{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:26:19Z","timestamp":1790357179922,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.str.2022.10.003","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T10:50:08Z","timestamp":1667386208000},"page":"1615-1625.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964"],"prefix":"10.1016","volume":"30","author":[{"given":"Susan","family":"Kelso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Kurinov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Angers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Sicheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2022.10.003_bib1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ymeth.2011.07.005","article-title":"The Phenix software for automated determination of macromolecular structures","volume":"55","author":"Adams","year":"2011","journal-title":"Methods"},{"key":"10.1016\/j.str.2022.10.003_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ph12020050","article-title":"CDK11 loss induces cell cycle dysfunction and death of BRAF and NRAS Melanoma Cells","volume":"12","author":"Ahmed","year":"2019","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.str.2022.10.003_bib3","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1021\/acschembio.5b00398","article-title":"Type II inhibitors targeting CDK2","volume":"10","author":"Alexander","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.str.2022.10.003_bib4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nrd4504","article-title":"The history and future of targeting cyclin-dependent kinases in cancer therapy","volume":"14","author":"Asghar","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.str.2022.10.003_bib5","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0896-6273(01)00465-2","article-title":"Dopamine and Glutamate Induce Distinct Striatal Splice Forms of Ania-6, an RNA Polymerase II-Associated Cyclin dence that some genes are induced as homeostatic responses to excessive dopaminergic stimulation and that such neuronal adaptations contribute t","volume":"32","author":"Berke","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.str.2022.10.003_bib6","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1021\/cb100410m","article-title":"Discovery of a potential allosteric ligand binding site in CDK2","volume":"6","author":"Betzi","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.str.2022.10.003_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s40265-020-01461-2","article-title":"Inhibiting CDK4\/6 in breast cancer with Palbociclib, Ribociclib, and Abemaciclib: similarities and differences","volume":"81","author":"Braal","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.str.2022.10.003_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gku936","article-title":"Easy quantitative assessment of genome editing by sequence trace decomposition","volume":"42","author":"Brinkman","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2022.10.003_bib9","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/15674","article-title":"The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases","volume":"1","author":"Brown","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.str.2022.10.003_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1097-2765(00)80239-7","article-title":"Identification and characterization of a novel cell cycle-regulated internal ribosome entry site","volume":"5","author":"Cornelis","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.str.2022.10.003_bib11","doi-asserted-by":"crossref","first-page":"25465","DOI":"10.1074\/jbc.M202266200","article-title":"Cyclin L is an RS domain protein involved in pre-mRNA splicing","volume":"277","author":"Dickinson","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2022.10.003_bib12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/15384101.2019.1577665","article-title":"CDK11p110 plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target","volume":"18","author":"Du","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.str.2022.10.003_bib13","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.10.003_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd.2018.21","article-title":"Kinase inhibitors: the road ahead","volume":"17","author":"Ferguson","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.str.2022.10.003_bib15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1101\/gr.8.9.929","article-title":"Duplication of a genomic region containing the Cdc2L1 -2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2","volume":"8","author":"Gururajan","year":"1998","journal-title":"Genome Res."},{"key":"10.1016\/j.str.2022.10.003_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","article-title":"XDS","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2022.10.003_bib40","doi-asserted-by":"crossref","first-page":"114433","DOI":"10.1016\/j.ejmech.2022.114433","article-title":"Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold","volume":"238","author":"Li","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.str.2022.10.003_bib17","doi-asserted-by":"crossref","first-page":"eaaw8412","DOI":"10.1126\/scitranslmed.aaw8412","article-title":"Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials","volume":"11","author":"Lin","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.str.2022.10.003_bib18","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1158\/1535-7163.MCT-16-0032","article-title":"Cyclin-dependent kinase 11 (CDK11) is required for ovarian cancer cell growth in\u00a0vitro and in\u00a0vivo, and its inhibition causes apoptosis and sensitizes cells to paclitaxel","volume":"15","author":"Liu","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.str.2022.10.003_bib19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/gb4184","article-title":"Cyclin-dependent kinases","volume":"15","author":"Malumbres","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.str.2022.10.003_bib20","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/ncb1109-1275","article-title":"Cyclin-dependent kinases : a family portrait","volume":"11","author":"Malumbres","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.str.2022.10.003_bib21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1042\/EBC20170040","article-title":"Structure-based discovery of cyclin-dependent protein kinase inhibitors","volume":"61","author":"Martin","year":"2017","journal-title":"Essays Biochem."