1016\/j.steroids.2019.108509_b0215","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.lfs.2007.07.024","article-title":"The modulatory role of androgens and progestins in the induction of vasorelaxation in human umbilical artery","volume":"81","author":"Perusqu\u00eda","year":"2007","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0220","doi-asserted-by":"crossref","first-page":"H1301","DOI":"10.1152\/ajpheart.00753.2009","article-title":"Do androgens play a beneficial role in the regulation of vascular tone? Nongenomic vascular effects of testosterone metabolites","volume":"298","author":"Perusqu\u00eda","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0225","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/01.fjc.0000161400.06704.1e","article-title":"Testosterone relaxes human internal mammary artery in vitro","volume":"45","author":"Yildiz","year":"2005","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0230","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1161\/01.CIR.91.4.1154","article-title":"Testosterone relaxes rabbit coronary arteries and aorta","volume":"91","author":"Yue","year":"1995","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0235","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1210\/en.2005-1243","article-title":"Selective inhibition of L-type Ca2+ channels in A7r5 cells by physiological levels of testosterone","volume":"147","author":"Hall","year":"2006","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0240","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ceca.2006.11.003","article-title":"Molecular requirements for L-type Ca2+ channel blockade by testosterone","volume":"42","author":"Scragg","year":"2007","journal-title":"Cell Calcium"},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0245","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbrc.2004.04.054","article-title":"Testosterone is a potent inhibitor of L-type Ca2+ channels","volume":"318","author":"Scragg","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0250","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00210-007-0213-3","article-title":"Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery","volume":"376","author":"Cairrao","year":"2008","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0255","doi-asserted-by":"crossref","first-page":"H1720","DOI":"10.1152\/ajpheart.2001.281.4.H1720","article-title":"Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel","volume":"281","author":"Deenadayalu","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0260","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1152\/jappl.2001.91.6.2742","article-title":"Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+ channel activation","volume":"91","author":"Ding","year":"2001","journal-title":"J. Appl. Physiol. (1985)"},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0265","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1254\/jphs.FP0060883","article-title":"Testosterone relaxes isolated human radial artery by potassium channel opening action","volume":"103","author":"Seyrek","year":"2007","journal-title":"J. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0270","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/sj.bjp.0704522","article-title":"Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels","volume":"135","author":"Tep-areenan","year":"2002","journal-title":"Br. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.steroids.2019.108509_b0275","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/BF03346526","article-title":"Testosterone acts as an efficacious vasodilator in isolated human pulmonary arteries and veins: evidence for a biphasic effect at physiological and supra-physiological concentrations","volume":"32","author":"Rowell","year":"2009","journal-title":"J. Endocrinol. Invest."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0280","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.steroids.2011.12.020","article-title":"Mechanisms involved in testosterone-induced relaxation to the pig urinary bladder neck","volume":"77","author":"Fernandes","year":"2012","journal-title":"Steroids"},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0285","first-page":"357","article-title":"Relaxant action of androgens, progestins and corticosteroids on the isolated ileum of the guinea pig","volume":"37","author":"Kubli-Garfias","year":"1987","journal-title":"Acta Physiol. Pharmacol. Latinoam."},{"issue":"17","key":"10.1016\/j.steroids.2019.108509_b0290","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/0024-3205(90)90183-R","article-title":"Non-genomic mechanism of action of delta-4 and 5-reduced androgens and progestins on the contractility of the isolated rat myometrium","volume":"47","author":"Perusqu\u00eda","year":"1990","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.steroids.2019.108509_b0295","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/sj.bjp.0706936","article-title":"Non-genomic effect of testosterone on airway smooth muscle","volume":"149","author":"Kouloumenta","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"1\u20133","key":"10.1016\/j.steroids.2019.108509_b0300","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ejphar.2008.10.039","article-title":"Modulatory role of endogenous androgens on airway smooth muscle tone in isolated guinea-pig and bovine trachea; involvement of \u03b22-adrenoceptors, the polyamine system and external calcium","volume":"601","author":"Bordallo","year":"2008","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JOE-14-0074","article-title":"Androgens are bronchoactive drugs that act by relaxing airway smooth muscle and preventing bronchospasm","volume":"222","author":"Monta\u00f1o","year":"2014","journal-title":"J. Endocrinol."