{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:46:44Z","timestamp":1783468004434,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","surgjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.surg.2004.05.024","type":"journal-article","created":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T15:25:31Z","timestamp":1093361131000},"page":"449-457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver"],"prefix":"10.1016","volume":"136","author":[{"given":"Masayuki","family":"Koizumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichiro","family":"Doi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidhartha S.","family":"Tulachan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Kami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George K.","family":"Gittes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2004.05.024_BIB1","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1056\/NEJM199411243312107","article-title":"The pathogenesis of insulin-dependent diabetes mellitus","volume":"331","author":"Atkinson","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.surg.2004.05.024_BIB2","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.surg.2004.05.024_BIB3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/73128","article-title":"Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells","volume":"6","author":"Ramiya","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.surg.2004.05.024_BIB4","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1210\/endo.137.9.8756573","article-title":"Formation of insulin-producing cells from pancreatic acinar AR42J cells by hepatocyte growth factor","volume":"137","author":"Mashima","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.surg.2004.05.024_BIB5","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/75050","article-title":"Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia","volume":"6","author":"Ferber","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.surg.2004.05.024_BIB6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0960-9822(02)01434-3","article-title":"Experimental conversion of liver to pancreas","volume":"13","author":"Horb","year":"2003","journal-title":"Curr Biol"},{"key":"10.1016\/j.surg.2004.05.024_BIB7","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.2337\/diabetes.51.5.1398","article-title":"Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin","volume":"51","author":"Kojima","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.surg.2004.05.024_BIB8","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.2337\/diabetes.51.8.2505","article-title":"PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells","volume":"51","author":"Yoshida","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.surg.2004.05.024_BIB9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1172\/JCI200316502","article-title":"In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion","volume":"111","author":"Ianus","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.surg.2004.05.024_BIB10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.cellbio.15.1.393","article-title":"Vertebrate endoderm development","volume":"15","author":"Wells","year":"1999","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.surg.2004.05.024_BIB11","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0959-437X(00)00234-3","article-title":"Hepatocyte differentiation: from the endoderm and beyond","volume":"11","author":"Zaret","year":"2001","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.surg.2004.05.024_BIB12","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1073\/pnas.78.4.2577","article-title":"Differentiation of regenerating pancreatic cells into hepatocyte-like cells","volume":"78","author":"Scarpelli","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.surg.2004.05.024_BIB13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0045-6039(86)90005-9","article-title":"Induction of hepatocytes in the pancreas of copper-depleted rats following copper repletion","volume":"18","author":"Rao","year":"1986","journal-title":"Cell Differ"},{"key":"10.1016\/j.surg.2004.05.024_BIB14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0002-9440(10)65315-1","article-title":"Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells","volume":"154","author":"Krakowski","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.surg.2004.05.024_BIB15","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/35046522","article-title":"Molecular basis of transdifferentiation of pancreas to liver","volume":"2","author":"Shen","year":"2000","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.surg.2004.05.024_BIB16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1177\/34.2.2418098","article-title":"Characterization of pancreatic-type tissue in the liver of rat induced by polychlorinated biphenyls","volume":"34","author":"Rao","year":"1986","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.surg.2004.05.024_BIB17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0014-4800(89)90060-9","article-title":"Metaplastic pancreatic cells in liver tumors induced by diethylnitrosamine","volume":"50","author":"Lee","year":"1989","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.surg.2004.05.024_BIB18","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.bbrc.2003.09.108","article-title":"Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis","volume":"310","author":"Miyatsuka","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.surg.2004.05.024_BIB19","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/371606a0","article-title":"Insulin-promoter-factor 1 is required for pancreas development in mice","volume":"371","author":"Jonsson","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.surg.2004.05.024_BIB20","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s001250100628","article-title":"Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function","volume":"44","author":"McKinnon","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.surg.2004.05.024_BIB21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1242\/dev.121.1.11","article-title":"Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny","volume":"121","author":"Guz","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.surg.2004.05.024_BIB22","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/(SICI)1097-4598(199905)22:5<592::AID-MUS7>3.0.CO;2-2","article-title":"Effective adenovirus-mediated gene expression in adult murine skeletal muscle","volume":"22","author":"Ishii","year":"1999","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.surg.2004.05.024_BIB23","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1067\/msy.2003.231","article-title":"Increased PDX-1 expression is associated with outcome in patients with pancreatic cancer","volume":"134","author":"Koizumi","year":"2003","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2004.05.024_BIB24","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1128\/jvi.54.3.711-719.1985","article-title":"Construction of nondefective adenovirus type 5 bearing a 2.8-kilobase hepatitis B virus DNA near the right end of its genome","volume":"54","author":"Saito","year":"1985","journal-title":"J Virol"},{"key":"10.1016\/j.surg.2004.05.024_BIB25","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1073\/pnas.93.3.1320","article-title":"Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome","volume":"93","author":"Miyake","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.surg.2004.05.024_BIB26","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1093\/nar\/23.19.3816","article-title":"Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase","volume":"23","author":"Kanegae","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.surg.2004.05.024_BIB27","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1101\/gad.846001","article-title":"Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes","volume":"15","author":"Grapin-Botton","year":"2001","journal-title":"Genes Dev"},{"key":"10.1016\/j.surg.2004.05.024_BIB28","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2337\/diabetes.50.7.1553","article-title":"Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas","volume":"50","author":"Heller","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.surg.2004.05.024_BIB29","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nm867","article-title":"NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice","volume":"9","author":"Kojima","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.surg.2004.05.024_BIB30","doi-asserted-by":"crossref","first-page":"31950","DOI":"10.1074\/jbc.M303127200","article-title":"Functional, persistent, and extended liver to pancreas transdifferentiation","volume":"278","author":"Ber","year":"2003","journal-title":"J Biol Chem"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606004002648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606004002648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T10:49:39Z","timestamp":1758538179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606004002648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0039606004002648"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2004.05.024","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver","name":"articletitle","label":"Article Title"},{"value":"Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.surg.2004.05.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}