{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T21:41:44Z","timestamp":1782250904477,"version":"3.54.5"},"reference-count":79,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.str.2021.07.006","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T11:24:32Z","timestamp":1631532272000},"page":"1128-1143.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites"],"prefix":"10.1016","volume":"29","author":[{"given":"Jonathan D.","family":"Hudson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-6805","authenticated-orcid":false,"given":"Elakkiya","family":"Tamilselvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-1805","authenticated-orcid":false,"given":"Marcos","family":"Sotomayor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon R.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2021.07.006_bib1","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1212\/WNL.0000000000002704","article-title":"Loss of function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection","volume":"86","author":"Aran","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.str.2021.07.006_bib2","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/hmg\/ddy019","article-title":"The female epilepsy protein PCDH19 is a new GABAAR-binding partner that regulates GABAergic transmission as well as migration and morphological maturation of hippocampal neurons","volume":"27","author":"Bassani","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.str.2021.07.006_bib3","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41050","article-title":"Tuning of delta-protocadherin adhesion through combinatorial diversity","volume":"7","author":"Bisogni","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.str.2021.07.006_bib4","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1083\/jcb.201007008","article-title":"Protocadherin-19 and N-cadherin interact to control cell movements during anterior neurulation","volume":"191","author":"Biswas","year":"2010","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.str.2021.07.006_bib5","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1091\/mbc.e13-08-0475","article-title":"Protocadherin-18b interacts with Nap1 to control motor axon growth and arborization in zebrafish","volume":"25","author":"Biswas","year":"2014","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.str.2021.07.006_bib6","article-title":"\u03b4-Protocadherins control neural progenitor cell proliferation by antagonizing Ryk and Wnt\/\u03b2-catenin signaling","author":"Biswas","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.str.2021.07.006_bib7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.tcb.2012.03.004","article-title":"Thinking outside the cell: how cadherins drive adhesion","volume":"22","author":"Brasch","year":"2012","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.str.2021.07.006_bib8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41586-019-1089-3","article-title":"Visualization of clustered protocadherin neuronal self-recognition complexes","volume":"569","author":"Brasch","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.str.2021.07.006_bib9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.mie.2015.05.001","article-title":"Calculations and publication-quality illustrations for analytical ultracentrifugation data","volume":"562","author":"Brautigam","year":"2015","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.str.2021.07.006_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.conb.2019.10.001","article-title":"The generation of a protocadherin cell-surface recognition code for neural circuit assembly","volume":"59","author":"Canzio","year":"2019","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.str.2021.07.006_bib11","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/mp.2016.231","article-title":"The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders","volume":"23","author":"Chang","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.str.2021.07.006_bib12","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/nprot.2017.064","article-title":"Use of fluorescence-detected sedimentation velocity to study high-affinity protein interactions","volume":"12","author":"Chaturvedi","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.str.2021.07.006_bib13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1083\/jcb.200602062","article-title":"Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity","volume":"174","author":"Chen","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.str.2021.07.006_bib14","doi-asserted-by":"crossref","first-page":"32128","DOI":"10.1074\/jbc.M705337200","article-title":"Structural elements necessary for oligomerization, trafficking, and cell sorting function of paraxial protocadherin","volume":"282","author":"Chen","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2021.07.006_bib15","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1083\/jcb.201507108","article-title":"Protocadherins control the modular assembly of neuronal columns in the zebrafish optic tectum","volume":"211","author":"Cooper","year":"2015","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.str.2021.07.006_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18529","article-title":"Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy","volume":"5","author":"Cooper","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.str.2021.07.006_bib17","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo generator","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.str.2021.07.006_bib18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/humu.22029","article-title":"PCDH19-related infantile epileptic encephalopathy: an unusual X-linked inheritance disorder","volume":"33","author":"Depienne","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.str.2021.07.006_bib19","doi-asserted-by":"crossref","first-page":"e1000381","DOI":"10.1371\/journal.pgen.1000381","article-title":"Sporadic infantile epileptic encephalopathy caused by mutations in PCDH19 resembles Dravet syndrome but mainly affects females","volume":"5","author":"Depienne","year":"2009","journal-title":"Plos Genet."