{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:05:45Z","timestamp":1786997145081,"version":"build-2736575974"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.steroids.2026.109746","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T16:39:50Z","timestamp":1767976790000},"page":"109746","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The protective effects of luteolin and oleuropein against dexamethasone-induced hyperlipidemia"],"prefix":"10.1016","volume":"227","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8831-3850","authenticated-orcid":false,"given":"Lourin Nasr","family":"Aziz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Omar","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim Taha","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.steroids.2026.109746_b0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s12291-018-0736-z","article-title":"Grape seed extract alleviates dexamethasone-induced hyperlipidemia, lipid peroxidation, and hematological alteration in rats","volume":"34","author":"Hasona","year":"2018","journal-title":"Indian J. Clin. Biochem."},{"issue":"8","key":"10.1016\/j.steroids.2026.109746_b0010","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23798","article-title":"The hepatoprotective potential of tannic acid against doxorubicin-induced hepatotoxicity: insights into its antioxidative, anti-inflammatory, and antiapoptotic mechanisms","volume":"38","author":"\u00d6zturk","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"4","key":"10.1016\/j.steroids.2026.109746_b0015","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23702","article-title":"Protective effects of esculetin against doxorubicin-induced toxicity correlated with oxidative stress in rat liver: in vivo and in silico studies","volume":"38","author":"K\u00f6ro\u011flu","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.steroids.2026.109746_b0020","doi-asserted-by":"crossref","unstructured":"Baumgart, Simon J., and Bernard Haendler. 2017. \u201cDrug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis.\u201d International Journal of Molecular Sciences 2017, Vol. 18, Page 1018 18 (5): 1018. https:\/\/doi.org\/10.3390\/IJMS18051018.","DOI":"10.3390\/ijms18051018"},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0025","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.steroids.2026.109746_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1362229","article-title":"Editorial: drug metabolism-induced organ toxicity","volume":"15","author":"Kadi","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.steroids.2026.109746_b0035","doi-asserted-by":"crossref","unstructured":"Cohen, Gerald M.. 2020. \u201cTarget Organ Toxicity. Volume 1,\u201d 240.","DOI":"10.1201\/9780367811068-1"},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0040","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/1735-5362.220964","article-title":"The effects of hydroalcoholic extract of allium elburzense wendelbo bulb on dexamethasone-induced dyslipidemia, hyperglycemia, and oxidative stress in rats","volume":"13","author":"Safaeian","year":"2018","journal-title":"Research in Pharmaceutical Sciences"},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0045","first-page":"399","article-title":"A review article on hyperlipidemia: types, treatments and new drug targets","volume":"7","author":"Shattat","year":"2015","journal-title":"Biomedical and Pharmacology Journal"},{"issue":"4","key":"10.1016\/j.steroids.2026.109746_b0050","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2131\/jts.42.455","article-title":"Dexamethasone-induced hepatomegaly and steatosis in larval zebrafish","volume":"42","author":"Yin","year":"2017","journal-title":"J. Toxicol. Sci."