{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:18:55Z","timestamp":1790864335390,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008605","name":"Indian National Science Academy","doi-asserted-by":"publisher","award":["SP\/VF-1\/2015-16\/761"],"award-info":[{"award-number":["SP\/VF-1\/2015-16\/761"]}],"id":[{"id":"10.13039\/100008605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012034","name":"Karnatak University Dharwad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.steroids.2020.108752","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T11:22:54Z","timestamp":1603279374000},"page":"108752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["High, not low-dose of stanozolol (Anabolic \u2013 androgenic steroid) impedes embryo implantation by attenuating endometrial receptivity in the mouse, Mus musculus"],"prefix":"10.1016","volume":"165","author":[{"given":"Chaitra R.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafisa H.","family":"Balasinor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laxmi S.","family":"Inamdar (Doddamani)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.steroids.2020.108752_b0005","series-title":"Anabolic Steroids in sports and exercise","first-page":"3","article-title":"Anabolic-androgenic steroids: A historical perspective and definition","author":"Kochakian","year":"1993"},{"key":"10.1016\/j.steroids.2020.108752_b0010","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1210\/jcem.86.11.7983","article-title":"Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseases","volume":"86","author":"Basaria","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2020.108752_b0015","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/bjp.2008.165","article-title":"Pharmacology of anabolic steroids","volume":"154","author":"Kicman","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.steroids.2020.108752_b0020","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0149-2918(01)80114-4","article-title":"A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids","volume":"23","author":"Shahidi","year":"2001","journal-title":"Clin. Ther."},{"key":"10.1016\/j.steroids.2020.108752_b0025","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/0363546503262202","article-title":"Current concepts in anabolic-androgenic steroids","volume":"32","author":"Evans","year":"2004","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.steroids.2020.108752_b0030","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2165\/00007256-200434080-00003","article-title":"Effects of androgenic-anabolic steroids in athletes","volume":"34","author":"Hartgens","year":"2004","journal-title":"Sports Med."},{"key":"10.1016\/j.steroids.2020.108752_b0035","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.toxlet.2005.06.005","article-title":"Adverse effects of anabolic steroids in athletes. A constant threat","author":"Maravelias","year":"2005","journal-title":"Toxicol. Letters"},{"key":"10.1016\/j.steroids.2020.108752_b0040","first-page":"182","article-title":"Medical issues associated with anabolic steroid use: Are they exaggerated?","volume":"5","author":"Hoffman","year":"2006","journal-title":"J. Sport. Sci. Med."},{"key":"10.1016\/j.steroids.2020.108752_b0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrg1808","article-title":"Roadmap to embryo implantation: clues from mouse models","volume":"7","author":"Wang","year":"2006","journal-title":"Nat. Rev. Gen."},{"key":"10.1016\/j.steroids.2020.108752_b0050","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1172\/JCI41229","article-title":"Making the blastocyst: lessons from the mouse","volume":"120","author":"Cockburn","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.steroids.2020.108752_b0055","doi-asserted-by":"crossref","unstructured":"R. Fernandez-Gonzalez, P. Moreira, A. Bilbao, A. Jimenez, M. Perez-Crespo, M.A Ramirez, F.R. De Fonseca,B. Pintado,A. Guterrez-Adan, Long-term effect of in vitro culture of mouse embryos with serum on mRNA expression of imprinting genes, development, and behavior,Proc.Natl.Acad.Sci.U.S.A.101(2004)5880\u20135885. http:\/\/doi.1073\/pnas.0308560101.","DOI":"10.1073\/pnas.0308560101"},{"key":"10.1016\/j.steroids.2020.108752_b0060","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1210\/endo.140.11.7148","article-title":"Differential uterine expression of estrogen and progesterone receptors correlates with uterine preparation for implantation and decidualization in the mouse","volume":"140","author":"Tan","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2020.108752_b0065","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/dbio.2000.9767","article-title":"Embryo implantation","volume":"223","author":"Carson","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.steroids.2020.108752_b0070","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2741\/spencer","article-title":"Biology of progesterone action during pregnancy recognition and maintenance of pregnancy","volume":"7","author":"Spencer","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.steroids.2020.108752_b0075","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.ogc.2004.08.008","article-title":"Hormonal regulation of implantation","volume":"31","author":"Kodaman","year":"2004","journal-title":"Obstet. Gyn. Clin. N. Am."},{"key":"10.1016\/j.steroids.2020.108752_b0080","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.anireprosci.2004.04.014","article-title":"Conceptus signals for establishment and maintenance of pregnancy","volume":"82\u201383","author":"Spencer","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.steroids.2020.108752_b0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0029-1242989","article-title":"Endometrial decidualization: Of mice and men","volume":"28","author":"Ramathal","year":"2010","journal-title":"Semin. Reprod. Med."