{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:48:53Z","timestamp":1791139733854,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,17]],"date-time":"2013-08-17T00:00:00Z","timestamp":1376697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.str.2013.07.006","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T12:17:49Z","timestamp":1375964269000},"page":"1648-1658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex"],"prefix":"10.1016","volume":"21","author":[{"given":"Rachel","family":"Coulthard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew\u00a0J.","family":"Deans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Swuec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Bowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen\u00a0C.","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil\u00a0Q.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2013.07.006_bib1","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics of nanosystems: application to microtubules and the ribosome","volume":"98","author":"Baker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2013.07.006_bib2","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/nbt1036","article-title":"Baculovirus expression system for heterologous multiprotein complexes","volume":"22","author":"Berger","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.str.2013.07.006_bib3","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1093\/hmg\/dds013","article-title":"The DNA translocase activity of FANCM protects stalled replication forks","volume":"21","author":"Blackford","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.str.2013.07.006_bib4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1101\/gad.1618708","article-title":"Crystal structure of the Mus81-Eme1 complex","volume":"22","author":"Chang","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.str.2013.07.006_bib5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.molcel.2007.01.003","article-title":"Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM","volume":"25","author":"Ciccia","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2013.07.006_bib6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.biochem.77.070306.102408","article-title":"Structural and functional relationships of the XPF\/MUS81 family of proteins","volume":"77","author":"Ciccia","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.str.2013.07.006_bib7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.molcel.2008.10.014","article-title":"FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex","volume":"32","author":"Collis","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2013.07.006_bib8","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1093\/nar\/26.18.4146","article-title":"Mapping of interaction domains between human repair proteins ERCC1 and XPF","volume":"26","author":"de Laat","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2013.07.006_bib9","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.molcel.2009.12.006","article-title":"FANCM connects the genome instability disorders Bloom\u2019s Syndrome and Fanconi Anemia","volume":"36","author":"Deans","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2013.07.006_bib10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrc3088","article-title":"DNA interstrand crosslink repair and cancer","volume":"11","author":"Deans","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.str.2013.07.006_bib11","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2013.07.006_bib12","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1093\/emboj\/21.8.2045","article-title":"The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif","volume":"21","author":"Enzlin","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.str.2013.07.006_bib13","unstructured":"Evans, P.R. (1993). Data reduction. Proceedings of CCP4 Study Weekend on Data Collection & Processing, 114\u2013122."},{"key":"10.1016\/j.str.2013.07.006_bib14","doi-asserted-by":"crossref","first-page":"16107","DOI":"10.1073\/pnas.0804777105","article-title":"Remodeling of DNA replication structures by the branch point translocase FANCM","volume":"105","author":"Gari","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2013.07.006_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.molcel.2007.11.032","article-title":"The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks","volume":"29","author":"Gari","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2013.07.006_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.molcel.2010.07.005","article-title":"The FANCM\/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response","volume":"39","author":"Huang","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2013.07.006_bib17","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1182\/blood-2007-09-113092","article-title":"Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM\/FAAP24","volume":"111","author":"Kim","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.str.2013.07.006_bib18","doi-asserted-by":"crossref","first-page":"53175","DOI":"10.1074\/jbc.M409243200","article-title":"Cooperation of the N-terminal Helicase and C-terminal endonuclease activities of Archaeal Hef protein in processing stalled replication forks","volume":"279","author":"Komori","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2013.07.006_bib19","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by Calpha geometry: phi,psi and Cbeta deviation","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.str.2013.07.006_bib20","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/ng1626","article-title":"A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M","volume":"37","author":"Meetei","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.str.2013.07.006_bib21","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nsmb981","article-title":"The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway","volume":"12","author":"Mosedale","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.str.2013.07.006_bib22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2013.07.006_bib23","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/sj.emboj.7600581","article-title":"Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition","volume":"24","author":"Newman","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.str.2013.07.006_bib24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0969-2126(03)00046-7","article-title":"X-ray and biochemical anatomy of an archaeal XPF\/Rad1\/Mus81 family nuclease: similarity between its endonuclease domain and restriction enzymes","volume":"11","author":"Nishino","year":"2003","journal-title":"Structure"},{"key":"10.1016\/j.str.2013.07.006_bib25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.str.2004.11.008","article-title":"Crystal structure and functional implications of Pyrococcus furiosus hef helicase domain involved in branched DNA processing","volume":"13","author":"Nishino","year":"2005","journal-title":"Structure"},{"key":"10.1016\/j.str.2013.07.006_bib26","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00018-004-4513-1","article-title":"Type II restriction endonucleases: structure and mechanism","volume":"62","author":"Pingoud","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.str.2013.07.006_bib27","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxicity assay for anticancer-drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.str.2013.07.006_bib28","doi-asserted-by":"crossref","first-page":"7016","DOI":"10.1093\/nar\/gks382","article-title":"Sequence, structure and functional diversity of PD-(D\/E)XK phosphodiesterase superfamily","volume":"40","author":"Steczkiewicz","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2013.07.006_bib29","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jsb.2006.05.009","article-title":"EMAN2: an extensible image processing suite for electron microscopy","volume":"157","author":"Tang","year":"2007","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.str.2013.07.006_bib30","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/ncomms1779","article-title":"The structure of the FANCM-MHF complex reveals physical features for functional assembly","volume":"3","author":"Tao","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2013.07.006_bib31","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1107\/S0907444900005072","article-title":"Maximum-likelihood density modification","volume":"56","author":"Terwilliger","year":"2000","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2013.07.006_bib32","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.str.2005.08.014","article-title":"The structure of the human ERCC1\/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair","volume":"13","author":"Tripsianes","year":"2005","journal-title":"Structure"},{"key":"10.1016\/j.str.2013.07.006_bib33","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1093\/nar\/gkm503","article-title":"Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization","volume":"35","author":"Tripsianes","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2013.07.006_bib34","doi-asserted-by":"crossref","first-page":"11236","DOI":"10.1073\/pnas.0504341102","article-title":"Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1","volume":"102","author":"Tsodikov","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2013.07.006_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/jsbi.1996.0004","article-title":"A new generation of the IMAGIC image processing system","volume":"116","author":"van Heel","year":"1996","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.str.2013.07.006_bib36","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.molcel.2012.12.010","article-title":"FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions","volume":"49","author":"Wang","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2013.07.006_bib37","first-page":"686","article-title":"Towards automated protein structure determination: BnP, the SnB-PHASES interface","volume":"217","author":"Weeks","year":"2002","journal-title":"Z.\u00a0Kristallogr."},{"key":"10.1016\/j.str.2013.07.006_bib38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.dnarep.2009.12.012","article-title":"The FANCM family of DNA helicases\/translocases","volume":"9","author":"Whitby","year":"2010","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.str.2013.07.006_bib39","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1093\/nar\/gkt354","article-title":"The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition","volume":"41","author":"Wienk","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2013.07.006_bib40","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/hmg\/ddn054","article-title":"FANCM of the Fanconi anemia core complex is required for both monoubiquitination and DNA repair","volume":"17","author":"Xue","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.str.2013.07.006_bib41","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.molcel.2010.01.039","article-title":"A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability","volume":"37","author":"Yan","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2013.07.006_bib42","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/nsmb.1502","article-title":"An equivalent metal ion in one- and two-metal-ion catalysis","volume":"15","author":"Yang","year":"2008","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212613002554?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212613002554?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T22:57:34Z","timestamp":1539471454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212613002554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0969212613002554"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2013.07.006","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Architecture and DNA Recognition Elements of the Fanconi Anemia FANCM-FAAP24 Complex","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2013.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}