{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T16:00:55Z","timestamp":1772121655961,"version":"3.50.1"},"reference-count":78,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["419240"],"award-info":[{"award-number":["419240"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2018-06070"],"award-info":[{"award-number":["RGPIN-2018-06070"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.str.2024.11.004","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T10:35:11Z","timestamp":1732876511000},"page":"51-61.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the structural proteome of an Alzheimer\u2019s disease rat brain model"],"prefix":"10.1016","volume":"33","author":[{"given":"Elnaz Khalili","family":"Samani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.M. Naimul","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Waas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander F.A.","family":"Keszei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahtab","family":"Heydari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Elizabeth","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnne","family":"McLaurin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-5540","authenticated-orcid":false,"given":"Thomas","family":"Kislinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad T.","family":"Mazhab-Jafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2024.11.004_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/alz.12328","article-title":"Alzheimer\u2019s disease facts and figures (2021)","volume":"17","author":"Monica Moore","year":"2021","journal-title":"Alzheimers Dement. J. Alzheimers Assoc."},{"key":"10.1016\/j.str.2024.11.004_bib2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.str.2024.11.004_bib3","article-title":"Alzheimer\u2019s disease drug development pipeline: 2023","volume":"9","author":"Cummings","year":"2023","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.str.2024.11.004_bib4","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.3390\/ijms24065383","article-title":"New Pathways Identify Novel Drug Targets for the Prevention and Treatment of Alzheimer\u2019s Disease","volume":"24","author":"Penke","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.str.2024.11.004_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1101\/gr.1984404","article-title":"Patterns of Insertions and Their Covariation With Substitutions in the Rat, Mouse, and Human\u00a0Genomes","volume":"14","author":"Yang","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.str.2024.11.004_bib6","doi-asserted-by":"crossref","first-page":"6245","DOI":"10.1523\/JNEUROSCI.3672-12.2013","article-title":"A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric a\u03b2, and frank neuronal loss","volume":"33","author":"Cohen","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.str.2024.11.004_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-18415-1","article-title":"Task-dependent learning and memory deficits in the TgF344-AD rat model of Alzheimer\u2019s disease: three key timepoints through middle-age in females","volume":"12","author":"Bernaud","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.str.2024.11.004_bib8","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3390\/ijms21061985","article-title":"Potential Role of Venular Amyloid in Alzheimer\u2019s Disease Pathogenesis","volume":"21","author":"Morrone","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.str.2024.11.004_bib9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40035-022-00300-6","article-title":"Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer\u2019s disease","volume":"11","author":"Morrone","year":"2022","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.str.2024.11.004_bib10","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1017\/S0033583516000068","article-title":"Single particle electron cryomicroscopy: trends, issues and future perspective","volume":"49","author":"Vinothkumar","year":"2016","journal-title":"Q.\u00a0Rev. Biophys."},{"key":"10.1016\/j.str.2024.11.004_bib11","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.3390\/molecules25184262","article-title":"Structural Heterogeneities of the Ribosome: New Frontiers and Opportunities for Cryo-EM","volume":"25","author":"Poitevin","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.str.2024.11.004_bib12","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41592-020-01021-2","article-title":"A \u201cBuild and Retrieve\u201d methodology to simultaneously solve cryo-EM structures of membrane proteins","volume":"18","author":"Su","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.11.004_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111876","article-title":"Toward structural-omics of the bovine retinal pigment epithelium","volume":"41","author":"Morgan","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.str.2024.11.004_bib14","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201580","article-title":"Simultaneous solving high-resolution structures of various enzymes from human kidney microsomes","volume":"6","author":"Lyu","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.str.2024.11.004_bib15","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201724","article-title":"A cryo-electron microscopic approach to elucidate protein structures from human brain microsomes","volume":"6","author":"Tringides","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.str.2024.11.004_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1154446","article-title":"Contribution of the dihydropyrimidinase-like proteins family in synaptic physiology and in neurodevelopmental