{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:44:23Z","timestamp":1791841463158,"version":"4.3.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":369,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24GM129547"],"award-info":[{"award-number":["U24GM129547"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["DP2-HL163810"],"award-info":[{"award-number":["DP2-HL163810"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["I-2121-20220331"],"award-info":[{"award-number":["I-2121-20220331"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"The University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP170644"],"award-info":[{"award-number":["RP170644"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["1S10OD020103-01"],"award-info":[{"award-number":["1S10OD020103-01"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["1S10OD021685-01A1"],"award-info":[{"award-number":["1S10OD021685-01A1"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006206","name":"Biological and Environmental Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006132","name":"Office of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["847236"],"award-info":[{"award-number":["847236"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007000","name":"Laboratory Directed Research and Development","doi-asserted-by":"publisher","award":["DE-AC02-76SF00515"],"award-info":[{"award-number":["DE-AC02-76SF00515"]}],"id":[{"id":"10.13039\/100007000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007000","name":"Laboratory Directed Research and Development","doi-asserted-by":"publisher","award":["U24 GM129539"],"award-info":[{"award-number":["U24 GM129539"]}],"id":[{"id":"10.13039\/100007000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.str.2024.09.021","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T10:40:34Z","timestamp":1729161634000},"page":"2244-2250.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["ATTRv-V30M amyloid fibrils from heart and nerves exhibit structural homogeneity"],"prefix":"10.1016","volume":"32","author":[{"given":"Binh An","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-1617","authenticated-orcid":false,"given":"Shumaila","family":"Afrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Yakubovska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Pedretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Pekala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Vaquer","family":"Alicea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kunach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lemoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kluve-Beckerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Saelices","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2024.09.021_bib1","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3390\/jcm11082148","article-title":"Treatment of Transthyretin Amyloid Cardiomyopathy: The Current Options, the Future, and the Challenges","volume":"11","author":"Tsch\u00f6pe","year":"2022","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.str.2024.09.021_bib2","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1007\/s00018-009-0109-0","article-title":"Transthyretin: the servant of many masters","volume":"66","author":"Buxbaum","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.str.2024.09.021_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2020.592644","article-title":"Modulation of the Mechanisms Driving Transthyretin Amyloidosis","volume":"13","author":"Bezerra","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.str.2024.09.021_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3109\/07853890.2015.1068949","article-title":"Evolving landscape in the management of transthyretin amyloidosis","volume":"47","author":"Hawkins","year":"2015","journal-title":"Ann. Med."},{"key":"10.1016\/j.str.2024.09.021_bib5","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/CIRCULATIONAHA.111.078915","article-title":"Transthyretin (TTR) cardiac amyloidosis","volume":"126","author":"Ruberg","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.str.2024.09.021_bib6","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1136\/jnnp-2021-327909","article-title":"Novel approaches to diagnosis and\u00a0management of hereditary transthyretin amyloidosis","volume":"93","author":"Carroll","year":"2022","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.str.2024.09.021_bib7","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41586-023-06437-2","article-title":"Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids","volume":"621","author":"Scheres","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.str.2024.09.021_bib8","doi-asserted-by":"crossref","first-page":"7141","DOI":"10.1038\/s41467-021-27481-4","article-title":"Structural basis for transthyretin amyloid formation in vitreous body of the eye","volume":"12","author":"Iakovleva","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.09.021_bib9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s42003-024-06588-6","article-title":"Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis","volume":"7","author":"Nguyen","year":"2024","journal-title":"Comms. Bio."