},{"key":"10.1016\/j.str.2021.07.006_bib20","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ng.149","article-title":"X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment","volume":"40","author":"Dibbens","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.str.2021.07.006_bib21","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1083\/jcb.201108115","article-title":"A complex of Protocadherin-19 and N-cadherin mediates a novel mechanism of cell adhesion","volume":"195","author":"Emond","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.str.2021.07.006_bib22","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D. Biol. Crystallogr."},{"key":"10.1016\/j.str.2021.07.006_bib24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.gde.2020.05.041","article-title":"The role of clustered protocadherins in neurodevelopment and neuropsychiatric diseases. Curr","volume":"65","author":"Flaherty","year":"2020","journal-title":"Opin. Genet. Dev."},{"key":"10.1016\/j.str.2021.07.006_bib25","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein identification and analysis tools on the ExPASy server","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.str.2021.07.006_bib26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.gde.2020.06.012","article-title":"Disentangling the paradox of the PCDH19 clustering epilepsy, a disorder of cellular mosaics","volume":"65","author":"Gecz","year":"2020","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.str.2021.07.006_bib27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.neuron.2016.04.004","article-title":"Structural basis of diverse homophilic recognition by clustered \u03b1- and \u03b2-protocadherins","volume":"90","author":"Goodman","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.str.2021.07.006_bib28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.20930","article-title":"gamma-Protocadherin structural diversity and functional implications","volume":"5","author":"Goodman","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.str.2021.07.006_bib29","doi-asserted-by":"crossref","first-page":"E9829","DOI":"10.1073\/pnas.1713449114","article-title":"Protocadherin cis-dimer architecture and recognition unit diversity","volume":"114","author":"Goodman","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"Suppl 1","key":"10.1016\/j.str.2021.07.006_bib30","first-page":"S162","article-title":"Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: a historical perspective","volume":"30","author":"Guex","year":"2009","journal-title":"Electrophoresis"},{"key":"10.1016\/j.str.2021.07.006_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yexcr.2017.03.001","article-title":"Evolution and diversity of cadherins and catenins","volume":"358","author":"Gul","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.str.2021.07.006_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1006960004440","article-title":"NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility","volume":"15","author":"Hansen","year":"1998","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.str.2021.07.006_bib33","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.str.2010.11.016","article-title":"The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins","volume":"19","author":"Harrison","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.str.2021.07.006_bib34","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/j.celrep.2020.02.003","article-title":"Family-wide structural and biophysical analysis of binding interactions among non-clustered \u03b4-protocadherins","volume":"30","author":"Harrison","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.str.2021.07.006_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/978-1-4614-8090-7_13","article-title":"Protocadherins in neurological diseases","volume":"8","author":"Hirabayashi","year":"2014","journal-title":"Adv. Neurobiol."},{"key":"10.1016\/j.str.2021.07.006_bib36","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1152\/physrev.00014.2011","article-title":"Cadherins in brain morphogenesis and wiring","volume":"92","author":"Hirano","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.str.2021.07.006_bib37","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.cell.2020.04.010","article-title":"Adhesion protein structure, molecular affinities, and principles of cell-cell recognition","volume":"181","author":"Honig","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.str.2021.07.006_bib39","doi-asserted-by":"crossref","first-page":"eaaz3893","DOI":"10.1126\/science.aaz3893","article-title":"Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCDH19 disorder","volume":"372","author":"Hoshina","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.str.2021.07.006_bib38","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuron.2013.03.031","article-title":"Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits","volume":"78","author":"Hoshina","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.str.2021.07.006_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J.