{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:46:36Z","timestamp":1792853196353,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T00:00:00Z","timestamp":1728086400000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.str.2023.07.011","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:28:31Z","timestamp":1692008911000},"page":"1174-1183.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1"],"prefix":"10.1016","volume":"31","author":[{"given":"Sai Sundar","family":"Rajan Raghavan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus W.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai Tidemand","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Skjold","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pontus","family":"Gourdon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinqiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor Grundtvig","family":"Theander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaituo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-4249","authenticated-orcid":false,"given":"Thomas","family":"Lavstsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2023.07.011_bib1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3389\/fimmu.2019.00830","article-title":"The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity","volume":"10","author":"Sierro","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.str.2023.07.011_bib2","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1056\/NEJMoa1400116","article-title":"Brain swelling and death in children with cerebral malaria","volume":"372","author":"Seydel","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.str.2023.07.011_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijpara.2016.08.002","article-title":"Severe malaria: what's new on the pathogenesis front?","volume":"47","author":"Wassmer","year":"2017","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.str.2023.07.011_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000933","article-title":"Plasmodium falciparum erythrocyte membrane protein 1 diversity in seven genomes--divide and conquer","volume":"6","author":"Rask","year":"2010","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.str.2023.07.011_bib5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nm0398-358","article-title":"Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria","volume":"4","author":"Bull","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.str.2023.07.011_bib6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1128\/IAI.67.2.733-739.1999","article-title":"Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: evidence for rare and prevalent variants","volume":"67","author":"Bull","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2023.07.011_bib7","doi-asserted-by":"crossref","first-page":"E3270","DOI":"10.1073\/pnas.1524294113","article-title":"Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass","volume":"113","author":"Bernabeu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2023.07.011_bib8","doi-asserted-by":"crossref","first-page":"839","DOI":"10.15252\/emmm.201606188","article-title":"Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRalpha1 domains","volume":"8","author":"Jespersen","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.str.2023.07.011_bib9","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.chom.2017.09.009","article-title":"Linking EPCR-Binding PfEMP1 to Brain Swelling in Pediatric Cerebral Malaria","volume":"22","author":"Kessler","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.str.2023.07.011_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00841-16","article-title":"The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1","volume":"85","author":"Mkumbaye","year":"2017","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2023.07.011_bib11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nature12216","article-title":"Severe malaria is associated with parasite binding to endothelial protein C receptor","volume":"498","author":"Turner","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.str.2023.07.011_bib12","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809164","article-title":"Cerebral malaria is associated with differential cytoadherence to brain endothelial cells","volume":"11","author":"Storm","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.str.2023.07.011_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s12916-017-0945-y","article-title":"Plasmodium falciparum EPCR-binding PfEMP1 expression increases with malaria disease severity and is elevated in retinopathy negative cerebral malaria","volume":"15","author":"Shabani","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.str.2023.07.011_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12837","article-title":"The structural basis for CD36 binding by the malaria parasite","volume":"7","author":"Hsieh","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2023.07.011_bib15","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1126\/science.272.5267.1502","article-title":"Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta","volume":"272","author":"Fried","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.str.2023.07.011_bib16","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41564-020-00858-9","article-title":"Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA","volume":"6","author":"Ma","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.str.2023.07.011_bib17","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1038\/s41467-021-23254-1","article-title":"Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2023.07.011_bib18","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1111\/cmi.12183","article-title":"Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes","volume":"15","author":"Smith","year":"2013","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.str.2023.07.011_bib19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.chom.2017.02.009","article-title":"Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral Malaria","volume":"21","author":"Lennartz","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.str.2023.07.011_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.chom.2014.11.007","article-title":"Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria","volume":"17","author":"Lau","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.str.2023.07.011_bib21","doi-asserted-by":"crossref","first-page":"6778","DOI":"10.1128\/IAI.01187-06","article-title":"Limited cross-reactivity among domains of the Plasmodium falciparum clone 3D7 erythrocyte membrane protein 1 family","volume":"74","author":"Joergensen","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.str.2023.07.011_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068368","article-title":"Expression of the domain cassette 8 Plasmodium falciparum erythrocyte membrane protein 1 is associated with cerebral malaria in Benin","volume":"8","author":"Bertin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.str.2023.07.011_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002781","article-title":"Structural basis for the ABO blood-group dependence of Plasmodium falciparum rosetting","volume":"8","author":"Vigan-Womas","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.str.2023.07.011_bib24","doi-asserted-by":"crossref","first-page":"24851","DOI":"10.1074\/jbc.C200163200","article-title":"The crystal structure of the endothelial protein C receptor and a bound phospholipid","volume":"277","author":"Oganesyan","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2023.07.011_bib25","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-18844-y","article-title":"Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)","volume":"12","author":"Erausquin","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.str.2023.07.011_bib26","doi-asserted-by":"crossref","first-page":"E1791","DOI":"10.1073\/pnas.1120455109","article-title":"Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children","volume":"109","author":"Lavstsen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2023.07.011_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/imr.12507","article-title":"The HIV-1 envelope glycoprotein structure: nailing down a moving target","volume":"275","author":"Ward","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.str.2023.07.011_bib28","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.abn8652","article-title":"Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement","volume":"375","author":"McCallum","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.str.2023.07.011_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cell.2005.05.033","article-title":"Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum","volume":"122","author":"Tolia","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.str.2023.07.011_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2023.07.011_bib31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsb.2015.08.008","article-title":"CTFFIND4: Fast and accurate defocus estimation from electron micrographs","volume":"192","author":"Rohou","year":"2015","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.str.2023.07.011_bib32","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jsb.2006.06.010","article-title":"Visualizing density maps with UCSF Chimera","volume":"157","author":"Goddard","year":"2007","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.str.2023.07.011_bib33","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2023.07.011_bib34","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1107\/S2059798318006551","article-title":"Real-space refinement in PHENIX for cryo-EM and crystallography","volume":"74","author":"Afonine","year":"2018","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.str.2023.07.011_bib35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.17219","article-title":"Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta","volume":"5","author":"Wang","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.str.2023.07.011_bib36","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2023.07.011_bib37","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2023.07.011_bib38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.12688\/wellcomeopenres.15590.1","article-title":"Evolutionary analysis of the most polymorphic gene family in falciparum malaria","volume":"4","author":"Otto","year":"2019","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.str.2023.07.011_bib39","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1038\/s41467-022-34630-w","article-title":"Muscle5: High-accuracy alignment ensembles enable unbiased assessments of sequence homology and phylogeny","volume":"13","author":"Edgar","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2023.07.011_bib40","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1093\/nar\/18.20.6097","article-title":"Sequence logos: a new way to display consensus sequences","volume":"18","author":"Schneider","year":"1990","journal-title":"Nucleic Acids Res."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212623002538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212623002538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:43:56Z","timestamp":1760841836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212623002538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S0969212623002538"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2023.07.011","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2023.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}