{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:45:38Z","timestamp":1781149538321,"version":"3.54.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":367,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.str.2024.07.021","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T15:04:13Z","timestamp":1724425453000},"page":"1611-1620.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Scorpion \u03b1-toxin Lqh\u03b1IT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels"],"prefix":"10.1016","volume":"32","author":[{"given":"Swastik","family":"Phulera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callum J.","family":"Dickson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Schwalen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Khoshouei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"Cassell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Condos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Whicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-2398","authenticated-orcid":false,"given":"Wilhelm A.","family":"Weihofen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2024.07.021_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1085\/jgp.201511492","article-title":"The hitchhiker\u2019s guide to the voltage-gated sodium channel galaxy","volume":"147","author":"Ahern","year":"2016","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.str.2024.07.021_bib2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1212\/WNL.0000000000002333","article-title":"Sodium channel Nav1.8: Emerging links to human disease","volume":"86","author":"Han","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.str.2024.07.021_bib3","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.str.2024.07.021_bib4","doi-asserted-by":"crossref","first-page":"7093","DOI":"10.1021\/jm501981g","article-title":"Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications","volume":"58","author":"de Lera Ruiz","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.str.2024.07.021_bib5","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1111\/j.1476-5381.2009.00437.x","article-title":"Subtype-selective targeting of voltage-gated sodium channels","volume":"158","author":"England","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.str.2024.07.021_bib6","doi-asserted-by":"crossref","first-page":"31679","DOI":"10.1074\/jbc.M402048200","article-title":"Molecular basis of the high insecticidal potency of scorpion alpha-toxins","volume":"279","author":"Karbat","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2024.07.021_bib7","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.cell.2019.06.031","article-title":"Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel","volume":"178","author":"Wisedchaisri","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.str.2024.07.021_bib8","doi-asserted-by":"crossref","first-page":"10910","DOI":"10.1073\/pnas.89.22.10910","article-title":"A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation","volume":"89","author":"West","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.07.021_bib9","doi-asserted-by":"crossref","first-page":"5072","DOI":"10.1038\/s41467-023-40514-4","article-title":"A mechanistic reinterpretation of fast inactivation in voltage-gated Na+ channels","volume":"14","author":"Liu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.07.021_bib10","doi-asserted-by":"crossref","first-page":"11474","DOI":"10.1002\/anie.202102196","article-title":"Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav 1.5 by the Antiarrhythmic Drug Quinidine","volume":"60","author":"Li","year":"2021","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.str.2024.07.021_bib11","doi-asserted-by":"crossref","first-page":"eaal4326","DOI":"10.1126\/science.aal4326","article-title":"Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution","volume":"355","author":"Shen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.str.2024.07.021_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau2596","article-title":"Structural basis for the modulation of voltage-gated sodium channels by animal toxins","volume":"362","author":"Shen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.str.2024.07.021_bib13","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100066118","article-title":"Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies","volume":"118","author":"Pan","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.07.021_bib14","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.aaw2999","article-title":"Molecular basis for pore blockade of human Na+ channel Nav1.2 by the \u03bc-conotoxin KIIIA","volume":"363","author":"Pan","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.str.2024.07.021_bib15","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1038\/s41467-022-28808-5","article-title":"Structural basis for modulation of human NaV1.3 by clinical drug and selective antagonist","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.07.021_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau2486","article-title":"Structure of the human voltage-gated sodium channel Nav1.4 in complex with \u03b21","volume":"362","author":"Pan","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.str.2024.07.021_bib17","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cell.2019.11.041","article-title":"Structure of the Cardiac Sodium Channel","volume":"180","author":"Jiang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.str.2024.07.021_bib18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41467-020-20078-3","article-title":"Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin","volume":"12","author":"Jiang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.07.021_bib19","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2220578120","article-title":"Cryo-EM structure of human voltage-gated sodium channel Na v 1.6","volume":"120","author":"Fan","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.07.021_bib20","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.aaw2493","article-title":"Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins","volume":"363","author":"Shen","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.str.2024.07.021_bib21","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2208211119","article-title":"Structural basis for high-voltage activation and subtype-specific inhibition of human Nav 1.8","volume":"119","author":"Huang","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.07.021_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2021.166967","article-title":"Structural Pharmacology of Voltage-Gated Sodium Channels","volume":"433","author":"Noreng","year":"2021","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2024.07.021_bib23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.toxicon.2006.09.023","article-title":"Voltage-gated sodium channel modulation by scorpion alpha-toxins","volume":"49","author":"Bosmans","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.str.2024.07.021_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/15569549809009247","article-title":"Functional Anatomy of Scorpion Toxins Affecting Sodium Channels","volume":"17","author":"Gordon","year":"1998","journal-title":"J.