{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T05:49:10Z","timestamp":1794203350963,"version":"4.8.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.surg.2009.11.013","type":"journal-article","created":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T06:44:53Z","timestamp":1265870693000},"page":"818-829","source":"Crossref","is-referenced-by-count":286,"title":["A meta-analysis comparing conservative treatment versus acute appendectomy for complicated appendicitis (abscess or phlegmon)"],"prefix":"10.1016","volume":"147","author":[{"given":"Constantinos","family":"Simillis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Symeonides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Shorthouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paris P.","family":"Tekkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2009.11.013_bib1","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S0140-6736(00)04934-5","article-title":"Bringing it all together: Lancet-Cochrane collaborate on systematic reviews","volume":"357","author":"Clarke","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.surg.2009.11.013_bib2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1159\/000055014","article-title":"Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement","volume":"23","author":"Moher","year":"2000","journal-title":"Onkologie"},{"key":"10.1016\/j.surg.2009.11.013_bib3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.surg.2009.11.013_bib4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"10.1016\/j.surg.2009.11.013_bib5","first-page":"719","article-title":"Statistical aspects of the analysis of data from retrospective studies of disease","volume":"22","author":"Mantel","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.surg.2009.11.013_bib6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0033-0620(85)80003-7","article-title":"Beta blockade during and after myocardial infarction: an overview of the randomized trials","volume":"27","author":"Yusuf","year":"1985","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.surg.2009.11.013_bib7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1136\/bmj.311.7007.753c","article-title":"Misleading meta-analysis","volume":"311","author":"Egger","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.surg.2009.11.013_bib8","unstructured":"Wells GA SB, O'Connell D, Peterson J, Welch V, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Paper presented at 3rd Symposium on Systematic Reviews: Beyond the Basics. Oxford, UK; 2000."},{"key":"10.1016\/j.surg.2009.11.013_bib9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.athoracsur.2003.07.002","article-title":"Off-pump myocardial revascularization is associated with less incidence of stroke in elderly patients","volume":"77","author":"Athanasiou","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib10","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(01)06069-X","article-title":"Effect of arterial revascularisation on survival: a systematic review of studies comparing bilateral and single internal mammary arteries","volume":"358","author":"Taggart","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.surg.2009.11.013_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/lap.2006.16.67","article-title":"Interval appendectomy: an old new operation","volume":"16","author":"Bass","year":"2006","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"10.1016\/j.surg.2009.11.013_bib12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1177\/000313480306901002","article-title":"Appendiceal abscess: immediate operation or percutaneous drainage?","volume":"69","author":"Brown","year":"2003","journal-title":"Am Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1089\/lap.1998.8.209","article-title":"Interval appendectomy for perforated appendicitis in children","volume":"8","author":"Bufo","year":"1998","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"10.1016\/j.surg.2009.11.013_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00383-004-1334-0","article-title":"Comparison of two methods for the management of appendicular mass in children","volume":"21","author":"Erdogan","year":"2005","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.surg.2009.11.013_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/bjs.1800820207","article-title":"Randomized controlled trial of appendicectomy versus antibiotic therapy for acute appendicitis","volume":"82","author":"Eriksson","year":"1995","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib16","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1001\/archsurg.1978.01370220030005","article-title":"Management of the appendiceal mass","volume":"113","author":"Foran","year":"1978","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/02724936.1993.11747672","article-title":"Management of appendicular mass in children","volume":"13","author":"Gahukamble","year":"1993","journal-title":"Ann Trop Paediatr"},{"key":"10.1016\/j.surg.2009.11.013_bib18","first-page":"539","article-title":"Appendiceal abscess-acute appendectomy or conservative treatment","volume":"135","author":"Gastrin","year":"1969","journal-title":"Acta Chir Scand"},{"key":"10.1016\/j.surg.2009.11.013_bib19","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cursur.2004.07.004","article-title":"The optimal management of adult patients presenting with appendiceal abscess: \u201cconservative\u201d vs immediate operative management","volume":"61","author":"Gee","year":"2004","journal-title":"Curr Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib20","first-page":"151","article-title":"[Appendiceal plastron: comparative study of emergency appendectomy with conservative treatment (195 cases)]","volume":"71","author":"Gomez-Lorenzo","year":"1987","journal-title":"Rev Esp Enferm Apar Dig"},{"key":"10.1016\/j.surg.2009.11.013_bib21","first-page":"389","article-title":"Early appendectomy versus an interval appendectomy for appendiceal abscess in children","volume":"88","author":"Handa","year":"1997","journal-title":"Fukuoka Igaku Zasshi"},{"key":"10.1016\/j.surg.2009.11.013_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jpedsurg.2006.09.005","article-title":"Matched analysis of nonoperative management vs immediate appendectomy for perforated appendicitis","volume":"42","author":"Henry","year":"2007","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib23","first-page":"359","article-title":"Comparison of critical conservative treatment versus emergency operation in children with ruptured appendicitis with tumor formation","volume":"103","author":"Ho","year":"2004","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.surg.2009.11.013_bib24","first-page":"18","article-title":"Ultraconservative management of appendiceal abscess","volume":"36","author":"Hoffmann","year":"1991","journal-title":"J R Coll Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib25","first-page":"33","article-title":"Conservative versus operative treatment of appendicular abscess. Experience of 147 consecutive patients","volume":"84","author":"Hurme","year":"1995","journal-title":"Ann Chir