{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:13:42Z","timestamp":1778660022649,"version":"3.51.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013209","name":"Hellenic Foundation for Research and Innovation","doi-asserted-by":"publisher","award":["3725"],"award-info":[{"award-number":["3725"]}],"id":[{"id":"10.13039\/501100013209","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003447","name":"State Scholarships Foundation","doi-asserted-by":"publisher","award":["MIS-5000432"],"award-info":[{"award-number":["MIS-5000432"]}],"id":[{"id":"10.13039\/501100003447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.steroids.2023.109309","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T18:56:11Z","timestamp":1694285771000},"page":"109309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Mining the ZINC database of natural products for specific, testosterone-like, OXER1 antagonists"],"prefix":"10.1016","volume":"199","author":[{"given":"Athanasios A.","family":"Panagiotopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Konstantinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stergios A.","family":"Pirintsos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Castanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilena","family":"Kampa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.steroids.2023.109309_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0968-0004(96)20031-3","article-title":"The growing phospholipase A2 superfamily of signal transduction enzymes","volume":"22","author":"Dennis","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.steroids.2023.109309_b0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jare.2017.11.004","article-title":"Arachidonic acid: Physiological roles and potential health benefits \u2013 a review","volume":"11","author":"Tallima","year":"2018","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.steroids.2023.109309_b0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.steroids.2019.01.006","article-title":"Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate and breast cancer: A comparative study of their expression","volume":"142","author":"Kalyvianaki","year":"2019","journal-title":"Steroids"},{"issue":"12","key":"10.1016\/j.steroids.2023.109309_b0020","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1016\/j.bmc.2018.05.036","article-title":"Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists","volume":"26","author":"Stepniewski","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.steroids.2023.109309_b0025","doi-asserted-by":"crossref","first-page":"44418","DOI":"10.1038\/srep44418","article-title":"Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer","volume":"7","author":"Kalyvianaki","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.steroids.2023.109309_b0030","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbalip.2014.10.008","article-title":"Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid","volume":"1851","author":"Powell","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 Molecular and Cell Biology of Lipids"},{"issue":"3","key":"10.1016\/j.steroids.2023.109309_b0035","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.prostaglandins.2009.05.002","article-title":"5-Oxo-ETE and the OXE receptor","volume":"89","author":"Grant","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0040","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1124\/jpet.107.134908","article-title":"Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity","volume":"325","author":"Patel","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.steroids.2023.109309_b0045","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bbrc.2005.06.191","article-title":"TG1019\/OXE, a G\u03b1i\/o-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis","volume":"334","author":"Hosoi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"8","key":"10.1016\/j.steroids.2023.109309_b0050","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.4049\/jimmunol.154.8.4123","article-title":"5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration","volume":"154","author":"Powell","year":"1995","journal-title":"J. Immunol."},{"issue":"13","key":"10.1016\/j.steroids.2023.109309_b0055","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1016\/S0021-9258(18)98347-X","article-title":"Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor","volume":"268","author":"Powell","year":"1993","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.steroids.2023.109309_b0060","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1124\/mol.63.3.471","article-title":"Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils","volume":"63","author":"Jones","year":"2003","journal-title":"Mol. Pharmacol."},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2220\/biomedres.23.101","article-title":"Identification of a G Protein-Coupled Receptor for 5-oxo-Eicosatetraenoic Acid","volume":"23","author":"Takeda","year":"2002","journal-title":"Biomed. Res."},{"key":"10.1016\/j.steroids.2023.109309_b0070","series-title":"XPharm: The Comprehensive Pharmacology Reference","first-page":"1","article-title":"Leukotriene Receptors","author":"Dent","year":"2007"},{"issue":"16","key":"10.1016\/j.steroids.2023.109309_b0075","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1042\/CS20190657","article-title":"Eicosanoid receptors as therapeutic targets for asthma","volume":"135","author":"Powell","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.steroids.2023.109309_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111487","article-title":"OXER1 mediates testosterone-induced calcium responses in prostate cancer cells","volume":"539","author":"Panagiotopoulos","year":"2022","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.steroids.2023.109309_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.600","article-title":"A simple open source bio-informatic method for initial exploration of GPCR ligands\u2019 agonistic\/antagonistic properties","author":"Panagiotopoulos","year":"2020","journal-title":"Pharmacol. Res. Perspect."