{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:47:25Z","timestamp":1792547245061,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":398,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BE1540\/23-2"],"award-info":[{"award-number":["BE1540\/23-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.str.2022.08.001","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T10:33:34Z","timestamp":1661164414000},"page":"1452-1461.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity"],"prefix":"10.1016","volume":"30","author":[{"given":"Melissa","family":"Dillenberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rahlfs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-6795","authenticated-orcid":false,"given":"Karin","family":"Fritz-Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2022.08.001_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.08.001_bib2","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1211485","article-title":"Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses","volume":"334","author":"Anastasiou","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.str.2022.08.001_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpara.2003.09.011","article-title":"Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions","volume":"34","author":"Becker","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.str.2022.08.001_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12859-018-2083-8","article-title":"How large B-factors can be in protein crystal structures","volume":"19","author":"Carugo","year":"2018","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.str.2022.08.001_bib5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2004.11.018","article-title":"Functional analysis, overexpression, and kinetic characterization of pyruvate kinase from Plasmodium falciparum","volume":"326","author":"Chan","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.str.2022.08.001_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.tmaid.2006.01.015","article-title":"Plasmodium falciparum pyruvate kinase as a novel target for antimalarial drug-screening","volume":"5","author":"Chan","year":"2007","journal-title":"Travel Med. Infect. Dis."},{"key":"10.1016\/j.str.2022.08.001_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature06667","article-title":"Pyruvate kinase M2 is a phosphotyrosine-binding protein","volume":"452","author":"Christofk","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.str.2022.08.001_bib8","doi-asserted-by":"crossref","first-page":"e46875","DOI":"10.1371\/journal.pone.0046875","article-title":"Crystal structure of Cryptosporidium parvum pyruvate kinase","volume":"7","author":"Cook","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.str.2022.08.001_bib9","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1128\/AAC.00914-16","article-title":"Identification of novel Plasmodium falciparum hexokinase inhibitors with antiparasitic activity","volume":"60","author":"Davis","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.str.2022.08.001_bib10","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.08.001_bib11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0076-6879(09)63040-8","article-title":"Identification and quantification of protein posttranslational modifications","volume":"463","author":"Farley","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.str.2022.08.001_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02842-20","article-title":"The key glycolytic enzyme phosphofructokinase is involved in resistance to antiplasmodial glycosides","volume":"11","author":"Fisher","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.str.2022.08.001_bib13","doi-asserted-by":"crossref","first-page":"26473","DOI":"10.1074\/jbc.R113.460261","article-title":"Regulation of protein function and signaling by reversible cysteine S-nitrosylation","volume":"288","author":"Gould","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2022.08.001_bib14","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.bbapap.2014.03.007","article-title":"Thiol-based redox switches. Biochim. Biophys","volume":"1844","author":"Groitl","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.str.2022.08.001_bib15","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1074\/jbc.R111.285742","article-title":"Regulation by S-nitrosylation of protein post-translational modification","volume":"287","author":"Hess","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2022.08.001_bib16","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1042\/BCJ20200897","article-title":"Comprehensive analyses of the cysteine thiol oxidation of PKM2 reveal the effects of multiple oxidation on cellular oxidative stress response","volume":"478","author":"Irokawa","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.str.2022.08.001_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semcdb.2015.08.004","article-title":"Function, regulation and role in cancer","volume":"43","author":"Israelsen","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.str.2022.08.001_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0969-2126(98)00021-5","article-title":"The allosteric regulation of pyruvate kinase by fructose-1, 6-bisphosphate","volume":"6","author":"Jurica","year":"1998","journal-title":"Structure"},{"key":"10.1016\/j.str.2022.08.001_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1107\/S0907444909047374","article-title":"Integration, scaling, space-group assignment and post-refinement","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.08.001_bib20","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1111\/febs.14097","article-title":"Oxidative stress in malaria and artemisinin combination therapy: pros and Cons","volume":"284","author":"Kavishe","year":"2017","journal-title":"FEBS. J."},{"key":"10.1016\/j.str.2022.08.001_bib21","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1089\/ars.2011.4029","article-title":"Protein S-glutathionylation in malaria parasites","volume":"15","author":"Kehr","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.str.2022.08.001_bib22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0166-6851(96)02734-X","article-title":"Glucose uptake in Plasmodium falciparum-infected erythrocytes is an equilibrative not an active process","volume":"82","author":"Kirk","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.str.2022.08.001_bib23","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/abbi.1997.0257","article-title":"Ligand-induced domain movement in pyruvate kinase: structure of the enzyme from rabbit muscle with Mg2+, K+, and l-phospholactate at 2.7 A resolution","volume":"345","author":"Larsen","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.str.2022.08.001_bib24","doi-asserted-by":"crossref","first-page":"6301","DOI":"10.1021\/bi00186a033","article-title":"Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate","volume":"33","author":"Larsen","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2022.08.001_bib25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1021\/cb900105q","article-title":"Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells","volume":"4","author":"Leonard","year":"2009","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.str.2022.08.001_bib26","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1074\/jbc.R111.275578","article-title":"Analysis and functional prediction of reactive cysteine residues","volume":"287","author":"Marino","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2022.08.001_bib27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cardiores.2004.01.013","article-title":"S-nitrosylation: a potential new paradigm in signal transduction","volume":"62","author":"Mart\u00ednez-Ruiz","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.str.2022.08.001_bib28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1089\/ars.2019.7963","article-title":"Redox regulation via glutaredoxin-1 and protein S-glutathionylation","volume":"32","author":"Matsui","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.str.2022.08.001_bib29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0969-2126(98)00043-4","article-title":"How