{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:15:54Z","timestamp":1776759354096,"version":"3.51.2"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.steroids.2023.109173","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T20:39:40Z","timestamp":1672951180000},"page":"109173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Synthesis, antiproliferative evaluation and in silico studies of a novel steroidal spiro morpholinone"],"prefix":"10.1016","volume":"192","author":[{"given":"Luis A.","family":"Cobos-Ontiveros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura L.","family":"Romero-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo B.","family":"Mastranzo-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Col\u00edn-Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Puerta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Padr\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1376-9671","authenticated-orcid":false,"given":"Pen\u00e9lope","family":"Merino-Montiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Vega Baez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Montiel-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.steroids.2023.109173_b0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.steroids.2011.10.013","article-title":"Tissue physiology and pathology of aromatase","volume":"77","author":"Stocco","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2023.109173_b0010","first-page":"1622","article-title":"A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription","volume":"77","author":"Bulun","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.steroids.2023.109173_b0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1210\/er.2004-0015","article-title":"Aromatase inhibitors in the treatment of breast cancer","volume":"26","author":"Brueggemeier","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.steroids.2023.109173_b0020","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.bmc.2005.10.002","article-title":"Panda, Substituted phenanthrenes with basic amino side chains: A new series of anti-breast cancer agents","volume":"14","author":"Shagufta","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0025","doi-asserted-by":"crossref","first-page":"8464","DOI":"10.1021\/jm300930n","article-title":"Novel aromatase inhibitors by structure-guided design","volume":"55","author":"Ghosh","year":"2012","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jsbmb.2011.02.001","article-title":"Aromatase, aromatase inhibitors, and breast cancer","volume":"125","author":"Chumsri","year":"2011","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.steroids.2023.109173_b0035","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ejmech.2015.08.010","article-title":"Shagufta, Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer","volume":"102","author":"Ahmad","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0040","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s11030-015-9621-3","article-title":"Synthesis and anticancer activity of novel fused pyrimidine hybrids of myrrhanone C, a bicyclic triterpene of Commiphora mukul gum resin","volume":"19","author":"Mallavadhani","year":"2015","journal-title":"Mol. Divers."},{"key":"10.1016\/j.steroids.2023.109173_b0045","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ejmech.2016.03.013","article-title":"Novel triazole hybrids of myrrhanone C, a natural polypodane triterpene: Synthesis, cytotoxic activity and cell based studies","volume":"114","author":"Chandrashekhar","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111974","article-title":"Synthesis and biological evaluation of some novel 1,2,3-triazole hybrids of myrrhanone B isolated from Commiphora mukul gum resin: Identification of potent antiproliferative leads active against prostate cancer cells (PC-3)","volume":"188","author":"Madasu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0055","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/s00044-021-02835-1","article-title":"Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A-C from guayule (Parthenium argentatum) resin","volume":"31","author":"Madasu","year":"2022","journal-title":"Med. Chem. Res."},{"key":"10.1016\/j.steroids.2023.109173_b0060","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1248\/cpb.59.327","article-title":"Synthesis and biological evaluation of 16E-arylidenosteroids as cytotoxic and anti-aromatase agents","volume":"59","author":"Bansal","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.steroids.2023.109173_b0065","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1021\/jm2000689","article-title":"Structure-based design of potent aromatase inhibitors by high-throughput docking","volume":"54","author":"Caporuscio","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejmech.2017.10.063","article-title":"Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs","volume":"143","author":"Romero-Hern\u00e1ndez","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0075","article-title":"Furanone, morpholinone and tetrahydrofuran derivatives from the marine-derived fungus Talaromyces sp. PSU-MF07","author":"Nuansri","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.steroids.2023.109173_b0080","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1021\/ol101716x","article-title":"Monanchocidin: A new apoptosis-inducing polycyclic guanidine alkaloid from the marine sponge monanchora pulchra","volume":"12","author":"Guzii","year":"2010","journal-title":"Org. Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0085","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.2165\/11200890-000000000-00000","article-title":"Rivaroxaban A review of its use for the prevention of venous thromboembolism after total hip or knee replacement surgery","volume":"69","author":"Duggan","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.steroids.2023.109173_b0090","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1080\/00397911.2019.1666284","article-title":"Efficient selective oxidation of alcohols to aldehydes catalyzed by a morpholinone nitroxide","volume":"49","author":"Dong","year":"2019","journal-title":"Synth. Commun."},{"key":"10.1016\/j.steroids.2023.109173_b0095","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1021\/acs.orglett.5b02693","article-title":"Enantioselective N-heterocyclic carbene catalyzed diene regenerative (4 + 2) annulation","volume":"17","author":"Levens","year":"2015","journal-title":"Org. Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0100","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.cclet.2013.07.017","article-title":"Synthesis of the major isomers of Aprepitant and Fosaprepitant","volume":"24","author":"Wan","year":"2013","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0105","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1021\/jm401767k","article-title":"Selective and potent morpholinone inhibitors of the MDM2\u2212p53 protein\u2212protein interaction","volume":"57","author":"Gonzalez","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0110","doi-asserted-by":"crossref","first-page":"4887","DOI":"10.1016\/j.ejmech.2011.07.045","article-title":"Synthesis and pharmacological evaluations of novel 2H-benzo[b][1,4] oxazin-3(4H)-one derivatives as a new class of anti-cancer agents","volume":"46","author":"Rajitha","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejmech.2014.03.087","article-title":"Synthesis of 6-cinnamoyl-2H-benzo[b][1,4]oxazin-3(4H)-ones and their effects on A549 lung cancer cell growth","volume":"79","author":"Zhou","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0120","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1016\/j.bmcl.2017.10.061","article-title":"Potential antimicrobial agents from triazole-functionalized 2H-benzo[b][1,4]oxazin-3(4H)-ones","volume":"27","author":"Bollu","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.steroids.2023.109173_b0125","doi-asserted-by":"crossref","first-page":"225","DOI":"10.21608\/ejchem.2019.16920.2030","article-title":"Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives","volume":"63","author":"Mhmood","year":"2020","journal-title":"Egypt. J. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0130","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.ejmech.2007.08.006","article-title":"Synthesis of novel 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones as anticonvulsant agents","volume":"43","author":"Piao","year":"2008","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0135","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0968-0896(02)00023-8","article-title":"Novel morpholinone-based d-Phe-Pro-Arg mimics as potential thrombin inhibitors: Design, synthesis, and X-ray crystal structure of an enzyme inhibitor complex","volume":"10","author":"Dahlgren","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0140","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.1016\/j.bmc.2003.09.031","article-title":"Novel 6-hydroxy-3-morpholinones as cornea permeable calpain inhibitors","volume":"11","author":"Nakamura","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114461","article-title":"Discovery of 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and selective CDK9 inhibitors that enable transient target engagement for the treatment of hematologic malignancies","volume":"238","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0150","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.ejmech.2019.06.021","article-title":"Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K\/mTOR dual inhibitors","volume":"178","author":"Yan","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0155","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1021\/jm0307990","article-title":"Synthesis and SAR of thrombin inhibitors incorporating a novel 4-amino-morpholinone scaffold: Analysis of X-ray crystal structure of enzyme inhibitor complex","volume":"46","author":"Nilsson","year":"2003","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0160","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/cmdc.201800739","article-title":"Synthesis and structure-activity relationship studies of benzo[b][1,4]oxazin-3(4H)-one analogues as inhibitors of mycobacterial thymidylate synthase X","volume":"14","author":"Modranka","year":"2019","journal-title":"ChemMedChem"},{"key":"10.1016\/j.steroids.2023.109173_b0165","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1134\/S1068162021060091","article-title":"One-pot regioselective synthesis of 7-bromo-2H-benzo[b][1,4]oxazin-3(4H)-one linked isoxazole hybrids as anti-cancer agents and their molecular docking studies","volume":"47","author":"Karthik","year":"2021","journal-title":"Russ. J. Bioorg. