{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:36:58Z","timestamp":1793122618302,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014362","name":"Central Marine Fisheries Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014362","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001503","name":"Indian Council of Agricultural Research","doi-asserted-by":"publisher","award":["MBT\/HLT\/SUB23"],"award-info":[{"award-number":["MBT\/HLT\/SUB23"]}],"id":[{"id":"10.13039\/501100001503","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.steroids.2021.108860","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T11:27:50Z","timestamp":1620386870000},"page":"108860","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Anti-inflammatory \u03b2-sitosterols from the Asiatic loop-root mangrove Rhizophora mucronata attenuate 5-lipoxygenase and cyclooxygenase-2 enzymes"],"prefix":"10.1016","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7105-8942","authenticated-orcid":false,"given":"Kajal","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minju","family":"Joy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vamshi Krishna","family":"Raola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.steroids.2021.108860_b0005","first-page":"40","article-title":"Potent antimicrobial activity of Rhizophora mucronata","volume":"3","author":"Kusuma","year":"2011","journal-title":"J. Ecobiotechnol."},{"issue":"4","key":"10.1016\/j.steroids.2021.108860_b0010","first-page":"152","article-title":"Plants-herbal wealth as a potential source of ayurvedic drugs","volume":"4","author":"Meena","year":"2009","journal-title":"Asian J. Tradit. Med."},{"key":"10.1016\/j.steroids.2021.108860_b0015","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1023\/A:1021397624349","article-title":"Bioactivities, bioactive compounds and chemical constituents of mangrove plants","volume":"10","author":"Bandaranayake","year":"2002","journal-title":"Wetl. Ecol. Manag."},{"issue":"5","key":"10.1016\/j.steroids.2021.108860_b0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s13659-013-0012-0","article-title":"Metabolites and bioactivities of Rhizophoraceae mangroves","volume":"3","author":"Nebula","year":"2013","journal-title":"Nat. Prod. Bioprospect."},{"issue":"4","key":"10.1016\/j.steroids.2021.108860_b0025","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1080\/14786419.2016.1174232","article-title":"Two rare antioxidative prenylated terpenoids from loop-root Asiatic mangrove Rhizophora mucronata (Family Rhizophoraceae) and their activity against pro-inflammatory cyclooxygenases and lipoxidase","volume":"31","author":"Raola","year":"2017","journal-title":"Nat. Prod. Res."},{"issue":"2","key":"10.1016\/j.steroids.2021.108860_b0030","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/14786410903315069","article-title":"Triterpenoids from the stem bark of Rhizophora mucronata","volume":"24","author":"Rohini","year":"2010","journal-title":"Nat. Prod. Res."},{"issue":"2","key":"10.1016\/j.steroids.2021.108860_b0035","first-page":"27","article-title":"Phytochemical screening and antibacterial activity of methanol extract of mangrove plant (Rhyzophora mucronata) from Porong River Estuary","volume":"1","author":"Nurdiani","year":"2012","journal-title":"J. Basic Sci. Technol."},{"issue":"3","key":"10.1016\/j.steroids.2021.108860_b0040","first-page":"482","article-title":"In vitro anti-inflammatory and anti-arthritic property of Rhizopora mucronata leaves","volume":"6","author":"Kumari","year":"2015","journal-title":"Int. J. Pharm. Sci. Res."},{"issue":"3","key":"10.1016\/j.steroids.2021.108860_b0045","first-page":"170","article-title":"Plant sterols and sterolins: a review of their immune-modulating properties","volume":"4","author":"Bouic","year":"1999","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.steroids.2021.108860_b0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/3-540-27661-0_7","article-title":"Plant sterols and stanols","volume":"170","author":"Tikkanen","year":"2005","journal-title":"Handb. Exp. Pharmacol."},{"issue":"12","key":"10.1016\/j.steroids.2021.108860_b0055","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/0031-9422(84)83022-8","article-title":"Sterols and fatty acids from three species of mangrove","volume":"23","author":"Misra","year":"1984","journal-title":"Phytochemistry"},{"issue":"1","key":"10.1016\/j.steroids.2021.108860_b0060","first-page":"10","article-title":"Valuable antioxidant and antimicrobial extracts from Rhizophora mucronata of Asiatic mangrove forests","volume":"6","author":"Imdadul","year":"2011","journal-title":"Res. J. Biotechnol."},{"key":"10.1016\/j.steroids.2021.108860_b0065","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.phytochem.2016.12.013","article-title":"Two rare antioxidant and anti-inflammatory oleanenes from loop root Asiatic mangrove Rhizophora mucronata","volume":"135","author":"Chakraborty","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.steroids.2021.108860_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.steroids.2018.04.007","article-title":"Previously undisclosed bioactive sterols from corbiculid bivalve clam Villorita cyprinoides with anti-inflammatory and antioxidant potentials","volume":"135","author":"Joy","year":"2018","journal-title":"Steroids"},{"issue":"6","key":"10.1016\/j.steroids.2021.108860_b0075","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.lwt.2007.06.013","article-title":"Antioxidant activity of three edible seaweeds from two areas in South East Asia","volume":"41","author":"Chew","year":"2008","journal-title":"LWT-Food Sci. Technol."