{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:00:45Z","timestamp":1772121645592,"version":"3.50.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2358,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Structure"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.str.2007.01.005","type":"journal-article","created":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T15:45:54Z","timestamp":1176911154000},"page":"215-224","source":"Crossref","is-referenced-by-count":55,"title":["Prediction of Protein-Protein Association Rates from a Transition-State Theory"],"prefix":"10.1016","volume":"15","author":[{"given":"Ramzi","family":"Alsallaq","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2007.01.005_bib1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/20726","article-title":"Structure of Cdc42 in complex with the GTPase-binding domain of the \u2018Wiskott-Aldrich syndrome\u2019 protein","volume":"399","author":"Abdul-Manan","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.str.2007.01.005_bib2","doi-asserted-by":"crossref","DOI":"10.1529\/biophysj.106.096024","article-title":"Energy landscape and transition state of protein-protein association","author":"Alsallaq","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/35011000","article-title":"A surprising simplicity to protein folding","volume":"405","author":"Baker","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.str.2007.01.005_bib4","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics of nanosystems: application to microtubules and the ribosome","volume":"98","author":"Baker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2007.01.005_bib5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0092-8674(95)90128-0","article-title":"Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex","volume":"83","author":"Bourne","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.str.2007.01.005_bib6","doi-asserted-by":"crossref","first-page":"7524","DOI":"10.1073\/pnas.84.21.7524","article-title":"Spin-glasses and the statistical-mechanics of protein folding","volume":"84","author":"Bryngelson","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2007.01.005_bib7","doi-asserted-by":"crossref","first-page":"8878","DOI":"10.1021\/bi00196a004","article-title":"Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-\u00c5 resolution","volume":"33","author":"Buckle","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2007.01.005_bib8","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1006\/jmbi.1993.1414","article-title":"Protein unfolding pathways explored through molecular-dynamics simulations","volume":"232","author":"Daggett","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib9","doi-asserted-by":"crossref","first-page":"14524","DOI":"10.1021\/bi0265022","article-title":"Glycosylation of erythropoietin affects receptor binding kinetics: role of electrostatic interactions","volume":"41","author":"Darling","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2007.01.005_bib10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/nsb0197-10","article-title":"From Levinthal to pathways to funnels","volume":"4","author":"Dill","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/prot.21070","article-title":"Electrostatic contribution to the binding stability of protein-protein complexes","volume":"65","author":"Dong","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.str.2007.01.005_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0006-3495(03)74453-1","article-title":"Comparison of calculation and experiment implicates significant electrostatic contributions to the binding stability of barnase and barstar","volume":"85","author":"Dong","year":"2003","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.280.5360.69","article-title":"The structure of the potassium channel: molecular basis of K+ conduction and selectivity","volume":"280","author":"Doyle","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.str.2007.01.005_bib14","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1126\/science.282.5389.740","article-title":"Pathways to a protein folding intermediate observed in a 1-microsecond simulation in aqueous solution","volume":"282","author":"Duan","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.str.2007.01.005_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/jmbi.1999.2919","article-title":"Computer simulation of protein-protein association kinetics: acetylcholinesterase-fasciculin","volume":"291","author":"Elcock","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib16","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1063\/1.436761","article-title":"Brownian dynamics with hydrodynamic interactions","volume":"69","author":"Ermak","year":"1978","journal-title":"J. Chem. Physiol."},{"key":"10.1016\/j.str.2007.01.005_bib17","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1016\/S0006-3495(02)75309-5","article-title":"Brownian dynamics simulation of rigid particles of arbitrary shape in external fields","volume":"83","author":"Fernandes","year":"2002","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/jmbi.2001.4577","article-title":"Experimental assignment of the structure of the transition state for the association of barnase and barstar","volume":"308","author":"Frisch","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib19","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/S0006-3495(97)78838-6","article-title":"Simulation of the diffusional association of barnase and barstar","volume":"72","author":"Gabdoulline","year":"1997","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib20","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1006\/jmbi.2000.4404","article-title":"Protein-protein association: investigation of factors influencing association rates by Brownian dynamics simulations","volume":"306","author":"Gabdoulline","year":"2001","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/1097-0134(20010215)42:3<345::AID-PROT50>3.0.CO;2-H","article-title":"Exploring the energy landscape of a \u03b2 hairpin in explicit solvent","volume":"42","author":"Garcia","year":"2001","journal-title":"Proteins"},{"key":"10.1016\/j.str.2007.01.005_bib22","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1529\/biophysj.106.085936","article-title":"A Brownian Dynamics study of the interactions of the luminal domains of the cytochrome b6f complex with plastocyanin and cytochrome c6: the effects of the Rieske FeS protein on the interactions","volume":"91","author":"Haddadian","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0092-8674(00)80736-9","article-title":"Crystal structure of the interleukin-4\/receptor \u03b1 chain complex reveals a mosaic binding