{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:49:24Z","timestamp":1786117764256,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006087","name":"National Autonomous University of Mexico Directorate General of Academic Staff Affairs","doi-asserted-by":"publisher","award":["IN202026"],"award-info":[{"award-number":["IN202026"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Steroids"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.steroids.2026.109818","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:51:31Z","timestamp":1780717891000},"page":"109818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Synthesis NMR characterization and X-ray structure of \u03b1,\u03b2-unsaturated steroid spiroketal lactones. evaluation of cytotoxicity and anti-inflammatory activity"],"prefix":"10.1016","volume":"233-234","author":[{"given":"Juan E.","family":"Hern\u00e1ndez-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimsi","family":"Campos-Xolalpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salud","family":"P\u00e9rez-Guti\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Flores-\u00c1lamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn A.","family":"Iglesias-Arteaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.steroids.2026.109818_bb0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4939-7183-1_2","article-title":"Chemical pathways of corticosteroids, industrial synthesis from sapogenins","volume":"1645","author":"Herr\u00e1iz","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.steroids.2026.109818_bb0010","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0039-128X(92)90016-3","article-title":"Steroid research at Syntex: \u201cthe pill\u201d and cortisone","volume":"57","author":"Djerassi","year":"1992","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2026.109818_bb0015","series-title":"Steroids made it possible","author":"Djerassi","year":"1990"},{"key":"10.1016\/j.steroids.2026.109818_bb0020","doi-asserted-by":"crossref","first-page":"10356","DOI":"10.1002\/chem.200901732","article-title":"Expeditious synthesis of hippuristanol and congeners with potent antiproliferative activities","volume":"15","author":"Li","year":"2009","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.steroids.2026.109818_bb0025","first-page":"153","article-title":"Morzycki, Cephalostatins and ritterazines","volume":"72","author":"Iglesias-Arteaga","year":"2013","journal-title":"Alkaloids: Chem. Biol."},{"key":"10.1016\/j.steroids.2026.109818_bb0030","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.steroids.2017.08.017","article-title":"Synthesis and in vitro anticancer activity of 23(23\u2032)E-benzylidenespirostanols derived from steroid sapogenins","volume":"128","author":"Ramos-Enr\u00edquez","year":"2017","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2026.109818_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2023.109286","article-title":"Synthesis, NMR characterization and cytotoxic activity of hybrid spirostanic sapogenins-estradiol dimers","volume":"199","author":"Ramos-Enr\u00edquez","year":"2023","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2026.109818_bb0040","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.steroids.2015.03.013","article-title":"Synthesis and radical scavenger properties of novel spirochromenes derived from steroid sapogenins","volume":"98","author":"Ramos-Enr\u00edquez","year":"2015","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2026.109818_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2022.109110","article-title":"An unexpected acid-catalyzed rearrangement of diacetoxy benzylidenespirostanes to spirochromene acetals and spiroindenes with radical scavenger activity","volume":"188","author":"Ramos-Enr\u00edquez","year":"2022","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2026.109818_bb0050","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.steroids.2012.02.016","article-title":"BF3\u00b7Et2O-induced stereoselective aldol reaction with benzaldehyde and steroid sapogenins and its application to a convenient synthesis of dinorcholanic lactones","volume":"77","author":"Ru\u00edz-P\u00e9rez","year":"2012","journal-title":"Steroids"},{"key":"10.1016\/j.steroids.2026.109818_bb0055","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1016\/j.tetlet.2014.04.042","article-title":"Synthesis of novel steroids bearing a spirochromene side chain by BF3\u00b7Et2O-catalyzed aldol condensation of spirostane sapogenins and salicylaldehyde","volume":"55","author":"Ramos-Enr\u00edquez","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.steroids.2026.109818_bb0060","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1055\/s-0040-1708018","article-title":"BF3\u00b7OEt2-catalyzed aldol condensation of steroid sapogenins and 2-oxoacids: a single-step conversion of steroid spiroketals into branched \u03b1,\u03b2-unsaturated spirolactones","volume":"52","author":"Hern\u00e1ndez-Mart\u00ednez","year":"2020","journal-title":"Synthesis"},{"key":"10.1016\/j.steroids.2026.109818_bb0065","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1055\/a-2093-3333","article-title":"Palladium-catalyzed synthesis of benzofuran spiroketals derived from cholesterol; NMR and X-ray characterization","volume":"55","author":"Garcia-Santos","year":"2023","journal-title":"Synthesis"},{"key":"10.1016\/j.steroids.2026.109818_bb0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.steroids.2026.109818_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor necrosis factor-\u03b1 signaling in macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.steroids.2026.109818_bb0080","series-title":"Efecto sin\u00e9rgico de la casiope\u00edna II Gly con drogas empleadas en el sector cl\u00ednico sobre la proliferaci\u00f3n del c\u00e1ncer cervicouterino (CCU) de HeLa","author":"Robledo Cadena","year":"2016"},{"key":"10.1016\/j.steroids.2026.109818_bb0085","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The L-arginine\u2013nitric oxide pathway","volume":"329","author":"Moncada","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.steroids.2026.109818_bb0090","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","article-title":"Inflammation and tumor progression: signaling pathways and targeted intervention","volume":"6","author":"Zhao","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.steroids.2026.109818_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10735-025-10402-w","article-title":"Evaluating TGF-\u03b21 gene expression and promoter polymorphism in cervical cancer progression","volume":"56","author":"Poleboyina","year":"2025","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.steroids.2026.109818_bb0100","first-page":"322","article-title":"Global burden of cervical cancer: current estimates, temporal trend and future projections based on the GLOBOCAN 2022","volume":"5","author":"Wu","year":"2025","journal-title":"J. Natl. Cancer Cent."}],"container-title":["Steroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X26000802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039128X26000802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:27:18Z","timestamp":1786026438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039128X26000802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":20,"alternative-id":["S0039128X26000802"],"URL":"https:\/\/doi.org\/10.1016\/j.steroids.2026.109818","relation":{},"ISSN":["0039-128X"],"issn-type":[{"value":"0039-128X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis NMR characterization and X-ray structure of \u03b1,\u03b2-unsaturated steroid spiroketal lactones. evaluation of cytotoxicity and anti-inflammatory activity","name":"articletitle","label":"Article Title"},{"value":"Steroids","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.steroids.2026.109818","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109818"}}