},{"issue":"1","key":"10.1016\/j.steroids.2023.109309_b0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/jpet.110.177246","article-title":"Novel oligomeric proanthocyanidin derivatives interact with membrane androgen sites and induce regression of hormone-independent prostate cancer","volume":"337","author":"Kampa","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.steroids.2023.109309_b0095","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bbrc.2021.11.024","article-title":"Enhanced OXER1 expression is indispensable for human cancer cell migration","volume":"584","author":"Kalyvianaki","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.steroids.2023.109309_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113930","article-title":"Targeting the OXE receptor as a potential novel therapy for asthma","volume":"179","author":"Powell","year":"2020","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0105","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/bph.15721","article-title":"Targeting the OXE receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates","volume":"179","author":"Cossette","year":"2022","journal-title":"Br. J. Pharmacol."},{"issue":"44","key":"10.1016\/j.steroids.2023.109309_b0110","doi-asserted-by":"crossref","first-page":"29664","DOI":"10.1021\/acsomega.1c04027","article-title":"New Antagonists of the Membrane Androgen Receptor OXER1 from the ZINC Natural Product Database","volume":"6","author":"Panagiotopoulos","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.steroids.2023.109309_b0115","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.chemolab.2017.08.003","article-title":"PyDescriptor: A new PyMOL plugin for calculating thousands of easily understandable molecular descriptors","volume":"169","author":"Masand","year":"2017","journal-title":"Chemom. Intel. Lab. Syst."},{"key":"10.1016\/j.steroids.2023.109309_b0120","series-title":"Dosage Form Design Parameters","first-page":"731","article-title":"Computer-Aided Prediction of Pharmacokinetic (ADMET) Properties","author":"Chandrasekaran","year":"2018"},{"key":"10.1016\/j.steroids.2023.109309_b0125","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1002\/jcc.23361","article-title":"QSARINS: A New Software for the Development, Analysis, and Validation of QSAR MLR Models","volume":"34","author":"Gramatica","year":"2013","journal-title":"J. Comput. Chem."},{"issue":"13","key":"10.1016\/j.steroids.2023.109309_b0130","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/jcc.23576","article-title":"QSARINS-chem: Insubria datasets and new QSAR\/QSPR models for environmental pollutants in QSARINS","volume":"35","author":"Gramatica","year":"2014","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.steroids.2023.109309_b0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0169-7439(98)00124-5","article-title":"The K correlation index: theory development and its application in chemometrics","volume":"46","author":"Todeschini","year":"1999","journal-title":"Chemom. Int. Lab. Syst."},{"key":"10.1016\/j.steroids.2023.109309_b0140","series-title":"Practical Genetic Algorithms","author":"Haupt","year":"2004"},{"issue":"4","key":"10.1016\/j.steroids.2023.109309_b0145","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1021\/ci00020a020","article-title":"Application of genetic function approximation to quantitative structure\u2013activity relationships and quantitative structure\u2013property relationships","volume":"34","author":"Rogers","year":"1994","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.steroids.2023.109309_b0150","doi-asserted-by":"crossref","unstructured":"L. Heo, H. Park, C. Seok, GalaxyRefine: Protein structure refinement driven by side-chain repacking, Nucleic Acids Res 41(Web Server issue) (2013) W384-8.","DOI":"10.1093\/nar\/gkt458"},{"issue":"Web Server issue","key":"10.1016\/j.steroids.2023.109309_b0155","doi-asserted-by":"crossref","first-page":"W210","DOI":"10.1093\/nar\/gku321","article-title":"GalaxySite: ligand-binding-site prediction by using molecular docking","volume":"42","author":"Heo","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"Suppl 1","key":"10.1016\/j.steroids.2023.109309_b0160","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/prot.24858","article-title":"Effective protein model structure refinement by loop modeling and overall relaxation","volume":"84","author":"Lee","year":"2016","journal-title":"Proteins"},{"issue":"W1","key":"10.1016\/j.steroids.2023.109309_b0165","doi-asserted-by":"crossref","first-page":"W502","DOI":"10.1093\/nar\/gkw360","article-title":"Galaxy7TM: flexible GPCR-ligand docking by structure refinement","volume":"44","author":"Lee","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.steroids.2023.109309_b0170","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/prot.25834","article-title":"Protein structure prediction using multiple deep neural networks in the 13th Critical Assessment of Protein Structure Prediction (CASP13)","volume":"87","author":"Senior","year":"2019","journal-title":"Proteins"},{"issue":"7792","key":"10.1016\/j.steroids.2023.109309_b0175","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41586-019-1923-7","article-title":"Improved protein structure prediction using potentials from deep learning","volume":"577","author":"Senior","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.steroids.2023.109309_b0180","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1107\/S1600576715022931","article-title":"Spherical polar Fourier assembly of protein complexes with arbitrary point group symmetry","volume":"49","author":"Ritchie","year":"2016","journal-title":"J. Appl. Cryst."