{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:48:17Z","timestamp":1782100097381,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T00:00:00Z","timestamp":1389139200000},"content-version":"vor","delay-in-days":372,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Structure"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.str.2012.10.005","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T11:17:17Z","timestamp":1352978237000},"page":"167-175","source":"Crossref","is-referenced-by-count":47,"title":["A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen"],"prefix":"10.1016","volume":"21","author":[{"given":"Patricia","family":"Lassaux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Peri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Ferrer-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise\u00a0J.","family":"Gourlay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Conchillo-Sol\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darawan","family":"Rinchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganjana","family":"Lertmemongkolchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Longhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Daura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2012.10.005_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2012.10.005_bib2","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1107\/S0021889810015608","article-title":"phenix.model_vs_data: a high-level tool for the calculation of crystallographic model and data statistics","volume":"43","author":"Afonine","year":"2010","journal-title":"J.\u00a0Appl. Cryst."},{"key":"10.1016\/j.str.2012.10.005_bib3","doi-asserted-by":"crossref","first-page":"6269","DOI":"10.1021\/j100308a038","article-title":"The missing term in effective pair potentials","volume":"91","author":"Berendsen","year":"1987","journal-title":"J.\u00a0Phys. Chem."},{"key":"10.1016\/j.str.2012.10.005_bib4","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2012.10.005_bib5","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/pro.97","article-title":"Selenomethionine incorporation in proteins expressed in Lactococcus lactis","volume":"18","author":"Berntsson","year":"2009","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2012.10.005_bib6","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.1128\/IAI.68.12.7069-7077.2000","article-title":"OppA of Listeria monocytogenes, an oligopeptide-binding protein required for bacterial growth at low temperature and involved in intracellular survival","volume":"68","author":"Borezee","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2012.10.005_bib7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2012.10.005_bib8","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/CMR.18.2.383-416.2005","article-title":"Melioidosis: epidemiology, pathophysiology, and management","volume":"18","author":"Cheng","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.str.2012.10.005_bib9","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/prot.20804","article-title":"The determinants of stability in the human prion protein: insights into folding and misfolding from the analysis of the change in the stabilization energy distribution in different conditions","volume":"62","author":"Colacino","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.str.2012.10.005_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1472-6807-6-17","article-title":"Similar folds with different stabilization mechanisms: the cases of Prion and Doppel proteins","volume":"6","author":"Colacino","year":"2006","journal-title":"BMC Struct. Biol."},{"key":"10.1016\/j.str.2012.10.005_bib11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444994003112","article-title":"The CCP4 suite: programs for protein crystallography","volume":"50","year":"1994","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"issue":"Suppl 1","key":"10.1016\/j.str.2012.10.005_bib12","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0035-9203(08)70002-6","article-title":"The global distribution of Burkholderia pseudomallei and melioidosis: an update","volume":"102","author":"Currie","year":"2008","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.str.2012.10.005_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/(SICI)1521-3773(19990115)38:1\/2<236::AID-ANIE236>3.0.CO;2-M","article-title":"Peptide folding: when simulation meets experiment","volume":"38","author":"Daura","year":"1999","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.str.2012.10.005_bib14","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.tibtech.2008.08.002","article-title":"Structure-based antigen design: a strategy for next generation vaccines","volume":"26","author":"Dormitzer","year":"2008","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.str.2012.10.005_bib15","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/pro.5560041110","article-title":"Crystal structure of the dipeptide binding protein from Escherichia coli involved in active transport and chemotaxis","volume":"4","author":"Dunten","year":"1995","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2012.10.005_bib16","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2012.10.005_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","article-title":"Scaling and assessment of data quality","volume":"62","author":"Evans","year":"2006","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2012.10.005_bib18","doi-asserted-by":"crossref","first-page":"13499","DOI":"10.1073\/pnas.0812080106","article-title":"A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens","volume":"106","author":"Felgner","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2012.10.005_bib19","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/j.bpj.2009.12.4332","article-title":"Prediction of protein-protein interaction sites using electrostatic desolvation profiles","volume":"98","author":"Fiorucci","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2012.10.005_bib20","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1128\/IAI.72.12.6757-6763.2004","article-title":"ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies","volume":"72","author":"Garmory","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2012.10.005_bib21","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1021\/jp210568a","article-title":"Identification of domains in protein structures from the analysis of intramolecular interactions","volume":"116","author":"Genoni","year":"2012","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.str.2012.10.005_bib22","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1128\/IAI.00404-07","article-title":"Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis","volume":"75","author":"Harland","year":"2007","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2012.10.005_bib23","doi-asserted-by":"crossref","first-page":"5945","DOI":"10.1128\/IAI.73.9.5945-5951.2005","article-title":"Humoral and cell-mediated adaptive immune responses are required for protection against Burkholderia pseudomallei challenge and bacterial clearance