{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:31:53Z","timestamp":1770744713595,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.surg.2014.02.010","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T02:15:43Z","timestamp":1392862543000},"page":"998-1005","source":"Crossref","is-referenced-by-count":60,"title":["Impact of prophylactic central compartment neck dissection on locoregional recurrence of differentiated thyroid cancer in clinically node-negative patients: A retrospective study of a large clinical series"],"prefix":"10.1016","volume":"155","author":[{"given":"Giovanni","family":"Conzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro Giorgio","family":"Cal\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio A.","family":"Sinisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"De Bellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pasquali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Mauriello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Gambardella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Medas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Polistena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Santini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Avenia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2014.02.010_bib1","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1089\/thy.2012.0043","article-title":"The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension","volume":"22","author":"Randolph","year":"2012","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2014.02.010_bib2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12020-013-9975-1","article-title":"Prophylactic central lymph node dissection in differentiated thyroid cancer","volume":"44","author":"Goddard","year":"2013","journal-title":"Endocrine"},{"key":"10.1016\/j.surg.2014.02.010_bib3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2014.02.010_bib4","first-page":"245","article-title":"Indicazioni alla linfoadenectomia cervicale nel carcinoma differenziato","volume":"Vol. 1","author":"Rosato","year":"2008"},{"key":"10.1016\/j.surg.2014.02.010_bib5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00268-006-0907-6","article-title":"Central lymph node dissection in differentiated thyroid cancer","volume":"31","author":"White","year":"2007","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2014.02.010_bib6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/thy.2009.1578","article-title":"The pros and cons of prophylactic central compartment lymph node dissection for papillary thyroid carcinoma","volume":"19","author":"Mazzaferri","year":"2009","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2014.02.010_bib7","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1210\/jc.2008-1931","article-title":"Prophylactic lymph node dissection for papillary thyroid cancer less than 2 cm: implications for radioiodine treatment","volume":"94","author":"Bonnet","year":"2009","journal-title":"J\u00a0Clin Endrocrinol Metab"},{"key":"10.1016\/j.surg.2014.02.010_bib8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12020-013-9877-2","article-title":"Total thyroidectomy, without prophylactic central lymph node dissection, in the treatment of differentiated thyroid cancer. Clinical retrospective study on 221 cases","volume":"44","author":"Conzo","year":"2013","journal-title":"Endocrine"},{"key":"10.1016\/j.surg.2014.02.010_bib9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.surg.2010.03.021","article-title":"Central neck lymph node dissection for papillary thyroid cancer: the reliability of surgeon judgment in predicting which patients will benefit","volume":"148","author":"Shen","year":"2010","journal-title":"Surgery"},{"issue":"6 Suppl","key":"10.1016\/j.surg.2014.02.010_bib10","first-page":"3","article-title":"New and old knowledge on differentiated thyroid cancer epidemiology and risk factors","volume":"35","author":"Agate","year":"2012","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.surg.2014.02.010_bib11","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1365-2265.2012.04412.x","article-title":"Lessons to be learned from the clinical management of a MEN 2A patient bearing a novel 634\/640\/700 triple mutation of the RET proto-oncogene","volume":"77","author":"Conzo","year":"2012","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.surg.2014.02.010_bib12","first-page":"522","article-title":"Cyclin D1 and D3 overexpression predicts malignant behavior in thyroid fine-needle aspirates suspicious for Hurthle cell neoplasms","volume":"117","author":"Troncone","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.surg.2014.02.010_bib13","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1530\/ERC-13-0157","article-title":"Assessing RET\/PTC in thyroid nodule fine-needle aspirates: the FISH point of view","volume":"20","author":"Caria","year":"2013","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.surg.2014.02.010_bib14","doi-asserted-by":"crossref","first-page":"e50725","DOI":"10.1371\/journal.pone.0050725","article-title":"Q-elastography in the presurgical diagnosis of thyroid nodules with indeterminate cytology","volume":"7","author":"Cantisani","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.surg.2014.02.010_bib15","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1089\/thy.2006.16.1151","article-title":"Trend in thyroid carcinoma size, age at diagnosis