\u00a0Mol. Graph."},{"key":"10.1016\/j.str.2021.07.006_bib43","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.str.2018.06.003","article-title":"Zooming in on cadherin-23: structural diversity and potential mechanisms of inherited deafness","volume":"26","author":"Jaiganesh","year":"2018","journal-title":"Structure"},{"key":"10.1016\/j.str.2021.07.006_bib44","doi-asserted-by":"crossref","first-page":"a029306","DOI":"10.1101\/cshperspect.a029306","article-title":"The cadherin superfamily in neural circuit assembly","volume":"10","author":"Jontes","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.str.2021.07.006_bib45","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/glycob\/cwm050","article-title":"NetCGlyc 1.0: prediction of mammalian C-mannosylation sites","volume":"17","author":"Julenius","year":"2007","journal-title":"Glycobiology"},{"key":"10.1016\/j.str.2021.07.006_bib46","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ejmg.2012.02.010","article-title":"A single gene deletion on 4q28.3: PCDH18\u2013a new candidate gene for intellectual disability?","volume":"55","author":"Kasnauskiene","year":"2012","journal-title":"Eur. J. Med. Genet."},{"key":"10.1016\/j.str.2021.07.006_bib47","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41380-018-0066-9","article-title":"A systematic review and meta-analysis of 271 PCDH19-variant individuals identifies psychiatric comorbidities, and association of seizure onset and disease severity","volume":"24","author":"Kolc","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.str.2021.07.006_bib48","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","article-title":"Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions","volume":"60","author":"Krissinel","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2021.07.006_bib49","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of macromolecular assemblies from crystalline state","volume":"372","author":"Krissinel","year":"2007","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2021.07.006_bib50","series-title":"Analytical Ultracentrifugation in Biochemistry and Polymer Science","first-page":"90","article-title":"Computer-aided interpretation of analytical sedimentation data for proteins","author":"Laue","year":"1992"},{"key":"10.1016\/j.str.2021.07.006_bib51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.semcdb.2017.07.040","article-title":"Neuronal territory formation by the atypical cadherins and clustered protocadherins","volume":"69","author":"Lefebvre","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.str.2021.07.006_bib52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.semcdb.2017.07.037","article-title":"\u03b4-Protocadherins: organizers of neural circuit assembly","volume":"69","author":"Light","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.str.2021.07.006_bib53","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ajhg.2007.12.009","article-title":"Structural variation of chromosomes in autism spectrum disorder","volume":"82","author":"Marshall","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.str.2021.07.006_bib54","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.str.2021.07.006_bib55","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/s42003-019-0586-0","article-title":"Identification of an adhesive interface for the non-clustered \u03b41 protocadherin-1 involved in respiratory diseases","volume":"2","author":"Modak","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.str.2021.07.006_bib56","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1107\/S0907444911001314","article-title":"REFMAC5 for the refinement of macromolecular crystal structures","volume":"67","author":"Murshudov","year":"2011","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2021.07.006_bib57","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.18449","article-title":"Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4","volume":"5","author":"Nicoludis","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.str.2021.07.006_bib58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.str.2021.07.006_bib59","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fnmol.2020.00117","article-title":"Protocadherins at the crossroad of signaling pathways","volume":"13","author":"Pancho","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.str.2021.07.006_bib60","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuron.2017.12.005","article-title":"Abnormal cell sorting underlies the unique X-linked inheritance of PCDH19 epilepsy","volume":"97","author":"Pederick","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.str.2021.07.006_bib61","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1007\/s00018-017-2572-3","article-title":"Regulation of neural circuit formation by protocadherins","volume":"74","author":"Peek","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.str.2021.07.006_bib62","doi-asserted-by":"crossref","first-page":"W314","DOI":"10.1093\/nar\/gku411","article-title":"DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach","volume":"42","author":"Pires","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2021.07.006_bib63","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/1097-0134(20001001)41:1<47::AID-PROT80>3.0.CO;2-8","article-title":"Discriminating between homodimeric and monomeric proteins in the crystalline