do kinases transfer phosphoryl groups?","volume":"6","author":"Matte","year":"1998","journal-title":"Structure"},{"key":"10.1016\/j.str.2022.08.001_bib30","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0959-440X(96)80013-3","article-title":"New structures of allosteric proteins revealing remarkable conformational changes","volume":"6","author":"Mattevi","year":"1996","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.str.2022.08.001_bib31","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/oxfordjournals.molbev.a026406","article-title":"Relationship between the occurrence of cysteine in proteins and the complexity of organisms","volume":"17","author":"Miseta","year":"2000","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.str.2022.08.001_bib32","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1042\/BCJ20180556","article-title":"Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation. Biochem","volume":"475","author":"Mitchell","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/j.str.2022.08.001_bib33","doi-asserted-by":"crossref","first-page":"12892","DOI":"10.1074\/jbc.M109.079905","article-title":"Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model","volume":"285","author":"Morgan","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2022.08.001_bib34","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1107\/S2059798315022408","article-title":"A new default restraint library for the protein backbone in Phenix: a conformation-dependent geometry goes mainstream. Acta Crystallogr","volume":"72","author":"Moriarty","year":"2016","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.str.2022.08.001_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1096-4959(03)00081-2","article-title":"Pyruvate kinase: current status of regulatory and functional properties","volume":"135","author":"Mu\u00f1oz","year":"2003","journal-title":"Comp. Biochem. Physiol"},{"key":"10.1016\/j.str.2022.08.001_bib36","doi-asserted-by":"crossref","first-page":"37924","DOI":"10.1074\/jbc.M508490200","article-title":"Pyruvate kinase revisited: the activating effect of K+","volume":"280","author":"Oria-Hern\u00e1ndez","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2022.08.001_bib37","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/jac\/dkaa032","article-title":"Oxidative and nitrosative stresses in cerebral malaria: can we target them to avoid a bad prognosis?","volume":"75","author":"Pereira","year":"2020","journal-title":"J.\u00a0Antimicrob. Chemother."},{"key":"10.1016\/j.str.2022.08.001_bib38","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.str.2022.08.001_bib39","doi-asserted-by":"crossref","first-page":"10449","DOI":"10.1038\/s41598-017-10093-8","article-title":"Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes","volume":"7","author":"Rahbari","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.str.2022.08.001_bib40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0022-2836(63)80023-6","article-title":"Stereochemistry of polypeptide chain configurations","volume":"7","author":"Ramachandran","year":"1963","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2022.08.001_bib41","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1006\/jmbi.1999.2918","article-title":"The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity","volume":"291","author":"Rigden","year":"1999","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2022.08.001_bib42","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1182\/blood.V72.6.1922.1922","article-title":"The enzymes of the glycolytic pathway in erythrocytes infected with Plasmodium falciparum malaria parasites","volume":"72","author":"Roth","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.str.2022.08.001_bib43","doi-asserted-by":"crossref","first-page":"111362","DOI":"10.1016\/j.molbiopara.2021.111362","article-title":"Identification of sulfenylation patterns in trophozoite stage Plasmodium falciparum using a non-dimedone based probe","volume":"242","author":"Schipper","year":"2021","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.str.2022.08.001_bib44","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0006-2952(00)00474-3","article-title":"Serine and alanine mutagenesis of the nine native cysteine residues of the human A(1) adenosine receptor","volume":"60","author":"Scholl","year":"2000","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.str.2022.08.001_bib45","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/pro.3691","article-title":"An overview of structure, function, and regulation of pyruvate kinases","volume":"28","author":"Schormann","year":"2019","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2022.08.001_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.niox.2014.08.010","article-title":"Sub-proteome S-nitrosylation analysis in Brassica juncea hints at the regulation of Brassicaceae specific as well as other vital metabolic pathway(s) by nitric oxide and suggests post-translational modifications cross-talk","volume":"43","author":"Sehrawat","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.str.2022.08.001_bib47","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1107\/S2052252520002456","article-title":"Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures","volume":"7","author":"Srivastava","year":"2020","journal-title":"IUCrJ"},{"key":"10.1016\/j.str.2022.08.001_bib48","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00249-020-01466-5","article-title":"The lid domain is important, but not essential, for catalysis of Escherichia coli pyruvate kinase","volume":"49","author":"Sugrue","year":"2020","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.str.2022.08.001_bib49","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1021\/acs.chemrev.8b00290","article-title":"Utility of B-factors in protein science: interpreting rigidity, flexibility, and internal motion and engineering thermostability.","volume":"119","author":"Sun","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.str.2022.08.001_bib50","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1089\/ars.2013.5553","article-title":"Protein S-nitrosylation in Plasmodium falciparum","volume":"20","author":"Wang","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.str.2022.08.001_bib51","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2022.08.001_bib52","series-title":"World Malaria Report 2021","year":"2021"},{"key":"10.1016\/j.str.2022.08.001_bib53","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/ars.2010.3540","article-title":"S-glutathionylation: from molecular mechanisms to health outcomes","volume":"15","author":"Xiong","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.str.2022.08.001_bib54","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.canlet.2013.06.008","article-title":"Regulation and function of pyruvate kinase M2 in cancer","volume":"339","author":"Yang","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.str.2022.08.001_bib55","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bbrc.2020.08.048","article-title":"Pyruvate kinase from Plasmodium falciparum: structural and kinetic insights into the allosteric mechanism","volume":"532","author":"Zhong","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.str.2022.08.001_bib56","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1107\/S0907444913013875","article-title":"'In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinase","volume":"69","author":"Zhong","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212622003161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212622003161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:53:41Z","timestamp":1778792021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212622003161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0969212622003161"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2022.08.001","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2022.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}