interface","volume":"97","author":"Hage","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.str.2007.01.005_bib24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molcel.2005.08.036","article-title":"An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins","volume":"20","author":"Hemsath","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2007.01.005_bib25","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1529\/biophysj.106.082891","article-title":"Similarity and difference in the unfolding of thermophilic and mesophilic cold shock proteins studied by molecular dynamics simulations","volume":"91","author":"Huang","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib26","doi-asserted-by":"crossref","first-page":"6836","DOI":"10.1021\/ja042641q","article-title":"Electrostatic recognition and induced fit in the \u03ba-PVIIA toxin binding to Shaker potassium channel","volume":"127","author":"Huang","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.str.2007.01.005_bib27","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1073\/pnas.93.6.2343","article-title":"Protein-protein interaction:\u00a0a genetic selection for compensating mutations at the barnase-barstar interface","volume":"93","author":"Jucovic","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2007.01.005_bib28","series-title":"Proteins, Amino Acids and Peptides as\u00a0Ions and Dipolar Ions","first-page":"586","article-title":"The theoretical interpretation of the properties of solutions of dipolar ions","author":"Kirkwood","year":"1943"},{"key":"10.1016\/j.str.2007.01.005_bib29","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1006\/jmbi.2000.3945","article-title":"Specificity in protein-protein interactions: the structural basis for dual recognition in endonuclease colicin-immunity protein complexes","volume":"301","author":"Kuhlmann","year":"2000","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib30","doi-asserted-by":"crossref","first-page":"7529","DOI":"10.1021\/jp045417w","article-title":"Simulation of electron transfer between cytochrome C2 and the bacterial photosynthetic reaction center: Brownian dynamics analysis of the native proteins and double mutants","volume":"109","author":"Lin","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.str.2007.01.005_bib31","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1093\/nar\/29.13.2860","article-title":"Amino acid-base interactions: a three-dimensional analysis of protein\u2013DNA interactions at an atomic level","volume":"29","author":"Luscombe","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2007.01.005_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0010-4655(95)00043-F","article-title":"Electrostatics and diffusion of molecules in solution: simulations with the University of Houston Brownian Dynamics program","volume":"91","author":"Madura","year":"1995","journal-title":"Comput. Phys. Comm."},{"key":"10.1016\/j.str.2007.01.005_bib33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/35050590","article-title":"Interaction of WASP\/Scar proteins with actin and vertebrate Arp2\/3 complex","volume":"3","author":"Marchand","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.str.2007.01.005_bib34","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/nature01428","article-title":"The complete folding pathway of a protein from nanoseconds to microseconds","volume":"421","author":"Mayor","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.str.2007.01.005_bib35","doi-asserted-by":"crossref","first-page":"16174","DOI":"10.1073\/pnas.0405745101","article-title":"Transition state and encounter complex for fast association of cytochrome c2 with bacterial reaction center","volume":"101","author":"Miyashita","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2007.01.005_bib36","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/36626","article-title":"Folding dynamics and mechanism of \u03b2-hairpin formation","volume":"390","author":"Munoz","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.str.2007.01.005_bib37","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1073\/pnas.89.8.3338","article-title":"Kinetics of protein-protein association explained by Brownian dynamics computer simulation","volume":"89","author":"Northrup","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2007.01.005_bib38","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1146\/annurev.physchem.48.1.545","article-title":"Theory of protein folding: the energy landscape perspective","volume":"48","author":"Onuchic","year":"1997","journal-title":"Annu. Rev. Phys. Chem."},{"key":"10.1016\/j.str.2007.01.005_bib39","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1006\/jmbi.1997.1081","article-title":"Importance of electrostatic interactions in the rapid binding of polypeptides to GroEL","volume":"269","author":"Perrett","year":"1997","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib40","doi-asserted-by":"crossref","first-page":"23265","DOI":"10.1074\/jbc.272.37.23265","article-title":"Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase","volume":"272","author":"Radic","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.str.2007.01.005_bib41","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1110\/ps.03517304","article-title":"Realistic protein-protein association rates from a simple diffusional model neglecting long-range interactions, free energy barriers, and landscape ruggedness","volume":"13","author":"Schlosshauer","year":"2004","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2007.01.005_bib42","doi-asserted-by":"crossref","first-page":"5145","DOI":"10.1021\/bi00070a025","article-title":"Interaction of barnase with its polypeptide inhibitor barstar studied by protein engineering","volume":"32","author":"Schreiber","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2007.01.005_bib43","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0022-2836(95)80064-6","article-title":"Energetics of protein-protein interactions: analysis of the barnase-barstar interface by single mutations and double mutant cycles","volume":"248","author":"Schreiber","year":"1995","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nsb0596-427","article-title":"Rapid, electrostatically assisted association of proteins","volume":"3","author":"Schreiber","year":"1996","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib45","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0969-2126(94)00096-4","article-title":"Stability and function: two constraints in the evolution of barstar and other proteins","volume":"2","author":"Schreiber","year":"1994","journal-title":"Structure"},{"key":"10.1016\/j.str.2007.01.005_bib46","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/prot.20489","article-title":"Exploring the charge space of protein\u2013protein association: a proteomic study","volume":"60","author":"Shaul","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.str.2007.01.005_bib47","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1432-1033.1996.0252h.x","article-title":"Global and local determinants for the kinetics of interleukin-4\/interleukin-4 