},{"issue":"1","key":"10.1016\/j.steroids.2023.109309_b0185","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/prot.10379","article-title":"Evaluation of protein docking predictions using Hex 3.1 in CAPRI rounds 1 and 2","volume":"52","author":"Ritchie","year":"2003","journal-title":"Proteins"},{"issue":"13","key":"10.1016\/j.steroids.2023.109309_b0190","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"5","key":"10.1016\/j.steroids.2023.109309_b0195","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1021\/acs.jcim.0c01434","article-title":"GalaxyWater-wKGB: Prediction of Water Positions on Protein Structure Using wKGB Statistical Potential","volume":"61","author":"Heo","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.steroids.2023.109309_b0200","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"issue":"24","key":"10.1016\/j.steroids.2023.109309_b0205","doi-asserted-by":"crossref","first-page":"6980","DOI":"10.1016\/j.bmc.2014.10.012","article-title":"Design and synthesis of 21-alkynylaryl pregnenolone derivatives and evaluation of their anticancer activity","volume":"22","author":"Szaloki","year":"2014","journal-title":"Bioorg. Med. Chem."},{"issue":"2\u20133","key":"10.1016\/j.steroids.2023.109309_b0210","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/minf.201000148","article-title":"On the Use of Local and Global QSPRs for the Prediction of Physico-chemical Properties of Polybrominated Diphenyl Ethers","volume":"30","author":"Papa","year":"2011","journal-title":"Mol Inform"},{"issue":"11","key":"10.1016\/j.steroids.2023.109309_b0215","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1021\/acs.jcim.5b00559","article-title":"ZINC 15\u2013Ligand Discovery for Everyone","volume":"55","author":"Sterling","year":"2015","journal-title":"J. Chem. Inf. Model."},{"issue":"5","key":"10.1016\/j.steroids.2023.109309_b0220","first-page":"694","article-title":"Principles of QSAR models validation: internal and external QSAR & Comb","volume":"26","author":"Gramatica","year":"2007","journal-title":"Sci."},{"issue":"5","key":"10.1016\/j.steroids.2023.109309_b0225","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.3390\/molecules17054791","article-title":"Comparison of Different Approaches to Define the Applicability Domain of QSAR Models","volume":"17","author":"Sahigara","year":"2012","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.steroids.2023.109309_b0230","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nchembio.962","article-title":"A biased ligand for OXE-R uncouples G\u03b1 and G\u03b2\u03b3 signaling within a heterotrimer","volume":"8","author":"Bl\u00e4ttermann","year":"2012","journal-title":"Nat. Chem. Biol."},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0235","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/prot.20035","article-title":"GEMDOCK: a generic evolutionary method for molecular docking","volume":"55","author":"Yang","year":"2004","journal-title":"Proteins"},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0240","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/prot.20387","article-title":"A pharmacophore-based evolutionary approach for screening selective estrogen receptor modulators","volume":"59","author":"Yang","year":"2005","journal-title":"Proteins"},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0245","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry","volume":"25","author":"Keiser","year":"2007","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.steroids.2023.109309_b0250","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1158\/1535-7163.MCT-05-0527","article-title":"Activation of membrane androgen receptors potentiates the antiproliferative effects of paclitaxel on human prostate cancer cells","volume":"5","author":"Kampa","year":"2006","journal-title":"Mol. Cancer Ther."},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0255","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1210\/jc.2004-0801","article-title":"Membrane androgen receptor activation induces apoptotic regression of human prostate cancer cells in vitro and in vivo","volume":"90","author":"Hatzoglou","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.steroids.2023.109309_b0260","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1096\/fj.02-0131fje","article-title":"The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton","volume":"16","author":"Kampa","year":"2002","journal-title":"FASEB J."},{"issue":"31","key":"10.1016\/j.steroids.2023.109309_b0265","doi-asserted-by":"crossref","first-page":"22278","DOI":"10.1074\/jbc.M611877200","article-title":"A conserved mechanism for steroid receptor translocation to the plasma membrane","volume":"282","author":"Pedram","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.steroids.2023.109309_b0270","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1095\/biolreprod63.3.736","article-title":"Rapid androgen actions on calcium signaling in rat sertoli cells and two human prostatic cell lines: similar biphasic responses between 1 picomolar and 100 nanomolar concentrations","volume":"63","author":"Lyng","year":"2000","journal-title":"Biol. Reprod."},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0275","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.yexcr.2005.06.011","article-title":"Monomeric and oligomeric flavanols are agonists of membrane androgen receptors","volume":"309","author":"Nifli","year":"2005","journal-title":"Exp. Cell Res."},{"issue":"8\u20139","key":"10.1016\/j.steroids.2023.109309_b0280","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.steroids.2009.10.004","article-title":"Conjugated and non-conjugated androgens differentially modulate specific early gene transcription in breast cancer in a cell-specific manner","volume":"75","author":"Notas","year":"2010","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2023.109309_b0285","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1476-4598-7-88","article-title":"Membrane androgen receptor activation triggers down-regulation of PI-3K\/Akt\/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells","volume":"7","author":"Papadopoulou","year":"2008","journal-title":"Mol. Cancer"},{"issue":"5","key":"10.1016\/j.steroids.2023.109309_b0290","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2164\/jandrol.106.000554","article-title":"Androgens induce increases in intracellular calcium via a G protein-coupled receptor in LNCaP prostate cancer cells","volume":"27","author":"Sun","year":"2006","journal-title":"J. Androl."