},{"issue":"December","key":"10.1016\/j.steroids.2026.109746_b0055","article-title":"The hepatocyte IKK:NF-\u039aB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis","volume":"54","author":"Heida","year":"2021","journal-title":"Mol. Metab."},{"issue":"Spec Iss 3","key":"10.1016\/j.steroids.2026.109746_b0060","first-page":"72","article-title":"A Study of the influence of dexamethasone on lipid profile and enzyme lactate dehydrogenase","volume":"8","author":"Dolatabadi","year":"2015","journal-title":"J. Med. Life"},{"issue":"9","key":"10.1016\/j.steroids.2026.109746_b0065","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1210\/me.2010-0192","article-title":"AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through P38 MAPK","volume":"24","author":"Nader","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"2","key":"10.1016\/j.steroids.2026.109746_b0070","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s13679-024-00556-1","article-title":"Role of glucocorticoids in metabolic dysfunction-associated steatotic liver disease","volume":"13","author":"Polyzos","year":"2024","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.steroids.2026.109746_b0075","doi-asserted-by":"crossref","unstructured":"Senoner, Thomas, and Wolfgang Dichtl. 2019. \u201cOxidative Stress in Cardiovascular Diseases: Still a Therapeutic Target?\u201d Nutrients 2019, Vol. 11, Page 2090 11 (9): 2090. https:\/\/doi.org\/10.3390\/NU11092090.","DOI":"10.3390\/nu11092090"},{"issue":"2","key":"10.1016\/j.steroids.2026.109746_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox10020171","article-title":"Oxidative stress and inflammation in cardiovascular diseases","volume":"10","author":"Pickering","year":"2021","journal-title":"Antioxidants"},{"issue":"February","key":"10.1016\/j.steroids.2026.109746_b0085","article-title":"Nandrolone decanoate induces liver damage via TGF-\u03b2\/Smad3\/MiR-29 and regulation of FAT\/CD36, PTP1B, HNF4A expression in male rats: rescue effect of N-acetylcysteine","volume":"256","author":"Mohammadpour-Asl","year":"2025","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"4","key":"10.1016\/j.steroids.2026.109746_b0090","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/13813455.2019.1640743","article-title":"Ameliorative effects of tropisetron on liver injury in streptozotocin-induced diabetic rats","volume":"127","author":"Aziz","year":"2021","journal-title":"Arch. Physiol. Biochem."},{"issue":"September","key":"10.1016\/j.steroids.2026.109746_b0095","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biopha.2018.05.121","article-title":"Increased hepatic FAT\/CD36, PTP1B and decreased HNF4A expression contributes to dyslipidemia associated with ethanol\u2013induced liver dysfunction: rescue effect of ginger extract","volume":"105","author":"Shirpoor","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0100","first-page":"233","article-title":"Transcriptional factors of FAT\/CD36, PTP1B, SREBP-1c and HNF4A are involved in dyslipidemia following cyclosporine a treatment in the liver of rats: the rescue effect of curcumin","volume":"80","author":"Shirpoor","year":"2025","journal-title":"Arch. Razi Inst."},{"issue":"6","key":"10.1016\/j.steroids.2026.109746_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e17613","article-title":"Luteolin reduces cardiac damage caused by hyperlipidemia in sprague-dawley rats","volume":"9","author":"Dong","year":"2023","journal-title":"Heliyon"},{"issue":"September","key":"10.1016\/j.steroids.2026.109746_b0110","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.21608\/mjcu.2019.65632","article-title":"Luteolin attenuates dexamethasone-induced skeletal muscle atrophy in male albino rats","volume":"87","author":"Hawila","year":"2019","journal-title":"The Medical Journal of Cairo University"},{"issue":"8","key":"10.1016\/j.steroids.2026.109746_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135637","article-title":"The flavone luteolin suppresses SREBP-2 expression and post-translational activation in hepatic cells","volume":"10","author":"Wong","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.steroids.2026.109746_b0120","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3177\/jnsv.69.259","article-title":"Luteolin ameliorates hepatic steatosis and enhances mitochondrial biogenesis via AMPK\/PGC-1\u03b1 pathway in western diet-fed mice","volume":"69","author":"Wang","year":"2023","journal-title":"J. Nutr. Sci. Vitaminol."