{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:54:54Z","timestamp":1792637694406,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.str.2026.01.003","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T16:07:52Z","timestamp":1770307672000},"page":"562-571.e8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Structural basis for pan-coronavirus inhibition of 3CL protease"],"prefix":"10.1016","volume":"34","author":[{"given":"Eswar R.","family":"Reddem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Forouhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Jekle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Wen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Oswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"McGowan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Vandyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Raboisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid N.","family":"Beigelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phinikoula S.","family":"Katsamba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Bahna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seetha","family":"Mannepalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Blatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Perlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian A.","family":"Symons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antitsa D.","family":"Stoycheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2026.01.003_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-2438-7_1","article-title":"Coronaviruses: An Overview of Their Replication and Pathogenesis","volume":"1282","author":"Fehr","year":"2015","journal-title":"Coronaviruses"},{"key":"10.1016\/j.str.2026.01.003_bib2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/jmv.25681","article-title":"Emerging coronaviruses: Genome structure, replication, and pathogenesis","volume":"92","author":"Chen","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.str.2026.01.003_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41579-022-00713-0","article-title":"SARS-CoV-2 pathogenesis","volume":"20","author":"Lamers","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.str.2026.01.003_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1213\/ANE.0000000000004845","article-title":"Coronaviruses and SARS-CoV-2: A Brief Overview","volume":"131","author":"Ludwig","year":"2020","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.str.2026.01.003_bib5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12931-020-01479-w","article-title":"From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses","volume":"21","author":"Zhu","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.str.2026.01.003_bib6","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1016\/j.jiph.2023.09.004","article-title":"An updated review on pathogenic coronaviruses (CoVs) amid the emergence of SARS-CoV-2 variants: A look into the repercussions and possible solutions","volume":"16","author":"Rabaan","year":"2023","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.str.2026.01.003_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41392-020-0190-2","article-title":"Overview of lethal human coronaviruses","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.str.2026.01.003_bib8","article-title":"COVID-19 outbreak: Impact on global economy","volume":"10","author":"Naseer","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.str.2026.01.003_bib9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.it.2021.07.001","article-title":"Why are there so few (or so many) circulating coronaviruses?","volume":"42","author":"Rice","year":"2021","journal-title":"Trends Immunol."},{"key":"10.1016\/j.str.2026.01.003_bib10","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2025.01.042","article-title":"Bat-infecting merbecovirus HKU5-CoV lineage 2 can use human ACE2 as a cell entry receptor","volume":"188","author":"Chen","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.str.2026.01.003_bib11","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/j.cell.2024.12.032","article-title":"Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses","volume":"188","author":"Park","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.str.2026.01.003_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.30802\/AALAS-CM-21-000092","article-title":"Coronaviruses: Troubling Crown of the Animal Kingdom","volume":"73","author":"Gozalo","year":"2023","journal-title":"Comp. Med."},{"key":"10.1016\/j.str.2026.01.003_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.628370","article-title":"A Review of SARS-CoV2: Compared With SARS-CoV and MERS-CoV","volume":"8","author":"Zhou","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.str.2026.01.003_bib14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13337-020-00632-9","article-title":"SARS-CoV, MERS-CoV, and 2019-nCoV viruses: an overview of origin, evolution, and genetic variations","volume":"31","author":"Krishnamoorthy","year":"2020","journal-title":"VirusDisease"},{"key":"10.1016\/j.str.2026.01.003_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41579-021-00630-8","article-title":"Structural biology of SARS-CoV-2 and implications for therapeutic development","volume":"19","author":"Yang","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.str.2026.01.003_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115491","article-title":"The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022","volume":"257","author":"Pang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.str.2026.01.003_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.medj.2024.01.013","article-title":"Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19","volume":"5","author":"Mao","year":"2024","journal-title":"Med"},{"key":"10.1016\/j.str.2026.01.003_bib18","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2400026","article-title":"Olgotrelvir as a Single-Agent Treatment of Nonhospitalized Patients with Covid-19","volume":"3","author":"Jiang","year":"2024","journal-title":"NEJM Evid."},{"key":"10.1016\/j.str.2026.01.003_bib19","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1021\/acs.jmedchem.4c02468","article-title":"From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 Variants","volume":"68","author":"Lemieux","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.str.2026.01.003_bib20","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbrc.2021.03.096","article-title":"ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model","volume":"555","author":"Vandyck","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.str.2026.01.003_bib21","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","article-title":"An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.str.2026.01.003_bib22","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1021\/acs.jmedchem.4c02561","article-title":"Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease","volume":"68","author":"Tuttle","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.str.2026.01.003_bib23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3390\/biom14070797","article-title":"Inhibitors of SARS-CoV-2 Main Protease (Mpro) as Anti-Coronavirus Agents","volume":"14","author":"Zag\u00f3rska","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.str.2026.01.003_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00869-22","article-title":"Genetic