{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:54:38Z","timestamp":1792497278741,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":685,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Structure"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.str.2011.06.014","type":"journal-article","created":{"date-parts":[[2011,9,2]],"date-time":"2011-09-02T15:46:24Z","timestamp":1314978384000},"page":"1283-1293","source":"Crossref","is-referenced-by-count":542,"title":["Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine"],"prefix":"10.1016","volume":"19","author":[{"given":"Andrew\u00a0S.","family":"Dor\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James\u00a0C.","family":"Errey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Hollenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Tehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Hurrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstie","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles","family":"Congreve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Magnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher\u00a0G.","family":"Tate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Weir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona\u00a0H.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2011.06.014_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2011.06.014_bib2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"The CCP4 suite: programs for protein crystallography","volume":"50","year":"1994","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2011.06.014_bib3","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1126\/science.1150577","article-title":"High-resolution crystal structure of an engineered human \u03b22-adrenergic G protein-coupled receptor","volume":"318","author":"Cherezov","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.str.2011.06.014_bib4","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1126\/science.1197410","article-title":"Structure of the human dopamine D3 receptor in complex with a D2\/D3 selective antagonist","volume":"330","author":"Chien","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.str.2011.06.014_bib5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.2174\/156802610791293145","article-title":"Adenosine receptor modeling: what does the A2A crystal structure tell us?","volume":"10","author":"Dal Ben","year":"2010","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.str.2011.06.014_bib6","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s00018-007-7051-9","article-title":"Caffeine analogs: biomedical impact","volume":"64","author":"Daly","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.str.2011.06.014_bib7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.physiol.69.022405.154749","article-title":"Beta-arrestins and cell signaling","volume":"69","author":"DeWire","year":"2007","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.str.2011.06.014_bib8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2011.06.014_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","article-title":"Scaling and assessment of data quality","volume":"62","author":"Evans","year":"2006","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2011.06.014_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1124\/pr.110.003285","article-title":"International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors\u2014an update","volume":"63","author":"Fredholm","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.str.2011.06.014_bib11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.bi.56.070187.003151","article-title":"G proteins: transducers of receptor-generated signals","volume":"56","author":"Gilman","year":"1987","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.str.2011.06.014_bib12","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1021\/jm801533x","article-title":"Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure","volume":"52","author":"Ivanov","year":"2009","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.str.2011.06.014_bib13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.sbi.2010.05.002","article-title":"The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design","volume":"20","author":"Jaakola","year":"2010","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.str.2011.06.014_bib14","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1126\/science.1164772","article-title":"The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist","volume":"322","author":"Jaakola","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.str.2011.06.014_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nrd1983","article-title":"Adenosine receptors as therapeutic targets","volume":"5","author":"Jacobson","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.str.2011.06.014_bib16","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1517\/13543784.14.6.729","article-title":"Istradefylline, a novel adenosine A2A receptor antagonist, for the treatment of Parkinson's disease","volume":"14","author":"Jenner","year":"2005","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.str.2011.06.014_bib17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0026-895X(25)09303-4","article-title":"Hydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognition","volume":"50","author":"Jiang","year":"1996","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.str.2011.06.014_bib18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1107\/S0907444909047374","article-title":"Integration, scaling, space-group assignment and post-refinement","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2011.06.014_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/prot.22507","article-title":"GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex","volume":"78","author":"Katritch","year":"2010","journal-title":"Proteins"},{"key":"10.1016\/j.str.2011.06.014_bib20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tips.2004.02.012","article-title":"Principles: receptor theory in pharmacology","volume":"25","author":"Kenakin","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.str.2011.06.014_bib21","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1021\/jm0300431","article-title":"Modeling the adenosine receptors: comparison of the binding domains of A2A agonists and antagonists","volume":"46","author":"Kim","year":"2003","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.str.2011.06.014_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jmb.2011.03.075","article-title":"Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor","volume":"409","author":"Lebon","year":"2011","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2011.06.014_bib23","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nature10136","article-title":"Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation","volume":"474","author":"Lebon","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.str.2011.06.014_bib24","doi-asserted-by":"crossref","first-page":"10744","DOI":"10.1073\/pnas.0804396105","article-title":"Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor","volume":"105","author":"Magnani","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2011.06.014_bib25","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Cryst."