},{"issue":"14","key":"10.1016\/j.steroids.2026.109746_b0125","doi-asserted-by":"crossref","first-page":"8634","DOI":"10.1002\/jsfa.13691","article-title":"Oleuropein mitigates non-alcoholic fatty liver disease (NAFLD) and modulates liver metabolites in high-fat diet-induced obese mice via activating PPAR\u03b1","volume":"104","author":"Zhou","year":"2024","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.steroids.2026.109746_b0130","doi-asserted-by":"crossref","unstructured":"Porcu, Cristiana, Silvia Sideri, Maurizio Martini, Alessandra Cocomazzi, Andrea Galli, Giovanni Tarantino, and Clara Balsano. 2018. \u201cOleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender.\u201d International Journal of Molecular Sciences 19 (12). https:\/\/doi.org\/10.3390\/IJMS19123948.","DOI":"10.3390\/ijms19123948"},{"issue":"May","key":"10.1016\/j.steroids.2026.109746_b0135","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2016.03.026","article-title":"Evaluation of hypocholesterolemic effect of oleuropein in cholesterol-fed rats","volume":"252","author":"Hadrich","year":"2016","journal-title":"Chem. Biol. Interact."},{"issue":"2\u20133","key":"10.1016\/j.steroids.2026.109746_b0140","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cbi.2008.08.014","article-title":"Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from chemlali olive leaves","volume":"176","author":"Jemai","year":"2008","journal-title":"Chem. Biol. Interact."},{"issue":"October","key":"10.1016\/j.steroids.2026.109746_b0145","article-title":"Sex differences in glucocorticoids-induced anabolic effects in rats","volume":"209","author":"Stopa","year":"2019","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.steroids.2026.109746_b0150","doi-asserted-by":"crossref","unstructured":"Murray, Alyssa, Sujeenthar Tharmalingam, Phong Nguyen, and T. C. Tai. 2021. \u201cUntargeted Metabolomics Reveals Sex-Specific Differences in Lipid Metabolism of Adult Rats Exposed to Dexamethasone in Utero.\u201d Scientific Reports 2021 11:1 11 (1): 20342-. https:\/\/doi.org\/10.1038\/s41598-021-99598-x.","DOI":"10.1038\/s41598-021-99598-x"},{"issue":"3","key":"10.1016\/j.steroids.2026.109746_b0155","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0022-2828(86)80415-1","article-title":"Sex differences in the distribution and regulation of glucocorticoid receptors in cardiac tissues of rats","volume":"18","author":"Turner","year":"1986","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"12","key":"10.1016\/j.steroids.2026.109746_b0160","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/JPER.18-0584","article-title":"The effect of luteolin in prevention of periodontal disease in wistar rats","volume":"90","author":"Yuce","year":"2019","journal-title":"J. Periodontol."},{"issue":"2","key":"10.1016\/j.steroids.2026.109746_b0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.repc.2021.05.011","article-title":"Oral administration of oleuropein and olive leaf extract has cardioprotective effects in rodents: a systematic review","volume":"41","author":"Menezes","year":"2022","journal-title":"Rev. Port. Cardiol."},{"issue":"5","key":"10.1016\/j.steroids.2026.109746_b0170","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1055\/s-0035-1546291","article-title":"Ketamine-Xylazine anesthesia in rats: intraperitoneal versus intravenous administration using a microsurgical femoral vein access","volume":"31","author":"Ritschl","year":"2015","journal-title":"J. Reconstr. Microsurg."