},{"key":"10.1016\/j.steroids.2020.108752_b0090","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.88.24.11408","article-title":"Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation","volume":"88","author":"Bhatt","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"6390","key":"10.1016\/j.steroids.2020.108752_b0095","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/359076a0","article-title":"Blastocyst implantation depends on maternal expression of leukemia inhibitory factor","volume":"359","author":"Stewart","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.steroids.2020.108752_b0100","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1242\/dev.122.9.2687","article-title":"Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression","volume":"122","author":"Benson","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.steroids.2020.108752_b0105","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1210\/mend.13.6.0284","article-title":"Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse","volume":"13","author":"Lim","year":"1999","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.steroids.2020.108752_b0110","doi-asserted-by":"crossref","unstructured":"L.S. Inamdar (Doddamani), Y. Jayamma, Acceleration of neutrophil precursors\u2019 maturation and immunostimulation of CD3+, CD4+ lymphocytes by stanozolol in mice, J. Steroid Biochem. Mol. Biol. 129 (2012) 172-178. http:\/\/doi.10.1016\/j.jsbmb.2011.11.008.","DOI":"10.1016\/j.jsbmb.2011.11.008"},{"issue":"5","key":"10.1016\/j.steroids.2020.108752_b0115","first-page":"32","article-title":"Anabolic-androgenic steroids (stanozolol) disrupts ovarian histoarchitecture and gestation in mice","volume":"4","author":"Jayamma","year":"2012","journal-title":"Int. J. Curr. Res."},{"key":"10.1016\/j.steroids.2020.108752_b0120","unstructured":"R.H. Strauss, C.E. Yesalis. Additional effects of anabolic steroids on women, in: C.E. Yesalis (Ed.), Anabolic Steroids in Sport and Exercise, Human Kinetics Publishers, lnc., Champaign, 1L, 1993, pp. 151-160."},{"key":"10.1016\/j.steroids.2020.108752_b0125","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1530\/jrf.0.0990395","article-title":"Effects of tamoxifen on the fertility of male rats","volume":"99","author":"Gill-Sharma","year":"1993","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.steroids.2020.108752_b0130","doi-asserted-by":"crossref","unstructured":"N. Balasinor, P. Parte, M. Gill-Sharma, H. Juneja, Effects of tamoxifen on sperm fertilizing ability and preimplantation embryo development. Mol. Cell. Endocrinol. 178 (2001) 199-206.http:\/\/doi.10.1016\/s0303-7207(01)00428-2.","DOI":"10.1016\/S0303-7207(01)00428-2"},{"key":"10.1016\/j.steroids.2020.108752_b0135","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0031-9384(96)00409-X","article-title":"The effects of 17\u03b1 - methyltestosterone, methandrostenolone, and nandrolone decanoate on the rat estrous cycle","volume":"61","author":"Blasberg","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.steroids.2020.108752_b0140","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0031-9384(97)00443-5","article-title":"Stanozolol, oxymetholone, and testosterone cypionate effects on the rat estrous cycle","volume":"63","author":"Clark","year":"1998","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.steroids.2020.108752_b0145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.contraception.2005.02.001","article-title":"Histological assessment of ovaries and uterus of rats subjected to nandrolone decanoate treatment","volume":"72","author":"Gerez","year":"2005","journal-title":"Contraception"},{"issue":"2","key":"10.1016\/j.steroids.2020.108752_b0150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejogrb.2006.07.037","article-title":"Administration of the anabolic androgenic steroid nandrolone decanoate to female rats causes alterations in the morphology of their uterus and a reduction in reproductive capacity","volume":"131","author":"Mobini-Far","year":"2007","journal-title":"Eu. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.steroids.2020.108752_b0155","first-page":"335","article-title":"Nandrolone decanoate and physical effort: histological and morphometrical assessment in adult rat uterus","author":"De Almeida Chuffa","year":"2010","journal-title":"Anat. Rec."},{"issue":"5","key":"10.1016\/j.steroids.2020.108752_b0160","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/iep.12144","article-title":"Effects of different doses of nandrolone decanoate on estrous cycle and ovarian tissue of rats after treatment and recovery periods","volume":"96","author":"Simao","year":"2015","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.steroids.2020.108752_b0165","doi-asserted-by":"crossref","unstructured":"N.R. Chappel, H. Sangi-Haghpeykar, W.E. Gibbons, C.S. Blesson, The effects of dihydrotestosterone on mouse early embryonic development, Fertil. Steril. 