{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:10:53Z","timestamp":1761059453770},"reference-count":24,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.surg.2012.08.040","type":"journal-article","created":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T04:38:00Z","timestamp":1352954280000},"page":"998-1007","source":"Crossref","is-referenced-by-count":14,"title":["Differentiation of small bowel and pancreatic neuroendocrine tumors by gene-expression profiling"],"prefix":"10.1016","volume":"152","author":[{"given":"Jennifer C.","family":"Carr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin A.","family":"Boese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip M.","family":"Spanheimer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi S.","family":"Dahdaleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Calva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Schafer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Thole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"O'Dorisio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Sue","family":"O'Dorisio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2012.08.040_bib1","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \u201ccarcinoid\u201d: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","volume":"26","author":"Yao","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.surg.2012.08.040_bib2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000225948","article-title":"ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: biochemical markers","volume":"90","author":"O'Toole","year":"2009","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.surg.2012.08.040_bib3","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/cncr.11105","article-title":"A\u00a05-decade analysis of 13,715 carcinoid tumors","volume":"97","author":"Modlin","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.surg.2012.08.040_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1001\/archsurg.2010.10","article-title":"Identification of unknown primary tumors in patients with neuroendocrine liver metastases","volume":"145","author":"Wang","year":"2010","journal-title":"Arch Surg"},{"key":"10.1016\/j.surg.2012.08.040_bib5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1245\/s10434-011-1997-4","article-title":"Comparison of clinicopathologic factors in 122 patients with resected pancreatic and ileal neuroendocrine tumors from a single institution","volume":"19","author":"Dahdaleh","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2012.08.040_bib6","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1200\/JCO.2009.22.8510","article-title":"Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group","volume":"27","author":"Rinke","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"issue":"Suppl 1","key":"10.1016\/j.surg.2012.08.040_bib7","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1530\/ERC-10-0271","article-title":"Therapeutic management of patients with gastroenteropancreatic neuroendocrine tumours","volume":"18","author":"Khan","year":"2011","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.surg.2012.08.040_bib8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1056\/NEJMoa1009290","article-title":"Everolimus for advanced pancreatic neuroendocrine tumors","volume":"364","author":"Yao","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.surg.2012.08.040_bib9","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJMoa1003825","article-title":"Sunitinib malate for the treatment of pancreatic neuroendocrine tumors","volume":"364","author":"Raymond","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.surg.2012.08.040_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1677\/ERC-07-0194","article-title":"Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis","volume":"15","author":"Duerr","year":"2008","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.surg.2012.08.040_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1200\/JCO.2008.21.5988","article-title":"Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway","volume":"28","author":"Missiaglia","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.surg.2012.08.040_bib12","doi-asserted-by":"crossref","first-page":"e22457","DOI":"10.1371\/journal.pone.0022457","article-title":"Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia","volume":"6","author":"Drozdov","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.surg.2012.08.040_bib13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1530\/ERC-10-0256","article-title":"Different gene expression profiles in metastasizing midgut carcinoid tumors","volume":"18","author":"Edfeldt","year":"2011","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.surg.2012.08.040_bib14","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s10585-011-9397-5","article-title":"Localization of sporadic neuroendocrine tumors by gene expression analysis of their metastases","volume":"28","author":"Posorski","year":"2011","journal-title":"Clin Exp Metastasis"},{"key":"10.1016\/j.surg.2012.08.040_bib15","unstructured":"Zhang J, Ruschhaupt M, Biczok R. ddCt method for qRT-PCR data analysis. 2011. Available at http:\/\/www.bioconductor.org\/packages\/2.9\/bioc\/vignettes\/ddCt\/inst\/doc\/rtPCR.pdf, 2012."},{"key":"10.1016\/j.surg.2012.08.040_bib16","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open-source clustering software","volume":"20","author":"de Hoon","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.surg.2012.08.040_bib17","doi-asserted-by":"crossref","first-page":"4164","DOI":"10.1073\/pnas.0308531101","article-title":"Metagenes and molecular pattern discovery using matrix factorization","volume":"101","author":"Brunet","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.surg.2012.08.040_bib18","first-page":"4144","article-title":"Identifying tumor origin using a gene expression-based classification map","volume":"63","author":"Buckhaults","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.surg.2012.08.040_bib19","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1053\/j.gastro.2006.09.007","article-title":"Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors","volume":"131","author":"Couvelard","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.surg.2012.08.040_bib20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-4598-4-9","article-title":"Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome","volume":"4","author":"Dilley","year":"2005","journal-title":"Mol Cancer"},{"key":"10.1016\/j.surg.2012.08.040_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1677\/erc.1.01153","article-title":"Gene expression profiles of progressive pancreatic endocrine tumours and their liver metastases reveal potential novel markers and therapeutic targets","volume":"13","author":"Capurso","year":"2006","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.surg.2012.08.040_bib22","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1245\/ASO.2004.03.077","article-title":"Identification of molecular markers specific for pancreatic neuroendocrine tumors by genetic profiling of core biopsies","volume":"11","author":"Bloomston","year":"2004","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2012.08.040_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.drudis.2008.11.011","article-title":"G-protein-coupled receptor-focused drug discovery using a target class platform approach","volume":"14","author":"Heilker","year":"2009","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.surg.2012.08.040_bib24","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.surg.2006.07.033","article-title":"Operative resection of primary carcinoid neoplasms in patients with liver metastases yields significantly better survival","volume":"140","author":"Givi","year":"2006","journal-title":"Surgery"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606012004953?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606012004953?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,21]],"date-time":"2018-10-21T06:50:27Z","timestamp":1540104627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606012004953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0039606012004953"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2012.08.040","relation":{},"ISSN":["0039-6060"],"issn-type":[{"type":"print","value":"0039-6060"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}