},{"key":"10.1016\/j.str.2024.09.021_bib10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41467-024-44820-3","article-title":"Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy","volume":"15","author":"Nguyen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.09.021_bib11","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1038\/s41467-019-13038-z","article-title":"Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis","volume":"10","author":"Schmidt","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.09.021_bib12","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.1038\/s41467-023-43301-3","article-title":"Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis","volume":"14","author":"Steinebrei","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.09.021_bib13","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1038\/s41467-022-33591-4","article-title":"Cryo-EM structure of an ATTRwt amyloid fibril from systemic non-hereditary transthyretin amyloidosis","volume":"13","author":"Steinebrei","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.09.021_bib14","article-title":"Amyloid fibril polymorphism in the heart of an ATTR amyloidosis patient with polyneuropathy attributed to the V122\u0394 variant","author":"Ahmed","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.str.2024.09.021_bib15","article-title":"Multi-organ structural homogeneity of amyloid fibrils in ATTRv-T60A amyloidosis patients, revealed by Cryo-EM","author":"Fernandez-Ramirez","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.str.2024.09.021_bib16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/joim.12585","article-title":"One mutation, two distinct disease variants: unravelling the impact of transthyretin amyloid fibril composition","volume":"281","author":"Suhr","year":"2017","journal-title":"J.\u00a0Intern. Med."},{"key":"10.1016\/j.str.2024.09.021_bib17","first-page":"76","article-title":"Enhanced fold recognition using efficient short fragment clustering","volume":"1","author":"Krissinel","year":"2012","journal-title":"J.\u00a0Mol. Biochem."},{"key":"10.1016\/j.str.2024.09.021_bib18","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1016\/j.cell.2021.08.013","article-title":"The expanding amyloid family: Structure, stability, function, and pathogenesis","volume":"184","author":"Sawaya","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.str.2024.09.021_bib19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s40120-020-00217-0","article-title":"A Narrative Review of the Role of Transthyretin in Health and Disease","volume":"9","author":"Liz","year":"2020","journal-title":"Neurol. Ther."},{"key":"10.1016\/j.str.2024.09.021_bib20","doi-asserted-by":"crossref","first-page":"7261","DOI":"10.1038\/s41467-022-34636-4","article-title":"Amyloid fibril structure from the vascular variant of systemic AA amyloidosis","volume":"13","author":"Banerjee","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.09.021_bib21","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/s41467-019-09033-z","article-title":"Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids","volume":"10","author":"Liberta","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.09.021_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105122","article-title":"Flanking regions, amyloid cores, and polymorphism: the potential interplay underlying structural diversity","volume":"299","author":"Bhopatkar","year":"2023","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2024.09.021_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam7621","article-title":"Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients","volume":"9","author":"Schonhoft","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.str.2024.09.021_bib24","first-page":"1088","article-title":"Structure-based probe reveals the presence of large transthyretin aggregates in plasma of ATTR amyloidosis patients","volume":"9","author":"Pedretti","year":"2024","journal-title":"J. Am. Coll. Cardiol. Basic. Trans. Science"},{"key":"10.1016\/j.str.2024.09.021_bib25","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/CIRCULATIONAHA.123.067225","article-title":"Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis","volume":"149","author":"Pedretti","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.str.2024.09.021_bib26","first-page":"1","article-title":"Detection of ATTR aggregates in the plasma of polyneuropathic patients with ATTR-V30M amyloidosis","author":"Pedretti","year":"2024","journal-title":"Amyloid\u202f: the international journal of experimental and clinical investigation\u202f: the official journal of the International Society of Amyloidosis"},{"key":"10.1016\/j.str.2024.09.021_bib27","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1042\/BCJ20210708","article-title":"New tools for automated cryo-EM single-particle analysis in RELION-4.0","volume":"478","author":"Kimanius","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.str.2024.09.021_bib28","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/s41592-019-0575-8","article-title":"Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs","volume":"16","author":"Bepler","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.09.021_bib29","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2024.09.021_bib30","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.str.2024.09.021_bib31","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1172\/JCI105784","article-title":"The characterization of soluble amyloid prepared in water","volume":"47","author":"Pras","year":"1968","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.str.2024.09.021_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1107\/S2052252520000081","article-title":"Estimation of high-order\u00a0aberrations and anisotropic magnification from cryo-EM data\u00a0sets in RELION-3.1","volume":"7","author":"Zivanov","year":"2020","journal-title":"IUCrJ"},{"key":"10.1016\/j.str.2024.09.021_bib33","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsb.2015.08.008","article-title":"CTFFIND4: Fast and accurate defocus estimation from electron micrographs","volume":"192","author":"Rohou","year":"2015","journal-title":"J.\u00a0Struct. Biol."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212624004210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212624004210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:47:51Z","timestamp":1778518071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212624004210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0969212624004210"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2024.09.021","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATTRv-V30M amyloid fibrils from heart and nerves exhibit structural homogeneity","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2024.09.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}