},{"issue":"6","key":"10.1016\/j.steroids.2026.109746_b0175","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin. Chem."},{"issue":"2","key":"10.1016\/j.steroids.2026.109746_b0180","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"issue":"3","key":"10.1016\/j.steroids.2026.109746_b0185","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-2944(75)90087-3","article-title":"A direct enzymic method for the determination of reduced glutathione in blood and other tissues","volume":"13","author":"Crowley","year":"1975","journal-title":"Biochem. Med."},{"issue":"2","key":"10.1016\/j.steroids.2026.109746_b0190","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(72)80218-3","article-title":"The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen","volume":"46","author":"Nishikimi","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.steroids.2026.109746_b0195","unstructured":"Bancroft, JD, and M Gamble. 2008. Theory and Practice of Histological Techniques."},{"key":"10.1016\/j.steroids.2026.109746_b0200","doi-asserted-by":"crossref","unstructured":"Alwahsh, Mohammad, Rahaf Alejel, Aya Hasan, Haneen Abuzaid, and Tariq Al-Qirim. 2024. \u201cThe Application of Metabolomics in Hyperlipidemia: Insights into Biomarker Discovery and Treatment Efficacy Assessment.\u201d Metabolites 2024, Vol. 14, Page 438 14 (8): 438. https:\/\/doi.org\/10.3390\/METABO14080438.","DOI":"10.3390\/metabo14080438"},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0205","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12944-018-0676-x","article-title":"Effect of hyperlipidemia on the incidence of cardio-cerebrovascular events in patients with type 2 diabetes","volume":"17","author":"Fan","year":"2018","journal-title":"Lipids Health Dis."},{"issue":"4","key":"10.1016\/j.steroids.2026.109746_b0210","first-page":"1481","article-title":"Anti-hyperlipidemic activity of methanolic extract of impatiens balsamina flowers against dexamethasone-induced hyperlipidemia in male wistar rats","volume":"86","author":"Aggunna","year":"2024","journal-title":"Indian J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.steroids.2026.109746_b0215","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4103\/RPS.RPS_148_23","article-title":"The effect of dracocephalum subcapitatum hydroalcoholic extract on dexamethasone-induced hyperlipidemic rats","volume":"19","author":"Safaeian","year":"2024","journal-title":"Research in Pharmaceutical Sciences"},{"issue":"2","key":"10.1016\/j.steroids.2026.109746_b0220","first-page":"59","article-title":"Hypolipidemic effect of N-acetylcysteine against dexamethasone-induced hyperlipidemia in rats","volume":"3","author":"Mada","year":"2019","journal-title":"Calabar Journal of Health Sciences"},{"issue":"5","key":"10.1016\/j.steroids.2026.109746_b0225","doi-asserted-by":"crossref","DOI":"10.1002\/phy2.103","article-title":"Glucocorticoid excess induces long-lasting changes in body composition in male C57Bl\/6J mice only with high-fat diet","volume":"1","author":"Auvinen","year":"2013","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.steroids.2026.109746_b0230","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2920530","article-title":"Herbal medicines targeting the improved \u03b2 -cell functions and \u03b2 -cell regeneration for the management of diabetes mellitus","volume":"2021","author":"Wickramasinghe","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"21","key":"10.1016\/j.steroids.2026.109746_b0235","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1021\/acs.jafc.6b00964","article-title":"Metabolic fate of luteolin in rats: its relationship to anti-inflammatory effect","volume":"64","author":"Kure","year":"2016","journal-title":"J. Agric. Food Chem."