108 (2017) (suppl 3) e155. http:\/\/doi.10.1016\/j.fertnstert.2017.07.467.","DOI":"10.1016\/j.fertnstert.2017.07.467"},{"key":"10.1016\/j.steroids.2020.108752_b0170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/humrep\/deh543","article-title":"Falling estradiol levels as a result of intentional reduction in gonadotrophin dose are not associated with poor IVF outcomes, whereas spontaneously falling estradiol levels result in low clinical pregnancy rates","volume":"20","author":"Fisher","year":"2005","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.steroids.2020.108752_b0175","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/09513590.2010.487584","article-title":"Expression of GPR30, ER\u03b1 and ER\u03b2 in endometrium during window of implantation in patients with polycystic ovary syndrome: a pilot study","volume":"27","author":"Wang","year":"2011","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.steroids.2020.108752_b0180","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S0021-9258(19)44363-9","article-title":"Binding of testosterone to uterine components of the immature rat","volume":"248","author":"Giannopoulos","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.steroids.2020.108752_b0185","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1210\/en.2004-1132","article-title":"Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways","volume":"146","author":"Nantermet","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2020.108752_b0190","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/j.fertnstert.2011.01.160","article-title":"Temporal expression pattern of progesterone receptor in the uterine luminal epithelium suggests its requirement during early events of implantation","volume":"95","author":"Sridaran","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.steroids.2020.108752_b0195","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1101\/gad.9.18.2266","article-title":"Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities","volume":"9","author":"Lydon","year":"1995","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.steroids.2020.108752_b0200","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3181\/00379727-183-42426","article-title":"Effects of dihydrotestosterone on progesterone secretion in pseudopregnant rats","volume":"183","author":"Sridaran","year":"1986","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"1\u20133","key":"10.1016\/j.steroids.2020.108752_b0205","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0303-7207(91)90060-6","article-title":"Effects of in vivo dihydrotestosterone treatment on changes in nocturnal surge of prolactin, luteal ultrastructure and P-450scc mRNA and protein content in pregnant rats","volume":"77","author":"Sridaran","year":"1991","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.steroids.2020.108752_b0210","series-title":"Endocrinology of pregnancy","first-page":"35","article-title":"Endocrinology of the transition from menstrual cycles to establishment of pregnancy in primates","author":"Stouffer","year":"1998"},{"key":"10.1016\/j.steroids.2020.108752_b0215","doi-asserted-by":"crossref","unstructured":"N. Binart, C. Helloco, C.J. Ormandy, J. Barra, P, Clement-Lacroix. N. Baran, P.A. Kelly, Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration, Endocrinology 141 (2000) 2691-2697. http:\/\/doi.10.1210\/endo.141.7.7568.","DOI":"10.1210\/endo.141.7.7568"},{"key":"10.1016\/j.steroids.2020.108752_b0220","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1210\/endo.141.5.7464","article-title":"Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR","volume":"141","author":"Reese","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.steroids.2020.108752_b0225","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1210\/jcem-60-2-258","article-title":"Gonadotropin-releasing hormone pulsatile administration restores luteinizing hormone pulsatility and normal testosterone levels in males with hyperprolactinemia","volume":"60","author":"Bouchard","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2020.108752_b0230","first-page":"2088","article-title":"Pulsatile GnRH stimulates normal cyclic ovarian function in amenorrhoeic lactating postpartum women","volume":"80","author":"Zinaman","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2020.108752_b0235","series-title":"Prolactin","first-page":"147","article-title":"Prolactin and infertility","author":"Oner","year":"2013"},{"key":"10.1016\/j.steroids.2020.108752_b0240","doi-asserted-by":"crossref","DOI":"10.1210\/en.2015-2032","article-title":"A role for androgens in epithelial proliferation and formation of glands in the mouse uterus","author":"Simitsidellis","year":"2016","journal-title":"Endocrinology 157"},{"issue":"1","key":"10.1016\/j.steroids.2020.108752_b0245","article-title":"Impaired receptivity and decidualization in DHEA-induced PCOS mice","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"issue":"6521","key":"10.1016\/j.steroids.2020.108752_b0250","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/374460a0","article-title":"Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice","volume":"374","author":"Satokata","year":"1995","journal-title":"Nature"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X20301781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X20301781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:26:56Z","timestamp":1777444016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X20301781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"alternative-id":["S0039128X20301781"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2020.108752","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High, not low-dose of stanozolol (Anabolic \u2013 androgenic steroid) impedes embryo implantation by attenuating endometrial receptivity in the mouse, Mus musculus","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2020.108752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108752"}}