receptor \u03b1 chain interaction. A biosensor study employing recombinant interleukin-4-binding protein","volume":"240","author":"Shen","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.str.2007.01.005_bib48","doi-asserted-by":"crossref","first-page":"11258","DOI":"10.1021\/ja0273851","article-title":"All-atom structure prediction and folding simulations of a stable protein","volume":"124","author":"Simmerling","year":"2002","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.str.2007.01.005_bib49","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature01160","article-title":"Absolute comparison of simulated and experimental protein-folding dynamics","volume":"420","author":"Snow","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.str.2007.01.005_bib50","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1529\/biophysj.105.075507","article-title":"Diffusional encounter of barnase and barstar","volume":"90","author":"Spaar","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib51","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/381148a0","article-title":"Strategy for rapid immobilization of prey by a fish-hunting marine snail","volume":"381","author":"Terlau","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.str.2007.01.005_bib52","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkm008","article-title":"Dros. Inf. Serv.PLAR: an accurate method for predicting DNA-binding sites on protein surfaces","author":"Tjong","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2007.01.005_bib53","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1006\/jmbi.1998.1747","article-title":"Electrostatic enhancement of diffusion-controlled protein-protein association: comparison of theory and experiment on barnase and barstar","volume":"278","author":"Vijayakumar","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib54","doi-asserted-by":"crossref","first-page":"13743","DOI":"10.1021\/bi00042a004","article-title":"Protein-protein interactions in colicin E9 DNase-immunity protein complexes. 1. Diffusion-controlled association and femtomolar binding for the cognate complex","volume":"34","author":"Wallis","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2007.01.005_bib55","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1021\/bi971884a","article-title":"Specificity in protein-protein recognition: conserved Im9 residues are the major determinations of stability in\u00a0the colicin E9 Dnase-Im9 complex","volume":"37","author":"Wallis","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2007.01.005_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.93.1.1","article-title":"Binding in the growth hormone receptor complex","volume":"93","author":"Wells","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2007.01.005_bib57","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0006-3495(93)81543-1","article-title":"Brownian dynamics study of the influences of electrostatic interaction and diffusion on protein-protein association kinetics","volume":"64","author":"Zhou","year":"1993","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib58","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1016\/S0006-3495(95)80100-1","article-title":"Calculation of translational friction and intrinsic viscosity. II. Application to globular proteins","volume":"69","author":"Zhou","year":"1995","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib59","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1063\/1.472530","article-title":"Effect of interaction potentials in diffusion-influenced reactions with small reactive regions","volume":"105","author":"Zhou","year":"1996","journal-title":"J. Chem. Physiol."},{"key":"10.1016\/j.str.2007.01.005_bib60","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1016\/S0006-3495(97)78272-9","article-title":"Enhancement of protein-protein association rate by interaction potential: accuracy of prediction based on local Boltzmann factor","volume":"73","author":"Zhou","year":"1997","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib61","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/1097-0282(200111)59:6<427::AID-BIP1047>3.0.CO;2-7","article-title":"Disparate ionic-strength dependencies of on and off rates in protein\u2013protein association","volume":"59","author":"Zhou","year":"2001","journal-title":"Biopolymers"},{"key":"10.1016\/j.str.2007.01.005_bib62","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1110\/ps.03216203","article-title":"Association and dissociation kinetics of colicin E3 and immunity protein 3: convergence of theory and experiment","volume":"12","author":"Zhou","year":"2003","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2007.01.005_bib63","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1088\/1478-3975\/2\/3\/R01","article-title":"How do biomolecular systems speed up and regulate rates of processes?","volume":"2","author":"Zhou","year":"2005","journal-title":"Phys. Biol."},{"key":"10.1016\/j.str.2007.01.005_bib64","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/prot.20500","article-title":"Interactions of macromolecules with salt ions: an electrostatic theory for the Hofmeister effect","volume":"61","author":"Zhou","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.str.2007.01.005_bib65","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/S0006-3495(96)79437-7","article-title":"Theory and simulation of the time-dependent rate coefficients of diffusion-influenced reactions","volume":"71","author":"Zhou","year":"1996","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2007.01.005_bib66","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.1073\/pnas.94.23.12372","article-title":"Design of fast enzymes by optimizing interaction potential in active site","volume":"94","author":"Zhou","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2007.01.005_bib67","doi-asserted-by":"crossref","first-page":"9280","DOI":"10.1073\/pnas.95.16.9280","article-title":"Conformation gating as a mechanism for enzyme specificity","volume":"95","author":"Zhou","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2007.01.005_bib68","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/S0006-3495(03)74641-4","article-title":"Robust biased Brownian dynamics for rate constant calculation","volume":"85","author":"Zou","year":"2003","journal-title":"Biophys. J."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212607000342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212607000342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T23:20:28Z","timestamp":1546903228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212607000342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0969212607000342"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2007.01.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717968026.793467691","asserted-by":"object"}]},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}