},{"issue":"17","key":"10.1016\/j.steroids.2026.109746_b0240","doi-asserted-by":"crossref","first-page":"135","DOI":"10.51745\/najfnr.8.17.135-148","article-title":"Seed from olive cake prevents hyperglycemia, hyperlipidemia, and oxidative stress in dexamethasone-induced diabetes rats","volume":"8","author":"Garba","year":"2024","journal-title":"North African Journal of Food and Nutrition Research"},{"issue":"7","key":"10.1016\/j.steroids.2026.109746_b0245","first-page":"8922","article-title":"Protective effects of luteolin on vascular endothelial injury in rats with atherosclerosis","volume":"12","author":"Su","year":"2019","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"9","key":"10.1016\/j.steroids.2026.109746_b0250","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13358","article-title":"Luteolin improves hypercholesterolemia and glucose intolerance through LXR\u03b1-dependent pathway in diet-induced obese mice","volume":"44","author":"Park","year":"2020","journal-title":"J. Food Biochem."},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19476337.2025.2463491","article-title":"Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents","volume":"23","author":"Laaboudi","year":"2025","journal-title":"CYTA - Journal of Food"},{"key":"10.1016\/j.steroids.2026.109746_b0260","doi-asserted-by":"crossref","unstructured":"Georgiou, Nikitas, Margarita Georgia Kakava, Efthymios Alexandros Routsi, Errikos Petsas, Nikolaos Stavridis, Christoforos Freris, Nikoletta Zoupanou, Kalliopi Moschovou, Sofia Kiriakidi, and Thomas Mavromoustakos. 2023. \u201cQuercetin: A Potential Polydynamic Drug.\u201d Molecules 2023, Vol. 28, Page 8141 28 (24): 8141. https:\/\/doi.org\/10.3390\/MOLECULES28248141.","DOI":"10.3390\/molecules28248141"},{"issue":"8","key":"10.1016\/j.steroids.2026.109746_b0265","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1007\/s12010-023-04544-4","article-title":"Luteolin mitigates diabetic dyslipidemia in rats by modulating ACAT-2, PPAR\u03b1, SREBP-2 proteins, and oxidative stress","volume":"195","author":"Shehnaz","year":"2023","journal-title":"Appl. Biochem. Biotechnol."},{"issue":"2","key":"10.1016\/j.steroids.2026.109746_b0270","first-page":"245","article-title":"Olive oil effectively mitigates ovariectomy-induced marrow adiposity assessed by MR spectroscopy in estrogen-deficient Rabbits","volume":"63","author":"Liu","year":"2021","journal-title":"Https:\/\/Doi.Org\/10.1177\/0284185120986937"},{"key":"10.1016\/j.steroids.2026.109746_b0399","doi-asserted-by":"crossref","unstructured":"Soliman, Hanan A., Mohamed A. El-Desouky, Walaa G. Hozayen, Rasha R. Ahmed, and Amal K. Khaliefa. 2016. \u201cHepatoprotective Effects of Parsley, Basil, and Chicory Aqueous Extracts against Dexamethasone-Induced in Experimental Rats.\u201d Journal of Intercultural Ethnopharmacology 5 (1): 65. https:\/\/doi.org\/10.5455\/JICE.20160124113555.","DOI":"10.5455\/jice.20160124113555"},{"key":"10.1016\/j.steroids.2026.109746_b0400","doi-asserted-by":"crossref","unstructured":"Deledda, Andrea, et al. \"Mitochondrial aging and senolytic natural products with protective potential.\" International Journal of Molecular Sciences 23.24 (2022): 16219.\u200f.","DOI":"10.3390\/ijms232416219"},{"key":"10.1016\/j.steroids.2026.109746_b0275","doi-asserted-by":"crossref","unstructured":"Sun, Peng, Liang Zhao, Nanhai Zhang, Jingxuan Zhou, Liebing Zhang, Wei Wu, Baoping Ji, and Feng Zhou. 2021. \u201cBioactivity of Dietary Polyphenols: The Role in LDL-C Lowering.