postinfection","volume":"73","author":"Healey","year":"2005","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2012.10.005_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/ct700301q","article-title":"GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation","volume":"4","author":"Hess","year":"2008","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.str.2012.10.005_bib25","doi-asserted-by":"crossref","first-page":"14842","DOI":"10.1074\/jbc.M110.193623","article-title":"Structural and biochemical characterization of NarE, an iron-containing ADP-ribosyltransferase from Neisseria meningitidis","volume":"286","author":"Koehler","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2012.10.005_bib26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1107\/S0907444905039107","article-title":"The integration of macromolecular diffraction data","volume":"62","author":"Leslie","year":"2006","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2012.10.005_bib27","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jmb.2004.10.089","article-title":"The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide","volume":"345","author":"Levdikov","year":"2005","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2012.10.005_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1107\/S0907444906045975","article-title":"Solving structures of protein complexes by molecular replacement with Phaser","volume":"63","author":"McCoy","year":"2007","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2012.10.005_bib29","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1007\/s00018-003-3054-3","article-title":"Bacterial oligopeptide-binding proteins","volume":"60","author":"Monnet","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.str.2012.10.005_bib30","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/prot.21963","article-title":"Relationship between energy distribution and fold stability: insights from molecular dynamics simulations of native and mutant proteins","volume":"72","author":"Morra","year":"2008","journal-title":"Proteins"},{"key":"10.1016\/j.str.2012.10.005_bib31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2012.10.005_bib32","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1099\/jmm.0.45766-0","article-title":"Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis","volume":"53","author":"Nelson","year":"2004","journal-title":"J.\u00a0Med. Microbiol."},{"key":"10.1016\/j.str.2012.10.005_bib33","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1073\/pnas.1106590108","article-title":"Structure-based approach to rationally design a chimeric protein for an effective vaccine against Group B Streptococcus infections","volume":"108","author":"Nuccitelli","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2012.10.005_bib34","doi-asserted-by":"crossref","first-page":"17880","DOI":"10.1073\/pnas.1004728107","article-title":"Elicitation of structure-specific antibodies by epitope scaffolds","volume":"107","author":"Ofek","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2012.10.005_bib35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrd2224","article-title":"More than one reason to rethink the use of peptides in vaccine design","volume":"6","author":"Purcell","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.str.2012.10.005_bib36","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/prot.20493","article-title":"Determinants of protein stability and folding: comparative analysis of beta-lactoglobulins and liver basic fatty acid binding protein","volume":"61","author":"Ragona","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.str.2012.10.005_bib37","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.clinthera.2010.07.020","article-title":"Progress toward development of vaccines against melioidosis: a review","volume":"32","author":"Sarkar-Tyson","year":"2010","journal-title":"Clin. Ther."},{"key":"10.1016\/j.str.2012.10.005_bib38","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.bpj.2010.01.014","article-title":"Predicting interaction sites from the energetics of isolated proteins: a new approach to epitope mapping","volume":"98","author":"Scarabelli","year":"2010","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2012.10.005_bib39","doi-asserted-by":"crossref","first-page":"10029","DOI":"10.1073\/pnas.1107324108","article-title":"Structural vaccinology to thwart antigenic variation in microbial pathogens","volume":"108","author":"Schneewind","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2012.10.005_bib40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1006\/jmbi.1999.2929","article-title":"Crystallographic and calorimetric analysis of peptide binding to OppA protein","volume":"291","author":"Sleigh","year":"1999","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2012.10.005_bib41","doi-asserted-by":"crossref","first-page":"30126","DOI":"10.1074\/jbc.M110.118513","article-title":"Exploiting antigenic diversity for vaccine design: the chlamydia ArtJ paradigm","volume":"285","author":"Soriani","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2012.10.005_bib42","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1093\/infdis\/jiq142","article-title":"Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis","volume":"203","author":"Suwannasaen","year":"2011","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.str.2012.10.005_bib43","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1128\/IAI.01837-05","article-title":"The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection","volume":"74","author":"Tanabe","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2012.10.005_bib44","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1107\/S0907444907048299","article-title":"Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains","volume":"63","author":"Tanabe","year":"2007","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2012.10.005_bib45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1110\/ps.03223804","article-title":"Understanding the determinants of stability and folding of small globular proteins from their energetics","volume":"13","author":"Tiana","year":"2004","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2012.10.005_bib46","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.1371\/journal.pntd.0000407","article-title":"Phenotypic and functional characterization of human memory T\u00a0cell responses to Burkholderia pseudomallei","volume":"3","author":"Tippayawat","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.str.2012.10.005_bib47","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1002\/anie.200502655","article-title":"Biomolecular modeling: goals, problems, perspectives","volume":"45","author":"van Gunsteren","year":"2006","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.str.2012.10.005_bib48","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/311123a0","article-title":"Correlation between segmental mobility and the location of antigenic determinants in proteins","volume":"311","author":"Westhof","year":"1984","journal-title":"Nature"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212612003796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212612003796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T06:24:02Z","timestamp":1540103042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212612003796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0969212612003796"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2012.10.005","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}