Surveillance of SARS-CoV-2 Mpro Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor Paxlovid","volume":"13","author":"Lee","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.str.2026.01.003_bib25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/cid\/ciae615","article-title":"Independent FDA Analyses of Nirmatrelvir\/Ritonavir Resistance in the Phase 2\/3 Trials EPIC-HR and EPIC-SR","volume":"80","author":"Rawson","year":"2025","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.str.2026.01.003_bib26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1093\/cid\/ciad494","article-title":"Nirmatrelvir Resistance\u2014de Novo E166V\/L50V Mutations in an Immunocompromised Patient Treated With Prolonged Nirmatrelvir\/Ritonavir Monotherapy Leading to Clinical and Virological Treatment Failure\u2014a Case Report","volume":"78","author":"Zuckerman","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.str.2026.01.003_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104559","article-title":"Global prevalence of SARS-CoV-2 3CL protease mutations associated with nirmatrelvir or ensitrelvir resistance","volume":"91","author":"Ip","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.str.2026.01.003_bib28","doi-asserted-by":"crossref","first-page":"13436","DOI":"10.1021\/acs.jmedchem.5c00088","article-title":"Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus2 3CLpro Inhibitor","volume":"68","author":"Bardiot","year":"2025","journal-title":"Journal of Medical Chemistry"},{"key":"10.1016\/j.str.2026.01.003_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2023.102667","article-title":"Structural biology of SARS-CoV-2 Mpro and drug discovery","volume":"82","author":"Duan","year":"2023","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.str.2026.01.003_bib30","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02815-22","article-title":"The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir","volume":"14","author":"Jochmans","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.str.2026.01.003_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2025.106212","article-title":"A novel cellular tool for screening human pan-coronavirus antivirals","volume":"240","author":"Chang","year":"2025","journal-title":"Antivir. Res."},{"key":"10.1016\/j.str.2026.01.003_bib32","doi-asserted-by":"crossref","first-page":"8647","DOI":"10.1128\/JVI.00298-08","article-title":"Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1","volume":"82","author":"Zhao","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.str.2026.01.003_bib33","doi-asserted-by":"crossref","first-page":"19403","DOI":"10.1074\/jbc.M115.651463","article-title":"Ligand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro) IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS","volume":"290","author":"Tomar","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.str.2026.01.003_bib34","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1038\/s41467-022-31210-w","article-title":"Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance","volume":"13","author":"Shaqra","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2026.01.003_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117618","article-title":"Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement","volume":"100","author":"Barton","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.str.2026.01.003_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/pathogens11010079","article-title":"Porcine Deltacoronaviruses: Origin, Evolution, Cross-Species Transmission and Zoonotic Potential","volume":"11","author":"Kong","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.str.2026.01.003_bib37","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3390\/v15030781","article-title":"Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses","volume":"15","author":"Zvornicanin","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.str.2026.01.003_bib38","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1128\/JVI.06540-11","volume":"86","author":"Woo","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.str.2026.01.003_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1107\/S2059798324001487","article-title":"Advanced exploitation of unmerged reflection data during processing and refinement with autoPROC and BUSTER","volume":"80","author":"Vonrhein","year":"2024","journal-title":"Acta Crystallogr. Sect. D"},{"key":"10.1016\/j.str.2026.01.003_bib40","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments","volume":"67","author":"Winn","year":"2011","journal-title":"Acta Crystallogr. Sect. D"},{"key":"10.1016\/j.str.2026.01.003_bib41","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2026.01.003_bib42","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.str.2026.01.003_bib43","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1107\/S0907444912001308","article-title":"Towards automated crystallographic structure refinement with phenix.refine","volume":"68","author":"Afonine","year":"2012","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2026.01.003_bib44","doi-asserted-by":"crossref","first-page":"13550","DOI":"10.1021\/acs.jmedchem.3c02469","article-title":"A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19","volume":"67","author":"Allerton","year":"2024","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.str.2026.01.003_bib45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jmb.2011.01.031","article-title":"Structure and Binding Mechanism of Vascular Endothelial Cadherin: A Divergent Classical Cadherin","volume":"408","author":"Brasch","year":"2011","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2026.01.003_bib46","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1107\/S1600577522009377","article-title":"AMX \u2013 the highly automated macromolecular crystallography (17-ID-1) beamline at the NSLS-II","volume":"29","author":"Schneider","year":"2022","journal-title":"J. Synchrotron Radiat."},{"key":"10.1016\/j.str.2026.01.003_bib47","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1107\/S1600577520016173","article-title":"FMX \u2013 the Frontier Microfocusing Macromolecular Crystallography Beamline at the National Synchrotron Light Source II","volume":"28","author":"Schneider","year":"2021","journal-title":"J. Synchrotron Radiat."},{"key":"10.1016\/j.str.2026.01.003_bib48","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1107\/S0907444913000061","article-title":"How good are my data and what is the resolution?","volume":"69","author":"Evans","year":"2013","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.str.2026.01.003_bib49","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. Sect. D"},{"key":"10.1016\/j.str.2026.01.003_bib50","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: More and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212626000055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212626000055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T14:49:18Z","timestamp":1775141358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212626000055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0969212626000055"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2026.01.003","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural basis for pan-coronavirus inhibition of 3CL protease","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2026.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}