},{"key":"10.1016\/j.str.2022.10.003_bib22","doi-asserted-by":"crossref","first-page":"259ra145","DOI":"10.1126\/scitranslmed.3010277","article-title":"TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis","volume":"6","author":"Matsuo","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.str.2022.10.003_bib23","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.str.2022.10.003_bib24","doi-asserted-by":"crossref","first-page":"e01456","DOI":"10.7554\/eLife.01456","article-title":"Collaboration gets the most out of software","volume":"2","author":"Morin","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.str.2022.10.003_bib25","article-title":"SCF-FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination","author":"O\u2019Brien","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.str.2022.10.003_bib26","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera - a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.str.2022.10.003_bib27","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.1021\/jm060216x","article-title":"Dissecting the determinants of cyclin-dependent kinase 2 and cyclin-dependent kinase 4 inhibitor selectivity","volume":"49","author":"Pratt","year":"2006","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.str.2022.10.003_bib28","doi-asserted-by":"crossref","first-page":"18639","DOI":"10.1074\/jbc.RA119.009107","article-title":"CDK11p58\u2013cyclin L1\u03b2 regulates abscission site assembly","volume":"294","author":"Renshaw","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2022.10.003_bib29","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1021\/jm960402a","article-title":"High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design","volume":"39","author":"Schulze-Gahmen","year":"1996","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.str.2022.10.003_bib30","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.str.2022.10.003_bib31","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1021\/acs.jmedchem.8b01469","article-title":"Cyclin-dependent kinase 2 inhibitors in cancer therapy: an update","volume":"62","author":"Tadesse","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.str.2022.10.003_bib32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0079-6603(04)77007-5","article-title":"Cyclin dependent kinase 11 in RNA transcription and splicing","volume":"77","author":"Trembley","year":"2004","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"10.1016\/j.str.2022.10.003_bib41","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/bioinformatics\/btp033","article-title":"Jalview Version 2 - A multiple sequence alignment editor and analysis workbench","volume":"25","author":"Waterhouse","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.str.2022.10.003_bib33","doi-asserted-by":"crossref","first-page":"W296","DOI":"10.1093\/nar\/gky427","article-title":"SWISS-MODEL: homology modelling of protein structures and complexes","volume":"46","author":"Waterhouse","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2022.10.003_bib34","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1038\/s41467-020-16559-0","article-title":"Quantifying CDK inhibitor selectivity in live cells","volume":"11","author":"Wells","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2022.10.003_bib35","doi-asserted-by":"crossref","first-page":"180112","DOI":"10.1098\/rsob.180112","article-title":"Structural insights into the functional diversity of the CDK\u2013cyclin family","volume":"8","author":"Wood","year":"2018","journal-title":"Open Biol."},{"key":"10.1016\/j.str.2022.10.003_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.chembiol.2018.10.015","article-title":"Differences in the conformational Energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition","volume":"26","author":"Wood","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.str.2022.10.003_bib37","first-page":"1913","article-title":"CDK inhibitors in cancer therapy, an overview of recent development","volume":"11","author":"Zhang","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.str.2022.10.003_bib38","doi-asserted-by":"crossref","first-page":"35314","DOI":"10.1074\/jbc.M202179200","article-title":"Interaction of p58PITSLRE, a G2\/M-specific protein kinase, with cyclin D3","volume":"277","author":"Zhang","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2022.10.003_bib39","doi-asserted-by":"crossref","first-page":"40846","DOI":"10.18632\/oncotarget.8519","article-title":"The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212622003926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212622003926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:42:02Z","timestamp":1760841722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212622003926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0969212622003926"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2022.10.003","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2022.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}