disorders","volume":"17","author":"Desprez","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.str.2024.11.004_bib17","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0891-5849(02)00914-0","article-title":"Proteomic identification of oxidatively modified proteins in alzheimer\u2019s disease brain. part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1","volume":"33","author":"Castegna","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.str.2024.11.004_bib18","doi-asserted-by":"crossref","first-page":"11949","DOI":"10.1073\/pnas.89.24.11949","article-title":"Detection of glutamine synthetase in the cerebrospinal fluid of Alzheimer diseased patients: a potential diagnostic biochemical marker","volume":"89","author":"Gunnersen","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.11.004_bib19","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1038\/s41467-023-38376-x","article-title":"Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer\u2019s disease","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.11.004_bib20","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1080\/15548627.2023.2181614","article-title":"Endolysosomal impairment by binding of amyloid beta or MAPT\/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease","volume":"19","author":"Kim","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.str.2024.11.004_bib21","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1471-4159.2006.04401.x","article-title":"The structure of human collapsin response mediator protein 2, a regulator of axonal growth","volume":"101","author":"Stenmark","year":"2007","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.str.2024.11.004_bib22","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41467-017-02811-7","article-title":"Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation","volume":"9","author":"Zheng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.11.004_bib23","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1523\/JNEUROSCI.4276-06.2006","article-title":"Collapsin Response Mediator Protein 1 Mediates Reelin Signaling in Cortical Neuronal Migration","volume":"26","author":"Yamashita","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.str.2024.11.004_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JAD-160076","article-title":"Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer\u2019s Disease: Comparison and Contrast with Microtubule-Associated Protein Tau","volume":"53","author":"Hensley","year":"2016","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.str.2024.11.004_bib25","doi-asserted-by":"crossref","first-page":"E8443","DOI":"10.1073\/pnas.1610531113","article-title":"Hierarchical CRMP2 posttranslational modifications control NaV1.7 function","volume":"113","author":"Dustrude","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.11.004_bib26","doi-asserted-by":"crossref","first-page":"6736","DOI":"10.1007\/s12035-019-1568-4","article-title":"Dysregulation of CRMP2 post-translational modifications drive its pathological functions","volume":"56","author":"Moutal","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.str.2024.11.004_bib27","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1021\/acschemneuro.0c00307","article-title":"Druggability of CRMP2 for Neurodegenerative Diseases","volume":"11","author":"Khanna","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.str.2024.11.004_bib28","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nature09372","article-title":"Direct visualization of secondary structures of F-actin by electron cryomicroscopy","volume":"467","author":"Fujii","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.str.2024.11.004_bib29","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1105\/tpc.18.00973","article-title":"Cryo-EM Structure of Actin Filaments from Zea mays Pollen[OPEN]","volume":"31","author":"Ren","year":"2019","journal-title":"Plant Cell"},{"key":"10.1016\/j.str.2024.11.004_bib30","article-title":"Weighted Gene Coexpression Network Analysis Reveals Essential Genes and Pathways in Bipolar Disorder","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.str.2024.11.004_bib31","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jgr.2015.09.004","article-title":"Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in \u03b2-amyloid-treated neuronal cells","volume":"40","author":"Hwang","year":"2016","journal-title":"J.\u00a0Ginseng Res."},{"key":"10.1016\/j.str.2024.11.004_bib32","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/s41592-019-0575-8","article-title":"Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs","volume":"16","author":"Bepler","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.11.004_bib33","article-title":"Cryo-EM structures of both ends of the actin filament explain why the barbed end elongates faster than the pointed end","author":"Chou","year":"2023","journal-title":"BioRxiv"},{"key":"10.1016\/j.str.2024.11.004_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/bj1050361","article-title":"3-Methylhistidine in actin and other muscle proteins","volume":"105","author":"Johnson","year":"1967","journal-title":"Biochem. J."