},{"issue":"12","key":"10.1016\/j.steroids.2023.109309_b0295","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003858","article-title":"GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome","volume":"3","author":"Pi","year":"2008","journal-title":"PLoS One"},{"issue":"51","key":"10.1016\/j.steroids.2023.109309_b0300","doi-asserted-by":"crossref","first-page":"39953","DOI":"10.1074\/jbc.M110.158063","article-title":"GPRC6A mediates the non-genomic effects of steroids","volume":"285","author":"Pi","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.steroids.2023.109309_b0305","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/pros.21442","article-title":"GPRC6A regulates prostate cancer progression","volume":"72","author":"Pi","year":"2012","journal-title":"Prostate"},{"issue":"11","key":"10.1016\/j.steroids.2023.109309_b0310","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1210\/en.2014-1201","article-title":"Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis","volume":"155","author":"Thomas","year":"2014","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.steroids.2023.109309_b0315","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1210\/en.2018-00987","article-title":"Membrane Androgen Receptors Unrelated to Nuclear Steroid Receptors","volume":"160","author":"Thomas","year":"2019","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.steroids.2023.109309_b0320","first-page":"1","article-title":"Principles of QSAR Modeling: Comments and Suggestions From Personal Experience","volume":"5","author":"Gramatica","year":"2020","journal-title":"Int. J. Quant. Structure-Prop. Rel."},{"issue":"11\u201312","key":"10.1016\/j.steroids.2023.109309_b0325","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/minf.201200075","article-title":"QSAR Modeling is not \u201cPush a Button and Find a Correlation\u201d: A Case Study of Toxicity of (Benzo-)triazoles on Algae","volume":"31","author":"Gramatica","year":"2012","journal-title":"Mol. Inform"},{"key":"10.1016\/j.steroids.2023.109309_b0330","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.620214","article-title":"Steroid Hormone Receptors: Links With Cell Cycle Machinery and Breast Cancer Progression","volume":"11","author":"Saha","year":"2021","journal-title":"Front. Oncol."},{"issue":"30","key":"10.1016\/j.steroids.2023.109309_b0335","doi-asserted-by":"crossref","first-page":"15588","DOI":"10.1074\/jbc.M116.734624","article-title":"Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer","volume":"291","author":"Miki","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.steroids.2023.109309_b0340","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41389-020-00291-x","article-title":"OXER1 and RACK1-associated pathway: a promising drug target for breast cancer progression","volume":"9","author":"Masi","year":"2020","journal-title":"Oncogenesis"},{"issue":"1","key":"10.1016\/j.steroids.2023.109309_b0345","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.canlet.2013.04.027","article-title":"OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells","volume":"336","author":"Sarveswaran","year":"2013","journal-title":"Cancer Lett."},{"issue":"4","key":"10.1016\/j.steroids.2023.109309_b0350","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1593\/neo.08166","article-title":"A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness","volume":"10","author":"Coppola","year":"2008","journal-title":"Neoplasia"},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108254","article-title":"Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects","volume":"33","author":"Cheng","year":"2020","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.steroids.2023.109309_b0360","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nsb941","article-title":"The crystal structure of the proprotein processing proteinase furin explains its stringent specificity","volume":"10","author":"Henrich","year":"2003","journal-title":"Nat. Struct. Biol."},{"issue":"1","key":"10.1016\/j.steroids.2023.109309_b0365","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/s42003-021-02701-1","article-title":"Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock","volume":"4","author":"Sakamoto","year":"2021","journal-title":"Commun. Biol."},{"issue":"2","key":"10.1016\/j.steroids.2023.109309_b0370","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020549","article-title":"Mint3 as a Potential Target for Cooling Down HIF-1alpha-Mediated Inflammation and Cancer Aggressiveness","volume":"11","author":"Tanaka","year":"2023","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.steroids.2023.109309_b0375","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0031-9422(00)00178-3","article-title":"Bisbenzylisoquinoline alkaloids from Guatteria boliviana (Annonaceae)","volume":"54","author":"Mahiou","year":"2000","journal-title":"Phytochemistry"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X2300137X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X2300137X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:51:36Z","timestamp":1778658696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X2300137X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":75,"alternative-id":["S0039128X2300137X"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2023.109309","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mining the ZINC database of natural products for specific, testosterone-like, OXER1 antagonists","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2023.109309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109309"}}