and histology in a retrospective study of 500 cases diagnosed over 20 years","volume":"16","author":"Trimboli","year":"2006","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2014.02.010_bib16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/RLU.0b013e318279bc65","article-title":"Aggressive papillary thyroid microcarcinoma: prognostic factors and therapeutic strategy","volume":"38","author":"Ardito","year":"2013","journal-title":"Clin Nucl Med"},{"key":"10.1016\/j.surg.2014.02.010_bib17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/thy.2010.0168","article-title":"Upregulation of endocrine gland-derived vascular endothelial growth factor in papillary thyroid cancers displaying infiltrative patterns, lymph node metastases, and Braf mutation","volume":"21","author":"Pasquali","year":"2011","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2014.02.010_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1477-7819-10-70","article-title":"Total thyroidectomy with ultrasonic dissector for cancer: multicentric experience","volume":"10","author":"Cirocchi","year":"2012","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.surg.2014.02.010_bib19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s12020-011-9559-x","article-title":"Time course of Graves\u2019 ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a 2-year longitudinal study","volume":"41","author":"De Bellis","year":"2012","journal-title":"Endocrine"},{"key":"10.1016\/j.surg.2014.02.010_bib20","first-page":"8","article-title":"Total parathyroidectomy without autotransplantation in the surgical treatment of chronic kidney disease","volume":"35","author":"Conzo","year":"2012","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.surg.2014.02.010_bib21","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s12020-012-9648-5","article-title":"Evaluation of \u201cputative\u201d role of intraoperative intact parathyroid hormone assay during parathyroidectomy for secondary hyperparathyroidism. A retrospective study on 35 consecutive patients","volume":"42","author":"Conzo","year":"2012","journal-title":"Endocrine"},{"issue":"Suppl 2","key":"10.1016\/j.surg.2014.02.010_bib22","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2482-13-S2-S4","article-title":"Impact of parathyroidectomy on cardiovascular outcomes and survival in chronic hemodialysis patients with secondary hyperparathyroidism. A retrospective study of 50 cases prior to the calcimimetics era","volume":"13","author":"Conzo","year":"2013","journal-title":"BMC Surg"},{"key":"10.1016\/j.surg.2014.02.010_bib23","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.surg.2012.08.053","article-title":"Prospective evaluation of total thyroidectomy versus ipsilateral versus bilateral central neck dissection in patients with clinically node-negative papillary thyroid carcinoma","volume":"152","author":"Raffaelli","year":"2012","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.02.010_bib24","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.surg.2010.09.019","article-title":"Influence of prophylactic central lymph node dissection on postoperative thyroglobulin levels and radioiodine treatment in papillary thyroid cancer","volume":"148","author":"Hughes","year":"2010","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.02.010_bib25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.surg.2009.06.046","article-title":"Routine bilateral central lymph node clearance for papillary thyroid cancer","volume":"146","author":"Sadowski","year":"2009","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.02.010_bib26","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.surg.2009.10.020","article-title":"Prophylactic central compartment dissection in thyroid cancer: a new avenue of debate","volume":"146","author":"Shaha","year":"2009","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.02.010_bib27","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.surg.2011.10.003","article-title":"Prophylactic central compartment neck dissection for papillary thyroid cancer: the search for justification continues","volume":"150","author":"McHenry","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.02.010_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/bjs.8985","article-title":"Prophylactic central neck dissection for papillary thyroid cancer","volume":"100","author":"Barczy\u0144ski","year":"2013","journal-title":"Br J Surg"},{"key":"10.1016\/j.surg.2014.02.010_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1089\/thy.2011.0317","article-title":"American Thyroid Association design and feasibility of a prospective randomized controlled trial of prophylactic central lymph node dissection for papillary thyroid carcinoma","volume":"22","author":"Carling","year":"2012","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2014.02.010_bib30","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1089\/thy.2010.0214","article-title":"Performing contralateral central lymph node dissection in papillary thyroid carcinoma: a decision approach","volume":"21","author":"Chae","year":"2011","journal-title":"Thyroid"},{"key":"10.1016\/j.surg.2014.02.010_bib31","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1097\/01.sla.0000250451.59685.67","article-title":"Total thyroidectomy plus neck dissection in differentiated papillary thyroid carcinoma patients. Pattern of nodal metastasis, morbidity, recurrence, and postoperative levels