{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:23:40Z","timestamp":1785936220336,"version":"3.56.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.str.2023.04.003","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T10:32:37Z","timestamp":1682677957000},"page":"644-650.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1"],"prefix":"10.1016","volume":"31","author":[{"given":"Carlos A.","family":"Elena-Real","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Urbanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xamuel L.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Morat\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Sagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Fournet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Esta\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Bellande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Allemand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Sibille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Melki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Bernad\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2023.04.003_bib1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","article-title":"The biology of huntingtin","volume":"89","author":"Saudou","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.str.2023.04.003_bib2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.str.2023.04.003_bib3","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jsb.2017.09.006","article-title":"Polyglutamine expansion diseases: more than simple repeats","volume":"201","author":"Silva","year":"2018","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.str.2023.04.003_bib4","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1101\/gad.888401","article-title":"Beyond the qs in the polyglutamine diseases","volume":"15","author":"Orr","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.str.2023.04.003_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.neuro.29.051605.113042","article-title":"Trinucleotide repeat disorders","volume":"30","author":"Orr","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.str.2023.04.003_bib6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/cbic.201900583","article-title":"Site-specific isotopic labeling (SSIL): access to high-resolution structural and dynamic information in low-complexity proteins","volume":"21","author":"Urbanek","year":"2020","journal-title":"Chembiochem"},{"key":"10.1016\/j.str.2023.04.003_bib7","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1021\/jacs.6b10893","article-title":"Structure and dynamics of the huntingtin exon-1 N-terminus: a solution NMR perspective","volume":"139","author":"Baias","year":"2017","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.str.2023.04.003_bib8","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jmb.2018.03.031","article-title":"Tadpole-like conformations of huntingtin exon 1 are characterized by conformational heterogeneity that persists regardless of polyglutamine length","volume":"430","author":"Newcombe","year":"2018","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2023.04.003_bib9","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nsmb.1570","article-title":"Polyglutamine disruption of the huntingtin exon 1\u00a0N terminus triggers a complex aggregation mechanism","volume":"16","author":"Thakur","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.str.2023.04.003_bib10","doi-asserted-by":"crossref","first-page":"19613","DOI":"10.1074\/jbc.RA118.004808","article-title":"The folding equilibrium of huntingtin exon-1 monomer depends on its polyglutamine tract","volume":"293","author":"Bravo-Arredondo","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2023.04.003_bib11","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1021\/jacs.8b02619","article-title":"Interaction of huntingtin exon-1 peptides with lipid-based micellar nanoparticles probed by solution NMR and Q-band pulsed EPR","volume":"140","author":"Ceccon","year":"2018","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.str.2023.04.003_bib12","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1002\/anie.201711530","article-title":"A general strategy to access structural information at atomic resolution in polyglutamine homorepeats","volume":"57","author":"Urbanek","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.str.2023.04.003_bib13","doi-asserted-by":"crossref","first-page":"7976","DOI":"10.1021\/jacs.0c02263","article-title":"Evidence of the reduced abundance of proline cis conformation in protein poly proline tracts","volume":"142","author":"Urbanek","year":"2020","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.str.2023.04.003_bib14","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.1021\/ja00046a080","article-title":"Site-specific isotopic labeling of proteins for NMR studies","volume":"114","author":"Ellman","year":"1992","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.str.2023.04.003_bib15","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1021\/jacs.5b12680","article-title":"Efficient isotope editing of proteins for site-directed vibrational spectroscopy","volume":"138","author":"Peuker","year":"2016","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.str.2023.04.003_bib16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1023\/A:1008276001545","article-title":"Dual amino acid-selective and site-directed stable-isotope labeling of the human c-ha-ras protein by cell-free