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0310","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1476-5381.1990.tb13003.x","article-title":"The role of the epithelium in modulating the responses of guinea-pig trachea induced by bradykinin in vitro","volume":"99","author":"Bramley","year":"1990","journal-title":"Br. J. Pharmacol."},{"issue":"3 Pt 1","key":"10.1016\/j.steroids.2019.108509_b0315","doi-asserted-by":"crossref","first-page":"C497","DOI":"10.1152\/ajpcell.1991.261.3.C497","article-title":"Acetylcholine Ca2+ stores refilling directly involves a dihydropyridine-sensitive channel in dog trachea","volume":"261","author":"Bourreau","year":"1991","journal-title":"Am. J. Physiol."},{"issue":"1\u20133","key":"10.1016\/j.steroids.2019.108509_b0320","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2013.09.060","article-title":"Sarcoplasmic reticulum Ca2+ refilling is determined by L-type Ca2+ and store operated Ca2+ channels in guinea pig airway smooth muscle","volume":"721","author":"Flores-Soto","year":"2013","journal-title":"Eur. J. Pharmacol."},{"issue":"21","key":"10.1016\/j.steroids.2019.108509_b0325","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.1073\/pnas.81.21.6899","article-title":"Pharmacomechanical coupling in smooth muscle may involve phosphatidylinositol metabolism","volume":"81","author":"Baron","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0330","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1152\/physrev.00006.2016","article-title":"The inositol trisphosphate\/calcium signaling pathway in health and disease","volume":"96","author":"Berridge","year":"2016","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0335","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1476-5381.1991.tb12524.x","article-title":"Inositol 1,4,5-trisphosphate- and guanosine 5'-O-(3-thiotriphosphate)-induced Ca2+ release in cultured airway smooth muscle","volume":"104","author":"Chopra","year":"1991","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0340","doi-asserted-by":"crossref","first-page":"L84","DOI":"10.1152\/ajplung.00446.2003","article-title":"LTD4 induces hyperresponsiveness to histamine in bovine airway smooth muscle: role of SR-ATPase Ca2+ pump and tyrosine kinase","volume":"288","author":"Carbajal","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"12","key":"10.1016\/j.steroids.2019.108509_b0345","doi-asserted-by":"crossref","first-page":"L1455","DOI":"10.1152\/ajplung.00148.2015","article-title":"Inositol 1,4,5-trisphosphate activates TRPC3 channels to cause extracellular Ca2+ influx in airway smooth muscle cells","volume":"309","author":"Song","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0350","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/00000542-199807000-00023","article-title":"Role of intracellular Ca2+ stores in the inhibitory effect of halothane on airway smooth muscle contraction","volume":"89","author":"Yamakage","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1016\/j.steroids.2019.108509_b0355","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1465-9921-7-119","article-title":"A key role for STIM1 in store operated calcium channel activation in airway smooth muscle","volume":"7","author":"Peel","year":"2006","journal-title":"Respir. Res."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0360","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1165\/rcmb.2007-0395OC","article-title":"ORAI and store-operated calcium influx in human airway smooth muscle cells","volume":"38","author":"Peel","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0365","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cell.2012.01.055","article-title":"SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling","volume":"149","author":"Palty","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0370","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1080\/19336950.2016.1212141","article-title":"Role of STIM1 in the surface expression of SARAF","volume":"11","author":"Albarran","year":"2017","journal-title":"Channels (Austin)"},{"issue":"11","key":"10.1016\/j.steroids.2019.108509_b0375","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1073\/pnas.0611692104","article-title":"Orai proteins interact with TRPC channels and confer responsiveness to store depletion","volume":"104","author":"Liao","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0380","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1165\/rcmb.2009-0091OC","article-title":"Functional role of canonical transient receptor potential 1 and canonical transient receptor potential 3 in normal and asthmatic airway smooth muscle cells","volume":"43","author":"Xiao","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.steroids.2019.108509_b0385","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2016.04.040","article-title":"Na+ permeates through L-type Ca2+ channel in bovine airway smooth muscle","volume":"782","author":"Sommer","year":"2016","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0390","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1165\/rcmb.2006-0096OC","article-title":"Acetylcholine-induced