\u201d Foods 2021, Vol. 10, Page 2666 10 (11): 2666. https:\/\/doi.org\/10.3390\/FOODS10112666.","DOI":"10.3390\/foods10112666"},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0280","doi-asserted-by":"crossref","first-page":"8188","DOI":"10.1038\/s41598-021-87628-7","article-title":"Olive leaf extract supplementation improves the vascular and metabolic alterations associated with aging in wistar rats","volume":"11","author":"Gonz\u00e1lez-Hedstr\u00f6m","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.steroids.2026.109746_b0285","doi-asserted-by":"crossref","unstructured":"Hamza, Amna M., Mayada S. Hassan, Rana F. Mousa, Amjad A. Jahil, Ali J. AL-Nuaimi, and Mahdi S. Hassan. 2022. \u201cEffect of Aloe Vera on Lipid and Sugar Levels in Male Rats Exposed to High Doses of Dexamethasone Therapy.\u201d International Journal of Health Sciences, August, 7885\u201394. https:\/\/doi.org\/10.53730\/IJHS.V6NS6.12181.","DOI":"10.53730\/ijhs.v6nS6.12181"},{"key":"10.1016\/j.steroids.2026.109746_b0290","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/647832","article-title":"Effects on liver lipid metabolism of the naturally occurring dietary flavone luteolin-7-glucoside","volume":"2015","author":"S\u00e1","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"4","key":"10.1016\/j.steroids.2026.109746_b0295","doi-asserted-by":"crossref","first-page":"297","DOI":"10.32598\/IJT.16.4.975.1","article-title":"Dexamethasone promotes the risk of cardiovascular disease in high fructose-exposed wistar rats","volume":"16","author":"Abdulkareem","year":"2022","journal-title":"Iranian Journal of Toxicology"},{"issue":"7","key":"10.1016\/j.steroids.2026.109746_b0300","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1002\/ptr.8217","article-title":"Luteolin: a promising multifunctional natural flavonoid for human diseases","volume":"38","author":"Zhu","year":"2024","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.steroids.2026.109746_b0305","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jsps.2010.05.005","article-title":"Cardioprotective and neuroprotective roles of oleuropein in olive","volume":"18","author":"Omar","year":"2010","journal-title":"Saudi Pharmaceutical Journal : SPJ"},{"issue":"13","key":"10.1016\/j.steroids.2026.109746_b0310","doi-asserted-by":"crossref","first-page":"7098","DOI":"10.1039\/D2FO00521B","article-title":"Combination of resveratrol and luteolin ameliorates \u03b1-naphthylisothiocyanate-induced cholestasis by regulating the bile acid homeostasis and suppressing oxidative stress","volume":"13","author":"Wu","year":"2022","journal-title":"Food Funct."},{"issue":"13","key":"10.1016\/j.steroids.2026.109746_b0315","doi-asserted-by":"crossref","DOI":"10.3390\/cells12131764","article-title":"Olive Leaf Extract (OLE) as a novel antioxidant that ameliorates the inflammatory response in cystic fibrosis","volume":"12","author":"Allegretta","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0320","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5455\/ajvs.47854","article-title":"Potential protective effect of ginseng on dexamethasone-induced liver damage via motivation of anti-apoptotic and antioxidant activities in rats","volume":"68","author":"Elkhrashy","year":"2021","journal-title":"Alexandria Journal of Veterinary Sciences"},{"issue":"26","key":"10.1016\/j.steroids.2026.109746_b0325","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1021\/acs.jafc.2c02015","article-title":"Orientin attenuated D-GalN\/LPS-induced liver injury through the inhibition of oxidative stress via Nrf2\/Keap1 pathway","volume":"70","author":"Li","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.steroids.2026.109746_b0330","doi-asserted-by":"crossref","unstructured":"Ghouizi, Asmae El, Driss Ousaaid, Hassan Laaroussi, Meryem Bakour, Abderrazak Aboulghazi, Rose Strutch Soutien, Christophe Hano, and Badiaa Lyoussi. 2023. \u201cFicus Carica (Linn.) Leaf and Bud Extracts and Their Combination Attenuates Type-1 Diabetes and Its Complications via the Inhibition of Oxidative Stress.