synthesis","volume":"11","author":"Yabuki","year":"1998","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.str.2023.04.003_bib17","doi-asserted-by":"crossref","first-page":"4154","DOI":"10.1111\/j.1742-4658.2006.05433.x","article-title":"N-labelled proteins by cell-free protein synthesis. Strategies for high-throughput NMR studies of proteins and protein-ligand complexes","volume":"273","author":"Ozawa","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.str.2023.04.003_bib18","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.3390\/biom10101458","article-title":"Robust cell-free expression of sub-pathological and pathological huntingtin exon-1 for nmr studies. General approaches for the isotopic labeling of low-complexity proteins","volume":"10","author":"Morat\u00f3","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.str.2023.04.003_bib19","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.str.2020.04.008","article-title":"Flanking regions determine the structure of the poly-glutamine in huntingtin through mechanisms common among glutamine-rich human proteins","volume":"28","author":"Urbanek","year":"2020","journal-title":"Structure"},{"key":"10.1016\/j.str.2023.04.003_bib20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41594-023-00920-0","article-title":"The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity","volume":"30","author":"Elena-Real","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.str.2023.04.003_bib21","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/anie.201108275","article-title":"Multiple-site labeling of proteins with unnatural amino acids","volume":"51","author":"Loscha","year":"2012","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.str.2023.04.003_bib22","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/s41467-018-03469-5","article-title":"Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids","volume":"9","author":"Martin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2023.04.003_bib23","doi-asserted-by":"crossref","first-page":"19587","DOI":"10.1021\/jacs.1c10104","article-title":"Through-space scalar 19F\u201319F couplings between fluorinated noncanonical amino acids for the detection of specific contacts in proteins","volume":"143","author":"Orton","year":"2021","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.str.2023.04.003_bib24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1021\/acs.biochem.0c00829","article-title":"In\u00a0vitro-constructed ribosomes enable multi-site incorporation of noncanonical amino acids into proteins","volume":"60","author":"Liu","year":"2021","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2023.04.003_bib25","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10858-018-0166-5","article-title":"POTENCI: prediction of temperature, neighbor and PH-corrected chemical shifts for intrinsically disordered proteins","volume":"70","author":"Nielsen","year":"2018","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.str.2023.04.003_bib26","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.str.2018.10.016","article-title":"Realistic ensemble models of intrinsically disordered proteins using a structure-encoding coil database","volume":"27","author":"Esta\u00f1a","year":"2019","journal-title":"Structure"},{"key":"10.1016\/j.str.2023.04.003_bib27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10858-010-9433-9","article-title":"SPARTA+: a modest improvement in empirical NMR chemical shift prediction by means of an artificial neural network","volume":"48","author":"Shen","year":"2010","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.str.2023.04.003_bib28","doi-asserted-by":"crossref","first-page":"e25323","DOI":"10.4161\/idp.25323","article-title":"SS-map: visualizing cooperative secondary structure elements in protein ensembles","volume":"1","author":"Iglesias","year":"2013","journal-title":"Intrinsically Disord. Proteins"},{"key":"10.1016\/j.str.2023.04.003_bib29","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1038\/s41467-019-09923-2","article-title":"Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor","volume":"10","author":"Escobedo","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2023.04.003_bib30","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/hmg\/ddh144","article-title":"Progressive decrease in chaperone protein levels in a mouse model of Huntington\u2019s disease and induction of stress proteins as a therapeutic approach","volume":"13","author":"Hay","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.str.2023.04.003_bib31","doi-asserted-by":"crossref","first-page":"282","DOI":"10.15252\/embj.201797212","article-title":"Complete suppression of htt fibrilization and disaggregation of htt fibrils by a trimeric chaperone complex","volume":"37","author":"Scior","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.str.2023.04.003_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fnins.2017.00145","article-title":"Chaperones in polyglutamine aggregation: beyond the Q-stretch","volume":"11","author":"Kuiper","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.str.2023.04.003_bib33","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/hmg\/9.19.2811","article-title":"Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila","volume":"9","author":"Chan","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.str.2023.04.003_bib34","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1038\/s41467-022-32370-5","article-title":"Identification of a