{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:31:23Z","timestamp":1790994683621,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":490,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.str.2022.03.018","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T10:33:48Z","timestamp":1650623628000},"page":"947-961.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8328-5301","authenticated-orcid":false,"given":"Anthony N.","family":"Hodder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janni","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Scally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Triglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Birkinshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brodie","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Favuzza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie H.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai-Hong","family":"Tham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Czabotar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kym","family":"Lowes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuyan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Murgolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel de","family":"Lera Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"McCauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-1048","authenticated-orcid":false,"given":"Brad E.","family":"Sleebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-9004","authenticated-orcid":false,"given":"Alan F.","family":"Cowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2022.03.018_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Cryst. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.03.018_bib2","doi-asserted-by":"crossref","first-page":"e1002199","DOI":"10.1371\/journal.ppat.1002199","article-title":"An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum","volume":"7","author":"Chen","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.str.2022.03.018_bib3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2016.07.055","article-title":"Malaria: biology and disease","volume":"167","author":"Cowman","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.str.2022.03.018_bib4","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/emboj\/cdg096","article-title":"Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes","volume":"22","author":"Duraisingh","year":"2003","journal-title":"Embo J."},{"key":"10.1016\/j.str.2022.03.018_bib5","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Cryst. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.03.018_bib6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Cryst. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.03.018_bib7","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1107\/S090744491003982X","article-title":"An introduction to data reduction: space-group determination, scaling and intensity statistics","volume":"67","author":"Evans","year":"2011","journal-title":"Acta Cryst. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.03.018_bib8","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1107\/S0907444913000061","article-title":"How good are my data and what is the resolution?","volume":"69","author":"Evans","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.03.018_bib9","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.chom.2020.02.005","article-title":"Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle","volume":"27","author":"Favuzza","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.str.2022.03.018_bib10","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.chom.2011.10.012","article-title":"Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa","volume":"10","author":"Giovannini","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.str.2022.03.018_bib11","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1128\/IAI.00144-07","article-title":"Characterization of a conserved rhoptry-associated leucine zipper-like protein\u00a0in the malaria parasite Plasmodium falciparum","volume":"76","author":"Haase","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2022.03.018_bib12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nsmb.3061","article-title":"Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes","volume":"22","author":"Hodder","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.str.2022.03.018_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pep.2017.03.018","article-title":"A high density CHO-S transient transfection system: comparison of ExpiCHO and Expi293","volume":"134","author":"Jain","year":"2017","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.str.2022.03.018_bib14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.str.2022.03.018_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"XDS","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Cryst. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.03.018_bib16","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/pro.4279","article-title":"Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme","volume":"31","author":"Kesari","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2022.03.018_bib17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/pro.5560070401","article-title":"Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes","volume":"7","author":"Khan","year":"1998","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2022.03.018_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-4939-8988-1_4","article-title":"FRET-based assays to determine calpain activity","volume":"1915","author":"McCartney","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.str.2022.03.018_bib19","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Cryst."},{"key":"10.1016\/j.str.2022.03.018_bib20","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.aan1478","article-title":"Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion","volume":"358","author":"Nasamu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.str.2022.03.018_bib21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/337615a0","article-title":"Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1","volume":"337","author":"Navia","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.str.2022.03.018_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.molbiopara.2004.12.003","article-title":"A novel Sushi domain-containing protein of Plasmodium falciparum","volume":"140","author":"O'Keeffe","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.str.2022.03.018_bib23","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1107\/S0907444905001307","article-title":"Auto-rickshaw: an automated crystal structure determination platform as an efficient tool for the validation of an X-ray diffraction experiment","volume":"61","author":"Panjikar","year":"2005","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.03.018_bib24","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1126\/science.aaf8675","article-title":"A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress","volume":"358","author":"Pino","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.str.2022.03.018_bib25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ijpara.2008.11.002","article-title":"Characterisation of PfRON6, a Plasmodium falciparum rhoptry neck protein with a novel cysteine-rich domain","volume":"39","author":"Proellocks","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.str.2022.03.018_bib26","doi-asserted-by":"crossref","first-page":"e17102","DOI":"10.1371\/journal.pone.0017102","article-title":"Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion","volume":"6","author":"Sahar","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.str.2022.03.018_bib27","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1093\/nar\/18.20.6097","article-title":"Sequence logos: a new way to display consensus sequences","volume":"18","author":"Schneider","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2022.03.018_bib28","doi-asserted-by":"crossref","first-page":"e1008049","DOI":"10.1371\/journal.ppat.1008049","article-title":"The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion","volume":"15","author":"Sherling","year":"2019","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.str.2022.03.018_bib29","series-title":"Grade","author":"Smart","year":"2011"},{"key":"10.1016\/j.str.2022.03.018_bib30","doi-asserted-by":"crossref","first-page":"e1005343","DOI":"10.1371\/journal.ppat.1005343","article-title":"Plasmodium falciparum adhesins play an essential role in signalling and activation of invasion into human erythrocytes","volume":"11","author":"Tham","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.str.2022.03.018_bib31","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.str.2022.03.018_bib32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41586-018-0779-6","article-title":"Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex","volume":"565","author":"Wong","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.str.2022.03.018_bib33","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/cmi.12287","article-title":"Conditional expression of apical membrane antigen 1 in Plasmodium falciparum shows it is required for erythrocyte invasion by merozoites","volume":"16","author":"Yap","year":"2014","journal-title":"Cell Microbiol."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212622000995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212622000995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:41:12Z","timestamp":1760841672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212622000995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0969212622000995"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2022.03.018","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-944781\/v1","asserted-by":"object"},{"id-type":"doi","id":"10.21203\/rs.3.rs-944781\/v2","asserted-by":"object"}]},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2022.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}