asynchronous calcium waves in intact human bronchial muscle bundle","volume":"36","author":"Dai","year":"2007","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0395","doi-asserted-by":"crossref","first-page":"L459","DOI":"10.1152\/ajplung.00092.2005","article-title":"Mechanism of ACh-induced asynchronous calcium waves and tonic contraction in porcine tracheal muscle bundle","volume":"290","author":"Dai","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0400","doi-asserted-by":"crossref","first-page":"L599","DOI":"10.1152\/ajplung.00324.2002","article-title":"Receptors and pathways mediating the effects of prostaglandin E2 on airway tone","volume":"284","author":"Tilley","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"18","key":"10.1016\/j.steroids.2019.108509_b0405","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1073\/pnas.1701420114","article-title":"IP3-mediated gating mechanism of the IP3 receptor revealed by mutagenesis and X-ray crystallography","volume":"114","author":"Hamada","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0410","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00210-003-0806-4","article-title":"Role of sarcoplasmic reticulum Ca2+ content in Ca2+ entry of bovine airway smooth muscle cells","volume":"368","author":"Bazan-Perkins","year":"2003","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"issue":"8\u20139","key":"10.1016\/j.steroids.2019.108509_b0415","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1139\/y05-063","article-title":"Resting calcium influx in airway smooth muscle","volume":"83","author":"Monta\u00f1o","year":"2005","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0420","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/sj.bjp.0705348","article-title":"Acetylcholine and tachykinins involvement in the caffeine-induced biphasic change in intracellular Ca2+ in bovine airway smooth muscle","volume":"139","author":"Monta\u00f1o","year":"2003","journal-title":"Br. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.steroids.2019.108509_b0425","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1021\/tx030011g","article-title":"Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor","volume":"16","author":"Fang","year":"2003","journal-title":"Chem. Res. Toxicol."},{"issue":"2\u20133","key":"10.1016\/j.steroids.2019.108509_b0430","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-2999(99)00161-2","article-title":"Possible role of Ca2+ channels in the vasodilating effect of 5\u03b2-dihydrotestosterone in rat aorta","volume":"371","author":"Perusqu\u00eda","year":"1999","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.steroids.2019.108509_b0435","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/thx.38.7.481","article-title":"Calcium-channel blockers and asthma","volume":"38","author":"Barnes","year":"1983","journal-title":"Thorax"},{"issue":"11","key":"10.1016\/j.steroids.2019.108509_b0440","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0039-128X(99)00054-9","article-title":"Discovery of the role of dihydrotestosterone in androgen action","volume":"64","author":"Bruchovsky","year":"1999","journal-title":"Steroids"},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0445","first-page":"6","article-title":"Homologous up-regulation of androgen receptor expression by androgen in vascular smooth muscle cells","volume":"63","author":"Ma","year":"2005","journal-title":"Horm. Res."},{"key":"10.1016\/j.steroids.2019.108509_b0450","doi-asserted-by":"crossref","first-page":"8423192","DOI":"10.1155\/2016\/8423192","article-title":"Sexual dimorphism in the regulation of estrogen, progesterone, and androgen receptors by sex steroids in the rat airway smooth muscle cells","volume":"2016","author":"Zarazua","year":"2016","journal-title":"Int. J. Endocrinol."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0455","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1365-2265.2012.04432.x","article-title":"Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study","volume":"77","author":"Sartorius","year":"2012","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0460","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1530\/EJE-18-1000","article-title":"Mechanisms in endocrinology: estradiol as a male hormone","volume":"181","author":"Russell","year":"2019","journal-title":"Eur. J. Endocrinol."},{"issue":"10","key":"10.1016\/j.steroids.2019.108509_b0465","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/me.2002-0070","article-title":"The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions","volume":"16","author":"Heinlein","year":"2002","journal-title":"Mol. Endocrinol."},{"issue":"8","key":"10.1016\/j.steroids.2019.108509_b0470","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.it.2012.04.005","article-title":"Interleukin-33 and the function of innate lymphoid cells","volume":"33","author":"Mirchandani","year":"2012","journal-title":"Trends Immunol."},{"issue":"12","key":"10.1016\/j.steroids.2019.108509_b0475","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.cellsig.2013.07.021","article-title":"IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases","volume":"25","author":"Song","year":"2013","journal-title":"Cell. Signal."