HTT-specific binding motif in DNAJB1 essential for suppression and disaggregation of HTT","volume":"13","author":"Ayala Mariscal","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2023.04.003_bib35","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nsmb.1700","article-title":"The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation","volume":"16","author":"Tam","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.str.2023.04.003_bib36","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1074\/jbc.M114.603332","article-title":"Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation","volume":"290","author":"Monsellier","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2023.04.003_bib37","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/bib\/bbz007","article-title":"Disentangling the complexity of low complexity proteins","volume":"21","author":"Mier","year":"2020","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.str.2023.04.003_bib38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41557-021-00840-w","article-title":"Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains","volume":"14","author":"Bremer","year":"2022","journal-title":"Nat. Chem."},{"key":"10.1016\/j.str.2023.04.003_bib39","doi-asserted-by":"crossref","first-page":"7128","DOI":"10.1074\/jbc.TM118.001190","article-title":"Prion-like low-complexity sequences: key regulators of protein solubility and phase behavior","volume":"294","author":"Franzmann","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2023.04.003_bib40","doi-asserted-by":"crossref","first-page":"R235","DOI":"10.1093\/hmg\/ddh251","article-title":"Polyalanine expansions in human","volume":"13","author":"Amiel","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.str.2023.04.003_bib41","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1038\/s41467-019-10490-9","article-title":"Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex","volume":"10","author":"Gauto","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2023.04.003_bib42","series-title":"Structural Proteomics: High-Throughput Methods","first-page":"257","article-title":"Cell-free protein synthesis for analysis by NMR spectroscopy","author":"Apponyi","year":"2008"},{"key":"10.1016\/j.str.2023.04.003_bib43","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1093\/emboj\/16.10.2968","article-title":"Rescuing an essential enzyme-RNA complex with a non-essential appended domain","volume":"16","author":"Whelihan","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.str.2023.04.003_bib44","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(98)01620-2","article-title":"Cell-free production and stable-isotope labeling of milligram quantities of proteins","volume":"442","author":"Kigawa","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.str.2023.04.003_bib45","doi-asserted-by":"crossref","first-page":"34690","DOI":"10.1074\/jbc.M111.261321","article-title":"Hsc70 protein interaction with soluble and fibrillar alpha-synuclein","volume":"286","author":"Pemberton","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2023.04.003_bib46","doi-asserted-by":"crossref","first-page":"8921","DOI":"10.1021\/bi00490a007","article-title":"Direct evidence for GTP and GDP-inorganic phosphate intermediates in microtubule assembly","volume":"29","author":"Melki","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2023.04.003_bib47","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/prot.20449","article-title":"The CCPN data model for NMR spectroscopy: development of a software pipeline","volume":"59","author":"Vranken","year":"2005","journal-title":"Proteins"},{"key":"10.1016\/j.str.2023.04.003_bib48","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1006\/jmbi.1998.1852","article-title":"Recommendations for the presentation of NMR structures of proteins and nucleic acids","volume":"280","author":"Markley","year":"1998","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2023.04.003_bib49","doi-asserted-by":"crossref","first-page":"D310","DOI":"10.1093\/nar\/gkt1242","article-title":"SCOP2 prototype: a new approach to protein structure mining","volume":"42","author":"Andreeva","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2023.04.003_bib50","doi-asserted-by":"crossref","first-page":"D376","DOI":"10.1093\/nar\/gkz1064","article-title":"The SCOP database in 2020: expanded classification of representative family and superfamily domains of known protein structures","volume":"48","author":"Andreeva","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2023.04.003_bib51","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/prot.22488","article-title":"Improved prediction of protein side-chain conformations with SCWRL4","volume":"77","author":"Krivov","year":"2009","journal-title":"Proteins"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212623001260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212623001260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:43:26Z","timestamp":1760841806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212623001260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0969212623001260"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2023.04.003","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multi-site-specific isotopic labeling accelerates high-resolution structural investigations of pathogenic huntingtin exon-1","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2023.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}