of serum parathyroid hormone","volume":"245","author":"Roh","year":"2007","journal-title":"Ann Surg"},{"issue":"Suppl 2","key":"10.1016\/j.surg.2014.02.010_bib32","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2482-13-S2-S3","article-title":"Predictive value of nodal metastases on local recurrence in the management of differentiated thyroid cancer. Retrospective clinical study","volume":"13","author":"Conzo","year":"2013","journal-title":"BMC Surg"},{"key":"10.1016\/j.surg.2014.02.010_bib33","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/s12020-013-0029-5","article-title":"The BRAF V600E mutation in papillary thyroid cancer with positive or suspected pre-surgical cytological finding is not associated with advanced stages or worse prognosis","volume":"45","author":"Barbaro","year":"2014","journal-title":"Endocrine"},{"key":"10.1016\/j.surg.2014.02.010_bib34","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/lary.20236","article-title":"Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone","volume":"119","author":"Chisholm","year":"2009","journal-title":"Laryngoscope"},{"key":"10.1016\/j.surg.2014.02.010_bib35","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.surg.2011.09.003","article-title":"A\u00a0multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer","volume":"150","author":"Popadich","year":"2011","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.02.010_bib36","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s00268-013-2089-3","article-title":"Influence of prophylactic neck dissection on rate of retreatment for papillary thyroid carcinoma","volume":"37","author":"Hartl","year":"2013","journal-title":"World J Surg"},{"key":"10.1016\/j.surg.2014.02.010_bib37","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/CCO.0b013e328333ac97","article-title":"Controversy surrounding the role for routine central lymph node dissection for differentiated thyroid cancer","volume":"22","author":"Carling","year":"2010","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.surg.2014.02.010_bib38","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1530\/eje.1.02158","article-title":"European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium","volume":"154","author":"Pacini","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.surg.2014.02.010_bib39","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1245\/s10434-013-2897-6","article-title":"Prophylactic central neck dissection in differentiated thyroid cancer: an assessment of the evidence","volume":"20","author":"Gyorki","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2014.02.010_bib40","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/MOO.0b013e328343af58","article-title":"Central compartment dissection for well differentiated thyroid cancer \u2026 and the band plays on","volume":"19","author":"Iyer","year":"2011","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.surg.2014.02.010_bib41","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1245\/s10434-013-3125-0","article-title":"A\u00a0meta-analysis of the effect of prophylactic central compartment neck dissection on locoregional recurrence rates in patients with papillary thyroid cancer","volume":"20","author":"Wang","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2014.02.010_bib42","first-page":"625193","article-title":"Differentiated thyroid cancer: indications and extent of central neck dissection\u2014our experience","volume":"2013","author":"Cal\u00f2","year":"2013","journal-title":"Int J Surg Oncol"},{"key":"10.1016\/j.surg.2014.02.010_bib43","first-page":"e343","article-title":"The current status of lymph node dissection in the treatment of papillary thyroid cancer. A literature review","volume":"164","author":"Conzo","year":"2013","journal-title":"Clin Ther"},{"key":"10.1016\/j.surg.2014.02.010_bib44","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.surg.2006.08.001","article-title":"Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid cancer","volume":"140","author":"Sywak","year":"2006","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.02.010_bib45","first-page":"61","article-title":"Role of prophylactic central neck dissection in cN0 papillary thyroid cancer","volume":"29","author":"Costa","year":"2009","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"10.1016\/j.surg.2014.02.010_bib46","first-page":"1187","article-title":"Impact of prophylactic central neck lymph node dissection on early recurrence in papillary thyroid carcinoma. World","volume":"34","author":"Moo","year":"2013","journal-title":"J Surg"},{"key":"10.1016\/j.surg.2014.02.010_bib47","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1245\/s10434-011-1833-x","article-title":"Impact of routine unilateral central neck dissection on preablative and postablative stimulated thyroglobulin levels after total thyroidectomy in papillary thyroid carcinoma","volume":"19","author":"Lang","year":"2012","journal-title":"Ann Surg Oncol"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606014000592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606014000592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T13:51:01Z","timestamp":1538833861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606014000592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0039606014000592"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2014.02.010","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}