Gynaecol"},{"key":"10.1016\/j.surg.2009.11.013_bib26","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s005950170068","article-title":"The management of appendiceal mass in children: is interval appendectomy necessary?","volume":"31","author":"Karaca","year":"2001","journal-title":"Surg Today"},{"key":"10.1016\/j.surg.2009.11.013_bib27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0022-3468(86)80221-4","article-title":"The avoidable excesses in the management of perforated appendicitis in children","volume":"21","author":"Karp","year":"1986","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib28","first-page":"123","article-title":"Treatment of appendiceal abscess","volume":"154","author":"Lewin","year":"1988","journal-title":"Acta Chir Scand"},{"key":"10.1016\/j.surg.2009.11.013_bib29","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/BF02235479","article-title":"Initial nonoperative management for periappendiceal abscess","volume":"44","author":"Oliak","year":"2001","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.surg.2009.11.013_bib30","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archsurg.1982.01380320013004","article-title":"Appendiceal abscess","volume":"117","author":"Paull","year":"1982","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib31","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.amjsurg.2007.08.021","article-title":"Complicated appendicitis in children: a clear role for drainage and delayed appendectomy","volume":"194","author":"Roach","year":"2007","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib32","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1053\/jpsu.2002.32895","article-title":"Prospective evaluation of nonsurgical versus surgical management of appendiceal mass","volume":"37","author":"Samuel","year":"2002","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib33","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00268-005-0304-6","article-title":"Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial","volume":"30","author":"Styrud","year":"2006","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/11024150201680001","article-title":"Management of appendiceal masses","volume":"168","author":"Tingstedt","year":"2002","journal-title":"Eur J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00268-005-7946-2","article-title":"Role of interval appendectomy in the management of complicated appendicitis in children","volume":"30","author":"Vane","year":"2006","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.amjsurg.2003.08.027","article-title":"Is delayed operative treatment worth the trouble with perforated appendicitis is children?","volume":"186","author":"Weber","year":"2003","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib37","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0009-9260(97)80153-5","article-title":"Appendiceal and peri-appendiceal air at CT: prevalence, appearance and clinical significance","volume":"52","author":"Rao","year":"1997","journal-title":"Clin Radiol"},{"key":"10.1016\/j.surg.2009.11.013_bib38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0039-6109(16)46587-4","article-title":"Evolving concepts in the pathogenesis of postinjury multiple organ failure","volume":"75","author":"Moore","year":"1995","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.surg.2009.11.013_bib39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1089\/sur.2004.5.349","article-title":"Predictors of outcome for children with perforated appendicitis initially treated with non-operative management","volume":"5","author":"Nadler","year":"2004","journal-title":"Surg Infect (Larchmt)"},{"key":"10.1016\/j.surg.2009.11.013_bib40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/jpsu.2001.20044","article-title":"The association of elevated percent bands on admission with failure and complications of interval appendectomy","volume":"36","author":"Kogut","year":"2001","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib41","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0022-3468(97)90624-2","article-title":"Histopathologic analysis of interval appendectomy specimens: support for the role of interval appendectomy","volume":"32","author":"Mazziotti","year":"1997","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib42","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0022-3468(96)90018-4","article-title":"Recurrent appendicitis after initial conservative management of appendiceal abscess","volume":"31","author":"Price","year":"1996","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib43","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/110241598750005417","article-title":"Interval appendicectomy: a retrospective study","volume":"164","author":"Eriksson","year":"1998","journal-title":"Eur J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib44","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1046\/j.0007-1323.2001.01912.x","article-title":"Conservative management of appendix mass in children","volume":"88","author":"Gillick","year":"2001","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0002-9610(00)00299-3","article-title":"Nonoperative management of perforated appendicitis without periappendiceal mass","volume":"179","author":"Oliak","year":"2000","journal-title":"Am J Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib46","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.jpedsurg.2007.04.011","article-title":"Routine interval appendectomy in children is not indicated","volume":"42","author":"Puapong","year":"2007","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.surg.2009.11.013_bib47","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1463-1318.2007.01377.x","article-title":"Routine interval appendectomy is unnecessary after conservative treatment of appendiceal mass","volume":"10","author":"Tekin","year":"2008","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.surg.2009.11.013_bib48","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/oxfordjournals.aje.a117324","article-title":"Meta-analysis\/Shmeta-analysis","volume":"140","author":"Shapiro","year":"1994","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.surg.2009.11.013_bib49","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/oxfordjournals.aje.a117327","article-title":"Is there is or is there ain't no baby? Dr. Shapiro replies to Drs. Petitti and Greenland","volume":"140","author":"Shapiro","year":"1994","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.surg.2009.11.013_bib50","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/oxfordjournals.aje.a117325","article-title":"Of babies and bathwater","volume":"140","author":"Petitti","year":"1994","journal-title":"Am J Epidemiol"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606009007594?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606009007594?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T02:04:55Z","timestamp":1685412295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606009007594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0039606009007594"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2009.11.013","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}