{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:42:34Z","timestamp":1791434554503,"version":"4.3.3"},"reference-count":78,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["OFIRG21nov-0014"],"award-info":[{"award-number":["OFIRG21nov-0014"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001107"],"award-info":[{"award-number":["MOH-001107"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Government of Singapore Ministry of Education","doi-asserted-by":"publisher","award":["MOE2019-T3-1-007"],"award-info":[{"award-number":["MOE2019-T3-1-007"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Government of Singapore Ministry of Education","doi-asserted-by":"publisher","award":["MOE-T2EP30120-0015"],"award-info":[{"award-number":["MOE-T2EP30120-0015"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Government of Singapore Ministry of Education","doi-asserted-by":"publisher","award":["RG98\/22"],"award-info":[{"award-number":["RG98\/22"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Government of Singapore Ministry of Education","doi-asserted-by":"publisher","award":["RG108\/20"],"award-info":[{"award-number":["RG108\/20"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Government of Singapore Ministry of Education","doi-asserted-by":"publisher","award":["RT24\/23"],"award-info":[{"award-number":["RT24\/23"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-CRP27-2021RS-0001"],"award-info":[{"award-number":["NRF-CRP27-2021RS-0001"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation","doi-asserted-by":"publisher","award":["NRF-CRP24-2020-0005"],"award-info":[{"award-number":["NRF-CRP24-2020-0005"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.str.2025.05.008","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:34:40Z","timestamp":1749119680000},"page":"1386-1397.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome"],"prefix":"10.1016","volume":"33","author":[{"given":"Ka Diam","family":"Go","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Fu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grennady","family":"Wirjanata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rya","family":"Ero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Pazicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy","family":"Dziekan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth","family":"Tjia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lescar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbynek","family":"Bozdech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-0835","authenticated-orcid":false,"given":"Yong-Gui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2025.05.008_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4269\/ajtmh.2007.77.181","article-title":"Artemisinin-based combination treatment of falciparum malaria","volume":"77","author":"Nosten","year":"2007","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.str.2025.05.008_bib2","unstructured":"Global Malaria Programme, T.W.H.O. (2018). Artemisinin resistance and artemisinin-based combination therapy efficacy. https:\/\/www.who.int\/docs\/default-source\/documents\/publications\/gmp\/who-cds-gmp-2018-26-eng.pdf."},{"key":"10.1016\/j.str.2025.05.008_bib3","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/QCO.0000000000000766","article-title":"Artemisinin and multidrug-resistant Plasmodium falciparum - a threat for malaria control and elimination","volume":"34","author":"Dhorda","year":"2021","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.str.2025.05.008_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00109-24","article-title":"Artemisinin-resistant malaria","volume":"37","author":"White","year":"2024","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.str.2025.05.008_bib5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1056\/NEJMoa2101746","article-title":"Evidence of Artemisinin-Resistant Malaria in Africa","volume":"385","author":"Balikagala","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.str.2025.05.008_bib6","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.medj.2021.11.005","article-title":"Artemisinin resistance in Africa: How urgent is the threat?","volume":"2","author":"Fidock","year":"2021","journal-title":"Med"},{"key":"10.1016\/j.str.2025.05.008_bib7","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1056\/NEJMc2117480","article-title":"Evidence of Artemisinin-Resistant Malaria in Africa","volume":"386","author":"Stokes","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.str.2025.05.008_bib8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMc1909337","article-title":"A Temporizing Solution to \"Artemisinin Resistance","volume":"381","author":"Chan","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.str.2025.05.008_bib9","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0020-7519(02)00194-7","article-title":"Artemisinin: mechanisms of action, resistance and toxicity","volume":"32","author":"Meshnick","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.str.2025.05.008_bib10","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1021\/acsinfecdis.9b00527","article-title":"Plasmodium falciparum Artemisinin Resistance: The Effect of Heme, Protein Damage, and Parasite Cell Stress Response","volume":"6","author":"Rosenthal","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.str.2025.05.008_bib11","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.pt.2016.05.010","article-title":"Artemisinin Action and Resistance in Plasmodium falciparum","volume":"32","author":"Tilley","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.str.2025.05.008_bib12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.mib.2013.07.005","article-title":"Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins","volume":"16","author":"Klonis","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.str.2025.05.008_bib13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.pt.2017.05.009","article-title":"Protein Degradation Systems as Antimalarial Therapeutic Targets","volume":"33","author":"Ng","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.str.2025.05.008_bib14","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10111","article-title":"Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2025.05.008_bib15","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1073\/pnas.1600459113","article-title":"Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7","volume":"113","author":"Ismail","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2025.05.008_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008485","article-title":"System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion","volume":"16","author":"Giannangelo","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.str.2025.05.008_bib17","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1038\/s41596-020-0310-z","article-title":"Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome","volume":"15","author":"Dziekan","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.str.2025.05.008_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau3174","article-title":"Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay","volume":"11","author":"Dziekan","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.str.2025.05.008_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/1471-2164-12-391","article-title":"Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription","volume":"12","author":"Mok","year":"2011","journal-title":"BMC Genom."