\u201d Foods 12 (4). https:\/\/doi.org\/10.3390\/FOODS12040759.","DOI":"10.3390\/foods12040759"},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0335","article-title":"Biochemical changes of dexamethasone on liver and kidney functions in laboratory mice mus musculus L","volume":"8","author":"Kathim","year":"2023","journal-title":"Bionatura"},{"issue":"18","key":"10.1016\/j.steroids.2026.109746_b0340","doi-asserted-by":"crossref","first-page":"52358","DOI":"10.1007\/s11356-023-26085-3","article-title":"Protective efficacy of luteolin against aflatoxinb1-induced toxicity, oxidative damage, and apoptosis in the rat liver","volume":"30","author":"Zaki","year":"2023","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"4","key":"10.1016\/j.steroids.2026.109746_b0345","first-page":"1259","article-title":"Oleuropein, a phenolic component of olea europaea l. ameliorates CCl4-induced liver injury in rats through the regulation of oxidative stress and inflammation","volume":"28","author":"Rahmani","year":"2024","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.steroids.2026.109746_b0350","doi-asserted-by":"crossref","unstructured":"Horby, Peter, Wei Shen Lim, Jonathan Emberson, Marion Mafham, Jennifer Bell, Louise Linsell, Natalie Staplin, et al. 2020. \u201cEffect of Dexamethasone in Hospitalized Patients with COVID-19 \u2013 Preliminary Report,\u201d June. https:\/\/doi.org\/10.1101\/2020.06.22.20137273.","DOI":"10.1101\/2020.06.22.20137273"},{"key":"10.1016\/j.steroids.2026.109746_b0401","doi-asserted-by":"crossref","unstructured":"Hussain, Md Sadique, Gaurav Gupta, Ahsas Goyal, Riya Thapa, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, et al. 2023. \u201cFrom Nature to Therapy: Luteolin\u2019s Potential as an Immune System Modulator in Inflammatory Disorders.\u201d Journal of Biochemical and Molecular Toxicology 37 (11). https:\/\/doi.org\/10.1002\/JBT.23482.","DOI":"10.1002\/jbt.23482"},{"key":"10.1016\/j.steroids.2026.109746_b0355","doi-asserted-by":"crossref","unstructured":"Micheli, Laura, Laura Bertini, Agnese Bonato, Noemi Villanova, Carla Caruso, Maurizia Caruso, Roberta Bernini, and Felice Tirone. 2023. \u201cRole of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota.\u201d Nutrients 15 (7). https:\/\/doi.org\/10.3390\/NU15071767.","DOI":"10.3390\/nu15071767"},{"issue":"4","key":"10.1016\/j.steroids.2026.109746_b0360","doi-asserted-by":"crossref","first-page":"441","DOI":"10.56808\/3027-7922.2626","article-title":"Antioxidant status, antihyperlipidemic activity, and serum electrolyte levels in dexamethasone-induced oxidative stress in wistar rats treated with Vitamin E","volume":"46","author":"Okon","year":"2022","journal-title":"The Thai Journal of Pharmaceutical Sciences"},{"key":"10.1016\/j.steroids.2026.109746_b0365","doi-asserted-by":"crossref","unstructured":"Maiuolo, Jessica, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Francesca Oppedisano, Saverio Nucera, Federica Scarano, et al. 2022. \u201cThe Employment of Genera Vaccinium, Citrus, Olea, and Cynara Polyphenols for the Reduction of Selected Anti-Cancer Drug Side Effects.\u201d Nutrients 14 (8). https:\/\/doi.org\/10.3390\/NU14081574.","DOI":"10.3390\/nu14081574"},{"issue":"14","key":"10.1016\/j.steroids.2026.109746_b0370","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147820","article-title":"Simultaneous high-performance recovery and extended acid-catalyzed hydrolysis of oleuropein and flavonoid glycosides of olive (Olea Europaea) leaves: hydrothermal versus ethanol organosolv treatment","volume":"25","author":"Refai","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.steroids.2026.109746_b0402","doi-asserted-by":"crossref","unstructured":"Bonesi, Marco, Monica R. Loizzo, Rosaria Acquaviva, Giuseppe A. Malfa, Francesca Aiello, and Rosa Tundis. 2017. \u201cAnti-Inflammatory and Antioxidant Agents from Salvia Genus (Lamiaceae): An Assessment of the Current State of Knowledge.