{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:52:29Z","timestamp":1777643549876,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/17587-4"],"award-info":[{"award-number":["2013\/17587-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/05549-0"],"award-info":[{"award-number":["2013\/05549-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.steroids.2021.108899","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T05:22:12Z","timestamp":1627968132000},"page":"108899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Nandrolone decanoate and resistance exercise affect body composition and energy metabolism"],"prefix":"10.1016","volume":"174","author":[{"given":"Renan","family":"Pozzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Cavalcante da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e2nia","family":"D'Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"02","key":"10.1016\/j.steroids.2021.108899_b0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1055\/s-2007-1024673","article-title":"Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females","volume":"12","author":"Kraemer","year":"1991","journal-title":"Int. J. Sports Med."},{"issue":"6","key":"10.1016\/j.steroids.2021.108899_b0010","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2114\/jpa.16.257","article-title":"Physical fitness and psychological benefits of strength training in community dwelling older adults","volume":"16","author":"Tsutsumi","year":"1997","journal-title":"Appl. Human Sci."},{"issue":"6","key":"10.1016\/j.steroids.2021.108899_b0015","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1159\/000442721","article-title":"Obesity management task force of the European Association for the Study of, European Guidelines for Obesity Management in Adults","volume":"8","author":"Yumuk","year":"2015","journal-title":"Obes Facts"},{"key":"10.1016\/j.steroids.2021.108899_b0020","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.lfs.2016.01.011","article-title":"Resistance training prevents the cardiovascular changes caused by high-fat diet","volume":"146","author":"Speretta","year":"2016","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.steroids.2021.108899_b0025","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.jocd.2015.04.011","article-title":"Exercise and sarcopenia","volume":"18","author":"Phu","year":"2015","journal-title":"J Clin Densitom."},{"issue":"1","key":"10.1016\/j.steroids.2021.108899_b0030","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/dmrr.2658","article-title":"Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training","volume":"32","author":"Orlando","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"issue":"3","key":"10.1016\/j.steroids.2021.108899_b0035","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.regpep.2003.10.003","article-title":"Increased hypocretin-1 (orexin-a) levels in cerebrospinal fluid of rats after short-term forced activity","volume":"117","author":"Martins","year":"2004","journal-title":"Regul. Pept."},{"issue":"1","key":"10.1016\/j.steroids.2021.108899_b0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00587058","article-title":"Isometric training of rats\u2013effects upon fast and slow muscle and modification by an anabolic hormone (nandrolone decanoate). II. Male rats","volume":"345","author":"Exner","year":"1973","journal-title":"Pflugers Arch."},{"issue":"1","key":"10.1016\/j.steroids.2021.108899_b0045","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/1570159X13666141210225414","article-title":"Anabolic Androgenic Steroid (AAS) related deaths: autoptic, histopathological and toxicological findings","volume":"13","author":"Frati","year":"2015","journal-title":"Curr. Neuropharmacol."},{"issue":"3","key":"10.1016\/j.steroids.2021.108899_b0050","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s00244-012-9848-2","article-title":"Nandrolone decanoate induces genetic damage in multiple organs of rats","volume":"64","author":"Pozzi","year":"2013","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"5","key":"10.1016\/j.steroids.2021.108899_b0055","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2174\/138955711795445916","article-title":"Anabolic androgenic steroids abuse and liver toxicity","volume":"11","author":"Neri","year":"2011","journal-title":"Mini Rev. Med. Chem."},{"issue":"3","key":"10.1016\/j.steroids.2021.108899_b0060","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0735-1097(03)00711-3","article-title":"Anabolic steroid-induced echocardiographic characteristics of professional football players?","volume":"42","author":"Scharhag","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.steroids.2021.108899_b0065","doi-asserted-by":"crossref","DOI":"10.5812\/ijhrba.24419","article-title":"Chronic administration of high doses of nandrolone decanoate on the pituitary-gonadal axis in male rats","volume":"4","author":"Shahraki","year":"2015","journal-title":"Int. J. High Risk Behav. Addict."},{"issue":"2","key":"10.1016\/j.steroids.2021.108899_b0070","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2165\/00007256-199723020-00004","article-title":"Resistance exercise overtraining and overreaching. Neuroendocrine responses","volume":"23","author":"Fry","year":"1997","journal-title":"Sports Med."