},{"key":"10.1016\/j.str.2011.06.014_bib26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrd2877","article-title":"Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008","volume":"8","author":"Michino","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.str.2011.06.014_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-3-642-13443-2_6","article-title":"Xanthines as adenosine receptor antagonists","volume":"200","author":"M\u00fcller","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.str.2011.06.014_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature06925","article-title":"Crystal structure of squid rhodopsin","volume":"453","author":"Murakami","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.str.2011.06.014_bib29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.289.5480.739","article-title":"Crystal structure of rhodopsin: a G protein-coupled receptor","volume":"289","author":"Palczewski","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.str.2011.06.014_bib30","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1476-5381.1995.tb15923.x","article-title":"The in\u00a0vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist","volume":"115","author":"Poucher","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.str.2011.06.014_bib31","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nature06325","article-title":"Crystal structure of the human \u03b22 adrenergic G-protein-coupled receptor","volume":"450","author":"Rasmussen","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.str.2011.06.014_bib32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nature09648","article-title":"Structure of a nanobody-stabilized active state of the \u03b2(2) adrenoceptor","volume":"469","author":"Rasmussen","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.str.2011.06.014_bib33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuropharm.2010.07.001","article-title":"The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery","volume":"60","author":"Robertson","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.str.2011.06.014_bib34","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1126\/science.1150609","article-title":"GPCR engineering yields high-resolution structural insights into \u03b22-adrenergic receptor function","volume":"318","author":"Rosenbaum","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.str.2011.06.014_bib35","first-page":"723","article-title":"Preladenant, a novel adenosine A(2A) receptor antagonist for the potential treatment of parkinsonism and other disorders","volume":"13","author":"Salamone","year":"2010","journal-title":"IDrugs"},{"key":"10.1016\/j.str.2011.06.014_bib36","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature07330","article-title":"Crystal structure of opsin in its G-protein-interacting conformation","volume":"455","author":"Scheerer","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.str.2011.06.014_bib37","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1073\/pnas.0711253105","article-title":"Conformational thermostabilization of the \u03b21-adrenergic receptor in a detergent-resistant form","volume":"105","author":"Serrano-Vega","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2011.06.014_bib38","first-page":"466","article-title":"Recent progress in the discovery of adenosine A(2A) receptor antagonists for the treatment of Parkinson's disease","volume":"13","author":"Shah","year":"2010","journal-title":"Curr. Opin. Drug Discov. Devel."},{"key":"10.1016\/j.str.2011.06.014_bib39","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jmb.2009.04.068","article-title":"Thermostabilization of the neurotensin receptor NTS1","volume":"390","author":"Shibata","year":"2009","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2011.06.014_bib40","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1073\/pnas.78.5.3260","article-title":"Adenosine receptors and behavioral actions of methylxanthines","volume":"78","author":"Snyder","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2011.06.014_bib41","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature09795","article-title":"The structural basis of agonist-induced activation in constitutively active rhodopsin","volume":"471","author":"Standfuss","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.str.2011.06.014_bib42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-60761-344-2_12","article-title":"Practical considerations of membrane protein instability during purification and crystallization","volume":"601","author":"Tate","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.str.2011.06.014_bib43","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.sbi.2009.07.004","article-title":"Engineering G protein-coupled receptors to facilitate their structure determination","volume":"19","author":"Tate","year":"2009","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.str.2011.06.014_bib44","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.jmb.2008.05.022","article-title":"Functional role of the \u201cionic lock\u201d\u2014an interhelical hydrogen-bond network in family A heptahelical receptors","volume":"380","author":"Vogel","year":"2008","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2011.06.014_bib45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/protein\/8.2.127","article-title":"LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions","volume":"8","author":"Wallace","year":"1995","journal-title":"Protein Eng."},{"key":"10.1016\/j.str.2011.06.014_bib46","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nature07101","article-title":"Structure of a beta1-adrenergic G-protein-coupled receptor","volume":"454","author":"Warne","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.str.2011.06.014_bib47","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature09746","article-title":"The structural basis for agonist and partial agonist action on a \u03b2(1)-adrenergic receptor","volume":"469","author":"Warne","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.str.2011.06.014_bib48","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.1194396","article-title":"Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists","volume":"330","author":"Wu","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.str.2011.06.014_bib49","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1126\/science.1202793","article-title":"Structure of an agonist-bound human A2A adenosine receptor","volume":"332","author":"Xu","year":"2011","journal-title":"Science"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212611002383?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212611002383?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T14:22:35Z","timestamp":1741530155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212611002383"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0969212611002383"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2011.06.014","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}