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0170","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1016\/j.bmcl.2012.05.038","article-title":"Haloenol pyranones and morpholinones as antineoplastic agents of prostate cancer","volume":"22","author":"Mock","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0175","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1021\/acs.orglett.5b00069","article-title":"Synthesis of the 5,6-dihydroxymorpholin-3-one fragment of Monanchocidin A","volume":"17","author":"Shi","year":"2015","journal-title":"Org. Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0180","doi-asserted-by":"crossref","first-page":"9258","DOI":"10.1021\/acs.orglett.0c03486","article-title":"Intramolecular 6-exo-dig post-Ugi cyclization of N-Substituted 2\u2013alkynamides: Direct access to functionalized morpholinone glycoconjugates","volume":"22","author":"Kumar","year":"2020","journal-title":"Org. Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0185","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1055\/s-0035-1560088","article-title":"Racemization-free synthesis of morpholinone derivatives from \u03b1-amino acids","volume":"47","author":"Samanta","year":"2015","journal-title":"Synthesis"},{"key":"10.1016\/j.steroids.2023.109173_b0190","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1021\/jo701554h","article-title":"Syntheses of (S, S)-Reboxetine via a catalytic stereospecific rearrangement of \u03b2-amino alcohols","volume":"73","author":"M\u00e9tro","year":"2008","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0195","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1021\/acscombsci.6b00050","article-title":"Efficient routes to a diverse array of amino alcohol-derived chiral fragments","volume":"18","author":"Haftchenary","year":"2016","journal-title":"ACS Comb. Sci."},{"key":"10.1016\/j.steroids.2023.109173_b0200","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1021\/acscatal.0c00211","article-title":"Iridium-catalyzed enantioselective and diastereoselective hydrogenation of 1,3-disubstituted isoquinolines","volume":"10","author":"Kim","year":"2020","journal-title":"ACS Catal."},{"key":"10.1016\/j.steroids.2023.109173_b0205","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1002\/ejoc.201200852","article-title":"Diversity-oriented synthesis of spiro- and fused azacycles from ketone molecular templates","volume":"28","author":"Maltais","year":"2012","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0210","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3390\/catal10101117","article-title":"Epoxide syntheses and ring-opening reactions in drug development","volume":"10","author":"Moschona","year":"2020","journal-title":"Catalysts"},{"key":"10.1016\/j.steroids.2023.109173_b0215","doi-asserted-by":"crossref","first-page":"5696","DOI":"10.1039\/b510920e","article-title":"Organolithium-mediated conversion of \u03b2-functionalised aziridines into alkynyl amino alcohols and diamines","author":"Huang","year":"2005","journal-title":"Chem. Commun."},{"key":"10.1016\/j.steroids.2023.109173_b0220","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1016\/j.tetlet.2012.08.013","article-title":"Regio-selective synthesis of 1,2-aminoalcohols from epoxides and chlorohydrins","volume":"53","author":"Murugan","year":"2012","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0225","doi-asserted-by":"crossref","first-page":"4311","DOI":"10.1039\/c2ob25357g","article-title":"Diastereoselective synthesis of vicinal amino alcohols","volume":"10","author":"Karjalainen","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0230","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0040-4020(00)00149-6","article-title":"The synthesis of vicinal amino alcohols","volume":"56","author":"Bergmeier","year":"2000","journal-title":"Tetrahedron"},{"key":"10.1016\/j.steroids.2023.109173_b0235","doi-asserted-by":"crossref","first-page":"6444","DOI":"10.1021\/acs.orglett.1c02258","article-title":"Synthesis of 1,2-aminoalcohols through enantioselective aminoallylation of ketones by Cu-catalyzed reductive coupling","volume":"23","author":"Klake","year":"2021","journal-title":"Org. Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0240","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1002\/ange.202014510","article-title":"Diastereodivergent synthesis of \u03b2-amino alcohols by dual-metalcatalyzed coupling of alkoxyallenes with aldimine esters","volume":"133","author":"Zhu","year":"2021","journal-title":"Angew. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0245","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fchem.2018.00247","article-title":"Selenazolyl-hydrazones as novel selective MAO inhibitors with antiproliferative and antioxidant activities: experimental and in-silico studies","volume":"6","author":"Elshaflu","year":"2018","journal-title":"Front. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0250","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/jcc.10128","article-title":"efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation","volume":"23","author":"Jakalian","year":"2012","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0255","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.steroids.2019.02.012","article-title":"Novel antimicrobial agents\u2019 discovery among the steroid derivatives","volume":"144","author":"Nadaraia","year":"2019","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2023.109173_b0260","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jhet.4174","article-title":"Heterocyclic steroids: Synthetic routes and biological characteristics of steroidal fused bicyclic pyrimidines","volume":"58","author":"Elattar","year":"2021","journal-title":"J. Heterocyclic Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2021.105997","article-title":"Heterocyclic androstane and estrane d-ring modified steroids: Microwave-assisted synthesis, steroid-converting enzyme inhibition, apoptosis induction, and effects on genes encoding estrogen inactivating enzymes","volume":"214","author":"Kulm\u00e1ny","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.steroids.2023.109173_b0270","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/app10010229","article-title":"Microwave-assisted synthesis, proton dissociation processes, and anticancer evaluation of novel D-ring-fused steroidal 5-amino-1-arylpyrazoles","volume":"10","author":"M\u00f3ty\u00e1n","year":"2020","journal-title":"Appl. Sci."},{"key":"10.1016\/j.steroids.2023.109173_b0275","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jsbmb.2014.01.015","article-title":"Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents","volume":"141","author":"Yu","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.steroids.2023.109173_b0280","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s11030-014-9516-8","article-title":"Synthesis of novel steroidal 16-spiroisoxazolines by 1,3-dipolar cycloaddition, and an evaluation of their antiproliferative activities in vitro","volume":"18","author":"Frank","year":"2014","journal-title":"Mol. Divers."},{"key":"10.1016\/j.steroids.2023.109173_b0285","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jccs.201500240","article-title":"Synthesis, voltammetric and analytical applications of some fluorine substituted spirosteroidalthiazolidin-4-one derivatives of sulfa drugs","volume":"63","author":"Makki","year":"2016","journal-title":"J. Chin. Chem. Soc."},{"key":"10.1016\/j.steroids.2023.109173_b0290","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.1016\/j.bmcl.2013.09.072","article-title":"Synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17\u03b2-hydroxysteroid dehydrogenase type 3","volume":"23","author":"Djigou\u00e9","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.steroids.2023.109173_b0295","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1016\/j.bmc.2015.07.049","article-title":"Design, chemical synthesis and biological evaluation of 3-spiromorpholinone\/3-spirocarbamate androsterone derivatives as inhibitors of 17\u03b2-hydroxysteroid dehydrogenase type 3","volume":"23","author":"Djigou\u00e9","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109173_b0300","unstructured":"World Cancer Research Fund International, Worldwide cancer data. https:\/\/www.wcrf.org\/cancer-trends\/worldwide-cancer-data\/ (accessed 27 July 2022)."},{"key":"10.1016\/j.steroids.2023.109173_b0305","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.3390\/molecules16053597","article-title":"Molecular docking of aromatase inhibitors","volume":"16","author":"Suvannang","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.steroids.2023.109173_b0310","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jsbmb.2018.02.009","article-title":"Testosterone complex and non-steroidal ligands of human aromatase","volume":"181","author":"Ghosh","year":"2018","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.steroids.2023.109173_b0315","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature07614","article-title":"Structural basis for androgen specificity and oestrogen synthesis in human aromatase","volume":"457","author":"Ghosh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.steroids.2023.109173_b0320","doi-asserted-by":"crossref","unstructured":"H. Niikawa, T. Suzuki, Y. Miki, S. Suzuki, S. Nagasaki, J. Akahira, S. Honma, D.B. Evans, S. Hayashi, T. Kondo, H. Sasano, Intratumoral estrogens and estrogen receptors in human non-small cell lung carcinoma, Clin. Cancer Res. 14 (2008) 4417\u20134426. 10.1158\/1078-0432.CCR-07-1950.","DOI":"10.1158\/1078-0432.CCR-07-1950"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X23000016?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X23000016?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:09:23Z","timestamp":1758535763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X23000016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":64,"alternative-id":["S0039128X23000016"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2023.109173","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, antiproliferative evaluation and in silico studies of a novel steroidal spiro morpholinone","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2023.109173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"109173"}}