},{"key":"10.1016\/j.steroids.2021.108860_b0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0962-4562(03)00083-3","article-title":"Inhibition of 5-lipoxygenase by essential oils and other natural fragment extracts","volume":"13","author":"Baylac","year":"2003","journal-title":"Int. J. Aromather."},{"issue":"1","key":"10.1016\/j.steroids.2021.108860_b0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0005-2760(95)00188-3","article-title":"Peroxidative oxidation of leuco dichloroluorescein by prostaglandin H synthase in prostaglandin biosynthesis from polyunsaturated fatty acids","volume":"1299","author":"Larsen","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"issue":"23","key":"10.1016\/j.steroids.2021.108860_b0090","doi-asserted-by":"crossref","first-page":"7159","DOI":"10.1016\/j.bmcl.2010.07.054","article-title":"The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life","volume":"20","author":"Wang","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"8","key":"10.1016\/j.steroids.2021.108860_b0095","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1096\/fj.12-205286","article-title":"Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663","volume":"26","author":"Gilbert","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.steroids.2021.108860_b0100","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.steroids.2019.05.001","article-title":"\u03b2-Sitosterol from Ifloga spicata (Forssk.) Sch. Bip. as potential anti-leishmanial agent against leishmania tropica: docking and molecular insights","volume":"148","author":"Majid Shah","year":"2019","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2021.108860_b0105","series-title":"Analysis of Sterols","first-page":"2","author":"Goad","year":"1997"},{"issue":"25","key":"10.1016\/j.steroids.2021.108860_b0110","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.lfs.2005.11.004","article-title":"Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants","volume":"78","author":"Cai","year":"2006","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.steroids.2021.108860_b0115","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1023\/A:1025063516054","article-title":"Evaluation of triterpenols and sterols as organic matter biomarkers in a mangrove ecosystem in northern Brazil","volume":"11","author":"Koch","year":"2003","journal-title":"Wetl. Ecol. Manag."},{"issue":"1","key":"10.1016\/j.steroids.2021.108860_b0120","doi-asserted-by":"crossref","first-page":"123","DOI":"10.21010\/ajtcam.v14i1.13","article-title":"Evaluation of the anti-inflammatory capacity of beta-sitosterol in rodent assays","volume":"14","author":"Paniagua-P\u00e9rez","year":"2016","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"issue":"3","key":"10.1016\/j.steroids.2021.108860_b0125","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0031-9422(02)00555-1","article-title":"Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units","volume":"62","author":"De-Eknamkul","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.steroids.2021.108860_b0130","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fct.2013.05.061","article-title":"Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages","volume":"59","author":"Jung","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"38","key":"10.1016\/j.steroids.2021.108860_b0135","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1021\/acs.jafc.6b02345","article-title":"Bioactivity of phytosterols and their production in plant in vitro cultures","volume":"64","author":"Miras-Moreno","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"6","key":"10.1016\/j.steroids.2021.108860_b0140","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.steroids.2009.02.004","article-title":"New 19-oxygenated and 4-methylated steroids from the Formosan soft coral Nephthea chabroli","volume":"74","author":"Cheng","year":"2009","journal-title":"Steroids"},{"issue":"8","key":"10.1016\/j.steroids.2021.108860_b0145","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.steroids.2005.01.001","article-title":"Polyhydroxylated steroids from the soft coral Sinularia dissecta","volume":"70","author":"Jin","year":"2005","journal-title":"Steroids"},{"issue":"8","key":"10.1016\/j.steroids.2021.108860_b0150","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.3390\/molecules21081047","article-title":"Plant resources, 13C-NMR spectral characteristic and pharmacological activities of dammarane-type triterpenoids","volume":"21","author":"Ruan","year":"2016","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.steroids.2021.108860_b0155","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/j.freeradbiomed.2004.09.001","article-title":"In vitro scavenging activity for reactive oxygen and nitrogen species by nonsteroidal anti-inflammatory indole, pyrrole, and oxazole derivative drugs","volume":"37","author":"Fernandes","year":"2004","journal-title":"Free Radic. Biol. Med."}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X21000726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X21000726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:19:47Z","timestamp":1793121587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X21000726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":31,"alternative-id":["S0039128X21000726"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2021.108860","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory \u03b2-sitosterols from the Asiatic loop-root mangrove Rhizophora mucronata attenuate 5-lipoxygenase and cyclooxygenase-2 enzymes","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2021.108860","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108860"}}