\u00a0Toxicol. Toxin Rev."},{"key":"10.1016\/j.str.2024.07.021_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav8573","article-title":"Structural basis of \u03b1-scorpion toxin action on Na(v) channels","volume":"363","author":"Clairfeuille","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.str.2024.07.021_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2011.00071","article-title":"Neurotoxins and their binding areas on voltage-gated sodium channels","volume":"2","author":"Stevens","year":"2011","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.str.2024.07.021_bib27","doi-asserted-by":"crossref","DOI":"10.1080\/19336950.2023.2287832","article-title":"A structural atlas of druggable sites on Na v channels","volume":"18","author":"Li","year":"2024","journal-title":"Channels"},{"key":"10.1016\/j.str.2024.07.021_bib28","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1046\/j.1460-9568.2000.00168.x","article-title":"Scorpion alpha and alpha-like toxins differentially interact with sodium channels in mammalian CNS and periphery","volume":"12","author":"Gilles","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.str.2024.07.021_bib29","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1046\/j.1460-9568.2002.02142.x","article-title":"Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3","volume":"16","author":"Chen","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.str.2024.07.021_bib30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.07.021_bib31","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1021\/bi961497l","article-title":"Solution Structures of a Highly Insecticidal Recombinant Scorpion \u03b1-Toxin and a Mutant with Increased Activity","volume":"36","author":"Tugarinov","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2024.07.021_bib32","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera-A visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.str.2024.07.021_bib33","doi-asserted-by":"crossref","first-page":"20684","DOI":"10.1074\/jbc.M109.021303","article-title":"Molecular Requirements for Recognition of Brain Voltage-gated Sodium Channels by Scorpion \u03b1-Toxins","volume":"284","author":"Kahn","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2024.07.021_bib34","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics of nanosystems: Application to microtubules and the ribosome","volume":"98","author":"Baker","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.07.021_bib35","unstructured":"The PyMOL Molecular Graphics System (Schr\u00f6dinger, LLC), Version 3.0."},{"key":"10.1016\/j.str.2024.07.021_bib36","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","article-title":"Inference of Macromolecular Assemblies from Crystalline State","volume":"372","author":"Krissinel","year":"2007","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2024.07.021_bib37","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1006\/jmbi.1993.1648","article-title":"Shape Complementarity at Protein\/Protein Interfaces","volume":"234","author":"Lawrence","year":"1993","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2024.07.021_bib38","doi-asserted-by":"crossref","first-page":"8034","DOI":"10.1074\/jbc.271.14.8034","article-title":"Scorpion Toxins Affecting Sodium Current Inactivation Bind to Distinct Homologous Receptor Sites on Rat Brain and Insect Sodium Channels","volume":"271","author":"Gordon","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2024.07.021_bib39","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1021\/bi0270438","article-title":"Exploration of the Functional Site of a Scorpion \u03b1-like Toxin by Site-Directed Mutagenesis","volume":"42","author":"Wang","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.str.2024.07.021_bib40","doi-asserted-by":"crossref","first-page":"35209","DOI":"10.1074\/jbc.M111.259507","article-title":"Elucidation of the molecular basis of selective recognition uncovers the interaction site for the core domain of scorpion alpha-toxins on sodium channels","volume":"286","author":"Gur","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2024.07.021_bib41","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3390\/molecules26051302","article-title":"Interactions of Sea Anemone Toxins with Insect Sodium Channel\u2014Insights from Electrophysiology and Molecular Docking Studies","volume":"26","author":"Niklas","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.str.2024.07.021_bib42","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0014-5793(93)81147-R","article-title":"Binding of an alpha scorpion toxin to insect sodium channels is not dependent on membrane potential","volume":"315","author":"Gordon","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.str.2024.07.021_bib43","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42166","article-title":"New tools for automated high-resolution cryo-EM structure determination in RELION-3","volume":"7","author":"Zivanov","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.str.2024.07.021_bib44","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2024.07.021_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jsb.2015.11.003","article-title":"Gctf: Real-time CTF determination and correction","volume":"193","author":"Zhang","year":"2016","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.str.2024.07.021_bib46","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX : a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2024.07.021_bib47","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","article-title":"MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy","volume":"14","author":"Zheng","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.07.021_bib48","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39383","article-title":"Cryo-EM structure of the benzodiazepine-sensitive \u03b11\u03b21\u03b32S tri-heteromeric GABAA receptor in complex with GABA","volume":"7","author":"Phulera","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.str.2024.07.021_bib49","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/bioinformatics\/btk023","article-title":"OPM: Orientations of Proteins in Membranes Database","volume":"22","author":"Lomize","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.str.2024.07.021_bib50","unstructured":"Molecular Operating Environment (MOE), 2022.02 Chemical Computing Group ULC, 910-1010 Sherbrooke St. W., Montreal, QC H3A 2R7, 2024."