},{"key":"10.1016\/j.str.2025.05.008_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03080","article-title":"Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine","volume":"3","author":"Wong","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.str.2025.05.008_bib21","first-page":"10515","article-title":"Dynamical features of the Plasmodium falciparum ribosome during translation","volume":"43","author":"Sun","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.str.2025.05.008_bib22","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1128\/MCB.01718-08","article-title":"Direct link between RACK1 function and localization at the ribosome in vivo","volume":"29","author":"Coyle","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.str.2025.05.008_bib23","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nsmb822","article-title":"Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM","volume":"11","author":"Sengupta","year":"2004","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.str.2025.05.008_bib24","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1126\/science.1198308","article-title":"Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1","volume":"331","author":"Rabl","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.str.2025.05.008_bib25","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/sj.embor.7400291","article-title":"Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome","volume":"5","author":"Nilsson","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.str.2025.05.008_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208273","article-title":"An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions","volume":"13","author":"Lim","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.str.2025.05.008_bib27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.exppara.2017.02.017","article-title":"Growth inhibitory effects of standard pro- and antioxidants on the human malaria parasite Plasmodium falciparum","volume":"180","author":"Wezena","year":"2017","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.str.2025.05.008_bib28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2011.05.002","article-title":"Malaria parasite clag3 genes determine channel-mediated nutrient uptake by infected red blood cells","volume":"145","author":"Nguitragool","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.str.2025.05.008_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002132","article-title":"Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance","volume":"13","author":"Dogovski","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.str.2025.05.008_bib30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nchembio.304","article-title":"Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin","volume":"6","author":"Schneider-Poetsch","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.str.2025.05.008_bib31","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1073\/pnas.1913525117","article-title":"Plasmodium chaperonin TRiC\/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy","volume":"117","author":"Lu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2025.05.008_bib32","doi-asserted-by":"crossref","first-page":"9114","DOI":"10.1073\/pnas.85.23.9114","article-title":"Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria","volume":"85","author":"Peterson","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2025.05.008_bib33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1260403","article-title":"Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance","volume":"347","author":"Mok","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.str.2025.05.008_bib34","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0022-2836(74)90188-0","article-title":"A thermodynamic approach to the problem of stabilization of globular protein structure: a calorimetric study","volume":"86","author":"Privalov","year":"1974","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2025.05.008_bib35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/pro.3986","article-title":"In-depth interrogation of protein thermal unfolding data with MoltenProt","volume":"30","author":"Kotov","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2025.05.008_bib36","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1126\/science.1260867","article-title":"Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates","volume":"347","author":"Straimer","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.str.2025.05.008_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01320-21","article-title":"Mutation in the Plasmodium falciparum BTB\/POZ Domain of K13 Protein Confers Artemisinin Resistance","volume":"66","author":"Paloque","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.str.2025.05.008_bib38","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature24482","article-title":"Visualization of chemical modifications in the human 80S ribosome structure","volume":"551","author":"Natchiar","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.str.2025.05.008_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nature12104","article-title":"Structures of the human and Drosophila 80S ribosome","volume":"497","author":"Anger","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.str.2025.05.008_bib40","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1126\/science.1212642","article-title":"The structure of the eukaryotic ribosome at 3.0 \u00c5 resolution","volume":"334","author":"Ben-Shem","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.str.2025.05.008_bib41","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1021\/ar100070k","article-title":"Heme as trigger and target for trioxane-containing antimalarial drugs","volume":"43","author":"Meunier","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.str.2025.05.008_bib42","article-title":"Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation","volume":"5","author":"Wang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.str.2025.05.008_bib43","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nature01813","article-title":"Artemisinins target the SERCA of Plasmodium falciparum","volume":"424","author":"Eckstein-Ludwig","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.str.2025.05.008_bib44","doi-asserted-by":"crossref","first-page":"19383","DOI":"10.1074\/jbc.274.27.19383","article-title":"Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite","volume":"274","author":"Pandey","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.str.2025.05.008_bib45","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3390\/molecules15031705","article-title":"The molecular mechanism of action of artemisinin--the debate continues","volume":"15","author":"O'Neill","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.str.2025.05.008_bib46","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.cell.2014.07.011","article-title":"Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate","volume":"158","author":"Lisewski","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.str.2025.05.008_bib47","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/nature14412","article-title":"A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria","volume":"520","author":"Mbengue","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.str.2025.05.008_bib48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev-biochem-062917-012837","article-title":"Horizontal Cell Biology: Monitoring Global Changes of Protein Interaction States with the Proteome-Wide Cellular Thermal Shift Assay (CETSA)","volume":"88","author":"Dai","year":"2019","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.str.2025.05.008_bib49","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-010715-103715","article-title":"The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies","volume":"56","author":"Martinez Molina","year":"2016","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.str.2025.05.008_bib50","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.cell.2018.03.065","article-title":"Modulation of Protein-Interaction States through the Cell Cycle","volume":"173","author":"Dai","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.str.2025.05.008_bib51","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1073\/pnas.0900653106","article-title":"Charting the molecular network of the drug target Bcr-Abl","volume":"106","author":"Brehme","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.str.2025.05.008_bib52","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1038\/s41467-018-07588-x","article-title":"The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background","volume":"9","author":"Zhu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2025.05.008_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006930","article-title":"Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites","volume":"14","author":"Rocamora","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.str.2025.05.008_bib54","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.chom.2017.11.005","article-title":"Inhibiting the Plasmodium eIF2alpha Kinase PK4 Prevents Artemisinin-Induced Latency","volume":"22","author":"Zhang","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.str.2025.05.008_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011118","article-title":"Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum","volume":"19","author":"Kucharski","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.str.2025.05.008_bib56","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1038\/s41467-018-06221-1","article-title":"Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome","volume":"9","author":"Bridgford","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2025.05.008_bib57","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41467-020-20805-w","article-title":"Artemisinin-resistant K13 mutations rewire Plasmodium falciparum\u2019s intra-erythrocytic metabolic program to enhance survival","volume":"12","author":"Mok","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2025.05.008_bib58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1126\/science.aax4735","article-title":"A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites","volume":"367","author":"Birnbaum","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.str.2025.05.008_bib59","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S1473-3099(13)70252-4","article-title":"Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies","volume":"13","author":"Witkowski","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.str.2025.05.008_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101954","article-title":"Association of the receptor for activated C-kinase 1 with ribosomes in Plasmodium falciparum","volume":"298","author":"Erath","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.str.2025.05.008_bib61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13059-016-1014-0","article-title":"The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum","volume":"17","author":"Bunnik","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.str.2025.05.008_bib62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.gene.2019.04.087","article-title":"Communication between RACK1\/Asc1 and uS3 (Rps3) is essential for RACK1\/Asc1 function in yeast Saccharomyces cerevisiae","volume":"706","author":"Singh","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.str.2025.05.008_bib63","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.biochi.2013.11.001","article-title":"Eukaryotic ribosomal protein S3: A constituent of translational machinery and an extraribosomal player in various cellular processes","volume":"99","author":"Graifer","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.str.2025.05.008_bib64","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/138920312801619385","article-title":"Ribozoomin'--translation initiation from the perspective of the ribosome-bound eukaryotic initiation factors (eIFs)","volume":"13","author":"Valasek","year":"2012","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.str.2025.05.008_bib65","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2025.05.008_bib66","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jsb.2012.09.006","article-title":"RELION: implementation of a Bayesian approach to cryo-EM structure determination","volume":"180","author":"Scheres","year":"2012","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.str.2025.05.008_bib67","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2025.05.008_bib68","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2025.05.008_bib69","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2025.05.008_bib70","first-page":"82","article-title":"Pymol: An open-source molecular graphics tool. CCP4 Newsl","volume":"40","author":"DeLano","year":"2002","journal-title":"Protein Crystallogr"},{"key":"10.1016\/j.str.2025.05.008_bib71","doi-asserted-by":"crossref","first-page":"10320","DOI":"10.1021\/acs.analchem.1c04200","article-title":"Solvent Precipitation SP3 (SP4) Enhances Recovery for Proteomics Sample Preparation without Magnetic Beads","volume":"94","author":"Johnston","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.str.2025.05.008_bib72","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature01097","article-title":"Genome sequence of the human malaria parasite Plasmodium falciparum","volume":"419","author":"Gardner","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.str.2025.05.008_bib73","series-title":"Bioinformatics for Comparative Proteomics","first-page":"25","article-title":"A Guide to UniProt for Protein Scientists","author":"O\u2019Donovan","year":"2011"},{"key":"10.1016\/j.str.2025.05.008_bib74","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0031-6997(25)00026-2","article-title":"What is synergy?","volume":"41","author":"Berenbaum","year":"1989","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.str.2025.05.008_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110890","article-title":"Cryo-EM structure of the entire FtsH-HflKC AAA protease complex","volume":"39","author":"Qiao","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.str.2025.05.008_bib76","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-0716-0966-8_7","article-title":"Multi-body Refinement of Cryo-EM Images in RELION","volume":"2215","author":"Nakane","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.str.2025.05.008_bib77","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ultramic.2013.06.004","article-title":"High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy","volume":"135","author":"Chen","year":"2013","journal-title":"Ultramicroscopy"},{"key":"10.1016\/j.str.2025.05.008_bib78","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212625001868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212625001868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T20:33:56Z","timestamp":1755808436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212625001868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":78,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0969212625001868"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2025.05.008","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2025.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}