},{"issue":"2","key":"10.1016\/j.steroids.2021.108899_b0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.tins.2012.12.005","article-title":"Hypothalamic control of energy balance: insights into the role of synaptic plasticity","volume":"36","author":"Dietrich","year":"2013","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.steroids.2021.108899_b0080","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1530\/JOE-14-0506","article-title":"20 years of leptin: what we know and what the future holds","volume":"223","author":"O'Rahilly","year":"2014","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.steroids.2021.108899_b0085","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.tvjl.2011.04.009","article-title":"The potential role of leptin and adiponectin in obesity: a comparative review","volume":"191","author":"Ricci","year":"2012","journal-title":"Vet. J."},{"issue":"7","key":"10.1016\/j.steroids.2021.108899_b0090","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1365-2826.2003.01045.x","article-title":"Hypothalamic-pituitary-adrenal responses to centrally administered orexin-A are suppressed in pregnant rats","volume":"15","author":"Brunton","year":"2003","journal-title":"J. Neuroendocrinol."},{"issue":"6","key":"10.1016\/j.steroids.2021.108899_b0095","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1111\/j.1460-9568.2004.03255.x","article-title":"Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus","volume":"19","author":"Muroya","year":"2004","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.steroids.2021.108899_b0100","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1139\/h04-002","article-title":"Physiological hypertrophy of the FHL muscle following 8 weeks of progressive resistance exercise in the rat","volume":"29","author":"Hornberger","year":"2004","journal-title":"Can. J. Appl. Physiol."},{"key":"10.1016\/j.steroids.2021.108899_b0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuroscience.2011.11.029","article-title":"Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms","volume":"202","author":"Cassilhas","year":"2012","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.steroids.2021.108899_b0110","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1139\/apnm-2015-0061","article-title":"Resistance training minimizes catabolic effects induced by sleep deprivation in rats","volume":"40","author":"M\u00f4nico-Neto","year":"2015","journal-title":"Appl. Physiol. Nutr. Metab."},{"issue":"5","key":"10.1016\/j.steroids.2021.108899_b0115","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2165\/00007256-200232050-00001","article-title":"Anabolic steroids: a review for the clinician","volume":"32","author":"Kutscher","year":"2002","journal-title":"Sports Med."},{"key":"10.1016\/j.steroids.2021.108899_b0120","doi-asserted-by":"crossref","unstructured":"F.G. Patane, A. Liberto, A.N. Maria Maglitto, P. Malandrino, M. Esposito, F. Amico, G. Cocimano, G.L. Rosi, D. Condorelli, N.D. Nunno, A. Montana, Nandrolone Decanoate: Use, Abuse and Side Effects, Medicina (Kaunas) 56(11) (2020).","DOI":"10.3390\/medicina56110606"},{"issue":"4","key":"10.1016\/j.steroids.2021.108899_b0125","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3109\/15376516.2012.755594","article-title":"DNA damage, p53, Ki-67 and COX-2 expression in rat tongue cells exposed to nandrolone decanoate","volume":"23","author":"Pozzi","year":"2013","journal-title":"Toxicol. Mech Methods"},{"key":"10.1016\/j.steroids.2021.108899_b0130","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.psyneuen.2014.08.009","article-title":"The beneficial effects of strength exercise on hippocampal cell proliferation and apoptotic signaling is impaired by anabolic androgenic steroids","volume":"50","author":"Novaes Gomes","year":"2014","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.steroids.2021.108899_b0135","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1176\/ajp.145.4.487","article-title":"Affective and psychotic symptoms associated with anabolic steroid use","volume":"145","author":"Pope","year":"1988","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.steroids.2021.108899_b0140","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"6","key":"10.1016\/j.steroids.2021.108899_b0145","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1503\/cmaj.051351","article-title":"Health benefits of physical activity: the evidence","volume":"174","author":"Warburton","year":"2006","journal-title":"CMAJ"},{"issue":"5","key":"10.1016\/j.steroids.2021.108899_b0150","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/01.SMJ.0000157531.04472.B2","article-title":"Abuse of supraphysiologic doses of anabolic steroids","volume":"98","author":"Hall","year":"2005","journal-title":"South. Med. J."},{"issue":"6","key":"10.1016\/j.steroids.2021.108899_b0155","first-page":"E973","article-title":"Anabolic steroids increase exercise tolerance, American journal of physiology","volume":"280","author":"Tamaki","year":"2001","journal-title":"Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.steroids.2021.108899_b0160","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s004210050347","article-title":"Adaptations in rat skeletal muscle following long-term resistance exercise training","volume":"77","author":"Duncan","year":"1998","journal-title":"Eur. J. Appl. Physiol. Occup. Physiol."