},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0480","first-page":"199","article-title":"Dehydroepiandrosterone attenuates allergic airway inflammation in Dermatophagoides farinae-sensitized mice","volume":"35","author":"Yu","year":"2002","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0485","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2011.12.020","article-title":"Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation","volume":"36","author":"Halim","year":"2012","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0490","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2014.01.011","article-title":"Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation","volume":"40","author":"Halim","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.steroids.2019.108509_b0495","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00416.2018","article-title":"Regulation of IL-17A and Implications for TGF-\u03b21 Co-modulation of Airway Smooth Muscle Remodeling in Severe Asthma","author":"Evasovic","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.steroids.2019.108509_b0500","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1540\/jsmr.53.37","article-title":"Mechanisms underlying the pathogenesis of hyper-contractility of bronchial smooth muscle in allergic asthma","volume":"53","author":"Sakai","year":"2017","journal-title":"J. Smooth Muscle Res."},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0505","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1165\/rcmb.2014-0429OC","article-title":"Influence of an Allergen-Specific Th17 Response on Remodeling of the Airways","volume":"54","author":"Peters","year":"2016","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0510","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1365-2222.2008.02971.x","article-title":"Pathogenesis of asthma","volume":"38","author":"Holgate","year":"2008","journal-title":"Clin. Exp. Allergy"},{"issue":"1","key":"10.1016\/j.steroids.2019.108509_b0515","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2332\/allergolint.R-07-154","article-title":"The airway epithelium is central to the pathogenesis of asthma","volume":"57","author":"Holgate","year":"2008","journal-title":"Allergol Int"},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0520","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2332\/allergolint.R-07-153","article-title":"Airway remodeling in asthma","volume":"56","author":"Sumi","year":"2007","journal-title":"Allergol. Int."},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0525","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1164\/rccm.200811-1730OC","article-title":"Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-\u03b21","volume":"180","author":"Hackett","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0530","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/01902148.2013.879966","article-title":"Effects and mechanism of dehydroepiandrosterone on epithelial-mesenchymal transition in bronchial epithelial cells","volume":"40","author":"Xu","year":"2014","journal-title":"Exp. Lung Res."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0535","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1210\/jcem.82.6.3988","article-title":"Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial","volume":"82","author":"Sih","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.steroids.2019.108509_b0540","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.amjmed.2010.12.027","article-title":"Testosterone deficiency","volume":"124","author":"Traish","year":"2011","journal-title":"Am. J. Med."},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0545","doi-asserted-by":"crossref","first-page":"M76","DOI":"10.1093\/gerona\/57.2.M76","article-title":"Andropause: clinical implications of the decline in serum testosterone levels with aging in men","volume":"57","author":"Matsumoto","year":"2002","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0550","first-page":"1966","article-title":"Effect of testosterone treatment on bone mineral density in men over 65 years of age","volume":"84","author":"Snyder","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.steroids.2019.108509_b0555","first-page":"2647","article-title":"Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age","volume":"84","author":"Snyder","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0560","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaci.2006.09.008","article-title":"Sex-related differences in immune development and the expression of atopy in early childhood","volume":"118","author":"Uekert","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"issue":"12","key":"10.1016\/j.steroids.2019.108509_b0565","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1093\/oxfordjournals.aje.a009413","article-title":"Gender differences in total and allergen-specific immunoglobulin E (IgE) concentrations in a population-based cohort from birth to age four years","volume":"147","author":"Johnson","year":"1998","journal-title":"Am. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0570","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.mehy.2011.01.006","article-title":"Do low testosterone levels contribute to the pathogenesis of asthma?","volume":"76","author":"Canguven","year":"2011","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.steroids.2019.108509_b0575","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1477-7827-9-57","article-title":"Second to fourth digit ratio (2D:4D) and concentrations of circulating sex hormones in adulthood","volume":"9","author":"Muller","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0580","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/CS20030386","article-title":"Testosterone-induced coronary vasodilatation occurs via a non-genomic mechanism: evidence of a direct calcium antagonism action","volume":"107","author":"Jones","year":"2004","journal-title":"Clin. Sci. (Lond)"},{"issue":"768","key":"10.1016\/j.steroids.2019.108509_b0585","first-page":"805","article-title":"Dehydroepiandrosterone sulphate concentrations in asthmatic patients: pilot study","volume":"97","author":"Dunn","year":"1984","journal-title":"N. Z. Med. J."},{"issue":"2\u20133","key":"10.1016\/j.steroids.2019.108509_b0590","first-page":"125","article-title":"Adrenocortical function in bronchial asthma","volume":"40","author":"Feher","year":"1983","journal-title":"Acta. Med. Hung."},{"issue":"1 Pt 1","key":"10.1016\/j.steroids.2019.108509_b0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0091-6749(96)70276-2","article-title":"Decreased adrenal sex steroid levels in the absence of glucocorticoid suppression in postmenopausal asthmatic women","volume":"97","author":"Weinstein","year":"1996","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0600","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s10753-010-9188-1","article-title":"Asthma and dehydroepiandrosterone (DHEA): facts and hypotheses","volume":"33","author":"Kasperska-Zajac","year":"2010","journal-title":"Inflammation"},{"issue":"3","key":"10.1016\/j.steroids.2019.108509_b0605","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/08820130801967833","article-title":"Effects of combined BCG and DHEA treatment in preventing the development of asthma","volume":"37","author":"Cui","year":"2008","journal-title":"Immunol. Invest."},{"issue":"4","key":"10.1016\/j.steroids.2019.108509_b0610","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s10875-011-9529-3","article-title":"Dehydroepiandrosterone suppresses eosinophil infiltration and airway hyperresponsiveness via modulation of chemokines and Th2 cytokines in ovalbumin-sensitized mice","volume":"31","author":"Liou","year":"2011","journal-title":"J. Clin. Immunol."},{"issue":"10","key":"10.1016\/j.steroids.2019.108509_b0615","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.bbadis.2012.06.012","article-title":"DHEA-S inhibits human neutrophil and human airway smooth muscle migration","volume":"1822","author":"Koziol-White","year":"2012","journal-title":"Biochim. Biophys. Acta, Mol. Cell. Biol. Lipids"},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0620","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2500\/aap.2010.31.3384","article-title":"Nebulized dehydroepiandrosterone-3-sulfate improves asthma control in the moderate-to-severe asthma results of a 6-week, randomized, double-blind, placebo-controlled study","volume":"31","author":"Wenzel","year":"2010","journal-title":"Allergy Asthma Proc"},{"issue":"2","key":"10.1016\/j.steroids.2019.108509_b0625","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s10875-012-9828-3","article-title":"Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells","volume":"33","author":"Vazquez-Tello","year":"2013","journal-title":"J. Clin. Immunol."},{"issue":"5","key":"10.1016\/j.steroids.2019.108509_b0630","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/bies.950180507","article-title":"Molecular mechanisms of anti-inflammatory action of glucocorticoids","volume":"18","author":"Cato","year":"1996","journal-title":"BioEssays"},{"issue":"6","key":"10.1016\/j.steroids.2019.108509_b0635","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1172\/JCI117943","article-title":"Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans","volume":"95","author":"Bamberger","year":"1995","journal-title":"J Clin Invest"},{"issue":"16","key":"10.1016\/j.steroids.2019.108509_b0640","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1074\/jbc.271.16.9550","article-title":"The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function","volume":"271","author":"Oakley","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.steroids.2019.108509_b0645","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1465-9921-10-100","article-title":"TGF-\u03b21 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids","volume":"10","author":"Doerner","year":"2009","journal-title":"Respir. Res."},{"issue":"8","key":"10.1016\/j.steroids.2019.108509_b0650","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1248\/bpb.27.1168","article-title":"Regulatory mechanism and physiological role of cytosolic phospholipase A2","volume":"27","author":"Hirabayashi","year":"2004","journal-title":"Biol. Pharm. Bull."}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X19301990?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X19301990?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:04:35Z","timestamp":1758535475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X19301990"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":130,"alternative-id":["S0039128X19301990"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2019.108509","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Androgens are effective bronchodilators with anti-inflammatory properties: A potential alternative for asthma therapy","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2019.108509","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108509"}}