{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:09:13Z","timestamp":1791014953649,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3180,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004588","name":"Istituto Pasteur-Fondazione Cenci Bolognetti","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004588","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["QLK3-CT-2002-02071"],"award-info":[{"award-number":["QLK3-CT-2002-02071"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.str.2004.09.007","type":"journal-article","created":{"date-parts":[[2004,11,10]],"date-time":"2004-11-10T11:57:13Z","timestamp":1100087833000},"page":"2001-2008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Insights into DNA Replication"],"prefix":"10.1016","volume":"12","author":[{"given":"Carmelinda","family":"Savino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Federici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Vallone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Nastopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mos\u00e8","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca M.","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius","family":"Tsernoglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2004.09.007_BIB1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0959-440X(95)80006-M","article-title":"Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates","volume":"5","author":"Arnold","year":"1995","journal-title":"Curr. Opin. Struct. Biol"},{"key":"10.1016\/j.str.2004.09.007_BIB2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.biochem.70.1.181","article-title":"Replisome-mediated DNA replication","volume":"70","author":"Benkovic","year":"2001","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.str.2004.09.007_BIB3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1093\/nar\/21.4.787","article-title":"Compilation, alignment, and phylogenetic relationships of DNA polymerases","volume":"21","author":"Braithwaite","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.str.2004.09.007_BIB4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","article-title":"Crystallography & NMR system","volume":"54","author":"Br\u00fcnger","year":"1998","journal-title":"Acta Crystallogr. D Biol. Crystallogr"},{"key":"10.1016\/j.str.2004.09.007_BIB5","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1126\/science.8036511","article-title":"Conserved structures and diversity of functions of RNA-binding proteins","volume":"265","author":"Burd","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.str.2004.09.007_BIB6","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/genetics\/152.4.1249","article-title":"Archaeal DNA replication","volume":"152","author":"Cann","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.str.2004.09.007_BIB7","first-page":"760","article-title":"The (Collaborative Computational Project 4, Number 4) CCP4 suite","volume":"50","author":"CCP4","year":"1994","journal-title":"Acta Crystallogr. D Biol. Crystallogr"},{"key":"10.1016\/j.str.2004.09.007_BIB8","doi-asserted-by":"crossref","first-page":"10881","DOI":"10.1093\/nar\/16.22.10881","article-title":"Multiple sequence alignment with hierarchical clustering","volume":"16","author":"Corpet","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.str.2004.09.007_BIB9","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0079-6107(99)00008-5","article-title":"Density modification for macromolecular phase improvement","volume":"72","author":"Cowtan","year":"1999","journal-title":"Prog. Biophys. Mol. Biol"},{"key":"10.1016\/j.str.2004.09.007_BIB10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/protein\/3.6.461","article-title":"An attempt to unify the structure of polymerases","volume":"3","author":"Delarue","year":"1990","journal-title":"Protein Eng"},{"key":"10.1016\/j.str.2004.09.007_BIB11","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1016\/S0969-2126(99)80017-3","article-title":"An open and closed case for all polymerases","volume":"7","author":"Doubli\u00e8","year":"1999","journal-title":"Structure"},{"key":"10.1016\/j.str.2004.09.007_BIB12","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/nsb867","article-title":"Structural basis for uracil recognition by archaeal family B DNA polymerases","volume":"9","author":"Fogg","year":"2002","journal-title":"Nat. Struct. Biol"},{"key":"10.1016\/j.str.2004.09.007_BIB13","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0092-8674(01)00367-1","article-title":"Structure of the replicating complex of a pol alpha family DNA polymerase","volume":"105","author":"Franklin","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.str.2004.09.007_BIB14","doi-asserted-by":"crossref","first-page":"9045","DOI":"10.1073\/pnas.96.16.9045","article-title":"A read-ahead function in archaeal DNA polymerases detects promutagenic template-strand uracil","volume":"96","author":"Greagg","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2004.09.007_BIB15","doi-asserted-by":"crossref","first-page":"4024","DOI":"10.1093\/nar\/gkg447","article-title":"Processing of DNA lesions by archaeal DNA polymerases from Sulfolobus solfataricus","volume":"31","author":"Gruz","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.str.2004.09.007_BIB16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/jmbi.2000.4403","article-title":"Crystal structure of DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis KOD1","volume":"306","author":"Hashimoto","year":"2001","journal-title":"J. Mol. Biol"},{"key":"10.1016\/j.str.2004.09.007_BIB17","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1073\/pnas.96.7.3600","article-title":"Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius","volume":"96","author":"Hopfner","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2004.09.007_BIB18","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1146\/annurev.bi.63.070194.004021","article-title":"Function and structure relationships in DNA polymerases","volume":"63","author":"Joyce","year":"1994","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.str.2004.09.007_BIB19","doi-asserted-by":"crossref","first-page":"16895","DOI":"10.1074\/jbc.R400006200","article-title":"DNA replication fidelity","volume":"279","author":"Kunkel","year":"2004","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.str.2004.09.007_BIB20","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1006\/jmbi.1993.1351","article-title":"Main-chain bond lengths and bond angles in protein structures","volume":"231","author":"Laskowski","year":"1993","journal-title":"J. Mol. Biol"},{"key":"10.1016\/j.str.2004.09.007_BIB21","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1107\/S0907444998002443","article-title":"Crystallization and preliminary X-ray diffraction studies of DNA polymerase from the thermophilic archaeon Sulfolobus solfataricus","volume":"54","author":"Nastopoulos","year":"1998","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.str.2004.09.007_BIB22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1097-2765(01)00278-7","article-title":"The Y-family of DNA polymerases","volume":"8","author":"Ohmori","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2004.09.007_BIB23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinoski","year":"1997","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.str.2004.09.007_BIB24","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1093\/nar\/28.23.4657","article-title":"Nucleotide-sequence-specific and non-specific interaction of T4 polymerases with its own mRNA","volume":"28","author":"Pavlov","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.str.2004.09.007_BIB25","doi-asserted-by":"crossref","first-page":"7887","DOI":"10.1016\/S0021-9258(17)37134-X","article-title":"Evidence that an archaeal alpha-like DNA polymerase has a modular organization of its associated catalytic activities","volume":"269","author":"Pisani","year":"1994","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.str.2004.09.007_BIB26","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1093\/nar\/20.11.2711","article-title":"A DNA polymerase from the archaeon Sulfolobus solfataricus shows sequence similarity to family B DNA polymerases","volume":"20","author":"Pisani","year":"1992","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.str.2004.09.007_BIB27","doi-asserted-by":"crossref","first-page":"9158","DOI":"10.1021\/bi960446l","article-title":"Domain organization and DNA-induced conformational changes of an archaeal family B DNA polymerase","volume":"35","author":"Pisani","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2004.09.007_BIB28","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/jmbi.2000.3728","article-title":"Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7","volume":"299","author":"Rodriguez","year":"2000","journal-title":"J. Mol. Biol"},{"key":"10.1016\/j.str.2004.09.007_BIB29","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0092-8674(00)81647-5","article-title":"Building a replisome from interacting pieces","volume":"99","author":"Shamoo","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.str.2004.09.007_BIB30","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0969-2126(00)80053-2","article-title":"Crystal structure of an archaebacterial DNA polymerase","volume":"7","author":"Zhao","year":"1999","journal-title":"Structure"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212604003338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212604003338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:19:32Z","timestamp":1760840372000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212604003338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0969212604003338"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2004.09.007","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Insights into DNA Replication","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2004.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}