\u201d Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 16 (2). https:\/\/doi.org\/10.2174\/1871523016666170502121419.","DOI":"10.2174\/1871523016666170502121419"},{"issue":"May","key":"10.1016\/j.steroids.2026.109746_b0375","article-title":"Mangiferin mitigates dexamethasone-induced insulin resistance in rats: insight into vascular dysfunction and hepatic steatosis","volume":"16","author":"Alsaedi","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.steroids.2026.109746_b0403","doi-asserted-by":"crossref","unstructured":"Huang, Chin Shiu, Chong Kuei Lii, Ai Hsuan Lin, Yu Wen Yeh, Hsien Tsung Yao, Chien Chun Li, Tsu Shing Wang, and Haw Wen Chen. 2012. \u201cProtection by Chrysin, Apigenin, and Luteolin against Oxidative Stress Is Mediated by the Nrf2-Dependent up-Regulation of Heme Oxygenase 1 and Glutamate Cysteine Ligase in Rat Primary Hepatocytes.\u201d Archives of Toxicology 87 (1): 167\u201378. https:\/\/doi.org\/10.1007\/S00204-012-0913-4.","DOI":"10.1007\/s00204-012-0913-4"},{"key":"10.1016\/j.steroids.2026.109746_b0380","series-title":"Food and Chemical Toxicology: an International Journal Published for the British Industrial Biological Research Association 153 (july)","article-title":"Hepatotoxic evaluation of toosendanin via biomarker quantification and pathway mapping of large-scale chemical proteomics","author":"Zhuo","year":"2021"},{"issue":"1","key":"10.1016\/j.steroids.2026.109746_b0404","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-44840-w","article-title":"Two Phase Kinetics of the Inflammatory Response from Hepatocyte-Peripheral Blood Mononuclear Cell Interactions","volume":"9","author":"Beringer","year":"2019","journal-title":"Scientific Reports"},{"key":"10.1016\/j.steroids.2026.109746_b0385","doi-asserted-by":"crossref","unstructured":"Laterza, Lucrezia, Anna Chiara Piscaglia, Stefano Bibb\u00f2, Vincenzo Arena, Massimo Brisigotti, Giovanna Fabbretti, Maria Loredana Stefanelli, et al. 2024. \u201cHistologic Disease Persists beyond Mucosal Healing and Could Predict Reactivation in Ulcerative Colitis.\u201d Journal of Personalized Medicine 2024, Vol. 14, Page 505 14 (5): 505. https:\/\/doi.org\/10.3390\/JPM14050505.","DOI":"10.3390\/jpm14050505"},{"key":"10.1016\/j.steroids.2026.109746_b0405","doi-asserted-by":"crossref","unstructured":"TATAR, Musa, and Kiymet Kubra T\u00dcFEKC\u0130. 2023. \u201cOleuropein Attenuates Placental Growth Factor Expression by Regulating Oxidative Stress and Apoptosis in Acrylamide Hepatotoxicity.\u201d Mehmet Akif Ersoy \u00dcniversitesi Veteriner Fak\u00fcltesi Dergisi 8 (2): 104\u201311. https:\/\/doi.org\/10.24880\/MAEUVFD.1240829.","DOI":"10.24880\/maeuvfd.1240829"},{"key":"10.1016\/j.steroids.2026.109746_b0390","doi-asserted-by":"crossref","unstructured":"Fernando, Pincha Devage Sameera Madushan, Dong Ok Ko, Mei Jing Piao, Kyoung Ah Kang, Herath Mudiyanselage Udari Lakmini Herath, and Jin Won Hyun. 2024. \u201cProtective Effect of Luteolin against Oxidative Stress\u2011mediated Cell Injury via Enhancing Antioxidant Systems.\u201d Molecular Medicine Reports 30 (1). https:\/\/doi.org\/10.3892\/MMR.2024.13244.","DOI":"10.3892\/mmr.2024.13244"}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X26000085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X26000085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T19:35:14Z","timestamp":1769801714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X26000085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":85,"alternative-id":["S0039128X26000085"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2026.109746","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The protective effects of luteolin and oleuropein against dexamethasone-induced hyperlipidemia","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2026.109746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109746"}}