{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:56:38Z","timestamp":1790870198784,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,10,1]],"date-time":"2027-10-01T00:00:00Z","timestamp":1822348800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM149533"],"award-info":[{"award-number":["R35GM149533"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR230054"],"award-info":[{"award-number":["RR230054"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP220582"],"award-info":[{"award-number":["RP220582"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000928","name":"The Welch Foundation","doi-asserted-by":"publisher","award":["I-2253-20250403"],"award-info":[{"award-number":["I-2253-20250403"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Structure"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.str.2026.08.002","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:17:28Z","timestamp":1787847448000},"page":"1319-1323.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b3-glutamyl carboxylase inhibition by Anisindione"],"prefix":"10.1016","volume":"34","author":[{"given":"Ning","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ke","family":"Tie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-9627","authenticated-orcid":false,"given":"Xiaofeng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.str.2026.08.002_bib1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0092-8674(88)90567-3","article-title":"The Molecular-Basis of Blood-Coagulation","volume":"53","author":"Furie","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.str.2026.08.002_bib2","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1126\/science.1749935","article-title":"Cloning and Expression of the Cdna for Human Gamma-Glutamyl Carboxylase","volume":"254","author":"Wu","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.str.2026.08.002_bib3","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1111\/j.1538-7836.2005.01419.x","article-title":"The vitamin K cycle","volume":"3","author":"Stafford","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.str.2026.08.002_bib4","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/MEJ.0000000000000541","article-title":"Vitamin K antagonists and emergencies","volume":"25","author":"Lapostolle","year":"2018","journal-title":"Eur. J. Emerg. Med."},{"key":"10.1016\/j.str.2026.08.002_bib5","doi-asserted-by":"crossref","first-page":"eabc5667","DOI":"10.1126\/science.abc5667","article-title":"Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation","volume":"371","author":"Liu","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.str.2026.08.002_bib6","first-page":"321","article-title":"Studies in Rats on Invitro Inhibition and Invivo Activity of Vitamin-K-Dependent Carboxylation","volume":"16","author":"Cocchetto","year":"1986","journal-title":"Haemostasis"},{"key":"10.1016\/j.str.2026.08.002_bib7","article-title":"Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase","volume":"16","author":"Wu","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2026.08.002_bib8","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41586-024-08484-9","article-title":"Structure and mechanism of vitamin-K-dependent \u03b3-glutamyl carboxylase","volume":"639","author":"Wang","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.str.2026.08.002_bib9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41422-025-01185-6","article-title":"Molecular basis of vitamin K-dependent protein \u03b3-glutamyl carboxylation","volume":"35","author":"Zhong","year":"2025","journal-title":"Cell Res."},{"key":"10.1016\/j.str.2026.08.002_bib10","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/s41422-025-01161-0","article-title":"Structural insights into the vitamin K-dependent \u03b3-carboxylation of osteocalcin","volume":"35","author":"Cao","year":"2025","journal-title":"Cell Res."},{"key":"10.1016\/j.str.2026.08.002_bib11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/s41586-025-08648-1","article-title":"Molecular basis of vitamin-K-driven \u03b3-carboxylation at the membrane interface","volume":"639","author":"Cao","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.str.2026.08.002_bib12","article-title":"Structural basis for the carboxylation and epoxidation of human gamma-glutamyl carboxylase","volume":"17","author":"Zhang","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.str.2026.08.002_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0075992","article-title":"Ligand Pose and Orientational Sampling in Molecular Docking","volume":"8","author":"Coleman","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.str.2026.08.002_bib14","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1182\/blood-2010-08-304303","article-title":"Functional study of the vitamin K cycle in mammalian cells","volume":"117","author":"Tie","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.str.2026.08.002_bib15","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.blre.2017.02.001","article-title":"Old and new oral anticoagulants: Food, herbal medicines and drug interactions","volume":"31","author":"Di Minno","year":"2017","journal-title":"Blood Rev."},{"key":"10.1016\/j.str.2026.08.002_bib16","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1017\/S1431927603445911","article-title":"SerialEM A Program for Automated Tilt Series Acquisition on Tecnai Microcopes Using Prediction of Specimen Position","volume":"9","author":"Mastronarde","year":"2003","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.str.2026.08.002_bib17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jsb.2015.08.008","article-title":"CTFFIND4: Fast and accurate defocus estimation from electron micrographs","volume":"192","author":"Rohou","year":"2015","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.str.2026.08.002_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-019-0437-z","article-title":"SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM","volume":"2","author":"Wagner","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.str.2026.08.002_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","article-title":"MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy","volume":"14","author":"Zheng","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2026.08.002_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42166","article-title":"New tools for automated high-resolution cryo-EM structure determination in RELION-3","volume":"7","author":"Zivanov","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.str.2026.08.002_bib21","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nmeth.4169","article-title":"cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination","volume":"14","author":"Punjani","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.str.2026.08.002_bib22","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.str.2026.08.002_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.str.2026.08.002_bib24","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF chimera - A visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.str.2026.08.002_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: Structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.str.2026.08.002_bib26","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1021\/ci100214a","article-title":"Rapid Context-Dependent Ligand Desolvation in Molecular Docking","volume":"50","author":"Mysinger","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.str.2026.08.002_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0022-2836(02)00777-5","article-title":"A model binding site for testing scoring functions in molecular docking","volume":"322","author":"Wei","year":"2002","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.str.2026.08.002_bib28","doi-asserted-by":"crossref","first-page":"13124","DOI":"10.1016\/S0021-9258(19)38275-4","article-title":"In vitro gamma-carboxylation of a 59-residue recombinant peptide including the propeptide and the gamma-carboxyglutamic acid domain of coagulation factor IX. Effect of mutations near the propeptide cleavage site","volume":"265","author":"Wu","year":"1990","journal-title":"J. Biol. Chem."}],"container-title":["Structure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212626002492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969212626002492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:11:50Z","timestamp":1790867510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969212626002492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0969212626002492"],"URL":"https:\/\/doi.org\/10.1016\/j.str.2026.08.002","relation":{},"ISSN":["0969-2126"],"issn-type":[{"value":"0969-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b3-glutamyl carboxylase inhibition by Anisindione","name":"articletitle","label":"Article Title"},{"value":"Structure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.str.2026.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}