state","volume":"41","author":"Ponstingl","year":"2000","journal-title":"Proteins"},{"key":"10.1016\/j.str.2021.07.006_bib64","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yexcr.2017.03.015","article-title":"Biophysical basis of cadherin mediated cell-cell adhesion","volume":"358","author":"Priest","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.str.2021.07.006_bib65","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainres.2012.06.020","article-title":"Cadherins and neuropsychiatric disorders","volume":"1470","author":"Redies","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.str.2021.07.006_bib66","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2015.09.026","article-title":"Molecular logic of neuronal self-recognition through protocadherin domain interactions","volume":"163","author":"Rubinstein","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.str.2021.07.006_bib67","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ng0997-92","article-title":"Epilepsy and mental retardation limited to females: an X-linked dominant disorder with male sparing","volume":"17","author":"Ryan","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.str.2021.07.006_bib69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.biopsych.2016.06.008","article-title":"Sociability deficits and altered amygdala circuits in mice lacking Pcdh10, an autism associated gene","volume":"81","author":"Schoch","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.str.2021.07.006_bib70","unstructured":"Schr\u00f6dinger, L.L.C. (2015). The {PyMOL} Molecular Graphics System, Version\u223c1.8."},{"key":"10.1016\/j.str.2021.07.006_bib71","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0006-3495(00)76713-0","article-title":"Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling","volume":"78","author":"Schuck","year":"2000","journal-title":"Biophys. J."},{"key":"10.1016\/j.str.2021.07.006_bib72","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0003-2697(03)00289-6","article-title":"On the analysis of protein self-association by sedimentation velocity analytical ultracentrifugation","volume":"320","author":"Schuck","year":"2003","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.str.2021.07.006_bib73","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.str.2021.07.006_bib74","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/epi.14003","article-title":"PCDH19-related epilepsy is associated with a broad neurodevelopmental spectrum","volume":"59","author":"Smith","year":"2018","journal-title":"Epilepsia"},{"key":"10.1016\/j.str.2021.07.006_bib76","first-page":"1","article-title":"Sorting out a promiscuous superfamily: towards cadherin connectomics","author":"Sotomayor","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.str.2021.07.006_bib77","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/emboj.2013.79","article-title":"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology","volume":"32","author":"Steentoft","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.str.2021.07.006_bib78","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.bi.59.070190.001321","article-title":"Cadherins: a molecular family important in selective cell-cell adhesion","volume":"59","author":"Takeichi","year":"1990","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.str.2021.07.006_bib79","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1111\/epi.13295","article-title":"PCDH19-related epilepsy in two mosaic male patients","volume":"57","author":"Terracciano","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.str.2021.07.006_bib80","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.aba6637","article-title":"An adhesion code ensures robust pattern formation during tissue morphogenesis","volume":"370","author":"Tsai","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.str.2021.07.006_bib81","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ceb.2018.05.003","article-title":"Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization","volume":"54","author":"Wickstr\u00f6m","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.str.2021.07.006_bib82","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fnmol.2012.00045","article-title":"Molecular codes for neuronal individuality and cell assembly in the brain","volume":"5","author":"Yagi","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.str.2021.07.006_bib83","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neuron.2007.08.020","article-title":"Activity-induced protocadherin arcadlin regulates dendritic spine number by triggering N-cadherin endocytosis via TAO2beta and p38 MAP kinases","volume":"56","author":"Yasuda","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.str.2021.07.006_bib84","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2010.04.012","article-title":"Precision mapping of an in\u00a0vivo N-glycoproteome reveals rigid topological and sequence constraints","volume":"141","author":"Zielinska","year":"2010","journal-title":"Cell"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212621002562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212621002562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:39:28Z","timestamp":1760841568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212621002562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":79,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S0969212621002562"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2021.07.006","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2021.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}