},{"key":"10.1016\/j.str.2024.07.021_bib51","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1021\/acs.jcim.9b00269","article-title":"PACKMOL-Memgen: A Simple-To-Use, Generalized Workflow for Membrane-Protein\u2013Lipid-Bilayer System Building","volume":"59","author":"Schott-Verdugo","year":"2019","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.str.2024.07.021_bib52","series-title":"AMBER 2016","author":"Case","year":"2016"},{"key":"10.1016\/j.str.2024.07.021_bib53","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1021\/ct200909j","article-title":"Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born","volume":"8","author":"G\u00f6tz","year":"2012","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.str.2024.07.021_bib54","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1021\/ct400314y","article-title":"Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald","volume":"9","author":"Salomon-Ferrer","year":"2013","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.str.2024.07.021_bib55","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.cpc.2012.09.022","article-title":"SPFP: Speed Without Compromise\u2014a Mixed Precision Model for GPU Accelerated Molecular Dynamics Simulations","volume":"184","author":"Le Grand","year":"2013","journal-title":"Comput. Phys. Commun."},{"key":"10.1016\/j.str.2024.07.021_bib56","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/acs.jctc.9b00591","article-title":"ff19SB: Amino-Acid-Specific Protein Backbone Parameters Trained against Quantum Mechanics Energy Surfaces in Solution","volume":"16","author":"Tian","year":"2020","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.str.2024.07.021_bib57","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of Simple Potential Functions for Simulating Liquid Water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J.\u00a0Chem. Phys."},{"key":"10.1016\/j.str.2024.07.021_bib58","doi-asserted-by":"crossref","first-page":"9617","DOI":"10.1039\/c2sm26007g","article-title":"GAFFlipid: a General Amber Force Field for the accurate molecular dynamics simulation of phospholipid","volume":"8","author":"Dickson","year":"2012","journal-title":"Soft Matter"},{"key":"10.1016\/j.str.2024.07.021_bib59","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1021\/jp3059992","article-title":"LIPID11: A Modular Framework for Lipid Simulations Using Amber","volume":"116","author":"Skjevik","year":"2012","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.str.2024.07.021_bib60","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1021\/ct4010307","article-title":"Lipid14: the Amber Lipid Force Field","volume":"10","author":"Dickson","year":"2014","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.str.2024.07.021_bib61","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/acs.jctc.1c01217","article-title":"Lipid21: Complex Lipid Membrane Simulations with AMBER","volume":"18","author":"Dickson","year":"2022","journal-title":"J.\u00a0Chem. Theory Comput."},{"key":"10.1016\/j.str.2024.07.021_bib62","doi-asserted-by":"crossref","first-page":"9020","DOI":"10.1021\/jp8001614","article-title":"Determination of Alkali and Halide Monovalent Ion Parameters for Use in Explicitly Solvated Biomolecular Simulations","volume":"112","author":"Joung","year":"2008","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.str.2024.07.021_bib63","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/jcc.20820","article-title":"GLYCAM06: A generalizable biomolecular force field","volume":"29","author":"Kirschner","year":"2008","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.str.2024.07.021_bib64","series-title":"Numerical Recipes: The Art of Scientific Computing","first-page":"515","article-title":"Conjugate Gradient Methods in Multidimensions","author":"Press","year":"2007"},{"key":"10.1016\/j.str.2024.07.021_bib65","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1080\/00268978800101881","article-title":"An Analysis of the Accuracy of Langevin and Molecular Dynamics Algorithms","volume":"65","author":"Pastor","year":"1988","journal-title":"Mol. Phys."},{"key":"10.1016\/j.str.2024.07.021_bib66","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular-Dynamics with Coupling to An External Bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J.\u00a0Chem. Phys."},{"key":"10.1016\/j.str.2024.07.021_bib67","series-title":"Computer Simulation of Liquids","author":"Allen","year":"2017"},{"key":"10.1016\/j.str.2024.07.021_bib68","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data","volume":"9","author":"Roe","year":"2013","journal-title":"J.\u00a0Chem. Theory Comput."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212624002843?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212624002843?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:52:49Z","timestamp":1759611169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212624002843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":68,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0969212624002843"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2024.07.021","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.01.26.577479","asserted-by":"object"}]},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Scorpion \u03b1-toxin Lqh\u03b1IT specifically interacts with a glycan at the pore domain of voltage-gated sodium channels","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2024.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}