},{"issue":"2","key":"10.1016\/j.steroids.2021.108899_b0165","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.appet.2007.03.007","article-title":"Effect of a moderate exercise on the regulatory hormones of food intake in rats","volume":"49","author":"Ebal","year":"2007","journal-title":"Appetite"},{"issue":"5","key":"10.1016\/j.steroids.2021.108899_b0170","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1742-7843.2009.00439.x","article-title":"Impact of nandrolone decanoate on gene expression in endocrine systems related to the adverse effects of anabolic androgenic steroids","volume":"105","author":"Alsio","year":"2009","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.steroids.2021.108899_b0175","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0169-328X(98)00320-9","article-title":"Down regulation of the prepro-orexin gene expression in genetically obese mice","volume":"65","author":"Yamamoto","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"issue":"7","key":"10.1016\/j.steroids.2021.108899_b0180","first-page":"2380","article-title":"Revisiting leptin's role in obesity and weight loss","volume":"118","author":"Ahima","year":"2008","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.steroids.2021.108899_b0185","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00421-010-1704-3","article-title":"Aging effects on exercise-induced alternations in plasma acylated ghrelin and leptin in male rats","volume":"111","author":"Hsu","year":"2011","journal-title":"Eur. J. Appl. Physiol."},{"key":"10.1016\/j.steroids.2021.108899_b0190","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2147\/DMSO.S24362","article-title":"Resistance training associated with the administration of anabolic-androgenic steroids improves insulin sensitivity in ovariectomized rats","volume":"4","author":"Urtado","year":"2011","journal-title":"Diabetes Metab. Syndr. Obes."},{"issue":"Suppl 3","key":"10.1016\/j.steroids.2021.108899_b0195","first-page":"S543","article-title":"Stimulation of leptin secretion by insulin","volume":"16","author":"Tsai","year":"2012","journal-title":"Indian J. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.steroids.2021.108899_b0200","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s00421-006-0300-z","article-title":"Hypertrophy with unilateral resistance exercise occurs without increases in endogenous anabolic hormone concentration","volume":"98","author":"Wilkinson","year":"2006","journal-title":"Eur. J. Appl. Physiol."},{"issue":"11","key":"10.1016\/j.steroids.2021.108899_b0205","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1249\/MSS.0000000000000147","article-title":"Are acute post-resistance exercise increases in testosterone, growth hormone, and IGF-1 necessary to stimulate skeletal muscle anabolism and hypertrophy?","volume":"45","author":"Schroeder","year":"2013","journal-title":"Med. Sci. Sports Exerc."},{"issue":"1-2","key":"10.1016\/j.steroids.2021.108899_b0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0006-8993(03)03223-2","article-title":"Anabolic androgenic steroid nandrolone decanoate reduces hypothalamic proopiomelanocortin mRNA levels","volume":"986","author":"Lindblom","year":"2003","journal-title":"Brain Res."},{"issue":"9","key":"10.1016\/j.steroids.2021.108899_b0215","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1210\/en.2005-0496","article-title":"Orexin expression and function: glucocorticoid manipulation, stress, and feeding studies","volume":"146","author":"Ford","year":"2005","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.steroids.2021.108899_b0220","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/oby.20045","article-title":"High and low activity rats: elevated intrinsic physical activity drives resistance to diet-induced obesity in non-bred rats","volume":"21","author":"Perez-Leighton","year":"2013","journal-title":"Obesity"},{"issue":"5","key":"10.1016\/j.steroids.2021.108899_b0225","doi-asserted-by":"crossref","first-page":"R1079","DOI":"10.1152\/ajpregu.00207.2002","article-title":"Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement, American journal of physiology","volume":"283","author":"Wu","year":"2002","journal-title":"Regul. Integr. Comp. Physiol."},{"issue":"11","key":"10.1016\/j.steroids.2021.108899_b0230","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/sleep\/30.11.1417","article-title":"Running promotes wakefulness and increases cataplexy in orexin knockout mice","volume":"30","author":"Espana","year":"2007","journal-title":"Sleep"},{"key":"10.1016\/j.steroids.2021.108899_b0235","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fnsys.2014.00211","article-title":"The orexin neuropeptide system: physical activity and hypothalamic function throughout the aging process","volume":"8","author":"Zink","year":"2014","journal-title":"Front. Syst. Neurosci."}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X21001112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X21001112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:26:33Z","timestamp":1777443993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X21001112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":47,"alternative-id":["S0039128X21001112"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2021.108899","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nandrolone decanoate and resistance exercise affect body composition and energy metabolism","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2021.108899","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"108899"}}