{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:26:04Z","timestamp":1784013964972,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surgery"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.surg.2014.09.013","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T13:52:45Z","timestamp":1418737965000},"page":"277-284","source":"Crossref","is-referenced-by-count":27,"title":["Assessment of clonality of multisegmental main duct intraductal papillary mucinous neoplasms of the pancreas based on GNAS mutation analysis"],"prefix":"10.1016","volume":"157","author":[{"given":"Koji","family":"Tamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ohtsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taketo","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyo","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Ideno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Aso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuyuki","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenoki","family":"Ohuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Takahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhide","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ushijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinao","family":"Oda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Mizumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.surg.2014.09.013_bib1","series-title":"Atlas of tumor pathology, AFIP fourth series, fascicle 6","first-page":"75","article-title":"Tumors of the pancreas","author":"Hruban","year":"2007"},{"key":"10.1016\/j.surg.2014.09.013_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.pan.2012.04.004","article-title":"International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas","volume":"12","author":"Tanaka","year":"2012","journal-title":"Pancreatology"},{"key":"10.1016\/j.surg.2014.09.013_bib3","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/1097-0142(20011001)92:7<1807::AID-CNCR1697>3.0.CO;2-0","article-title":"Clonality and field cancerization in intraductal papillary-mucinous tumors of the pancreas","volume":"92","author":"Izawa","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.surg.2014.09.013_bib4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/00000658-199710000-00010","article-title":"Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas","volume":"226","author":"Z'graggen","year":"1997","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2014.09.013_bib5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/SLA.0b013e3182378a18","article-title":"Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas","volume":"255","author":"Matthaei","year":"2012","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2014.09.013_bib6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/SLA.0b013e3182a690ff","article-title":"Treatment strategy for main duct intraductal papillary mucinous neoplasms of the pancreas based on the assessment of recurrence in the remnant pancreas after resection: a retrospective review","volume":"259","author":"Tamura","year":"2014","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2014.09.013_bib7","doi-asserted-by":"crossref","first-page":"i6","DOI":"10.1136\/gut.2004.041525","article-title":"Barrett\u2019s oesophagus: from metaplasia to dysplasia and cancer","volume":"54","author":"Fl\u00e9jou","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.surg.2014.09.013_bib8","doi-asserted-by":"crossref","first-page":"92ra66","DOI":"10.1126\/scitranslmed.3002543","article-title":"Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development","volume":"3","author":"Wu","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.surg.2014.09.013_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/srep00161","article-title":"Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas","volume":"1","author":"Furukawa","year":"2011","journal-title":"Sci Rep"},{"key":"10.1016\/j.surg.2014.09.013_bib10","series-title":"World Health Organization classification of tumors, pathology and genetics of tumors of the digestive system","first-page":"304","article-title":"Intraductal papillary-mucinous neoplasms of the pancreas","author":"Adsay","year":"2010"},{"key":"10.1016\/j.surg.2014.09.013_bib11","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1002\/cncr.22301","article-title":"Role of intraoperative cytology combined with histology in detecting continuous and skip type intraductal cancer existence for intraductal papillary mucinous carcinoma of the pancreas","volume":"107","author":"Eguchi","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.surg.2014.09.013_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.surg.2013.06.059","article-title":"Intraoperative irrigation cytology of the remnant pancreas to detect remnant distinct pancreatic ductal adenocarcinoma in patients with intraductal papillary mucinous neoplasm undergoing partial pancreatectomy","volume":"155","author":"Mori","year":"2014","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.09.013_bib13","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/nature09515","article-title":"Distant metastasis occurs late during the genetic evolution of pancreatic cancer","volume":"467","author":"Yachida","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.surg.2014.09.013_bib14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11605-010-1411-8","article-title":"High-throughput mutation profiling in intraductal papillary mucinous neoplasm (IPMN)","volume":"15","author":"Lubezky","year":"2011","journal-title":"J\u00a0Gastrointest Surg"},{"key":"10.1016\/j.surg.2014.09.013_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2011.04.003","article-title":"Intraductal papillary mucinous neoplasm","volume":"43","author":"Shi","year":"2012","journal-title":"Hum Pathol"},{"key":"10.1016\/j.surg.2014.09.013_bib16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jhep.2011.07.018","article-title":"GNAS-activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation","volume":"56","author":"Nault","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.surg.2014.09.013_bib17","doi-asserted-by":"crossref","first-page":"21188","DOI":"10.1073\/pnas.1118046108","article-title":"Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways","volume":"108","author":"Wu","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.surg.2014.09.013_bib18","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1245\/s10434-013-3096-1","article-title":"Clinicopathological correlates of activating GNAS mutations in intraductal papillary mucinous neoplasm (IPMN) of the pancreas","volume":"20","author":"Dal Molin","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.surg.2014.09.013_bib19","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1136\/gutjnl-2012-302823","article-title":"Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts","volume":"62","author":"Kanda","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.surg.2014.09.013_bib20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/SLA.0b013e31828cd008","article-title":"Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype","volume":"258","author":"Ideno","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2014.09.013_bib21","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/SLA.0b013e318281b824","article-title":"Preoperative histological subtype classification of intraductal papillary mucinous neoplasms (IPMN) by pancreatic juice cytology with MUC stain","volume":"257","author":"Hara","year":"2013","journal-title":"Ann Surg"},{"key":"10.1016\/j.surg.2014.09.013_bib22","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1136\/gut.2010.232272","article-title":"Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes","volume":"60","author":"Mino-Kenudson","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.surg.2014.09.013_bib23","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.surg.2009.11.011","article-title":"Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type","volume":"147","author":"Sadakari","year":"2010","journal-title":"Surgery"},{"key":"10.1016\/j.surg.2014.09.013_bib24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/SLA.0b013e318287ab73","article-title":"Pathohistological subtype predicts survival in patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas","volume":"258","author":"Distler","year":"2013","journal-title":"Ann Surg"}],"container-title":["Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606014006059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0039606014006059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T23:57:41Z","timestamp":1538006261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0039606014006059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S0039606014006059"],"URL":"https:\/\/doi.org\/10.1016\/j.surg.2014.09.013","relation":{},"ISSN":["0039-6060"],"issn-type":[{"value":"0039-6060","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]}}}