},{"key":"10.1016\/j.str.2024.11.004_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.tibs.2013.02.004","article-title":"Protein methylation at the surface and buried deep: thinking outside the histone box","volume":"38","author":"Clarke","year":"2013","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.str.2024.11.004_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41586-018-0821-8","article-title":"SETD3 is an actin histidine methyltransferase that prevents primary dystocia","volume":"565","author":"Wilkinson","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.str.2024.11.004_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50963","article-title":"Profilin and formin constitute a pacemaker system for robust actin filament growth","volume":"8","author":"Funk","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.str.2024.11.004_bib38","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-022-05241-8","article-title":"Structural basis of actin filament assembly and aging","volume":"611","author":"Oosterheert","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.str.2024.11.004_bib39","series-title":"Diet and Nutrition in Dementia and Cognitive Decline","first-page":"761","article-title":"Chapter 70 - Glutamine as a Potential Neuroprotectant in Alzheimer\u2019s Disease","author":"Chen","year":"2015"},{"key":"10.1016\/j.str.2024.11.004_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1750-1326-6-55","article-title":"Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer\u2019s disease mouse model: mechanism for deficient glutamatergic transmission?","volume":"6","author":"Olabarria","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.str.2024.11.004_bib41","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jmb.2007.10.029","article-title":"Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design","volume":"375","author":"Krajewski","year":"2008","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.str.2024.11.004_bib42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3390\/biom12010135","article-title":"Mass Spectrometry-Based Structural Proteomics for Metal Ion\/Protein Binding Studies","volume":"12","author":"Lin","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.str.2024.11.004_bib43","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.str.2024.11.004_bib44","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1126\/science.aaz2924","article-title":"Structure of V-ATPase from the mammalian brain","volume":"367","author":"Abbas","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.str.2024.11.004_bib45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1128\/MMBR.70.1.177-191.2006","article-title":"The where, when, and how of organelle acidification by the yeast vacuolar H+-ATPase","volume":"70","author":"Kane","year":"2006","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.str.2024.11.004_bib46","doi-asserted-by":"crossref","first-page":"17025","DOI":"10.1016\/S0021-9258(17)46944-4","article-title":"Disassembly and reassembly of the yeast vacuolar H(+)-ATPase in\u00a0vivo","volume":"270","author":"Kane","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2024.11.004_bib47","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41594-022-00757-z","article-title":"Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation","volume":"29","author":"Vasanthakumar","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.str.2024.11.004_bib48","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1074\/jbc.270.10.5649","article-title":"Regulation of plasma membrane V-ATPase activity by dissociation of peripheral subunits","volume":"270","author":"Sumner","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2024.11.004_bib49","doi-asserted-by":"crossref","first-page":"16591","DOI":"10.1074\/jbc.M513344200","article-title":"Distinct Priming Kinases Contribute to Differential Regulation of Collapsin Response Mediator Proteins by Glycogen Synthase Kinase-3 in\u00a0Vivo","volume":"281","author":"Cole","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.str.2024.11.004_bib50","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2443.2005.00827.x","article-title":"Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3\u03b2 phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer\u2019s disease","volume":"10","author":"Uchida","year":"2005","journal-title":"Gene Cell."},{"key":"10.1016\/j.str.2024.11.004_bib51","doi-asserted-by":"crossref","first-page":"E4462","DOI":"10.1073\/pnas.1700111114","article-title":"Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis","volume":"114","author":"Tobe","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.11.004_bib52","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s12035-011-8166-4","article-title":"Collapsin Response Mediator Protein-2: An Emerging Pathologic Feature and Therapeutic Target for Neurodisease Indications","volume":"43","author":"Hensley","year":"2011","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.str.2024.11.004_bib53","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/mp.2017.117","article-title":"Blocking CRMP2 SUMOylation reverses neuropathic pain","volume":"23","author":"Moutal","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.str.2024.11.004_bib54","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1523\/JNEUROSCI.5247-09.2010","article-title":"Proteomic Identification of Binding Partners for the Brain Metabolite Lanthionine Ketimine (LK) and Documentation of LK Effects on Microglia and Motoneuron Cell Cultures","volume":"30","author":"Hensley","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.str.2024.11.004_bib55","doi-asserted-by":"crossref","first-page":"908","DOI":"10.3390\/ijms21030908","article-title":"Dendritic Spines in Alzheimer\u2019s Disease: How the Actin Cytoskeleton Contributes to Synaptic Failure","volume":"21","author":"Pelucchi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.str.2024.11.004_bib56","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.43676","article-title":"Structural insights into SETD3-mediated histidine methylation on \u03b2-actin","volume":"8","author":"Guo","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.str.2024.11.004_bib57","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3389\/fpsyt.2018.00561","article-title":"Elevated Glutamate and Glutamine Levels in the Cerebrospinal Fluid of Patients With Probable Alzheimer\u2019s Disease and Depression","volume":"9","author":"Madeira","year":"2018","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.str.2024.11.004_bib58","doi-asserted-by":"crossref","first-page":"10540","DOI":"10.1073\/pnas.88.23.10540","article-title":"Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease","volume":"88","author":"Smith","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2024.11.004_bib59","doi-asserted-by":"crossref","first-page":"604","DOI":"10.4161\/cib.3.6.13364","article-title":"On the role of v-ATPase V0a1\u2013dependent degradation in Alzheimer Disease","volume":"3","author":"Williamson","year":"2010","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/j.str.2024.11.004_bib60","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41581-019-0160-5","article-title":"The (pro)renin receptor in health and disease","volume":"15","author":"Ichihara","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.str.2024.11.004_bib61","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1038\/s41467-018-05886-y","article-title":"Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors","volume":"9","author":"Pareja","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2024.11.004_bib62","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.11.004_bib63","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.str.2024.11.004_bib64","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/s41594-023-01101-9","article-title":"Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments","volume":"30","author":"Oosterheert","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.str.2024.11.004_bib65","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2024.11.004_bib66","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ymeth.2011.07.005","article-title":"The Phenix software for automated determination of macromolecular structures","volume":"55","author":"Adams","year":"2011","journal-title":"Methods"},{"key":"10.1016\/j.str.2024.11.004_bib67","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2024.11.004_bib68","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pro.3235","article-title":"UCSF ChimeraX: Meeting modern challenges in visualization and analysis","volume":"27","author":"Goddard","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2024.11.004_bib69","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1021\/ac403185a","article-title":"Combine and conquer: surfactants, solvents, and chaotropes for robust mass spectrometry based analyses of membrane proteins","volume":"86","author":"Waas","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.str.2024.11.004_bib70","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1021\/acs.jproteome.8b00916","article-title":"SP2: Rapid and Automatable Contaminant Removal from Peptide Samples for Proteomic Analyses","volume":"18","author":"Waas","year":"2019","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.str.2024.11.004_bib71","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1021\/acs.jproteome.0c00544","article-title":"Fast Deisotoping Algorithm and Its Implementation in the MSFragger Search Engine","volume":"20","author":"Teo","year":"2021","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.str.2024.11.004_bib72","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nmeth.4256","article-title":"MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics","volume":"14","author":"Kong","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.11.004_bib73","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41592-020-0912-y","article-title":"Philosopher: a versatile toolkit for shotgun proteomics data analysis","volume":"17","author":"da Veiga Leprevost","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.11.004_bib74","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal. Chem."},{"key":"10.1016\/j.str.2024.11.004_bib75","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmeth1113","article-title":"Semi-supervised learning for peptide identification from shotgun proteomics datasets","volume":"4","author":"K\u00e4ll","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2024.11.004_bib76","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1021\/acs.jproteome.9b00205","article-title":"PTMProphet: Fast and Accurate Mass Modification Localization for the Trans-Proteomic Pipeline","volume":"18","author":"Shteynberg","year":"2019","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.str.2024.11.004_bib77","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/bioinformatics\/bty770","article-title":"PDV: an integrative proteomics data viewer","volume":"35","author":"Li","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.str.2024.11.004_bib78","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212624004945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212624004945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T02:58:54Z","timestamp":1767322734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212624004945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0969212624004945"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2024.11.004","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.07.11.602936","asserted-by":"object"}]},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the structural proteome of an Alzheimer\u2019s disease rat brain model","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2024.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}